PMC:5827048 / 2630-3747
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5827048","sourcedb":"PMC","sourceid":"5827048","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5827048","text":"Several diagnostic methods are introduced for identification of children with AKI, but none of them could accurately predict the outcome of disease in the initial stages (6). Over the past decade, many studies have shown that multiple serum and urine biomarkers are useful for early detection of kidney injury and have a better prognostic role than previous diagnostic tools (7-9). After three meta-analyses we reached a conclusion indicating that biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and Cystatin C are accurate predictors of AKI (10-12). However, it is yet to be studied which one of these biomarkers and their sources (serum or urine) have greater value in prediction of AKI. A meta-analysis reported that serum Cystatin C has a greater diagnostic value in detection of AKI in children and adolescents than its urine level (10). Existing evidence regarding NGAL is however inconclusive and further research needs to be carried out (13-15). The present study aimed to assess the value of urinary NGAL (uNGAL) and serum Cystatin C in early diagnosis of hospitalized children with AKI.","tracks":[{"project":"2_test","denotations":[{"id":"29503827-12748199-27799467","span":{"begin":171,"end":172},"obj":"12748199"},{"id":"29503827-17072653-27799468","span":{"begin":376,"end":377},"obj":"17072653"},{"id":"29503827-18277143-27799468","span":{"begin":376,"end":377},"obj":"18277143"},{"id":"29503827-18649981-27799469","span":{"begin":967,"end":969},"obj":"18649981"}],"attributes":[{"subj":"29503827-12748199-27799467","pred":"source","obj":"2_test"},{"subj":"29503827-17072653-27799468","pred":"source","obj":"2_test"},{"subj":"29503827-18277143-27799468","pred":"source","obj":"2_test"},{"subj":"29503827-18649981-27799469","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"29503827-12748199-27799467","span":{"begin":171,"end":172},"obj":"12748199"},{"id":"29503827-17072653-27799468","span":{"begin":376,"end":377},"obj":"17072653"},{"id":"29503827-18277143-27799468","span":{"begin":376,"end":377},"obj":"18277143"},{"id":"29503827-18649981-27799469","span":{"begin":967,"end":969},"obj":"18649981"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"29503827-12748199-27799467","pred":"source","obj":"MyTest"},{"subj":"29503827-17072653-27799468","pred":"source","obj":"MyTest"},{"subj":"29503827-18277143-27799468","pred":"source","obj":"MyTest"},{"subj":"29503827-18649981-27799469","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e4ec93","default":true},{"id":"MyTest","color":"#da93ec"}]}]}}