PMC:6354430 / 50599-51215 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6354430","sourcedb":"PMC","sourceid":"6354430","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6354430","text":"Conclusions\nThis study provides evidence that CSF1R signaling is critically important for cellular immunity during WNV neurotropic infection. Pharmacologic antagonism of CSF1R signaling limits expression of co-stimulatory signals through depletion of CNS cellular sources and decreased expression on peripheral APCS. This reduces local restimulation of antiviral CD8+ T cells within the CNS and results in loss of virologic control and increased mortality. These data raise important considerations regarding the use of CSF1R antagonists for the treatment of neurological disorders associated with neuroinflammation.","divisions":[{"label":"Title","span":{"begin":0,"end":11}}],"tracks":[]}