Id |
Subject |
Object |
Predicate |
Lexical cue |
T11000 |
0-13 |
RB |
denotes |
Interestingly |
T11001 |
31-39 |
VBD |
denotes |
observed |
T11002 |
13-15 |
, |
denotes |
, |
T11003 |
15-17 |
PRP |
denotes |
we |
T11004 |
18-30 |
RB |
denotes |
occasionally |
T11005 |
40-47 |
JJ |
denotes |
serious |
T11006 |
48-61 |
NNS |
denotes |
malformations |
T11007 |
62-64 |
IN |
denotes |
of |
T11008 |
65-74 |
NN |
denotes |
forebrain |
T11009 |
75-78 |
CC |
denotes |
and |
T11010 |
79-84 |
JJ |
denotes |
nasal |
T11011 |
85-95 |
NNS |
denotes |
structures |
T11012 |
96-98 |
IN |
denotes |
in |
T11013 |
99-104 |
NN |
denotes |
Ptdsr |
T11014 |
105-113 |
NN |
denotes |
knockout |
T11015 |
104-105 |
HYPH |
denotes |
- |
T11016 |
114-121 |
NNS |
denotes |
embryos |
T11017 |
122-126 |
WDT |
denotes |
that |
T11018 |
132-142 |
VBN |
denotes |
associated |
T11019 |
127-131 |
VBD |
denotes |
were |
T11020 |
143-147 |
IN |
denotes |
with |
T11021 |
148-157 |
JJ |
denotes |
bilateral |
T11022 |
158-170 |
NN |
denotes |
anophthalmia |
T11023 |
171-172 |
-LRB- |
denotes |
( |
T11024 |
172-175 |
VB |
denotes |
see |
T11025 |
176-179 |
IN |
denotes |
for |
T11026 |
180-187 |
NN |
denotes |
example |
T11027 |
188-191 |
DT |
denotes |
the |
T11028 |
199-205 |
NN |
denotes |
embryo |
T11029 |
192-198 |
NN |
denotes |
mutant |
T11030 |
206-208 |
IN |
denotes |
in |
T11031 |
209-215 |
NN |
denotes |
Figure |
T11032 |
216-218 |
NN |
denotes |
1g |
T11033 |
218-219 |
-RRB- |
denotes |
) |
T11034 |
219-220 |
. |
denotes |
. |
T11035 |
220-412 |
sentence |
denotes |
This suggests that Ptdsr is involved in the regulation of differentiation processes within forebrain regions, and that ablation of Ptdsr function might secondarily affect early eye formation. |
T11036 |
221-225 |
DT |
denotes |
This |
T11037 |
226-234 |
VBZ |
denotes |
suggests |
T11038 |
235-239 |
IN |
denotes |
that |
T11039 |
249-257 |
VBN |
denotes |
involved |
T11040 |
240-245 |
NN |
denotes |
Ptdsr |
T11041 |
246-248 |
VBZ |
denotes |
is |
T11042 |
258-260 |
IN |
denotes |
in |
T11043 |
261-264 |
DT |
denotes |
the |
T11044 |
265-275 |
NN |
denotes |
regulation |
T11045 |
276-278 |
IN |
denotes |
of |
T11046 |
279-294 |
NN |
denotes |
differentiation |
T11047 |
295-304 |
NNS |
denotes |
processes |
T11048 |
305-311 |
IN |
denotes |
within |
T11049 |
312-321 |
NN |
denotes |
forebrain |
T11050 |
322-329 |
NNS |
denotes |
regions |
T11051 |
329-331 |
, |
denotes |
, |
T11052 |
331-334 |
CC |
denotes |
and |
T11053 |
335-339 |
IN |
denotes |
that |
T11054 |
385-391 |
VB |
denotes |
affect |
T11055 |
340-348 |
NN |
denotes |
ablation |
T11056 |
349-351 |
IN |
denotes |
of |
T11057 |
352-357 |
NN |
denotes |
Ptdsr |
T11058 |
358-366 |
NN |
denotes |
function |
T11059 |
367-372 |
MD |
denotes |
might |
T11060 |
373-384 |
RB |
denotes |
secondarily |
T11061 |
392-397 |
JJ |
denotes |
