PMC:6194691 / 189181-189904 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-23434588-30706599","span":{"begin":232,"end":235},"obj":"23434588"},{"id":"30340614-23812703-30706600","span":{"begin":429,"end":432},"obj":"23812703"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The recent explosion of interest in perivascular routes for delivery to and removal of substances from the parenchyma stems largely from observations made using two photon fluorescence microscopy and magnetic resonance imaging [25, 526]. These led to the proposal that there is a “glymphatic pathway” through which CSF flows into and within the parenchyma propelling “the waste products of metabolism into the paravenous space” [136]. As discussed in this review there is convincing evidence for perivascular routes of access to the parenchyma from CSF and also exit from the parenchyma to CSF and/or lymph. However, the balance of available evidence does not support a “glymphatic pathway” for flow through the parenchyma."}

{"project":"2_test","denotations":[{"id":"30340614-23434588-30706599","span":{"begin":232,"end":235},"obj":"23434588"},{"id":"30340614-23812703-30706600","span":{"begin":429,"end":432},"obj":"23812703"}],"text":"The recent explosion of interest in perivascular routes for delivery to and removal of substances from the parenchyma stems largely from observations made using two photon fluorescence microscopy and magnetic resonance imaging [25, 526]. These led to the proposal that there is a “glymphatic pathway” through which CSF flows into and within the parenchyma propelling “the waste products of metabolism into the paravenous space” [136]. As discussed in this review there is convincing evidence for perivascular routes of access to the parenchyma from CSF and also exit from the parenchyma to CSF and/or lymph. However, the balance of available evidence does not support a “glymphatic pathway” for flow through the parenchyma."}