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{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"TfR has been shown to be accessible to antibodies on both surfaces of the endothelial cells [280, 624]. This suggests that transferrin could bind to or dissociate from TfR on either side. Furthermore there is effective transfer across the blood–brain barrier of low-affinity antibodies to TfR [625], which strongly suggests that there can be transcytosis of substances bound to the TfR.","tracks":[]}