PMC:5985360 / 12088-14146 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5985360","sourcedb":"PMC","sourceid":"5985360","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5985360","text":"Distributions of βS and the Classical Haplotypes\nIn the 1000 Genomes Project data, we identified 137 sickle carriers and 0 sickle homozygotes; we predicted the classical haplotypes for all 137 carriers (Table 2). The Benin haplotype was the predominant haplotype in the samples of Esan and Yoruba from Nigeria, the CAR haplotype was the predominant haplotype in the sample of Luhya from Kenya, and the Senegal haplotype was the predominant haplotype in the samples of Mende from Sierra Leone and Mandinka from the Gambia. There was limited representation of the Arabian/Indian (one) and Cameroon (two) haplotypes. The average sickle allele frequency was 12.0% and did not statistically differ among the five continental African samples (χ42=1.48, p=0.830; Table S1). The distribution of matrilines comprised 1 A2, 2 B2, 1 J2, 8 L0, 24 L1, 43 L2, 49 L3, 3 L4, 2 L5, 1 T2, and 3 U6 haplogroups. The distribution of patrilines comprised 2 A1a, 5 E1a, 54 E1b1a, 1 E1b1b, 2 E2b, 1 G2a, 1 I2a, and 2 R1b haplogroups. Of the 54 E1b1a, 29 were E1b1a1a1f and 23 were E1b1a1a1g.\nTable 2 Distribution of Classical Sickle Haplotypes\nSamplea Arabian/Indian Benin Cameroon CAR Senegal Atypical\nACB 0 4 0 2 3 0\nASW 0 1 1 0 0 0\nCLM 0 0 0 1 0 1\nESN 0 18 1 0 5 0\nGWD 0 2 0 0 24 0\nLWK 1 0 0 19 0 0\nMSL 0 3 0 0 17 1\nPUR 0 0 0 1 2 0\nYRI 0 19 0 0 10 1\nBaganda 0 0 0 14 0 0\nZulu 0 0 0 1 0 0\na The population codes are as follows: ACB, African Caribbean in Barbados; ASW, People with African Ancestry in Southwest USA; CLM, Colombians in Medellín, Colombia; ESN, Esan in Nigeria; GWD, Gambian in Western Division, Mandinka; LWK, Luhya in Webuye, Kenya; MSL, Mende in Sierra Leone; PUR, Puerto Ricans in Puerto Rico; and YRI, Yoruba in Ibadan, Nigeria.\nIn the African Genome Variation Project data, we identified 14 sickle carriers in the Baganda and one sickle carrier in the Zulu. We predicted that all 15 of these individuals carried the CAR haplotype (Table 2). In the Qatar sample, we identified four sickle carriers, all with insufficient information to predict the 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