PMC:549712 / 8151-8503 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T2750","span":{"begin":8,"end":13},"obj":"NNS"},{"id":"T2753","span":{"begin":3,"end":4},"obj":"-LRB-"},{"id":"T2754","span":{"begin":4,"end":6},"obj":"NN"},{"id":"T2755","span":{"begin":6,"end":7},"obj":"-RRB-"},{"id":"T2756","span":{"begin":14,"end":17},"obj":"IN"},{"id":"T2757","span":{"begin":18,"end":22},"obj":"NN"},{"id":"T2758","span":{"begin":23,"end":32},"obj":"NN"},{"id":"T2759","span":{"begin":33,"end":34},"obj":"-LRB-"},{"id":"T2760","span":{"begin":34,"end":36},"obj":"CD"},{"id":"T2761","span":{"begin":36,"end":37},"obj":"-RRB-"},{"id":"T2762","span":{"begin":37,"end":39},"obj":","},{"id":"T2763","span":{"begin":39,"end":43},"obj":"RB"},{"id":"T2764","span":{"begin":44,"end":54},"obj":"VBG"},{"id":"T2765","span":{"begin":55,"end":56},"obj":"DT"},{"id":"T2766","span":{"begin":68,"end":74},"obj":"NN"},{"id":"T2767","span":{"begin":57,"end":62},"obj":"NN"},{"id":"T2768","span":{"begin":63,"end":67},"obj":"JJ"},{"id":"T2769","span":{"begin":62,"end":63},"obj":"HYPH"},{"id":"T2770","span":{"begin":75,"end":77},"obj":"IN"},{"id":"T2771","span":{"begin":78,"end":79},"obj":"DT"},{"id":"T2772","span":{"begin":112,"end":122},"obj":"NN"},{"id":"T2773","span":{"begin":80,"end":84},"obj":"JJ"},{"id":"T2774","span":{"begin":84,"end":86},"obj":","},{"id":"T2775","span":{"begin":86,"end":94},"obj":"JJ"},{"id":"T2776","span":{"begin":95,"end":100},"obj":"NN"},{"id":"T2777","span":{"begin":101,"end":103},"obj":"NN"},{"id":"T2778","span":{"begin":100,"end":101},"obj":"HYPH"},{"id":"T2779","span":{"begin":104,"end":111},"obj":"JJ"},{"id":"T2780","span":{"begin":122,"end":123},"obj":"."},{"id":"T2781","span":{"begin":123,"end":225},"obj":"sentence"},{"id":"T2782","span":{"begin":124,"end":127},"obj":"DT"},{"id":"T2783","span":{"begin":161,"end":165},"obj":"NN"},{"id":"T2784","span":{"begin":128,"end":133},"obj":"RB"},{"id":"T2785","span":{"begin":134,"end":145},"obj":"VBN"},{"id":"T2786","span":{"begin":146,"end":154},"obj":"NN"},{"id":"T2787","span":{"begin":155,"end":160},"obj":"NN"},{"id":"T2788","span":{"begin":170,"end":175},"obj":"VBN"},{"id":"T2789","span":{"begin":166,"end":169},"obj":"VBD"},{"id":"T2790","span":{"begin":176,"end":187},"obj":"NN"},{"id":"T2791","span":{"begin":188,"end":189},"obj":"-LRB-"},{"id":"T2792","span":{"begin":199,"end":207},"obj":"VBN"},{"id":"T2793","span":{"begin":189,"end":198},"obj":"RB"},{"id":"T2794","span":{"begin":208,"end":210},"obj":"IN"},{"id":"T2795","span":{"begin":211,"end":213},"obj":"IN"},{"id":"T2796","span":{"begin":214,"end":219},"obj":"NN"},{"id":"T2797","span":{"begin":220,"end":221},"obj":"SYM"},{"id":"T2798","span":{"begin":221,"end":222},"obj":"HYPH"},{"id":"T2799","span":{"begin":222,"end":223},"obj":"SYM"},{"id":"T2800","span":{"begin":223,"end":224},"obj":"-RRB-"},{"id":"T2801","span":{"begin":224,"end":225},"obj":"."