early |
T11062 |
402-411 |
NN |
denotes |
formation |
T11063 |
398-401 |
NN |
denotes |
eye |
T11064 |
411-412 |
. |
denotes |
. |
T11065 |
412-639 |
sentence |
denotes |
Li et al. [31] found smaller lenses in Ptdsr-knockout mice and described the formation of retinal protrusions, although anophthalmia and specific differentiation defects of retinal cell layers were not reported in their study. |
T11066 |
413-415 |
NNP |
denotes |
Li |
T11067 |
428-433 |
VBD |
denotes |
found |
T11068 |
416-418 |
FW |
denotes |
et |
T11069 |
419-422 |
FW |
denotes |
al. |
T11070 |
423-424 |
-LRB- |
denotes |
[ |
T11071 |
424-426 |
CD |
denotes |
31 |
T11072 |
426-427 |
-RRB- |
denotes |
] |
T11073 |
434-441 |
JJR |
denotes |
smaller |
T11074 |
442-448 |
NNS |
denotes |
lenses |
T11075 |
449-451 |
IN |
denotes |
in |
T11076 |
452-457 |
NN |
denotes |
Ptdsr |
T11077 |
458-466 |
NN |
denotes |
knockout |
T11078 |
457-458 |
HYPH |
denotes |
- |
T11079 |
467-471 |
NNS |
denotes |
mice |
T11080 |
472-475 |
CC |
denotes |
and |
T11081 |
476-485 |
VBD |
denotes |
described |
T11082 |
486-489 |
DT |
denotes |
the |
T11083 |
490-499 |
NN |
denotes |
formation |
T11084 |
500-502 |
IN |
denotes |
of |
T11085 |
503-510 |
JJ |
denotes |
retinal |
T11086 |
511-522 |
NNS |
denotes |
protrusions |
T11087 |
522-524 |
, |
denotes |
, |
T11088 |
524-532 |
IN |
denotes |
although |
T11089 |
615-623 |
VBN |
denotes |
reported |
T11090 |
533-545 |
NN |
denotes |
anophthalmia |
T11091 |
546-549 |
CC |
denotes |
and |
T11092 |
550-558 |
JJ |
denotes |
specific |
T11093 |
575-582 |
NNS |
denotes |
defects |
T11094 |
559-574 |
NN |
denotes |
differentiation |
T11095 |
583-585 |
IN |
denotes |
of |
T11096 |
586-593 |
JJ |
denotes |
retinal |
T11097 |
599-605 |
NNS |
denotes |
layers |
T11098 |
594-598 |
NN |
denotes |
cell |
T11099 |
606-610 |
VBD |
denotes |
were |
T11100 |
611-614 |
RB |
denotes |
not |
T11101 |
624-626 |
IN |
denotes |
in |
T11102 |
627-632 |
PRP$ |
denotes |
their |
T11103 |
633-638 |
NN |
denotes |
study |
T11104 |
638-639 |
. |
denotes |
. |
T11105 |
639-875 |
sentence |
denotes |
Li et al. proposed [31] that the eye phenotype they observed could be explained by failed removal of apoptotic cells during eye development, but we think that the observed defects are unrelated to a failure of apoptotic cell clearance. |
T11106 |
640-642 |
NNP |
denotes |
Li |
T11107 |
650-658 |
VBN |
denotes |
proposed |
T11108 |
643-645 |
FW |
denotes |
et |
T11109 |
646-649 |
FW |
denotes |
al. |
T11110 |
659-660 |
-LRB- |
denotes |
[ |
T11111 |
660-662 |
CD |
denotes |
31 |
T11112 |
662-663 |
-RRB- |
denotes |
] |
T11113 |
664-668 |
IN |
denotes |
that |
T11114 |
710-719 |
VBN |
denotes |
explained |
T11115 |
669-672 |
DT |
denotes |
the |
T11116 |
677-686 |
NN |
denotes |
phenotype |
T11117 |
673-676 |
NN |
denotes |
eye |
T11118 |
687-691 |
PRP |
denotes |
