PMC:5917310 / 11172-13363 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5917310","sourcedb":"PMC","sourceid":"5917310","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5917310","text":"Association with previous antibiotic exposure\nOf the 765 individuals harbouring S. aureus strains, 208 were found not to have taken antibiotics in the previous 4 years (27.1%). Of the subjects, 18.1% had taken one box, 13.0% two boxes, 11.5% three boxes of antibiotics, and 30.3% more than three boxes. The mean number of boxes of antibiotics consumed in the previous 4 years was 3.3 (SD: 5.2 and range 0–66), with penicillin being the most frequent antibiotic taken (mean of 1.5 packages; SD: 2.3), followed by ophthalmological presentations including antibacterial drugs (mean of 0.5 containers; SD: 2.9) and topical antibiotics (0.3 boxes; SD: 0.8).\nAlthough not statistically significant, a trend was shown in which patients who had more than one antibiotic dispensed in the previous 4 years tended to harbour more staphylococcal strains resistant to any antibiotic compared to those without using antibiotics (OR, 1.07; 95% CI, 0.99–1.16; P = 0.55). Isolation of penicillin-resistant staphylococci was significantly associated with the previous number of packages of penicillin (OR, 1.18; 95% CI, 1.04–1.35) but not with other antibiotics packages. No association was observed between the number of boxes among individuals harbouring S. aureus resistant to oxacillin, clindamycin or azithromycin. However, we did observe a statistically significant association between harbouring MRSA and the previous prescription of any antibiotics (OR, 1.6; 95% CI, 1.16–2.20) (Table 2).\nTable 2. Association of the previous number of antibiotics boxes dispensed and the staphylococcal resistance. A multivariate logistic regression analysis model.\nVariable 95% CI OR P value\nStaphylococcus aureus resistance\n Age (years) 0.98–1.00 0.99 0.24\n Sex (women) 0.45–1.14 0.72 0.16\n Any antibioticsa 0.99–1.16 1.07 0.55\nPenicillin-resistant Staphylococcus aureus\n Age (years) 0.99–1.01 1.00 0.76\n Sex (women) 0.46–1.01 0.70 0.11\n Penicillin packages (number) 1.04–1.35 1.18 0.01\nMethicillin-resistant Staphylococcus aureus (MRSA)\n Age (years) 0.99–1.05 1.02 0.22\n Sex (women) 0.15–2.43 0.61 0.48\n Any antibioticsa 1.16–2.20 1.60 \u003c0.01\naHave taken one or more antibiotic boxes.","divisions":[{"label":"title","span":{"begin":0,"end":45}},{"label":"p","span":{"begin":46,"end":652}},{"label":"p","span":{"begin":653,"end":1478}},{"label":"label","span":{"begin":1479,"end":1487}},{"label":"caption","span":{"begin":1489,"end":1640}},{"label":"p","span":{"begin":1489,"end":1640}},{"label":"table","span":{"begin":1641,"end":2149}},{"label":"tr","span":{"begin":1641,"end":1670}},{"label":"th","span":{"begin":1641,"end":1649}},{"label":"th","span":{"begin":1651,"end":1657}},{"label":"th","span":{"begin":1659,"end":1661}},{"label":"th","span":{"begin":1663,"end":1670}},{"label":"tr","span":{"begin":1671,"end":1703}},{"label":"td","span":{"begin":1671,"end":1703}},{"label":"tr","span":{"begin":1704,"end":1739}},{"label":"td","span":{"begin":1704,"end":1716}},{"label":"td","span":{"begin":1718,"end":1727}},{"label":"td","span":{"begin":1729,"end":1733}},{"label":"td","span":{"begin":1735,"end":1739}},{"label":"tr","span":{"begin":1740,"end":1775}},{"label":"td","span":{"begin":1740,"end":1752}},{"label":"td","span":{"begin":1754,"end":1763}},{"label":"td","span":{"begin":1765,"end":1769}},{"label":"td","span":{"begin":1771,"end":1775}},{"label":"tr","span":{"begin":1776,"end":1816}},{"label":"td","span":{"begin":1776,"end":1793}},{"label":"td","span":{"begin":1795,"end":1804}},{"label":"td","span":{"begin":1806,"end":1810}},{"label":"td","span":{"begin":1812,"end":1816}},{"label":"tr","span":{"begin":1817,"end":1859}},{"label":"td","span":{"begin":1817,"end":1859}},{"label":"tr","span":{"begin":1860,"end":1895}},{"label":"td","span":{"begin":1860,"end":1872}},{"label":"td","span":{"begin":1874,"end":1883}},{"label":"td","span":{"begin":1885,"end":1889}},{"label":"td","span":{"begin":1891,"end":1895}},{"label":"tr","span":{"begin":1896,"end":1931}},{"label":"td","span":{"begin":1896,"end":1908}},{"label":"td","span":{"begin":1910,"end":1919}},{"label":"td","span":{"begin":1921,"end":1925}},{"label":"td","span":{"begin":1927,"end":1931}},{"label":"tr","span":{"begin":1932,"end":1984}},{"label":"td","span":{"begin":1932,"end":1961}},{"label":"td","span":{"begin":1963,"end":1972}},{"label":"td","span":{"begin":1974,"end":1978}},{"label":"td","span":{"begin":1980,"end":1984}},{"label":"tr","span":{"begin":1985,"end":2035}},{"label":"td","span":{"begin":1985,"end":2035}},{"label":"tr","span":{"begin":2036,"end":2071}},{"label":"td","span":{"begin":2036,"end":2048}},{"label":"td","span":{"begin":2050,"end":2059}},{"label":"td","span":{"begin":2061,"end":2065}},{"label":"td","span":{"begin":2067,"end":2071}},{"label":"tr","span":{"begin":2072,"end":2107}},{"label":"td","span":{"begin":2072,"end":2084}},{"label":"td","span":{"begin":2086,"end":2095}},{"label":"td","span":{"begin":2097,"end":2101}},{"label":"td","span":{"begin":2103,"end":2107}},{"label":"tr","span":{"begin":2108,"end":2149}},{"label":"td","span":{"begin":2108,"end":2125}},{"label":"td","span":{"begin":2127,"end":2136}},{"label":"td","span":{"begin":2138,"end":2142}},{"label":"td","span":{"begin":2144,"end":2149}}],"tracks":[]}