PMC:5985360 / 24984-25552 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5985360","sourcedb":"PMC","sourceid":"5985360","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5985360","text":"There are two models of the origins of the sickle allele. The multicentric model posits five independent occurrences of the same mutation within the last few thousand years. The unicentric model posits a single occurrence and an older age. We used whole-genome-sequence data to provide insight into this issue. Using haplotypic classification and phylogenetic network analysis, we found clear and consistent evidence for a single origin of the sickle mutation. After accounting for recombination, we estimated that the sickle mutation is 259 [123,395] generations old.","tracks":[]}