PMC:6218602 / 70542-71438 JSONTXT

{"project":"2_test","denotations":[{"id":"30425662-25468173-41865540","span":{"begin":140,"end":142},"obj":"25468173"},{"id":"30425662-20060103-41865540","span":{"begin":140,"end":142},"obj":"20060103"},{"id":"30425662-21791169-41865540","span":{"begin":140,"end":142},"obj":"21791169"},{"id":"30425662-22037126-41865541","span":{"begin":523,"end":526},"obj":"22037126"},{"id":"30425662-22581236-41865542","span":{"begin":528,"end":531},"obj":"22581236"},{"id":"30425662-26303936-41865543","span":{"begin":533,"end":536},"obj":"26303936"},{"id":"30425662-28638205-41865544","span":{"begin":654,"end":657},"obj":"28638205"},{"id":"30425662-28203084-41865545","span":{"begin":674,"end":677},"obj":"28203084"},{"id":"30425662-24465247-41865546","span":{"begin":700,"end":703},"obj":"24465247"},{"id":"30425662-22581236-41865547","span":{"begin":886,"end":889},"obj":"22581236"},{"id":"30425662-26088110-41865548","span":{"begin":891,"end":894},"obj":"26088110"}],"text":"Based on observations of the dysconnectivity of fronto-temporal circuits from functional neuroimaging studies of patients experiencing AVH (60–62), clinical studies have used tDCS to improve the dysconnectivity of these circuits to decrease AVH in patients with schizophrenia. In these studies, the anode electrode is applied over the left DLPFC (abnormally hypoactive) with the cathode electrode applied over the TPJ (abnormally hyperactive) to modulate the circuit and alleviate the severity of the AVH in schizophrenia (218, 221, 222). Results have been mixed in the ability of tDCS to reduce severity and frequency of AVH. For reviews see Li et al. (223), Ponde et al. (224), and Agarwal et al. (225). Studies that have reported a stronger and longer lasting response have had a higher number of treatment sessions and/or shorter time interval between sessions within their design (221, 226)."}