PMC:6218602 / 11054-12378 JSONTXT

{"project":"2_test","denotations":[{"id":"30425662-4572581-41865337","span":{"begin":632,"end":634},"obj":"4572581"},{"id":"30425662-11619863-41865338","span":{"begin":841,"end":843},"obj":"11619863"},{"id":"30425662-11619863-41865339","span":{"begin":1317,"end":1319},"obj":"11619863"},{"id":"30425662-29560880-41865339","span":{"begin":1317,"end":1319},"obj":"29560880"},{"id":"30425662-21106830-41865339","span":{"begin":1317,"end":1319},"obj":"21106830"},{"id":"30425662-23739835-41865339","span":{"begin":1317,"end":1319},"obj":"23739835"}],"text":"Theoretical models of disconnectivity and the investigation of connectomics and brain network organization have been examined in schizophrenia since the early nineteenth century. Historically, there have been a number of influential figures who have made major contributions to the development of modern day network-based science known as connectomics. One of the very first connectionist pioneers in psychiatry was Wilhelm Griesinger (1817–1868), a German neurologist and psychiatrist who initially proposed that mental illnesses are brain disorders with pathological and neuroanatomical origins similar to neurological disorders (17). From his teachings, his student Theodor Hermann Meynert (1833–1892), a German-Austrian neuropathologist, anatomist and psychiatrist, made further contributions to this biological model of mental illness (18). His work was based primarily on neuroanatomical and histological studies where he worked to characterize various afferent and efferent white matter (WM) fiber tracts of the cerebral cortex. Meynert believed that association fibers connecting regional areas of the brain are the most disrupted in psychiatric diseases, which has been consistently demonstrated by several structural and functional magnetic resonance imaging (MRI) studies of schizophrenia in recent times (18–21)."}