PMC:6019327 / 84677-85555
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6019327","sourcedb":"PMC","sourceid":"6019327","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6019327","text":"Subsequent studies evaluated the effects of repeated obstructive apnea, as occurs in patients with OSA, on cardiac structure, function, and electrophysiology.310 In a rat model of repeated OSA for 4 weeks, atrial conduction slowed considerably in association with connexin downregulation and atrial fibrosis. Left ventricular dilation, hypertrophy, and diastolic dysfunction also occurred. In addition to the remodeling-induced AF substrate caused by repeated apneic episodes, AF inducibility was further enhanced by superimposed episodes of acute obstructive apnea in over 80% of the rats.310 The role of atrial remodeling by repeated OSA is supported by electroanatomical studies in the clinical electrophysiology lab, with OSA associated with prolonged atrial conduction times, slower conduction, reduced electrogram amplitudes, and widespread complex atrial electrograms.311","tracks":[{"project":"2_test","denotations":[{"id":"28506916-25440097-45814650","span":{"begin":158,"end":161},"obj":"25440097"},{"id":"28506916-25440097-45814650","span":{"begin":158,"end":161},"obj":"25440097"},{"id":"28506916-25440097-29307430","span":{"begin":590,"end":593},"obj":"25440097"},{"id":"28506916-25440097-29307430","span":{"begin":590,"end":593},"obj":"25440097"},{"id":"28506916-22016075-29307431","span":{"begin":875,"end":878},"obj":"22016075"},{"id":"28506916-22016075-29307431","span":{"begin":875,"end":878},"obj":"22016075"},{"id":"T60390","span":{"begin":158,"end":161},"obj":"25440097"},{"id":"T31221","span":{"begin":158,"end":161},"obj":"25440097"},{"id":"T89281","span":{"begin":590,"end":593},"obj":"25440097"},{"id":"T82150","span":{"begin":590,"end":593},"obj":"25440097"},{"id":"T73406","span":{"begin":875,"end":878},"obj":"22016075"},{"id":"T99497","span":{"begin":875,"end":878},"obj":"22016075"},{"id":"T46624","span":{"begin":158,"end":161},"obj":"25440097"},{"id":"T86495","span":{"begin":158,"end":161},"obj":"25440097"},{"id":"T46846","span":{"begin":590,"end":593},"obj":"25440097"},{"id":"T62135","span":{"begin":590,"end":593},"obj":"25440097"},{"id":"T97796","span":{"begin":875,"end":878},"obj":"22016075"},{"id":"T14661","span":{"begin":875,"end":878},"obj":"22016075"}],"attributes":[{"subj":"28506916-25440097-45814650","pred":"source","obj":"2_test"},{"subj":"28506916-25440097-45814650","pred":"source","obj":"2_test"},{"subj":"28506916-25440097-29307430","pred":"source","obj":"2_test"},{"subj":"28506916-25440097-29307430","pred":"source","obj":"2_test"},{"subj":"28506916-22016075-29307431","pred":"source","obj":"2_test"},{"subj":"28506916-22016075-29307431","pred":"source","obj":"2_test"},{"subj":"T60390","pred":"source","obj":"2_test"},{"subj":"T31221","pred":"source","obj":"2_test"},{"subj":"T89281","pred":"source","obj":"2_test"},{"subj":"T82150","pred":"source","obj":"2_test"},{"subj":"T73406","pred":"source","obj":"2_test"},{"subj":"T99497","pred":"source","obj":"2_test"},{"subj":"T46624","pred":"source","obj":"2_test"},{"subj":"T86495","pred":"source","obj":"2_test"},{"subj":"T46846","pred":"source","obj":"2_test"},{"subj":"T62135","pred":"source","obj":"2_test"},{"subj":"T97796","pred":"source","obj":"2_test"},{"subj":"T14661","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9bec93","default":true}]}]}}