PMC:55322 / 21085-22024 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/55322","sourcedb":"PMC","sourceid":"55322","source_url":"https://www.ncbi.nlm.nih.gov/pmc/55322","text":"As genomic annotation proceeds, the number of protein-coding genes will become clearer. Our approach seems to rule out artifactual or genomic contamination as the predominant explanation for transcriptional units with unknown function or protein homology. Ensembl has recently listed a count of 170,160 'confirmed' exons, whereas we report 299,014 in complete ORFs and many more in untranslated regions, suggesting that our approach identifies considerable additional transcription. We point out that only 58% of known genes exhibit protein homology (Table 1) and, for example, a large proportion of transcriptional units have not been functionally classified in Drosophila [4]. We therefore propose that most of the unclassified transcriptional units are in fact coding - the lack of protein homology may reflect difficulty in studying these proteins, or rapid gene evolution, and some portion is likely to function at the RNA level [33].","tracks":[{"project":"2_test","denotations":[{"id":"11516338-10731132-44573066","span":{"begin":675,"end":676},"obj":"10731132"},{"id":"11516338-11125087-44573067","span":{"begin":935,"end":937},"obj":"11125087"}],"attributes":[{"subj":"11516338-10731132-44573066","pred":"source","obj":"2_test"},{"subj":"11516338-11125087-44573067","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93b1","default":true}]}]}}