PMC:6194691 / 99487-100067 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"It is often said that transport of lactate across the blood–brain barrier is slow (see e.g. Pardridge’s account [189]). But these statements refer to the amounts transported not the permeability. The lactate clearance (= PS product) calculated for low concentrations from the kinetic constants that Pardridge presents, Kt = 1.8 mM and Tmax = 91 nmol g−1 min−1, is 50 µL g−1 min−1, close to that stated above. Quistorff et al. [353] and Boumezbeur et al. [352] have emphasized that lactate from the periphery can be an important source of energy in the brain during heavy exercise.","tracks":[{"project":"MyTest","denotations":[{"id":"30340614-6361813-30706286","span":{"begin":113,"end":116},"obj":"6361813"},{"id":"30340614-18653766-30706287","span":{"begin":427,"end":430},"obj":"18653766"},{"id":"30340614-20962220-30706288","span":{"begin":455,"end":458},"obj":"20962220"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"30340614-6361813-30706286","pred":"source","obj":"MyTest"},{"subj":"30340614-18653766-30706287","pred":"source","obj":"MyTest"},{"subj":"30340614-20962220-30706288","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"30340614-6361813-30706286","span":{"begin":113,"end":116},"obj":"6361813"},{"id":"30340614-18653766-30706287","span":{"begin":427,"end":430},"obj":"18653766"},{"id":"30340614-20962220-30706288","span":{"begin":455,"end":458},"obj":"20962220"}],"attributes":[{"subj":"30340614-6361813-30706286","pred":"source","obj":"2_test"},{"subj":"30340614-18653766-30706287","pred":"source","obj":"2_test"},{"subj":"30340614-20962220-30706288","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93dbec","default":true},{"id":"2_test","color":"#ece393"}]}]}}