PMC:6194691 / 136317-136877 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-9580550-30706429","span":{"begin":34,"end":37},"obj":"9580550"},{"id":"30340614-25446623-30706430","span":{"begin":253,"end":256},"obj":"25446623"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"As already mentioned, Lee et al. [360] found that brain endothelial cells have glutaminase activity, and thus following glutamine transport from ISF into the cells, at least some of the glutamine will be broken down to glutamate and NH4+. Helms et al. [391, 392] have suggested that some of the glutamate can be metabolized further releasing more NH4+. As a consequence of metabolism within the endothelial cells, glutamine removal from the parenchyma and glutamine appearance in plasma need not be the same. Glutamine net flux cannot be assessed in isolation."}

{"project":"2_test","denotations":[{"id":"30340614-9580550-30706429","span":{"begin":34,"end":37},"obj":"9580550"},{"id":"30340614-25446623-30706430","span":{"begin":253,"end":256},"obj":"25446623"}],"text":"As already mentioned, Lee et al. [360] found that brain endothelial cells have glutaminase activity, and thus following glutamine transport from ISF into the cells, at least some of the glutamine will be broken down to glutamate and NH4+. Helms et al. [391, 392] have suggested that some of the glutamate can be metabolized further releasing more NH4+. As a consequence of metabolism within the endothelial cells, glutamine removal from the parenchyma and glutamine appearance in plasma need not be the same. Glutamine net flux cannot be assessed in isolation."}