PMC:6365940 / 22037-23918 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6365940","sourcedb":"PMC","sourceid":"6365940","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6365940","text":"Table 3 Effects of digoxin on the sensitivity of SW1990/Gem and Panc-1/Gem cells to different anticancer drugs.\nGroup SW1990/Gem Panc-1/Gem\nIC50 RF IC50 RF\nGemcitabine (μM) Control 519.59 ± 31.14 1 283.47 ± 21.7 1\nDigoxin 20 nM 98.55 ± 6.12 5.27 72.47 ± 6 3.91\nDigoxin 40 nM 37.18 ± 4.75 13.97 39.54 ± 4.61 7.17\nDigoxin 80 nM 14.5 ± 2.03 35.83 13.87 ± 2.16 20.43\n\u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028\nEtoposide (μM) Control 633.19 ± 40.77 1 445.82 ± 30.85 1\nDigoxin 20 nM 445.77 ± 22.04 1.42 327.28 ± 20.82 1.36\nDigoxin 40 nM 232.98 ± 18.38 2.72 172.46 ± 10.57 2.59\nDigoxin 80 nM 110.95 ± 13.63 5.71 119.34 ± 12.85 3.74\n\u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028\nPaclitaxel (nM) Control 293.07 ± 19.72 1 216.53 ± 16.27 1\nDigoxin 20 nM 209.57 ± 17.65 1.4 144.27 ± 11.57 1.5\nDigoxin 40 nM 61.04 ± 4.99 4.8 67.82 ± 4.05 3.19\nDigoxin 80 nM 35.77 ± 4.31 8.19 37.01 ± 4.99 5.85\n\u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028\nCisplatin (μM) Control 186.47 ± 11.41 1 155.53 ± 11.78 1\nDigoxin 20 nM 112.87 ± 8.52 1.65 107.17 ± 7.35 1.45\nDigoxin 40 nM 86.24 ± 6.39 2.16 68.15 ± 6.24 2.28\nDigoxin 80 nM 51.73 ± 6.28 3.6 58.44 ± 6.06 2.66\n\u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028\n5-FU (μM) Control 185.38 ± 14.67 1 168.39 ± 10.8 1\nDigoxin 20 nM 118.23 ± 10.08 1.57 110.88 ± 7.6 1.52\nDigoxin 40 nM 86.55 ± 7.17 2.14 73.46 ± 7.73 2.29\nDigoxin 80 nM 55.25 ± 7.06 3.36 38.89 ± 4.72 4.33\n\u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028\nAra-C (μM) Control 16.88 ± 1.15 1 10.93 ± 0.96 1\nDigoxin 20 nM 11.4 ± 1.07 1.48 8.5 ± 0.74 1.29\nDigoxin 40 nM 6.65 ± 0.5 2.54 4.66 ± 0.3 2.35\nDigoxin 80 nM 2.99 ± 0.32 5.65 1.61 ± 0.33 6.79\n\u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028 \u2028\u2028\nDoxorubicin (μM) Control 29.24 ± 2.74 1 24.4 ± 1.84 1\nDigoxin 20 nM 14.03 ± 1.54 2.08 15.02 ± 1.68 1.62\nDigoxin 40 nM 11.06 ± 1.19 2.64 10.82 ± 1.16 2.26\nDigoxin 80 nM 6.74 ± 0.47 4.34 7.52 ± 0.92 3.24\nEffects of digoxin on the sensitivity of SW1990/Gem and Panc-1/Gem cells to different anticancer drugs were detected by MTT assay. Data were expressed as mean ± SD of three independent 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