PMC:6218602 / 48624-49107 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218602","sourcedb":"PMC","sourceid":"6218602","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218602","text":"It is difficult to map the underlying circuit pathology in ultra-resistant schizophrenia due to the heterogeneity of the illness and limited studies that have explicitly examined this population. Due to multidimensional symptom domains resistant to clozapine, ultra-resistant schizophrenia can be described as the most severe phenotype of the illness that is mediated by multiple mechanisms far beyond dysregulated striatal hyperdopaminergia and glutamate NMDA receptor hypofunction.","tracks":[]}