PMC:6019327 / 95153-95913
Annnotations
2_test
{"project":"2_test","denotations":[{"id":"28506916-18988654-29307509","span":{"begin":220,"end":223},"obj":"18988654"},{"id":"28506916-18988654-29307509","span":{"begin":220,"end":223},"obj":"18988654"},{"id":"28506916-18426850-29307510","span":{"begin":318,"end":321},"obj":"18426850"},{"id":"28506916-18426850-29307510","span":{"begin":318,"end":321},"obj":"18426850"},{"id":"28506916-24496537-29307511","span":{"begin":380,"end":383},"obj":"24496537"},{"id":"28506916-24496537-29307511","span":{"begin":380,"end":383},"obj":"24496537"},{"id":"28506916-21173356-29307512","span":{"begin":515,"end":518},"obj":"21173356"},{"id":"28506916-21173356-29307512","span":{"begin":515,"end":518},"obj":"21173356"},{"id":"28506916-17311809-29307513","span":{"begin":602,"end":605},"obj":"17311809"},{"id":"28506916-17311809-29307513","span":{"begin":602,"end":605},"obj":"17311809"},{"id":"28506916-23383330-29307514","span":{"begin":757,"end":760},"obj":"23383330"},{"id":"28506916-23383330-29307514","span":{"begin":757,"end":760},"obj":"23383330"},{"id":"T66169","span":{"begin":220,"end":223},"obj":"18988654"},{"id":"T62093","span":{"begin":220,"end":223},"obj":"18988654"},{"id":"T29752","span":{"begin":318,"end":321},"obj":"18426850"},{"id":"T69379","span":{"begin":318,"end":321},"obj":"18426850"},{"id":"T83138","span":{"begin":380,"end":383},"obj":"24496537"},{"id":"T78817","span":{"begin":380,"end":383},"obj":"24496537"},{"id":"T15419","span":{"begin":515,"end":518},"obj":"21173356"},{"id":"T45083","span":{"begin":515,"end":518},"obj":"21173356"},{"id":"T68867","span":{"begin":602,"end":605},"obj":"17311809"},{"id":"T22195","span":{"begin":602,"end":605},"obj":"17311809"},{"id":"T84525","span":{"begin":757,"end":760},"obj":"23383330"},{"id":"T77738","span":{"begin":757,"end":760},"obj":"23383330"},{"id":"T48531","span":{"begin":220,"end":223},"obj":"18988654"},{"id":"T14300","span":{"begin":220,"end":223},"obj":"18988654"},{"id":"T6912","span":{"begin":318,"end":321},"obj":"18426850"},{"id":"T50361","span":{"begin":318,"end":321},"obj":"18426850"},{"id":"T97867","span":{"begin":380,"end":383},"obj":"24496537"},{"id":"T31220","span":{"begin":380,"end":383},"obj":"24496537"},{"id":"T81799","span":{"begin":515,"end":518},"obj":"21173356"},{"id":"T66863","span":{"begin":515,"end":518},"obj":"21173356"},{"id":"T19291","span":{"begin":602,"end":605},"obj":"17311809"},{"id":"T39588","span":{"begin":602,"end":605},"obj":"17311809"},{"id":"T97350","span":{"begin":757,"end":760},"obj":"23383330"},{"id":"T79015","span":{"begin":757,"end":760},"obj":"23383330"}],"text":"Extreme levels of exercise are a known cause of cardiac fibrosis, particularly in hinge point locations of the heart, such as the right ventricle; however, the significance of MRI-detected fibrosis remains controversial.349 Athletes who experience higher levels of fibrosis also have higher levels of coronary calcium.364 In turn, fibrosis is a well-established risk factor of AF.365 In one study, the fibrotic changes caused by vigorous exercise were reversed after an 8-week period of physical activity cessation.366 One study showed an increase in collagen and other fibrosis biomarkers in athletes.367 Murine models have found that losartan reduces all fibrosis biomarkers and the histologic findings of fibrosis induced by long-term intensive exercise.368"}