they |
T11119 |
692-700 |
VBD |
denotes |
observed |
T11120 |
701-706 |
MD |
denotes |
could |
T11121 |
707-709 |
VB |
denotes |
be |
T11122 |
720-722 |
IN |
denotes |
by |
T11123 |
723-729 |
JJ |
denotes |
failed |
T11124 |
730-737 |
NN |
denotes |
removal |
T11125 |
738-740 |
IN |
denotes |
of |
T11126 |
741-750 |
JJ |
denotes |
apoptotic |
T11127 |
751-756 |
NNS |
denotes |
cells |
T11128 |
757-763 |
IN |
denotes |
during |
T11129 |
764-767 |
NN |
denotes |
eye |
T11130 |
768-779 |
NN |
denotes |
development |
T11131 |
779-781 |
, |
denotes |
, |
T11132 |
781-784 |
CC |
denotes |
but |
T11133 |
785-787 |
PRP |
denotes |
we |
T11134 |
788-793 |
VBP |
denotes |
think |
T11135 |
794-798 |
IN |
denotes |
that |
T11136 |
820-823 |
VBP |
denotes |
are |
T11137 |
799-802 |
DT |
denotes |
the |
T11138 |
812-819 |
NNS |
denotes |
defects |
T11139 |
803-811 |
VBN |
denotes |
observed |
T11140 |
824-833 |
JJ |
denotes |
unrelated |
T11141 |
834-836 |
IN |
denotes |
to |
T11142 |
837-838 |
DT |
denotes |
a |
T11143 |
839-846 |
NN |
denotes |
failure |
T11144 |
847-849 |
IN |
denotes |
of |
T11145 |
850-859 |
JJ |
denotes |
apoptotic |
T11146 |
860-864 |
NN |
denotes |
cell |
T11147 |
865-874 |
NN |
denotes |
clearance |
T11148 |
874-875 |
. |
denotes |
. |
T11149 |
875-1028 |
sentence |
denotes |
A recent comprehensive kinetic analysis of apoptosis induction during mouse retinal development described four major peaks of apoptotic cell death [42]. |
T11150 |
876-877 |
DT |
denotes |
A |
T11151 |
907-915 |
NN |
denotes |
analysis |
T11152 |
878-884 |
JJ |
denotes |
recent |
T11153 |
885-898 |
JJ |
denotes |
comprehensive |
T11154 |
899-906 |
JJ |
denotes |
kinetic |
T11155 |
972-981 |
VBD |
denotes |
described |
T11156 |
916-918 |
IN |
denotes |
of |
T11157 |
919-928 |
NN |
denotes |
apoptosis |
T11158 |
929-938 |
NN |
denotes |
induction |
T11159 |
939-945 |
IN |
denotes |
during |
T11160 |
946-951 |
NN |
denotes |
mouse |
T11161 |
960-971 |
NN |
denotes |
development |
T11162 |
952-959 |
NN |
denotes |
retinal |
T11163 |
982-986 |
CD |
denotes |
four |
T11164 |
993-998 |
NNS |
denotes |
peaks |
T11165 |
987-992 |
JJ |
denotes |
major |
T11166 |
999-1001 |
IN |
denotes |
of |
T11167 |
1002-1011 |
JJ |
denotes |
apoptotic |
T11168 |
1017-1022 |
NN |
denotes |
death |
T11169 |
1012-1016 |
NN |
denotes |
cell |
T11170 |
1023-1024 |
-LRB- |
denotes |
[ |
T11171 |
1024-1026 |
CD |
denotes |
42 |
T11172 |
1026-1027 |
-RRB- |
denotes |
] |
T11173 |
1027-1028 |
. |
denotes |
. |
T11174 |
1028-1318 |
sentence |
denotes |
This study demonstrated that there is an initial phase of cell death during the invagination of the optic cup (E10.5), followed by subsequent waves of apoptosis induction immediately before and after birth (E18.5 to postnatal day P2), and from postnatal days P9 to P10 and P14 to P16 [42]. |
T11175 |
1029-1033 |
DT |
