PMC:5985360 / 34742-35326 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5985360","sourcedb":"PMC","sourceid":"5985360","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5985360","text":"Our findings support classification of sickle haplotypes based on three clusters. Notably, we found that the Senegal haplotype is substructured into two clusters, one containing only Senegal haplotypes and one containing Benin and Senegal haplotypes. This substructuring of haplotypes might have confounded previous assessments of clinical phenotype or disease severity. At the same time, the identification of markers linked to the sickle allele provides an opportunity to investigate possible cis-effects, such as differential expression of HBD, HBE1, and HBG2, on disease severity.","tracks":[]}