PMC:5848821 / 25814-27308 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5848821","sourcedb":"PMC","sourceid":"5848821","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5848821","text":"Different treatments and different reasons to treat the diaphragm in patients with TETs and pleural involvement can be distinguished. For metastases to the diaphragm, partial or complete resection of the diaphragm or just pleurectomy of the diaphragm can be performed. The reason to perform diaphragmatic surgery is purely oncologic: metastasis to the diaphragmatic pleura with our without involvement of diaphragmatic musculature. Despite the respectable number of patients with this rare disease entity and the multicentre nature of this work, no recommendation can be given on whether just pleurectomy or full-thickness resections will result in different outcomes concerning recurrence rates or survival. Since patients with diaphragmatic involvement had concurrent nodules on other pleural sites, the isolated analysis of the issue of diaphragmatic resection or pleurectomy cannot be selectively answered (46.1% recurrences [12 of 26 R0 resections] after complete or partial diaphragmatic resections vs 44.4% recurrences [4 of 9 R0 resections] after diaphragmatic pleurectomy only). Another indication for treatment of the diaphragm in this patient cohort is in patients with tumour infiltration or inseparable tumour adherence to the phrenic nerve. In cases with obligatory demand for oncologic resection of the phrenic nerve, diaphragmatic plication is performed to flatten the paralyzed dome of the diaphragm and thus provide sufficient space for the lung to expand (functional reason).","tracks":[]}