PMC:55322 / 39374-40111 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/55322","sourcedb":"PMC","sourceid":"55322","source_url":"https://www.ncbi.nlm.nih.gov/pmc/55322","text":"An intriguing clinical observation follows from these data and the tissue-specific observations. It had been noted [52] that the aneuploidies that are compatible with survival until birth (trisomies 13,18 and 21, as well as X and Y aneuploidy) appeared to occur in relatively gene-poor chromosomes. Our data confirm these observations. However, the most obvious models for the deleterious effects of aneuploidy should instead depend on the total number of genes. In examining our HINT transcripts we have found that in fact the total number of embryo-specific transcripts is lowest on these five chromosomes (Figure 3). We suggest that trisomy of other chromosomes may exceed a limit of survivable dosage compensation during development.","tracks":[]}