PMC:6218809 / 4584-5276 JSONTXT

{"project":"2_test","denotations":[{"id":"30388403-28450586-2049222","span":{"begin":240,"end":241},"obj":"28450586"},{"id":"30388403-28450586-2049223","span":{"begin":480,"end":481},"obj":"28450586"}],"text":"A model for the DUP4 variant, based on analysis of mis-mapping positions of short-read sequences, was put forward that involved a duplication of the GYPE gene, deletion of the GYPB gene, and generation of two copies of a GYPB-A fusion gene.5 It is not clear exactly how the GYPB-A fusion protein confers protection against malaria, but it has been suggested that it could affect interactions with Plasmodium falciparum receptors and host band 3 protein at the erythrocyte surface.5 A complete characterization of the DUP4 allele is therefore important to understand the mechanistic basis for this protective effect and to facilitate design of treatments mimicking the mechanism of protection."}