PMC:6019327 / 83928-84676 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6019327","sourcedb":"PMC","sourceid":"6019327","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6019327","text":"That altered autonomic nerve activity is not the entire explanation for the influence of sleep apnea in AF occurrence was shown in a study of sleep apnea in a rat model of obesity.309 Obstructive apnea promoted AF induction in obese rats much more than in lean rats, with only partial protection (\u003c50%) by autonomic blockade. On the other hand, obstructive episodes caused LA dilation that was enhanced in obese rats by obesity-associated left-ventricular diastolic dysfunction. Prevention of LA dilation fully prevented apnea-associated AF. In this model, neither obstructive apnea nor obesity was enough to cause significant AF vulnerability; the interaction appeared necessary to cause the degree of LA dilation needed to allow for AF induction.","tracks":[{"project":"2_test","denotations":[{"id":"28506916-22440155-29307428","span":{"begin":180,"end":183},"obj":"22440155"},{"id":"28506916-22440155-29307428","span":{"begin":180,"end":183},"obj":"22440155"},{"id":"T9731","span":{"begin":180,"end":183},"obj":"22440155"},{"id":"T34061","span":{"begin":180,"end":183},"obj":"22440155"},{"id":"T14274","span":{"begin":180,"end":183},"obj":"22440155"},{"id":"T38576","span":{"begin":180,"end":183},"obj":"22440155"}],"attributes":[{"subj":"28506916-22440155-29307428","pred":"source","obj":"2_test"},{"subj":"28506916-22440155-29307428","pred":"source","obj":"2_test"},{"subj":"T9731","pred":"source","obj":"2_test"},{"subj":"T34061","pred":"source","obj":"2_test"},{"subj":"T14274","pred":"source","obj":"2_test"},{"subj":"T38576","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93c0","default":true}]}]}}