PMC:6218809 / 5300-7151
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218809","sourcedb":"PMC","sourceid":"6218809","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218809","text":"Study Population, Samples, and Phenotypic Data\nThe study population is from the coastal village of Nyamisati in the Rufiji delta in Tanzania.29 Human genomic DNA was extracted from whole peripheral blood, as previously described,30 with informed consent from participants or their guardians and approval of the local ethics committees of the Muhimbili University of Health and Allied Sciences and National Institute of Medical Research in Tanzania and the Regional Ethical Committee of Stockholm in Sweden.\nPhenotypic data spanning 7 years, from 1993 to 1999, was collected using annual total population surveys and annual records of malarial episodes, as previously described.30 The total population survey provided information on asymptomatic parasite load (parasites per μL) and hemoglobin levels. A single hemoglobin value was generated for each individual from annual total population surveys carried out over 7 years, corrected for age, sex, and parasite load prior to genetic analysis. A single parasite load value was generated for each individual from asymptomatic parasitemia recorded during annual total population surveys carried out over 7 years. This single value was corrected for age and sex prior to genetic analysis.\nAll clinical malarial episodes were recorded and confirmed by microscopy. Multiple clinical episodes were recorded if the recurrence was greater than 4 weeks apart. A small proportion (1%) of individuals presented with a clinical episode at the time of the total population survey, and these samples were included in the analysis. A single clinical episode value was generated for each individual from records of all malarial episodes occurring in the village during a period of 7 years. The phenotypic data derived for clinical episodes, parasite load, and hemoglobin have previously been described in detail.30, 31","divisions":[{"label":"title","span":{"begin":0,"end":46}},{"label":"p","span":{"begin":47,"end":506}},{"label":"p","span":{"begin":507,"end":1234}}],"tracks":[{"project":"2_test","denotations":[{"id":"30388403-25423887-2049224","span":{"begin":141,"end":143},"obj":"25423887"},{"id":"30388403-19022401-2049225","span":{"begin":229,"end":231},"obj":"19022401"},{"id":"30388403-19022401-2049226","span":{"begin":677,"end":679},"obj":"19022401"},{"id":"30388403-19022401-2049227","span":{"begin":1845,"end":1847},"obj":"19022401"},{"id":"30388403-22484763-2049228","span":{"begin":1849,"end":1851},"obj":"22484763"}],"attributes":[{"subj":"30388403-25423887-2049224","pred":"source","obj":"2_test"},{"subj":"30388403-19022401-2049225","pred":"source","obj":"2_test"},{"subj":"30388403-19022401-2049226","pred":"source","obj":"2_test"},{"subj":"30388403-19022401-2049227","pred":"source","obj":"2_test"},{"subj":"30388403-22484763-2049228","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93eca8","default":true}]}]}}