PMC:6194691 / 23223-24095 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-29023798-30705931","span":{"begin":141,"end":143},"obj":"29023798"},{"id":"30340614-18208483-30705932","span":{"begin":145,"end":147},"obj":"18208483"},{"id":"30340614-13760238-30705933","span":{"begin":149,"end":151},"obj":"13760238"},{"id":"30340614-23489283-30705934","span":{"begin":153,"end":156},"obj":"23489283"},{"id":"30340614-18208483-30705935","span":{"begin":339,"end":341},"obj":"18208483"},{"id":"30340614-29754206-30705936","span":{"begin":343,"end":345},"obj":"29754206"},{"id":"30340614-26975356-30705937","span":{"begin":347,"end":349},"obj":"26975356"},{"id":"30340614-23818064-30705938","span":{"begin":550,"end":552},"obj":"23818064"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"It is quite evident that solutes even as large as amyloid-β have access to the basement membranes between the smooth muscle cells (see e.g. [16, 70, 93, 102]), but it is not known whether the solutes reach these locations via an intramural route with movement along basement membranes as favoured by Carare, Weller, Hawkes and colleagues [70, 88, 95] or via extramural pathways with subsequent penetration from these into the basement membranes within the vessel wall (see Figure 21 in Sect. 5.7.1.2) or some mixture of the two. Arbel-Ornath et al. [87] used two-photon imaging to investigate the position of a 3 kDa fluorescent dextran during efflux following injection into the parenchyma. Shortly after injection they saw fluorescence within the parenchyma, in perivascular spaces surrounding small arteries and, at lower concentration, between the smooth muscle cells."}

{"project":"2_test","denotations":[{"id":"30340614-29023798-30705931","span":{"begin":141,"end":143},"obj":"29023798"},{"id":"30340614-18208483-30705932","span":{"begin":145,"end":147},"obj":"18208483"},{"id":"30340614-13760238-30705933","span":{"begin":149,"end":151},"obj":"13760238"},{"id":"30340614-23489283-30705934","span":{"begin":153,"end":156},"obj":"23489283"},{"id":"30340614-18208483-30705935","span":{"begin":339,"end":341},"obj":"18208483"},{"id":"30340614-29754206-30705936","span":{"begin":343,"end":345},"obj":"29754206"},{"id":"30340614-26975356-30705937","span":{"begin":347,"end":349},"obj":"26975356"},{"id":"30340614-23818064-30705938","span":{"begin":550,"end":552},"obj":"23818064"}],"text":"It is quite evident that solutes even as large as amyloid-β have access to the basement membranes between the smooth muscle cells (see e.g. [16, 70, 93, 102]), but it is not known whether the solutes reach these locations via an intramural route with movement along basement membranes as favoured by Carare, Weller, Hawkes and colleagues [70, 88, 95] or via extramural pathways with subsequent penetration from these into the basement membranes within the vessel wall (see Figure 21 in Sect. 5.7.1.2) or some mixture of the two. Arbel-Ornath et al. [87] used two-photon imaging to investigate the position of a 3 kDa fluorescent dextran during efflux following injection into the parenchyma. Shortly after injection they saw fluorescence within the parenchyma, in perivascular spaces surrounding small arteries and, at lower concentration, between the smooth muscle cells."}