denotes |
This |
T11176 |
1034-1039 |
NN |
denotes |
study |
T11177 |
1040-1052 |
VBD |
denotes |
demonstrated |
T11178 |
1053-1057 |
IN |
denotes |
that |
T11179 |
1064-1066 |
VBZ |
denotes |
is |
T11180 |
1058-1063 |
EX |
denotes |
there |
T11181 |
1067-1069 |
DT |
denotes |
an |
T11182 |
1078-1083 |
NN |
denotes |
phase |
T11183 |
1070-1077 |
JJ |
denotes |
initial |
T11184 |
1084-1086 |
IN |
denotes |
of |
T11185 |
1087-1091 |
NN |
denotes |
cell |
T11186 |
1092-1097 |
NN |
denotes |
death |
T11187 |
1098-1104 |
IN |
denotes |
during |
T11188 |
1105-1108 |
DT |
denotes |
the |
T11189 |
1109-1121 |
NN |
denotes |
invagination |
T11190 |
1122-1124 |
IN |
denotes |
of |
T11191 |
1125-1128 |
DT |
denotes |
the |
T11192 |
1135-1138 |
NN |
denotes |
cup |
T11193 |
1129-1134 |
JJ |
denotes |
optic |
T11194 |
1139-1140 |
-LRB- |
denotes |
( |
T11195 |
1140-1145 |
NN |
denotes |
E10.5 |
T11196 |
1145-1146 |
-RRB- |
denotes |
) |
T11197 |
1146-1148 |
, |
denotes |
, |
T11198 |
1148-1156 |
VBN |
denotes |
followed |
T11199 |
1157-1159 |
IN |
denotes |
by |
T11200 |
1160-1170 |
JJ |
denotes |
subsequent |
T11201 |
1171-1176 |
NNS |
denotes |
waves |
T11202 |
1177-1179 |
IN |
denotes |
of |
T11203 |
1180-1189 |
NN |
denotes |
apoptosis |
T11204 |
1190-1199 |
NN |
denotes |
induction |
T11205 |
1200-1211 |
RB |
denotes |
immediately |
T11206 |
1212-1218 |
IN |
denotes |
before |
T11207 |
1219-1222 |
CC |
denotes |
and |
T11208 |
1223-1228 |
IN |
denotes |
after |
T11209 |
1229-1234 |
NN |
denotes |
birth |
T11210 |
1235-1236 |
-LRB- |
denotes |
( |
T11211 |
1236-1241 |
NN |
denotes |
E18.5 |
T11212 |
1242-1244 |
IN |
denotes |
to |
T11213 |
1245-1254 |
JJ |
denotes |
postnatal |
T11214 |
1255-1258 |
NN |
denotes |
day |
T11215 |
1259-1261 |
NN |
denotes |
P2 |
T11216 |
1261-1262 |
-RRB- |
denotes |
) |
T11217 |
1262-1264 |
, |
denotes |
, |
T11218 |
1264-1267 |
CC |
denotes |
and |
T11219 |
1268-1272 |
IN |
denotes |
from |
T11220 |
1273-1282 |
JJ |
denotes |
postnatal |
T11221 |
1288-1290 |
NN |
denotes |
P9 |
T11222 |
1283-1287 |
NNS |
denotes |
days |
T11223 |
1291-1293 |
IN |
denotes |
to |
T11224 |
1294-1297 |
NN |
denotes |
P10 |
T11225 |
1298-1301 |
CC |
denotes |
and |
T11226 |
1302-1305 |
NN |
denotes |
P14 |
T11227 |
1306-1308 |
IN |
denotes |
to |
T11228 |
1309-1312 |
NN |
denotes |
P16 |
T11229 |
1313-1314 |
-LRB- |
denotes |
[ |
T11230 |
1314-1316 |
CD |
denotes |
42 |
T11231 |
1316-1317 |
-RRB- |
denotes |
] |
T11232 |
1317-1318 |
. |
denotes |
. |
T11233 |
1318-1574 |
sentence |
denotes |
Thus, besides the formation of the inner and outer layers of the optic cup in early eye development, other major phases of retinal cell apoptosis take place only postnatally and correspond to important periods in the establishment of neuronal connections. |
T11234 |
1319-1323 |
RB |
denotes |
Thus |
T11235 |
1465-1469 |
VBP |
denotes |
