PMC:6194691 / 98671-99486 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-27799072-30706282","span":{"begin":270,"end":271},"obj":"27799072"},{"id":"30340614-24989463-30706283","span":{"begin":598,"end":601},"obj":"24989463"},{"id":"30340614-25130422-30706284","span":{"begin":603,"end":606},"obj":"25130422"},{"id":"30340614-4266858-30706285","span":{"begin":718,"end":721},"obj":"4266858"},{"id":"30340614-2050746-30706285","span":{"begin":718,"end":721},"obj":"2050746"},{"id":"30340614-20962220-30706285","span":{"begin":718,"end":721},"obj":"20962220"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"When at rest and even more during nervous activity, there is net production of lactate within the brain parenchyma and thus there must be means for its efflux. Clearance of lactate from the brain has recently been reviewed in some detail [146] (see also footnote 26 in [4]). In brief lactic acid is transported across the blood–brain barrier by passive transport mediated by MCT1 (SLC16A1) present in both luminal and abluminal membranes. Lactate both enters and leaves the brain by this route. Lactate is generated within the brain by partial metabolism of glucose and by metabolism of glutamate [347, 348]). Under resting conditions when lactate concentrations are low, the clearance, CL = PS ~ 60–100 µL g−1 min−1 [349–352], far exceeds the expected clearance, ~ 1 µL g−1 min−1, by a strictly perivascular route."}

{"project":"2_test","denotations":[{"id":"30340614-27799072-30706282","span":{"begin":270,"end":271},"obj":"27799072"},{"id":"30340614-24989463-30706283","span":{"begin":598,"end":601},"obj":"24989463"},{"id":"30340614-25130422-30706284","span":{"begin":603,"end":606},"obj":"25130422"},{"id":"30340614-4266858-30706285","span":{"begin":718,"end":721},"obj":"4266858"},{"id":"30340614-2050746-30706285","span":{"begin":718,"end":721},"obj":"2050746"},{"id":"30340614-20962220-30706285","span":{"begin":718,"end":721},"obj":"20962220"}],"text":"When at rest and even more during nervous activity, there is net production of lactate within the brain parenchyma and thus there must be means for its efflux. Clearance of lactate from the brain has recently been reviewed in some detail [146] (see also footnote 26 in [4]). In brief lactic acid is transported across the blood–brain barrier by passive transport mediated by MCT1 (SLC16A1) present in both luminal and abluminal membranes. Lactate both enters and leaves the brain by this route. Lactate is generated within the brain by partial metabolism of glucose and by metabolism of glutamate [347, 348]). Under resting conditions when lactate concentrations are low, the clearance, CL = PS ~ 60–100 µL g−1 min−1 [349–352], far exceeds the expected clearance, ~ 1 µL g−1 min−1, by a strictly perivascular route."}