PMC:6194691 / 93169-93897 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"In one of the first attempts to establish the mechanism of glucose transport at the blood–brain barrier, Buschiazzo et al. [319] found that 3-O-methyl-d-glucose, a non-metabolizable derivative of glucose, competes with glucose for transport, and furthermore that an inward gradient of glucose could drive 3-O-methyl-d-glucose uphill out of the brain, i.e. there is counter-transport for GLUT1 at the blood–brain barrier just as in red blood cells. Further evidence that GLUT1 behaves in a similar manner in the two environments was obtained by Betz et al. [327] who found that the rate of glucose influx was increased by increasing the concentration of glucose within the brain, i.e. there is trans-stimulation (see Appendix D).","tracks":[{"project":"MyTest","denotations":[{"id":"30340614-5473139-30706265","span":{"begin":124,"end":127},"obj":"5473139"},{"id":"30340614-1182146-30706266","span":{"begin":557,"end":560},"obj":"1182146"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"30340614-5473139-30706265","pred":"source","obj":"MyTest"},{"subj":"30340614-1182146-30706266","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"30340614-5473139-30706265","span":{"begin":124,"end":127},"obj":"5473139"},{"id":"30340614-1182146-30706266","span":{"begin":557,"end":560},"obj":"1182146"}],"attributes":[{"subj":"30340614-5473139-30706265","pred":"source","obj":"2_test"},{"subj":"30340614-1182146-30706266","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ec93ac","default":true},{"id":"2_test","color":"#93c6ec"}]}]}}