PMC:6194691 / 171103-171918 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-17659523-30706543","span":{"begin":658,"end":661},"obj":"17659523"},{"id":"30340614-17579656-30706544","span":{"begin":683,"end":686},"obj":"17579656"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"There is regulation of transport across the blood–brain barrier both for glucose and for ions like Na+, K+ or Cl−. Regulation of glucose transport serves primarily to achieve the correct flux to support metabolism whereas regulation of ion transport is important to maintain the correct concentrations in extracellular fluid. The actual glucose concentration in ISF is relatively unimportant so long as it remains well above the Km for hexokinase (0.04–0.05 mM, see Sect. 5.3) but low enough to avoid formation of unwanted glycation products. The requirements for the regulation of the glucose transporter, GLUT1, were considered in detail by Barros et al. [314] and Simpson et al. [315]. Thus this section considers only the principles and the extent to which regulation can be obtained by altering glucose efflux."}

{"project":"2_test","denotations":[{"id":"30340614-17659523-30706543","span":{"begin":658,"end":661},"obj":"17659523"},{"id":"30340614-17579656-30706544","span":{"begin":683,"end":686},"obj":"17579656"}],"text":"There is regulation of transport across the blood–brain barrier both for glucose and for ions like Na+, K+ or Cl−. Regulation of glucose transport serves primarily to achieve the correct flux to support metabolism whereas regulation of ion transport is important to maintain the correct concentrations in extracellular fluid. The actual glucose concentration in ISF is relatively unimportant so long as it remains well above the Km for hexokinase (0.04–0.05 mM, see Sect. 5.3) but low enough to avoid formation of unwanted glycation products. The requirements for the regulation of the glucose transporter, GLUT1, were considered in detail by Barros et al. [314] and Simpson et al. [315]. Thus this section considers only the principles and the extent to which regulation can be obtained by altering glucose efflux."}