take |
T11236 |
1323-1325 |
, |
denotes |
, |
T11237 |
1325-1332 |
IN |
denotes |
besides |
T11238 |
1333-1336 |
DT |
denotes |
the |
T11239 |
1337-1346 |
NN |
denotes |
formation |
T11240 |
1347-1349 |
IN |
denotes |
of |
T11241 |
1350-1353 |
DT |
denotes |
the |
T11242 |
1370-1376 |
NNS |
denotes |
layers |
T11243 |
1354-1359 |
JJ |
denotes |
inner |
T11244 |
1360-1363 |
CC |
denotes |
and |
T11245 |
1364-1369 |
JJ |
denotes |
outer |
T11246 |
1377-1379 |
IN |
denotes |
of |
T11247 |
1380-1383 |
DT |
denotes |
the |
T11248 |
1390-1393 |
NN |
denotes |
cup |
T11249 |
1384-1389 |
JJ |
denotes |
optic |
T11250 |
1394-1396 |
IN |
denotes |
in |
T11251 |
1397-1402 |
JJ |
denotes |
early |
T11252 |
1407-1418 |
NN |
denotes |
development |
T11253 |
1403-1406 |
NN |
denotes |
eye |
T11254 |
1418-1420 |
, |
denotes |
, |
T11255 |
1420-1425 |
JJ |
denotes |
other |
T11256 |
1432-1438 |
NNS |
denotes |
phases |
T11257 |
1426-1431 |
JJ |
denotes |
major |
T11258 |
1439-1441 |
IN |
denotes |
of |
T11259 |
1442-1449 |
JJ |
denotes |
retinal |
T11260 |
1455-1464 |
NN |
denotes |
apoptosis |
T11261 |
1450-1454 |
NN |
denotes |
cell |
T11262 |
1470-1475 |
NN |
denotes |
place |
T11263 |
1476-1480 |
RB |
denotes |
only |
T11264 |
1481-1492 |
RB |
denotes |
postnatally |
T11265 |
1493-1496 |
CC |
denotes |
and |
T11266 |
1497-1507 |
VBP |
denotes |
correspond |
T11267 |
1508-1510 |
IN |
denotes |
to |
T11268 |
1511-1520 |
JJ |
denotes |
important |
T11269 |
1521-1528 |
NNS |
denotes |
periods |
T11270 |
1529-1531 |
IN |
denotes |
in |
T11271 |
1532-1535 |
DT |
denotes |
the |
T11272 |
1536-1549 |
NN |
denotes |
establishment |
T11273 |
1550-1552 |
IN |
denotes |
of |
T11274 |
1553-1561 |
JJ |
denotes |
neuronal |
T11275 |
1562-1573 |
NNS |
denotes |
connections |
T11276 |
1573-1574 |
. |
denotes |
. |
T11277 |
1574-1799 |
sentence |
denotes |
Furthermore, cell death during normal retinal development occurs in retinal layers distinct from the inner granular layer where we observed the most pronounced differentiation defects in the Ptdsr -/- mutants described here. |
T11278 |
1575-1586 |
RB |
denotes |
Furthermore |
T11279 |
1633-1639 |
VBZ |
denotes |
occurs |
T11280 |
1586-1588 |
, |
denotes |
, |
T11281 |
1588-1592 |
NN |
denotes |
cell |
T11282 |
1593-1598 |
NN |
denotes |
death |
T11283 |
1599-1605 |
IN |
denotes |
during |
T11284 |
1606-1612 |
JJ |
denotes |
normal |
T11285 |
1621-1632 |
NN |
denotes |
development |
T11286 |
1613-1620 |
JJ |
denotes |
retinal |
T11287 |
1640-1642 |
IN |
denotes |
in |
T11288 |
1643-1650 |
JJ |
denotes |
retinal |
T11289 |
1651-1657 |
NNS |
denotes |
layers |
T11290 |
1658-1666 |
JJ |
denotes |
distinct |
T11291 |
1667-1671 |
IN |
denotes |
from |
T11292 |
1672-1675 |
DT |
denotes |
the |
T11293 |
1691-1696 |
NN |
denotes |
layer |
T11294 |
1676-1681 |
JJ |
denotes |
inner |
T11295 |
1682-1690 |
