PMC:6218809 / 3682-4583
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218809","sourcedb":"PMC","sourceid":"6218809","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218809","text":"Recent work studying the host genetic contribution to severe malaria identified a SNV allele at a nearby non-repeated region in linkage disequilibrium with a complex structural variant at the glycophorin locus protective against severe malaria.5, 20 This structural variant, called DUP4, is restricted to East African populations and is responsible for a glycophorin B-glycophorin A fusion gene product that is detected using serology as the blood group antigen Dantu NE+. This DUP4 variant confers a clinically important protective effect, with carriers ∼40% less likely to develop cerebral malaria.5 Given that glycophorin A and glycophorin B are erythrocyte receptors for the Plasmodium falciparum cell surface receptors MSP-1, EBA-175, and EBL-1, respectively, it is likely that this protective effect is mediated by an altered ability of the parasite to invade the host erythrocyte.25, 26, 27, 28","tracks":[{"project":"2_test","denotations":[{"id":"30388403-28450586-2049215","span":{"begin":244,"end":245},"obj":"28450586"},{"id":"30388403-26416757-2049216","span":{"begin":247,"end":249},"obj":"26416757"},{"id":"30388403-28450586-2049217","span":{"begin":600,"end":601},"obj":"28450586"},{"id":"30388403-1310320-2049218","span":{"begin":887,"end":889},"obj":"1310320"},{"id":"30388403-8009226-2049219","span":{"begin":891,"end":893},"obj":"8009226"},{"id":"30388403-19279206-2049220","span":{"begin":895,"end":897},"obj":"19279206"},{"id":"30388403-25778531-2049221","span":{"begin":899,"end":901},"obj":"25778531"}],"attributes":[{"subj":"30388403-28450586-2049215","pred":"source","obj":"2_test"},{"subj":"30388403-26416757-2049216","pred":"source","obj":"2_test"},{"subj":"30388403-28450586-2049217","pred":"source","obj":"2_test"},{"subj":"30388403-1310320-2049218","pred":"source","obj":"2_test"},{"subj":"30388403-8009226-2049219","pred":"source","obj":"2_test"},{"subj":"30388403-19279206-2049220","pred":"source","obj":"2_test"},{"subj":"30388403-25778531-2049221","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec9593","default":true}]}]}}