PMC:6218602 / 45834-46438 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218602","sourcedb":"PMC","sourceid":"6218602","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218602","text":"Negative and cognitive symptom domain circuitry involves cortical brainstem glutamate projections that communicate within the mesocortical dopamine circuit. Glutamatergic projections from the cortex onto hypofunctioning NMDA glutamate receptors located on cortical parvalbumin+ interneurons leads to the excessive release of glutamate in the VTA. The excessive stimulation of pyramidal VTA neurons then leads to the inhibition (off circuit phenotype) of mesocortical dopamine neurons and insufficient dopamine release in the PFC and subsequent negative and cognitive symptoms in schizophrenia (130, 131).","tracks":[{"project":"2_test","denotations":[{"id":"30425662-14744162-41865463","span":{"begin":599,"end":602},"obj":"14744162"}],"attributes":[{"subj":"30425662-14744162-41865463","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#afec93","default":true}]}]}}