PMC:6194691 / 151981-152685 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-8633046-30706498","span":{"begin":319,"end":322},"obj":"8633046"},{"id":"30340614-9042383-30706498","span":{"begin":319,"end":322},"obj":"9042383"},{"id":"30340614-10936885-30706498","span":{"begin":319,"end":322},"obj":"10936885"},{"id":"30340614-17077814-30706499","span":{"begin":388,"end":391},"obj":"17077814"},{"id":"30340614-22751174-30706500","span":{"begin":393,"end":396},"obj":"22751174"},{"id":"30340614-17694066-30706501","span":{"begin":699,"end":702},"obj":"17694066"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The receptor for advanced glycation end products (RAGE) mediates transport of Aβ from blood-to-brain. Aβ-clusterin blood-to-brain transport by LRP2 can also be demonstrated under experimental conditions, however, in vivo it is likely that the Aβ-clusterin complexes are out-competed by clusterin for inwards transport [470–472]. The net flux of complexes via LRP2 is thus brain-to-blood [429, 464]. sLRP1 is released from LRP1 at the luminal membrane by removal of the membrane binding domain. Aβ complexes with sLRP1 are apparently not transported across the blood–brain barrier but can be delivered to the liver. Thus these serve as a sink reducing backflux of Aβ that has emerged from the brain [469]."}

{"project":"2_test","denotations":[{"id":"30340614-8633046-30706498","span":{"begin":319,"end":322},"obj":"8633046"},{"id":"30340614-9042383-30706498","span":{"begin":319,"end":322},"obj":"9042383"},{"id":"30340614-10936885-30706498","span":{"begin":319,"end":322},"obj":"10936885"},{"id":"30340614-17077814-30706499","span":{"begin":388,"end":391},"obj":"17077814"},{"id":"30340614-22751174-30706500","span":{"begin":393,"end":396},"obj":"22751174"},{"id":"30340614-17694066-30706501","span":{"begin":699,"end":702},"obj":"17694066"}],"text":"The receptor for advanced glycation end products (RAGE) mediates transport of Aβ from blood-to-brain. Aβ-clusterin blood-to-brain transport by LRP2 can also be demonstrated under experimental conditions, however, in vivo it is likely that the Aβ-clusterin complexes are out-competed by clusterin for inwards transport [470–472]. The net flux of complexes via LRP2 is thus brain-to-blood [429, 464]. sLRP1 is released from LRP1 at the luminal membrane by removal of the membrane binding domain. Aβ complexes with sLRP1 are apparently not transported across the blood–brain barrier but can be delivered to the liver. Thus these serve as a sink reducing backflux of Aβ that has emerged from the brain [469]."}