},{"id":"T2802","span":{"begin":225,"end":313},"obj":"sentence"},{"id":"T2803","span":{"begin":226,"end":238},"obj":"JJ"},{"id":"T2804","span":{"begin":248,"end":252},"obj":"NNS"},{"id":"T2805","span":{"begin":239,"end":244},"obj":"NN"},{"id":"T2806","span":{"begin":244,"end":245},"obj":"SYM"},{"id":"T2807","span":{"begin":245,"end":246},"obj":"HYPH"},{"id":"T2808","span":{"begin":246,"end":247},"obj":"SYM"},{"id":"T2809","span":{"begin":253,"end":257},"obj":"VBD"},{"id":"T2810","span":{"begin":258,"end":264},"obj":"JJ"},{"id":"T2811","span":{"begin":265,"end":268},"obj":"CC"},{"id":"T2812","span":{"begin":269,"end":276},"obj":"JJ"},{"id":"T2813","span":{"begin":277,"end":280},"obj":"CC"},{"id":"T2814","span":{"begin":281,"end":287},"obj":"VBD"},{"id":"T2815","span":{"begin":288,"end":290},"obj":"DT"},{"id":"T2816","span":{"begin":299,"end":312},"obj":"NNS"},{"id":"T2817","span":{"begin":291,"end":298},"obj":"JJ"},{"id":"T2818","span":{"begin":312,"end":313},"obj":"."},{"id":"T2820","span":{"begin":314,"end":319},"obj":"NN"},{"id":"T2821","span":{"begin":324,"end":328},"obj":"NNS"},{"id":"T2822","span":{"begin":320,"end":321},"obj":"SYM"},{"id":"T2823","span":{"begin":321,"end":322},"obj":"HYPH"},{"id":"T2824","span":{"begin":322,"end":323},"obj":"SYM"},{"id":"T2825","span":{"begin":334,"end":346},"obj":"VBN"},{"id":"T2826","span":{"begin":329,"end":333},"obj":"VBD"},{"id":"T2827","span":{"begin":347,"end":349},"obj":"TO"}],"relations":[{"id":"R1404","pred":"compound","subj":"T2757","obj":"T2758"},{"id":"R1405","pred":"pobj","subj":"T2758","obj":"T2756"},{"id":"R1406","pred":"punct","subj":"T2759","obj":"T2760"},{"id":"R1408","pred":"punct","subj":"T2761","obj":"T2760"},{"id":"R1410","pred":"advmod","subj":"T2763","obj":"T2764"},{"id":"R1412","pred":"det","subj":"T2765","obj":"T2766"},{"id":"R1413","pred":"dobj","subj":"T2766","obj":"T2764"},{"id":"R1414","pred":"npadvmod","subj":"T2767","obj":"T2768"},{"id":"R1415","pred":"amod","subj":"T2768","obj":"T2766"},{"id":"R1416","pred":"punct","subj":"T2769","obj":"T2768"},{"id":"R1417","pred":"prep","subj":"T2770","obj":"T2764"},{"id":"R1418","pred":"det","subj":"T2771","obj":"T2772"},{"id":"R1419","pred":"pobj","subj":"T2772","obj":"T2770"},{"id":"R1420","pred":"amod","subj":"T2773","obj":"T2772"},{"id":"R1421","pred":"punct","subj":"T2774","obj":"T2772"},{"id":"R1422","pred":"amod","subj":"T2775","obj":"T2772"},{"id":"R1423","pred":"nmod","subj":"T2776","obj":"T2777"},{"id":"R1424","pred":"nmod","subj":"T2777","obj":"T2772"},{"id":"R1425","pred":"punct","subj":"T2778","obj":"T2777"},{"id":"R1426","pred":"amod","subj":"T2779","obj":"T2772"},{"id":"R1428","pred":"det","subj":"T2782","obj":"T2783"},{"id":"R1429","pred":"nsubjpass","subj":"T2783","obj":"T2788"},{"id":"R1430","pred":"advmod","subj":"T2784","obj":"T2785"},{"id":"R1431","pred":"amod","subj":"T2785","obj":"T2783"},{"id":"R1432","pred":"compound","subj":"T2786","obj":"T2783"},{"id":"R1433","pred":"compound","subj":"T2787","obj":"T2783"},{"id":"R1434","pred":"auxpass","subj":"T2789","obj":"T2788"},{"id":"R1435","pred":"oprd","subj":"T2790","obj":"T2788"},{"id":"R1436","pred":"punct","subj":"T2791","obj":"T2792"},{"id":