PMC:6323551 / 18377-19749
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6323551","sourcedb":"PMC","sourceid":"6323551","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6323551","text":"Next, we focused on the disease nodes with the highest number of direct connections with other diseases in the network. The degree property (K) of the network represents the number of neighbors for each node. We observed that on average each disease shares direct links with seven other diseases (K = 7, Figure 3). With links to 32 diseases, hypothyroidism had the highest degree property (K = 32) in the network. In hypothyroidism, a disorder of the endocrine system, the thyroid gland does not produce enough thyroid hormones, and this deficiency can lead to the development of other diseases. Some comorbidities observed in the DDN were morbid obesity,32, 33 type 2 diabetes mellitus (MIM: 125853),34 vitamin D deficiency,35 hypertensive heart disease,36 thyroid cancer, and rheumatoid arthritis.37 On the other end of the scale, five diseases (blepharitis; “acute, but ill-defined, cerebrovascular disease; hyposmolality and/or hyponatremia; pain in joint; and goiter) had links to only one neighboring disease (K = 1). Thus, representing cross-phenotype associations in the form of networks enabled visualization of complex interconnections between different diseases.\nFigure 3 Disease Neighbors\nIn a network, the degree property is the number of direct connections between one node and other nodes. This plot presents the distribution of degrees observed in the DDN.","divisions":[{"label":"label","span":{"begin":1174,"end":1182}},{"label":"p","span":{"begin":1183,"end":1200}}],"tracks":[{"project":"2_test","denotations":[{"id":"30598166-27366725-2050504","span":{"begin":655,"end":657},"obj":"27366725"},{"id":"30598166-16487017-2050505","span":{"begin":659,"end":661},"obj":"16487017"},{"id":"30598166-23671867-2050506","span":{"begin":701,"end":703},"obj":"23671867"},{"id":"30598166-24533019-2050507","span":{"begin":725,"end":727},"obj":"24533019"},{"id":"30598166-24662620-2050508","span":{"begin":755,"end":757},"obj":"24662620"}],"attributes":[{"subj":"30598166-27366725-2050504","pred":"source","obj":"2_test"},{"subj":"30598166-16487017-2050505","pred":"source","obj":"2_test"},{"subj":"30598166-23671867-2050506","pred":"source","obj":"2_test"},{"subj":"30598166-24533019-2050507","pred":"source","obj":"2_test"},{"subj":"30598166-24662620-2050508","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#df93ec","default":true}]}]}}