PMC:6323551 / 4928-5884 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6323551","sourcedb":"PMC","sourceid":"6323551","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6323551","text":"Previous networks based on gene-disease associations, such as the Human Disease Network, used gene-disease associations cataloged in the Online Mendelian Inheritance in Man (OMIM) database.11 Other studies have used summary statistics from the GWAS catalog and/or the Genetic Associations Database (GAD) to investigate SNP-phenotype associations by using network-based analyses.6 However, because these networks are based on summary statistics from disparate studies they have several critical limitations. First, differences in disease phenotype definitions across different studies can impact the interpretation of the association results,12 leading to a high false positive rate. Second, in most cases, networks constructed from summary statistics are limited to providing individual-level genotype and phenotype information. This limitation can restrict the design of follow-up studies conducted on the new hypotheses derived from the network analyses.","tracks":[{"project":"2_test","denotations":[{"id":"30598166-17502601-2050483","span":{"begin":189,"end":191},"obj":"17502601"},{"id":"30598166-25592579-2050484","span":{"begin":378,"end":379},"obj":"25592579"},{"id":"30598166-24026307-2050485","span":{"begin":641,"end":643},"obj":"24026307"}],"attributes":[{"subj":"30598166-17502601-2050483","pred":"source","obj":"2_test"},{"subj":"30598166-25592579-2050484","pred":"source","obj":"2_test"},{"subj":"30598166-24026307-2050485","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9493ec","default":true}]}]}}