PMC:6194691 / 246983-247507 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"The polar headgroups of lipid membranes produce a large dipole potential (membrane core positive) which favours permeation of anions over cations (see e.g. [529, 614–619]. None of the descriptors that are suitable for describing neutral molecules can be expected to allow the LFER approach to be able to cope with this difference. It is thus not at all surprising that when Abraham came to consider charged molecules explicitly, he found it necessary to introduce descriptors that allow for the charge on the molecule [168].","tracks":[]}