PMC:5623723 / 5437-7194
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5623723","sourcedb":"PMC","sourceid":"5623723","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5623723","text":"Lycium barbarum (Gouqi or wolfberry) is well known as a traditional Chinese medicine and healthy food supplement in China and other countries (Amagase et al., 2009). Lycium barbarum polysaccharide (LBP) is a mixed compound extracted from the fruits of Guoqi, composing primarily of rhamnose, arabinose, xylose, galactose, mannose and galacturonic acid (Zou et al., 2010). Recent years, many studies have investigated LBP’s structures, bioactive components and degradation. Studies have found that the water-soluble LBP containing 3.75% proteins has a β-D-(1 → 6)-galactan as a backbone with highly branched polysaccharide (Wang Z. et al., 2014; Yuan et al., 2016). A new study reported that a p-LBP was isolated and purified from LBP-and p-LBP was a homogeneous heteropolysaccharide as a pectin molecule with an average molecular weight of 64 kDa, approximately 87 nm hollow sphere in 0.05 mol/L sodium sulfate solution (Liu et al., 2016). Many studies have shown that LBP has strong anti-oxidative effects in diverse injury types, including doxorubicin-induced cardiotoxicity (Xin et al., 2011) and oxidative liver injury (Wu et al., 2010; Xiao et al., 2012). In addition, some studies showed that LBP plays beneficial roles in aging (Tang and He, 2013), hypoglycemia (Zhu et al., 2013) and anti-radiation or chemotherapy damages (Gong et al., 2005). Concerning nervous system damage, LBP protected ganglion cells against acute ocular hypertension (Mi et al., 2012), partial optic transection injuries (Li et al., 2013) and retinal ischemia/reperfusion injury (Li et al., 2011). Furthermore, LBP can prevent cortical neurons from damage against ischemic insults through anti-oxidative and anti-apoptotic mechanisms (Rui et al., 2012; Wang T. et al., 2014).","tracks":[{"project":"2_test","denotations":[{"id":"29021742-19185773-32379596","span":{"begin":159,"end":163},"obj":"19185773"},{"id":"29021742-24767036-32379597","span":{"begin":639,"end":643},"obj":"24767036"},{"id":"29021742-26505952-32379598","span":{"begin":658,"end":662},"obj":"26505952"},{"id":"29021742-27178915-32379599","span":{"begin":933,"end":937},"obj":"27178915"},{"id":"29021742-21056614-32379600","span":{"begin":1090,"end":1094},"obj":"21056614"},{"id":"29021742-20193709-32379601","span":{"begin":1135,"end":1139},"obj":"20193709"},{"id":"29021742-22138659-32379602","span":{"begin":1154,"end":1158},"obj":"22138659"},{"id":"29021742-24146495-32379603","span":{"begin":1249,"end":1253},"obj":"24146495"},{"id":"29021742-23987311-32379604","span":{"begin":1282,"end":1286},"obj":"23987311"},{"id":"29021742-15869449-32379605","span":{"begin":1345,"end":1349},"obj":"15869449"},{"id":"29021742-23094016-32379606","span":{"begin":1461,"end":1465},"obj":"23094016"},{"id":"29021742-23894366-32379607","span":{"begin":1515,"end":1519},"obj":"23894366"},{"id":"29021742-21298100-32379608","span":{"begin":1573,"end":1577},"obj":"21298100"},{"id":"29021742-22562802-32379609","span":{"begin":1729,"end":1733},"obj":"22562802"},{"id":"29021742-24595452-32379610","span":{"begin":1751,"end":1755},"obj":"24595452"}],"attributes":[{"subj":"29021742-19185773-32379596","pred":"source","obj":"2_test"},{"subj":"29021742-24767036-32379597","pred":"source","obj":"2_test"},{"subj":"29021742-26505952-32379598","pred":"source","obj":"2_test"},{"subj":"29021742-27178915-32379599","pred":"source","obj":"2_test"},{"subj":"29021742-21056614-32379600","pred":"source","obj":"2_test"},{"subj":"29021742-20193709-32379601","pred":"source","obj":"2_test"},{"subj":"29021742-22138659-32379602","pred":"source","obj":"2_test"},{"subj":"29021742-24146495-32379603","pred":"source","obj":"2_test"},{"subj":"29021742-23987311-32379604","pred":"source","obj":"2_test"},{"subj":"29021742-15869449-32379605","pred":"source","obj":"2_test"},{"subj":"29021742-23094016-32379606","pred":"source","obj":"2_test"},{"subj":"29021742-23894366-32379607","pred":"source","obj":"2_test"},{"subj":"29021742-21298100-32379608","pred":"source","obj":"2_test"},{"subj":"29021742-22562802-32379609","pred":"source","obj":"2_test"},{"subj":"29021742-24595452-32379610","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"29021742-19185773-32379596","span":{"begin":159,"end":163},"obj":"19185773"},{"id":"29021742-24767036-32379597","span":{"begin":639,"end":643},"obj":"24767036"},{"id":"29021742-26505952-32379598","span":{"begin":658,"end":662},"obj":"26505952"},{"id":"29021742-27178915-32379599","span":{"begin":933,"end":937},"obj":"27178915"},{"id":"29021742-21056614-32379600","span":{"begin":1090,"end":1094},"obj":"21056614"},{"id":"29021742-20193709-32379601","span":{"begin":1135,"end":1139},"obj":"20193709"},{"id":"29021742-22138659-32379602","span":{"begin":1154,"end":1158},"obj":"22138659"},{"id":"29021742-24146495-32379603","span":{"begin":1249,"end":1253},"obj":"24146495"},{"id":"29021742-23987311-32379604","span":{"begin":1282,"end":1286},"obj":"23987311"},{"id":"29021742-15869449-32379605","span":{"begin":1345,"end":1349},"obj":"15869449"},{"id":"29021742-23094016-32379606","span":{"begin":1461,"end":1465},"obj":"23094016"},{"id":"29021742-23894366-32379607","span":{"begin":1515,"end":1519},"obj":"23894366"},{"id":"29021742-21298100-32379608","span":{"begin":1573,"end":1577},"obj":"21298100"},{"id":"29021742-22562802-32379609","span":{"begin":1729,"end":1733},"obj":"22562802"},{"id":"29021742-24595452-32379610","span":{"begin":1751,"end":1755},"obj":"24595452"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"29021742-19185773-32379596","pred":"source","obj":"MyTest"},{"subj":"29021742-24767036-32379597","pred":"source","obj":"MyTest"},{"subj":"29021742-26505952-32379598","pred":"source","obj":"MyTest"},{"subj":"29021742-27178915-32379599","pred":"source","obj":"MyTest"},{"subj":"29021742-21056614-32379600","pred":"source","obj":"MyTest"},{"subj":"29021742-20193709-32379601","pred":"source","obj":"MyTest"},{"subj":"29021742-22138659-32379602","pred":"source","obj":"MyTest"},{"subj":"29021742-24146495-32379603","pred":"source","obj":"MyTest"},{"subj":"29021742-23987311-32379604","pred":"source","obj":"MyTest"},{"subj":"29021742-15869449-32379605","pred":"source","obj":"MyTest"},{"subj":"29021742-23094016-32379606","pred":"source","obj":"MyTest"},{"subj":"29021742-23894366-32379607","pred":"source","obj":"MyTest"},{"subj":"29021742-21298100-32379608","pred":"source","obj":"MyTest"},{"subj":"29021742-22562802-32379609","pred":"source","obj":"MyTest"},{"subj":"29021742-24595452-32379610","pred":"source","obj":"MyTest"}]}],"config":{"attribute 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