JJ |
denotes |
granular |
T11296 |
1697-1702 |
WRB |
denotes |
where |
T11297 |
1706-1714 |
VBD |
denotes |
observed |
T11298 |
1703-1705 |
PRP |
denotes |
we |
T11299 |
1715-1718 |
DT |
denotes |
the |
T11300 |
1751-1758 |
NNS |
denotes |
defects |
T11301 |
1719-1723 |
RBS |
denotes |
most |
T11302 |
1724-1734 |
JJ |
denotes |
pronounced |
T11303 |
1735-1750 |
NN |
denotes |
differentiation |
T11304 |
1759-1761 |
IN |
denotes |
in |
T11305 |
1762-1765 |
DT |
denotes |
the |
T11306 |
1776-1783 |
NNS |
denotes |
mutants |
T11307 |
1766-1771 |
NN |
denotes |
Ptdsr |
T11308 |
1772-1773 |
SYM |
denotes |
- |
T11309 |
1773-1774 |
HYPH |
denotes |
/ |
T11310 |
1774-1775 |
SYM |
denotes |
- |
T11311 |
1784-1793 |
VBN |
denotes |
described |
T11312 |
1794-1798 |
RB |
denotes |
here |
T11313 |
1798-1799 |
. |
denotes |
. |
T11314 |
1799-2072 |
sentence |
denotes |
Other studies that connect the postnatal elimination of apoptotic photoreceptor cells to Ptdsr-mediated macrophage engulfment [43] should be interpreted with extreme caution as these studies were based on the monoclonal anti-Ptdsr antibody mAb 217G8E9 [26,43] (see below). |
T11315 |
1800-1805 |
JJ |
denotes |
Other |
T11316 |
1806-1813 |
NNS |
denotes |
studies |
T11317 |
1941-1952 |
VBN |
denotes |
interpreted |
T11318 |
1814-1818 |
WDT |
denotes |
that |
T11319 |
1819-1826 |
VBP |
denotes |
connect |
T11320 |
1827-1830 |
DT |
denotes |
the |
T11321 |
1841-1852 |
NN |
denotes |
elimination |
T11322 |
1831-1840 |
JJ |
denotes |
postnatal |
T11323 |
1853-1855 |
IN |
denotes |
of |
T11324 |
1856-1865 |
JJ |
denotes |
apoptotic |
T11325 |
1880-1885 |
NNS |
denotes |
cells |
T11326 |
1866-1879 |
NN |
denotes |
photoreceptor |
T11327 |
1886-1888 |
IN |
denotes |
to |
T11328 |
1889-1894 |
NN |
denotes |
Ptdsr |
T11329 |
1895-1903 |
VBN |
denotes |
mediated |
T11330 |
1894-1895 |
HYPH |
denotes |
- |
T11331 |
1915-1925 |
NN |
denotes |
engulfment |
T11332 |
1904-1914 |
NN |
denotes |
macrophage |
T11333 |
1926-1927 |
-LRB- |
denotes |
[ |
T11334 |
1927-1929 |
CD |
denotes |
43 |
T11335 |
1929-1930 |
-RRB- |
denotes |
] |
T11336 |
1931-1937 |
MD |
denotes |
should |
T11337 |
1938-1940 |
VB |
denotes |
be |
T11338 |
1953-1957 |
IN |
denotes |
with |
T11339 |
1958-1965 |
JJ |
denotes |
extreme |
T11340 |
1966-1973 |
NN |
denotes |
caution |
T11341 |
1974-1976 |
IN |
denotes |
as |
T11342 |
1996-2001 |
VBN |
denotes |
based |
T11343 |
1977-1982 |
DT |
denotes |
these |
T11344 |
1983-1990 |
NNS |
denotes |
studies |
T11345 |
1991-1995 |
VBD |
denotes |
were |
T11346 |
2002-2004 |
IN |
denotes |
on |
T11347 |
2005-2008 |
DT |
denotes |
the |
T11348 |
2031-2039 |
NN |
denotes |
antibody |
T11349 |
2009-2019 |
JJ |
denotes |
monoclonal |
T11350 |
2020-2030 |
JJ |
denotes |
anti-Ptdsr |
T11351 |
2040-2043 |
NN |
denotes |
mAb |
T11352 |
2044-2051 |
CD |
denotes |
217G8E9 |
T11353 |
