PMC:6019327 / 429593-430234
Annnotations
2_test
{"project":"2_test","denotations":[{"id":"28506916-19808491-29309151","span":{"begin":136,"end":140},"obj":"19808491"},{"id":"28506916-19808491-29309151","span":{"begin":136,"end":140},"obj":"19808491"},{"id":"28506916-23002373-29309152","span":{"begin":141,"end":145},"obj":"23002373"},{"id":"28506916-23002373-29309152","span":{"begin":141,"end":145},"obj":"23002373"},{"id":"28506916-24390386-29309153","span":{"begin":146,"end":150},"obj":"24390386"},{"id":"28506916-24390386-29309153","span":{"begin":146,"end":150},"obj":"24390386"},{"id":"28506916-19095714-29309154","span":{"begin":151,"end":155},"obj":"19095714"},{"id":"28506916-19095714-29309154","span":{"begin":151,"end":155},"obj":"19095714"},{"id":"28506916-26969217-29309155","span":{"begin":156,"end":160},"obj":"26969217"},{"id":"28506916-26969217-29309155","span":{"begin":156,"end":160},"obj":"26969217"},{"id":"28506916-23002373-29309156","span":{"begin":355,"end":359},"obj":"23002373"},{"id":"28506916-23002373-29309156","span":{"begin":355,"end":359},"obj":"23002373"},{"id":"28506916-19095714-29309157","span":{"begin":360,"end":364},"obj":"19095714"},{"id":"28506916-19095714-29309157","span":{"begin":360,"end":364},"obj":"19095714"},{"id":"28506916-16286593-29309158","span":{"begin":463,"end":467},"obj":"16286593"},{"id":"28506916-16286593-29309158","span":{"begin":463,"end":467},"obj":"16286593"},{"id":"28506916-24681044-29309159","span":{"begin":637,"end":641},"obj":"24681044"},{"id":"28506916-24681044-29309159","span":{"begin":637,"end":641},"obj":"24681044"},{"id":"T25045","span":{"begin":136,"end":140},"obj":"19808491"},{"id":"T40206","span":{"begin":136,"end":140},"obj":"19808491"},{"id":"T35102","span":{"begin":141,"end":145},"obj":"23002373"},{"id":"T73561","span":{"begin":141,"end":145},"obj":"23002373"},{"id":"T10167","span":{"begin":146,"end":150},"obj":"24390386"},{"id":"T44482","span":{"begin":146,"end":150},"obj":"24390386"},{"id":"T893","span":{"begin":151,"end":155},"obj":"19095714"},{"id":"T22112","span":{"begin":151,"end":155},"obj":"19095714"},{"id":"T20232","span":{"begin":156,"end":160},"obj":"26969217"},{"id":"T21112","span":{"begin":156,"end":160},"obj":"26969217"},{"id":"T6059","span":{"begin":355,"end":359},"obj":"23002373"},{"id":"T29000","span":{"begin":355,"end":359},"obj":"23002373"},{"id":"T75470","span":{"begin":360,"end":364},"obj":"19095714"},{"id":"T79214","span":{"begin":360,"end":364},"obj":"19095714"},{"id":"T29749","span":{"begin":463,"end":467},"obj":"16286593"},{"id":"T16494","span":{"begin":463,"end":467},"obj":"16286593"},{"id":"T68713","span":{"begin":637,"end":641},"obj":"24681044"},{"id":"T85870","span":{"begin":637,"end":641},"obj":"24681044"},{"id":"T1742","span":{"begin":136,"end":140},"obj":"19808491"},{"id":"T42112","span":{"begin":136,"end":140},"obj":"19808491"},{"id":"T14111","span":{"begin":141,"end":145},"obj":"23002373"},{"id":"T18459","span":{"begin":141,"end":145},"obj":"23002373"},{"id":"T96058","span":{"begin":146,"end":150},"obj":"24390386"},{"id":"T9334","span":{"begin":146,"end":150},"obj":"24390386"},{"id":"T59066","span":{"begin":151,"end":155},"obj":"19095714"},{"id":"T55007","span":{"begin":151,"end":155},"obj":"19095714"},{"id":"T70559","span":{"begin":156,"end":160},"obj":"26969217"},{"id":"T83567","span":{"begin":156,"end":160},"obj":"26969217"},{"id":"T89988","span":{"begin":355,"end":359},"obj":"23002373"},{"id":"T71135","span":{"begin":355,"end":359},"obj":"23002373"},{"id":"T36620","span":{"begin":360,"end":364},"obj":"19095714"},{"id":"T3790","span":{"begin":360,"end":364},"obj":"19095714"},{"id":"T40143","span":{"begin":463,"end":467},"obj":"16286593"},{"id":"T34162","span":{"begin":463,"end":467},"obj":"16286593"},{"id":"T10558","span":{"begin":637,"end":641},"obj":"24681044"},{"id":"T86389","span":{"begin":637,"end":641},"obj":"24681044"}],"text":"The majority of published cost-effectiveness studies have compared AF ablation to AADs as second-line therapy in patients with PAF.1119,1120,1122,1124,1128,1129 In general, these studies have reported acceptable cost-effectiveness ratios—in the range of $27,000 to $59,000 (Canadian) per quality-adjusted life year (QALY) gained over 5-year time horizons.1122,1128 Results would be more favorable if ablation were found to significantly reduce the risk of stroke.1118 U.S. experts have recently indicated that cost-effectiveness ratios below $50,000 per QALY indicate high value, and between $50 and $150,000 indicate intermediate value.1130"}