PMC:5985359 / 1200-2911
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5985359","sourcedb":"PMC","sourceid":"5985359","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5985359","text":"Fuchs endothelial corneal dystrophy (FECD [MIM: 613267]) is a common, degenerative, age-related condition that usually presents during the fifth to sixth decade. The disease primarily affects the posterior cornea with the hallmark being the formation of focal excrescences of Descemet membrane (DM) termed “guttae.” Isolated guttae are common in the elderly and a case definition for FECD usually requires that the guttae are confluent. When assessed with specular microscopy, the prevalence of guttae is higher in white (11.2% \u003e55 years) than East Asian (5.5% \u003e50 years) populations and higher in females (5.5%–11%) than males (1.5%–7%).1, 2 An estimate of the prevalence of confluent guttae in individuals of white or black ethnicity \u003e50 years with assessment by slit-lamp biomicroscopy reported a figure of 4.5%.3 Confluent guttae can be associated with a loss of corneal endothelial cell density to a critical stage when the remaining endothelium is unable to maintain appropriate stromal dehydration leading to fluid accumulation, painful epithelial bullae, and progressive corneal clouding reducing visual acuity.4, 5, 6 Early-stage disease is typically managed with topical hypertonic saline to reduce symptoms, such as corneal swelling, but surgical intervention is currently the only treatment option available to individuals with advanced disease to restore bilateral vision and prevent blindness.6 Full or partial keratoplasty are invasive procedures that rely upon specialist facilities and the availability of healthy donor material, of which there is a global shortage.7 These issues, coupled with the global aging population, highlight the need for alternative and effective treatment strategies.","tracks":[{"project":"2_test","denotations":[{"id":"29526280-16581419-2044747","span":{"begin":638,"end":639},"obj":"16581419"},{"id":"29526280-12097795-2044748","span":{"begin":641,"end":642},"obj":"12097795"},{"id":"29526280-6072991-2044749","span":{"begin":815,"end":816},"obj":"6072991"},{"id":"29526280-26937169-2044750","span":{"begin":1119,"end":1120},"obj":"26937169"},{"id":"29526280-26310151-2044751","span":{"begin":1122,"end":1123},"obj":"26310151"},{"id":"29526280-25228793-2044752","span":{"begin":1125,"end":1126},"obj":"25228793"},{"id":"29526280-25228793-2044753","span":{"begin":1407,"end":1408},"obj":"25228793"},{"id":"29526280-10998945-2044754","span":{"begin":1583,"end":1584},"obj":"10998945"}],"attributes":[{"subj":"29526280-16581419-2044747","pred":"source","obj":"2_test"},{"subj":"29526280-12097795-2044748","pred":"source","obj":"2_test"},{"subj":"29526280-6072991-2044749","pred":"source","obj":"2_test"},{"subj":"29526280-26937169-2044750","pred":"source","obj":"2_test"},{"subj":"29526280-26310151-2044751","pred":"source","obj":"2_test"},{"subj":"29526280-25228793-2044752","pred":"source","obj":"2_test"},{"subj":"29526280-25228793-2044753","pred":"source","obj":"2_test"},{"subj":"29526280-10998945-2044754","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#a693ec","default":true}]}]}}