2052-2053 |
-LRB- |
denotes |
[ |
T11354 |
2056-2058 |
CD |
denotes |
43 |
T11355 |
2053-2055 |
CD |
denotes |
26 |
T11356 |
2055-2056 |
, |
denotes |
, |
T11357 |
2058-2059 |
-RRB- |
denotes |
] |
T11358 |
2060-2061 |
-LRB- |
denotes |
( |
T11359 |
2061-2064 |
VB |
denotes |
see |
T11360 |
2065-2070 |
RB |
denotes |
below |
T11361 |
2070-2071 |
-RRB- |
denotes |
) |
T11362 |
2071-2072 |
. |
denotes |
. |
R6423 |
T11000 |
T11001 |
advmod |
Interestingly,observed |
R6424 |
T11002 |
T11001 |
punct |
", ",observed |
R6425 |
T11003 |
T11001 |
nsubj |
we,observed |
R6426 |
T11004 |
T11001 |
advmod |
occasionally,observed |
R6427 |
T11005 |
T11006 |
amod |
serious,malformations |
R6428 |
T11006 |
T11001 |
dobj |
malformations,observed |
R6429 |
T11007 |
T11006 |
prep |
of,malformations |
R6430 |
T11008 |
T11007 |
pobj |
forebrain,of |
R6431 |
T11009 |
T11008 |
cc |
and,forebrain |
R6432 |
T11010 |
T11011 |
amod |
nasal,structures |
R6433 |
T11011 |
T11008 |
conj |
structures,forebrain |
R6434 |
T11012 |
T11006 |
prep |
in,malformations |
R6435 |
T11013 |
T11014 |
compound |
Ptdsr,knockout |
R6436 |
T11014 |
T11016 |
compound |
knockout,embryos |
R6437 |
T11015 |
T11014 |
punct |
-,knockout |
R6438 |
T11016 |
T11012 |
pobj |
embryos,in |
R6439 |
T11017 |
T11018 |
dep |
that,associated |
R6440 |
T11018 |
T11006 |
relcl |
associated,malformations |
R6441 |
T11019 |
T11018 |
auxpass |
were,associated |
R6442 |
T11020 |
T11018 |
prep |
with,associated |
R6443 |
T11021 |
T11022 |
amod |
bilateral,anophthalmia |
R6444 |
T11022 |
T11020 |
pobj |
anophthalmia,with |
R6445 |
T11023 |
T11024 |
punct |
(,see |
R6446 |
T11024 |
T11001 |
parataxis |
see,observed |
R6447 |
T11025 |
T11024 |
prep |
for,see |
R6448 |
T11026 |
T11025 |
pobj |
example,for |
R6449 |
T11027 |
T11028 |
det |
the,embryo |
R6450 |
T11028 |
T11024 |
dobj |
embryo,see |
R6451 |
T11029 |
T11028 |
compound |
mutant,embryo |
R6452 |
T11030 |
T11028 |
prep |
in,embryo |
R6453 |
T11031 |
T11032 |
compound |
Figure,1g |
R6454 |
T11032 |
T11030 |
pobj |
1g,in |
R6455 |
T11033 |
T11024 |
punct |
),see |
R6456 |
T11034 |
T11001 |
punct |
.,observed |
R6457 |
T11036 |
T11037 |
nsubj |
This,suggests |
R6458 |
T11038 |
T11039 |
mark |
that,involved |
R6459 |
T11039 |
T11037 |
advcl |
involved,suggests |
R6460 |
T11040 |
T11039 |
nsubjpass |
Ptdsr,involved |
R6461 |
T11041 |
T11039 |
auxpass |
is,involved |
R6462 |
T11042 |
T11039 |
prep |
in,involved |
R6463 |
T11043 |
T11044 |
det |
the,regulation |
R6464 |
T11044 |
T11042 |
pobj |
regulation,in |
R6465 |
T11045 |
T11044 |
prep |
of,regulation |
R6466 |
T11046 |
T11047 |
compound |
differentiation,processes |
R6467 |
T11047 |
T11045 |
pobj |
processes,of |
R6468 |
T11048 |
T11044 |
prep |
within,regulation |
R6469 |
T11049 |
T11050 |
compound |
forebrain,regions |
R6470 |
T11050 |
T11048 |
pobj |
regions,within |
R6471 |