"R1437","pred":"parataxis","subj":"T2792","obj":"T2790"},{"id":"R1438","pred":"advmod","subj":"T2793","obj":"T2792"},{"id":"R1439","pred":"prep","subj":"T2794","obj":"T2792"},{"id":"R1440","pred":"prep","subj":"T2795","obj":"T2792"},{"id":"R1441","pred":"pobj","subj":"T2796","obj":"T2795"},{"id":"R1442","pred":"punct","subj":"T2797","obj":"T2796"},{"id":"R1443","pred":"punct","subj":"T2798","obj":"T2796"},{"id":"R1444","pred":"punct","subj":"T2799","obj":"T2796"},{"id":"R1445","pred":"punct","subj":"T2800","obj":"T2792"},{"id":"R1446","pred":"punct","subj":"T2801","obj":"T2788"},{"id":"R1447","pred":"amod","subj":"T2803","obj":"T2804"},{"id":"R1448","pred":"nsubj","subj":"T2804","obj":"T2809"},{"id":"R1449","pred":"nmod","subj":"T2805","obj":"T2804"},{"id":"R1450","pred":"punct","subj":"T2806","obj":"T2805"},{"id":"R1451","pred":"punct","subj":"T2807","obj":"T2805"},{"id":"R1452","pred":"punct","subj":"T2808","obj":"T2805"},{"id":"R1453","pred":"acomp","subj":"T2810","obj":"T2809"},{"id":"R1454","pred":"cc","subj":"T2811","obj":"T2810"},{"id":"R1455","pred":"conj","subj":"T2812","obj":"T2810"},{"id":"R1456","pred":"cc","subj":"T2813","obj":"T2809"},{"id":"R1457","pred":"conj","subj":"T2814","obj":"T2809"},{"id":"R1458","pred":"det","subj":"T2815","obj":"T2816"},{"id":"R1459","pred":"dobj","subj":"T2816","obj":"T2814"},{"id":"R1460","pred":"amod","subj":"T2817","obj":"T2816"},{"id":"R1461","pred":"punct","subj":"T2818","obj":"T2809"},{"id":"R1462","pred":"nmod","subj":"T2820","obj":"T2821"},{"id":"R1463","pred":"nsubjpass","subj":"T2821","obj":"T2825"},{"id":"R1464","pred":"punct","subj":"T2822","obj":"T2820"},{"id":"R1465","pred":"punct","subj":"T2823","obj":"T2820"},{"id":"R1466","pred":"punct","subj":"T2824","obj":"T2820"},{"id":"R1467","pred":"auxpass","subj":"T2826","obj":"T2825"}],"text":"em (ES) cells for gene targeting [33], thus generating a Ptdsr-null allele in a pure, isogenic C57BL/6J genetic background. The newly established knockout mouse line was named Ptdsrtm1Gbf (hereafter referred to as Ptdsr -/-). Heterozygous Ptdsr+/- mice were viable and fertile and showed no obvious abnormalities. Ptdsr +/- mice were intercrossed to ge"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2585","span":{"begin":8,"end":13},"obj":"CL:0002322"},{"id":"T2586","span":{"begin":4,"end":6},"obj":"_FRAGMENT"},{"id":"T2587","span":{"begin":8,"end":13},"obj":"CL_GO_EXT:cell"},{"id":"T2588","span":{"begin":18,"end":22},"obj":"SO_EXT:0000704"},{"id":"T2589","span":{"begin":57,"end":62},"obj":"PR_EXT:000009218"},{"id":"T2590","span":{"begin":63,"end":67},"obj":"SO_EXT:sequence_nullness"},{"id":"T2591","span":{"begin":68,"end":74},"obj":"SO_EXT:0001023"},{"id":"T2592","span":{"begin":104,"end":111},"obj":"SO_EXT:0000704"},{"id":"T2593","span":{"begin":155,"end":160},"obj":"NCBITaxon:10088"},{"id":"T2594","span":{"begin":176,"end":181},"obj":"PR_EXT:000009218"},{"id":"T2595","span":{"begin":214,"end":219},"obj":"PR_EXT:000009218"},{"id":"T2596","span":{"begin":220,"end":221},