PMC:6194691 / 130715-131980 JSONTXT

{"project":"MyTest","denotations":[{"id":"30340614-10518579-30706414","span":{"begin":169,"end":172},"obj":"10518579"},{"id":"30340614-11083230-30706414","span":{"begin":169,"end":172},"obj":"11083230"},{"id":"30340614-11095508-30706414","span":{"begin":169,"end":172},"obj":"11095508"},{"id":"30340614-13940861-30706415","span":{"begin":257,"end":260},"obj":"13940861"},{"id":"30340614-14109206-30706416","span":{"begin":262,"end":265},"obj":"14109206"},{"id":"30340614-9726963-30706417","span":{"begin":299,"end":302},"obj":"9726963"},{"id":"30340614-11847106-30706417","span":{"begin":299,"end":302},"obj":"11847106"},{"id":"30340614-12634921-30706417","span":{"begin":299,"end":302},"obj":"12634921"},{"id":"30340614-29593549-30706418","span":{"begin":391,"end":394},"obj":"29593549"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The large influxes of neutral amino acids from blood-to-brain seen in the early work and ascribed to system L have subsequently been shown to be mediated by 4F2hc/Lat1 [401–403]. The discovery that not only can this system mediate exchanges of amino acids [404, 405] but the exchange is obligatory [406–408] has far reaching consequences for amino acid transport at the blood–brain barrier [409]. It provides an important part of the explanation for how it is that there are large unidirectional fluxes (influx and efflux) but only small net fluxes. In order for system L to mediate a net inward flux of one amino acid, it must have net outward flux of another. An exchanger of neutral solutes, like system L, tends to equilibrate the concentration ratios for all of its substrates. Thus predicting the flux of any one of the amino acids across a membrane requires knowledge of the concentrations of all of the substrates on both sides of the membrane.20 Consumption of any system L substrate within the parenchyma will by reducing its ISF concentration tend to lead to net inward flux of that substrate and net outward flux of others. Similarly production of any system L substrate will tend to lead to its net outward flux together with net inward flux of others."}

{"project":"2_test","denotations":[{"id":"30340614-10518579-30706414","span":{"begin":169,"end":172},"obj":"10518579"},{"id":"30340614-11083230-30706414","span":{"begin":169,"end":172},"obj":"11083230"},{"id":"30340614-11095508-30706414","span":{"begin":169,"end":172},"obj":"11095508"},{"id":"30340614-13940861-30706415","span":{"begin":257,"end":260},"obj":"13940861"},{"id":"30340614-14109206-30706416","span":{"begin":262,"end":265},"obj":"14109206"},{"id":"30340614-9726963-30706417","span":{"begin":299,"end":302},"obj":"9726963"},{"id":"30340614-11847106-30706417","span":{"begin":299,"end":302},"obj":"11847106"},{"id":"30340614-12634921-30706417","span":{"begin":299,"end":302},"obj":"12634921"},{"id":"30340614-29593549-30706418","span":{"begin":391,"end":394},"obj":"29593549"}],"text":"The large influxes of neutral amino acids from blood-to-brain seen in the early work and ascribed to system L have subsequently been shown to be mediated by 4F2hc/Lat1 [401–403]. The discovery that not only can this system mediate exchanges of amino acids [404, 405] but the exchange is obligatory [406–408] has far reaching consequences for amino acid transport at the blood–brain barrier [409]. It provides an important part of the explanation for how it is that there are large unidirectional fluxes (influx and efflux) but only small net fluxes. In order for system L to mediate a net inward flux of one amino acid, it must have net outward flux of another. An exchanger of neutral solutes, like system L, tends to equilibrate the concentration ratios for all of its substrates. Thus predicting the flux of any one of the amino acids across a membrane requires knowledge of the concentrations of all of the substrates on both sides of the membrane.20 Consumption of any system L substrate within the parenchyma will by reducing its ISF concentration tend to lead to net inward flux of that substrate and net outward flux of others. Similarly production of any system L substrate will tend to lead to its net outward flux together with net inward flux of others."}