PMC:6194691 / 237409-238688 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"The limitation of movements from cisterna magna towards the IIIrd ventricle occurs presumably because the volume displaced in the to and fro fluid movements through the cerebral aqueduct [7, 602] is too small for efficient transfer of solutes. More movement occurs in the opposite direction as a consequence of net flow. However, Vartan Kurtcuoglu (personal communication) has pointed out that simulation of the convective mixing in the IIIrd ventricle and aqueduct indicates that the transient jet of fluid entering the IIIrd ventricle from the aqueduct in each cardiac cycle (see the sub-figures for 0.2 T and 0.3 T in Figure 8 of [8]) is as long as the aqueduct itself implying that some transfer from the IVth to the IIIrd ventricle should occur. The data reported by Ringstad et al. [15] indicate that gadobutrol added to lumbar CSF does reach the IIIrd ventricle in control patients, but at a low concentration, while the concentration seen in patients with idiopathic normal pressure hydrocephalus is substantially higher. This is consistent with the view that the net flow through the aqueduct is normally from IIIrd to IVth ventricle but in communicating hydrocephalus it is reversed in direction (for references, review and discussion see sections 4.2.2–4.2.5 in [41]).","tracks":[]}