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2597","span":{"begin":222,"end":223},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2598","span":{"begin":239,"end":244},"obj":"PR_EXT:000009218"},{"id":"T2599","span":{"begin":244,"end":245},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T2600","span":{"begin":246,"end":247},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2601","span":{"begin":248,"end":252},"obj":"NCBITaxon:10088"},{"id":"T2602","span":{"begin":314,"end":319},"obj":"PR_EXT:000009218"},{"id":"T2603","span":{"begin":320,"end":321},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T2604","span":{"begin":322,"end":323},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2605","span":{"begin":324,"end":328},"obj":"NCBITaxon:10088"}],"relations":[{"id":"R1343","pred":"_lexicallyChainedTo","subj":"T2585","obj":"T2586"}],"text":"em (ES) cells for gene targeting [33], thus generating a Ptdsr-null allele in a pure, isogenic C57BL/6J genetic background. The newly established knockout mouse line was named Ptdsrtm1Gbf (hereafter referred to as Ptdsr -/-). Heterozygous Ptdsr+/- mice were viable and fertile and showed no obvious abnormalities. Ptdsr +/- mice were intercrossed to ge"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T2507","span":{"begin":8,"end":13},"obj":"CL:0002322"},{"id":"T2508","span":{"begin":4,"end":6},"obj":"_FRAGMENT"},{"id":"T2509","span":{"begin":18,"end":22},"obj":"SO:0000704"},{"id":"T2510","span":{"begin":57,"end":62},"obj":"PR:000009218"},{"id":"T2511","span":{"begin":68,"end":74},"obj":"SO:0001023"},{"id":"T2512","span":{"begin":104,"end":111},"obj":"SO:0000704"},{"id":"T2513","span":{"begin":155,"end":160},"obj":"NCBITaxon:10088"},{"id":"T2514","span":{"begin":176,"end":181},"obj":"PR:000009218"},{"id":"T2515","span":{"begin":214,"end":219},"obj":"PR:000009218"},{"id":"T2516","span":{"begin":239,"end":244},"obj":"PR:000009218"},{"id":"T2517","span":{"begin":248,"end":252},"obj":"NCBITaxon:10088"},{"id":"T2518","span":{"begin":314,"end":319},"obj":"PR:000009218"},{"id":"T2519","span":{"begin":324,"end":328},"obj":"NCBITaxon:10088"}],"relations":[{"id":"R1341","pred":"_lexicallyChainedTo","subj":"T2507","obj":"T2508"}],"text":"em (ES) cells for gene targeting [33], thus generating a Ptdsr-null allele in a pure, isogenic C57BL/6J genetic background. The newly established knockout mouse line was named Ptdsrtm1Gbf (hereafter referred to as Ptdsr -/-). Heterozygous Ptdsr+/- mice were viable and fertile and showed no obvious abnormalities. Ptdsr +/- mice were intercrossed to ge"}

{"project":"2_test","denotations":[{"id":"15345036-8398989-55938505","span":{"begin":34,"end":36},"obj":"8398989"}],"text":"em (ES) cells for gene targeting [33], thus generating a Ptdsr-null allele in a pure, isogenic C57BL/6J genetic background. The newly established knockout mouse line was named Ptdsrtm1Gbf (hereafter referred to as Ptdsr -/-). Heterozygous Ptdsr+/- mice were viable and fertile and showed no obvious abnormalities. Ptdsr +/- mice were intercrossed to ge"}