PMC:6039596 / 1985-3085 JSONTXT

{"project":"2_test","denotations":[{"id":"29952992-15956972-68408827","span":{"begin":348,"end":349},"obj":"15956972"},{"id":"29952992-24457040-68408828","span":{"begin":470,"end":471},"obj":"24457040"},{"id":"29952992-16890287-68408829","span":{"begin":553,"end":554},"obj":"16890287"},{"id":"29952992-19960343-68408830","span":{"begin":788,"end":789},"obj":"19960343"},{"id":"29952992-22213860-68408830","span":{"begin":788,"end":789},"obj":"22213860"},{"id":"29952992-25556492-68408830","span":{"begin":788,"end":789},"obj":"25556492"},{"id":"29952992-27464795-68408830","span":{"begin":788,"end":789},"obj":"27464795"},{"id":"29952992-26954070-68408830","span":{"begin":788,"end":789},"obj":"26954070"},{"id":"29952992-16843501-68408831","span":{"begin":1094,"end":1096},"obj":"16843501"},{"id":"29952992-14724582-68408832","span":{"begin":1097,"end":1099},"obj":"14724582"}],"text":"The single nucleotide polymorphism (SNP) is the most common form of human genetic variations. A growing number of studies reported that specific SNPs locus in DNA repair gene would affect the expression or activity of certain enzymes and the ability to repair damage. Defects in DNA repair gene may lead to genetic instability and tumorigenesis.[1,2] The human RAD51 gene, located on chromosome 15q15.1, is an essential member in the DNA repair of double-strand breaks.[3] There are 2 kinds of SNPs in RAD51 gene (rs1801320), namely, 153G/C and 172G/T.[4] Of the 2, RAD51 153G/C is more common and there have been numerous reports evaluating the association between RAD51 153G/C and non small cell lung cancer, myeloid leukemia, head and neck cancer, esophagus cancer, and breast cancer.[5–12] The potential carcinogenic mechanism of RAD51 153G/C is to affect the splitting, transcription, translation efficiency, and stability of mRNA through the combination of regulatory elements with 5’-UTR, and finally leads to changes in polypeptide product level and causes changes in protein function.[13,14]"}

{"project":"PubTator4TogoVar","denotations":[{"id":"13441","span":{"begin":514,"end":523},"obj":"SNP"}],"attributes":[{"id":"A13441","pred":"resolved_to","subj":"13441","obj":"tmVar:rs1801320;VariantGroup:0;CorrespondingGene:5888;RS#:1801320;CorrespondingSpecies:9606"}],"text":"The single nucleotide polymorphism (SNP) is the most common form of human genetic variations. A growing number of studies reported that specific SNPs locus in DNA repair gene would affect the expression or activity of certain enzymes and the ability to repair damage. Defects in DNA repair gene may lead to genetic instability and tumorigenesis.[1,2] The human RAD51 gene, located on chromosome 15q15.1, is an essential member in the DNA repair of double-strand breaks.[3] There are 2 kinds of SNPs in RAD51 gene (rs1801320), namely, 153G/C and 172G/T.[4] Of the 2, RAD51 153G/C is more common and there have been numerous reports evaluating the association between RAD51 153G/C and non small cell lung cancer, myeloid leukemia, head and neck cancer, esophagus cancer, and breast cancer.[5–12] The potential carcinogenic mechanism of RAD51 153G/C is to affect the splitting, transcription, translation efficiency, and stability of mRNA through the combination of regulatory elements with 5’-UTR, and finally leads to changes in polypeptide product level and causes changes in protein function.[13,14]"}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"13441","span":{"begin":514,"end":523},"obj":"SNP"},{"id":"T1","span":{"begin":514,"end":523},"obj":"SNP"}],"attributes":[{"id":"A13441","pred":"resolved_to","subj":"13441","obj":"tmVar:rs1801320;VariantGroup:0;CorrespondingGene:5888;RS#:1801320;CorrespondingSpecies:9606"}],"text":"The single nucleotide polymorphism (SNP) is the most common form of human genetic variations. A growing number of studies reported that specific SNPs locus in DNA repair gene would affect the expression or activity of certain enzymes and the ability to repair damage. Defects in DNA repair gene may lead to genetic instability and tumorigenesis.[1,2] The human RAD51 gene, located on chromosome 15q15.1, is an essential member in the DNA repair of double-strand breaks.[3] There are 2 kinds of SNPs in RAD51 gene (rs1801320), namely, 153G/C and 172G/T.[4] Of the 2, RAD51 153G/C is more common and there have been numerous reports evaluating the association between RAD51 153G/C and non small cell lung cancer, myeloid leukemia, head and neck cancer, esophagus cancer, and breast cancer.[5–12] The potential carcinogenic mechanism of RAD51 153G/C is to affect the splitting, transcription, translation efficiency, and stability of mRNA through the combination of regulatory elements with 5’-UTR, and finally leads to changes in polypeptide product level and causes changes in protein function.[13,14]"}