PMC:5533949 / 3639-4635 JSONTXT

{"project":"2_test","denotations":[{"id":"28287612-25422241-79067495","span":{"begin":217,"end":219},"obj":"25422241"},{"id":"28287612-22842912-79067496","span":{"begin":221,"end":223},"obj":"22842912"},{"id":"28287612-24980149-79067497","span":{"begin":225,"end":227},"obj":"24980149"},{"id":"28287612-25081869-79067498","span":{"begin":229,"end":231},"obj":"25081869"},{"id":"28287612-26631616-79067499","span":{"begin":233,"end":235},"obj":"26631616"},{"id":"28287612-22842912-79067500","span":{"begin":372,"end":374},"obj":"22842912"},{"id":"28287612-24980149-79067501","span":{"begin":376,"end":378},"obj":"24980149"},{"id":"28287612-25422241-79067502","span":{"begin":482,"end":484},"obj":"25422241"},{"id":"28287612-25081869-79067503","span":{"begin":486,"end":488},"obj":"25081869"},{"id":"28287612-26631616-79067504","span":{"begin":610,"end":612},"obj":"26631616"},{"id":"28287612-22842912-79067505","span":{"begin":699,"end":701},"obj":"22842912"},{"id":"28287612-24980149-79067506","span":{"begin":703,"end":705},"obj":"24980149"},{"id":"28287612-26631616-79067507","span":{"begin":752,"end":754},"obj":"26631616"},{"id":"28287612-25422241-79067508","span":{"begin":820,"end":822},"obj":"25422241"},{"id":"28287612-25081869-79067509","span":{"begin":824,"end":826},"obj":"25081869"}],"text":"Structural maintenance of chromosomes 4 (SMC4), an SMC family member, encodes the SMC4 protein that is highly expressed in multiple tumors, suggesting an oncogenic role for SMC4 in cancer pathogenesis and progression.19, 20, 21, 22, 23 In hepatocellular carcinoma, SMC4 is highly expressed and correlates with tumor dedifferentiation, advanced stage and vascular invasion.20, 21 In colorectal cancer, elevated SMC4 expression promotes tumor cell growth rate, migration and invasion.19, 22 In prostate cancer, higher expression of SMC4 is significantly associated with the metastatic cascade and poor prognosis.23 Importantly, SMC4 knockdown via RNA interference suppresses cancer cell proliferation,20, 21 reducing the migration and invasive capability23 and the degree of malignancy, thereby improving overall survival,19, 22 suggesting that SMC4 may serve as a significant prognostic factor and potential therapeutic target. However, its expression and potential roles in glioma remain unknown."}