PMC:6218602 / 51072-52076 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218602","sourcedb":"PMC","sourceid":"6218602","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218602","text":"The amino acid glycine is a co-agonist of the NMDA receptor and it is required along with glutamate to activate the NMDA ion channel (139, 140). The binding site for glycine (located on the NR1 subunit) of the NMDA receptor was first discovered by Johnson and Ascher (1987) by preclinical electrophysiology studies using the outside-out patch clamp method. The NMDA receptor response was then observed to be potentiated by glycine. The distinct binding site (glycine B receptor) was separate from the strychnine-sensitive glycine inhibitory receptor as NMDA receptor potentiation by glycine was not blocked by strychnine (139). In clinical studies, reduced plasma concentrations of glycine have been found in patients with schizophrenia and have been correlated with a greater number of negative symptoms (141, 142), supporting the use of glycine as a strategy to improve NMDA receptor functioning in those patients identified as having treatment resistance specific to the negative symptom domain (138).","tracks":[{"project":"2_test","denotations":[{"id":"30425662-2433595-41865473","span":{"begin":134,"end":137},"obj":"2433595"},{"id":"30425662-2841759-41865474","span":{"begin":139,"end":142},"obj":"2841759"},{"id":"30425662-2433595-41865475","span":{"begin":622,"end":625},"obj":"2433595"},{"id":"30425662-14720317-41865476","span":{"begin":806,"end":809},"obj":"14720317"},{"id":"30425662-16135636-41865477","span":{"begin":811,"end":814},"obj":"16135636"}],"attributes":[{"subj":"30425662-2433595-41865473","pred":"source","obj":"2_test"},{"subj":"30425662-2841759-41865474","pred":"source","obj":"2_test"},{"subj":"30425662-2433595-41865475","pred":"source","obj":"2_test"},{"subj":"30425662-14720317-41865476","pred":"source","obj":"2_test"},{"subj":"30425662-16135636-41865477","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecbc","default":true}]}]}}