PMC:6194691 / 252211-253000 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"15 There has been a claim that \"The glymphatic [perivascular] pathway is important for the brain-wide delivery of nutrients, specifically glucose\" [109]. This was based on results presented by Lundgaard et al. [629] for movements of a near-infrared 2-deoxyglucose probe (2DG-IR). However, Lundgaard et al. showed that 2DG-IR could not be delivered across the blood–brain barrier and thus it is at best a poor substrate for GLUT1. Since GLUT1 is essential for the normal entry and distribution of glucose, the results for 2DG-IR cannot be used to infer the relative importance of the blood–brain barrier and perivascular routes for the distribution of glucose. Petit and Magistretti [344] have also criticized the use of 2DG-IR as a probe for glucose movements into astrocytes and neurons.","divisions":[{"label":"label","span":{"begin":0,"end":2}}],"tracks":[]}