PMC:6194691 / 172490-173471
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"CMRglc of stimulated nervous tissue isn’t easy to measure, partly because a region large enough to assay is likely to contain both stimulated and unstimulated tissue. Using quantitative autoradiography in rats exposed to monotonic sounds, Cruz et al. [517] were able to see as much as 85% increase in CMRglc in tonotopic bands of the inferior colliculus. Using PET imaging in human subjects viewing a reversing checkerboard pattern, Fox et al. [518] saw 50% increases in the visual cortex. Using measured arterio-venous concentration differences in human volunteers undergoing exhausting cycling or rowing exercise, Quistorff et al. ([353], data from [519]) found more than twofold increases in glucose uptake rate across the blood–brain barrier. (There was also a substantial uptake of lactate). From these and other studies, in order to support nervous activity it must be possible to increase the net flux across the blood–brain barrier by at least twofold within a few minutes.","tracks":[{"project":"MyTest","denotations":[{"id":"30340614-17265468-30706545","span":{"begin":252,"end":255},"obj":"17265468"},{"id":"30340614-3260686-30706546","span":{"begin":445,"end":448},"obj":"3260686"},{"id":"30340614-18653766-30706547","span":{"begin":635,"end":638},"obj":"18653766"},{"id":"30340614-14608005-30706548","span":{"begin":652,"end":655},"obj":"14608005"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"30340614-17265468-30706545","pred":"source","obj":"MyTest"},{"subj":"30340614-3260686-30706546","pred":"source","obj":"MyTest"},{"subj":"30340614-18653766-30706547","pred":"source","obj":"MyTest"},{"subj":"30340614-14608005-30706548","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"30340614-17265468-30706545","span":{"begin":252,"end":255},"obj":"17265468"},{"id":"30340614-3260686-30706546","span":{"begin":445,"end":448},"obj":"3260686"},{"id":"30340614-18653766-30706547","span":{"begin":635,"end":638},"obj":"18653766"},{"id":"30340614-14608005-30706548","span":{"begin":652,"end":655},"obj":"14608005"}],"attributes":[{"subj":"30340614-17265468-30706545","pred":"source","obj":"2_test"},{"subj":"30340614-3260686-30706546","pred":"source","obj":"2_test"},{"subj":"30340614-18653766-30706547","pred":"source","obj":"2_test"},{"subj":"30340614-14608005-30706548","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ec93bc","default":true},{"id":"2_test","color":"#93d6ec"}]}]}}