T11051 |
T11039 |
punct |
", ",involved |
R6472 |
T11052 |
T11039 |
cc |
and,involved |
R6473 |
T11053 |
T11054 |
mark |
that,affect |
R6474 |
T11054 |
T11039 |
conj |
affect,involved |
R6475 |
T11055 |
T11054 |
nsubj |
ablation,affect |
R6476 |
T11056 |
T11055 |
prep |
of,ablation |
R6477 |
T11057 |
T11058 |
compound |
Ptdsr,function |
R6478 |
T11058 |
T11056 |
pobj |
function,of |
R6479 |
T11059 |
T11054 |
aux |
might,affect |
R6480 |
T11060 |
T11054 |
advmod |
secondarily,affect |
R6481 |
T11061 |
T11062 |
amod |
early,formation |
R6482 |
T11062 |
T11054 |
dobj |
formation,affect |
R6483 |
T11063 |
T11062 |
compound |
eye,formation |
R6484 |
T11064 |
T11037 |
punct |
.,suggests |
R6485 |
T11066 |
T11067 |
nsubj |
Li,found |
R6486 |
T11068 |
T11069 |
advmod |
et,al. |
R6487 |
T11069 |
T11066 |
advmod |
al.,Li |
R6488 |
T11070 |
T11071 |
punct |
[,31 |
R6489 |
T11071 |
T11066 |
parataxis |
31,Li |
R6490 |
T11072 |
T11071 |
punct |
],31 |
R6491 |
T11073 |
T11074 |
amod |
smaller,lenses |
R6492 |
T11074 |
T11067 |
dobj |
lenses,found |
R6493 |
T11075 |
T11074 |
prep |
in,lenses |
R6494 |
T11076 |
T11077 |
compound |
Ptdsr,knockout |
R6495 |
T11077 |
T11079 |
compound |
knockout,mice |
R6496 |
T11078 |
T11077 |
punct |
-,knockout |
R6497 |
T11079 |
T11075 |
pobj |
mice,in |
R6498 |
T11080 |
T11067 |
cc |
and,found |
R6499 |
T11081 |
T11067 |
conj |
described,found |
R6500 |
T11082 |
T11083 |
det |
the,formation |
R6501 |
T11083 |
T11081 |
dobj |
formation,described |
R6502 |
T11084 |
T11083 |
prep |
of,formation |
R6503 |
T11085 |
T11086 |
amod |
retinal,protrusions |
R6504 |
T11086 |
T11084 |
pobj |
protrusions,of |
R6505 |
T11087 |
T11067 |
punct |
", ",found |
R6506 |
T11088 |
T11089 |
mark |
although,reported |
R6507 |
T11089 |
T11067 |
advcl |
reported,found |
R6508 |
T11090 |
T11089 |
nsubjpass |
anophthalmia,reported |
R6509 |
T11091 |
T11090 |
cc |
and,anophthalmia |
R6510 |
T11092 |
T11093 |
amod |
specific,defects |
R6511 |
T11093 |
T11090 |
conj |
defects,anophthalmia |
R6512 |
T11094 |
T11093 |
compound |
differentiation,defects |
R6513 |
T11095 |
T11093 |
prep |
of,defects |
R6514 |
T11096 |
T11097 |
amod |
retinal,layers |
R6515 |
T11097 |
T11095 |
pobj |
layers,of |
R6516 |
T11098 |
T11097 |
compound |
cell,layers |
R6517 |
T11099 |
T11089 |
auxpass |
were,reported |
R6518 |
T11100 |
T11089 |
neg |
not,reported |
R6519 |
T11101 |
T11089 |
prep |
in,reported |
R6520 |
T11102 |
T11103 |
poss |
their,study |
R6521 |
T11103 |
T11101 |
pobj |
study,in |
R6522 |
T11104 |
T11067 |
punct |
.,found |
R6523 |
T11106 |
T11107 |
nsubj |
Li,proposed |
R6524 |
T11108 |
T11109 |
advmod |
et,al. |
R6525 |
T11109 |
T11106 |
advmod |
al.,Li |
R6526 |
T11110 |
T11111 |
punct |
[,31 |
R6527 |
T11111 |
T11107 |
parataxis |
31,proposed |
R6528 |
T11112 |
T11111 |
punct |
],31 |
R6529 |
T11113 |
T11114 |
mark |
that,explained |
R6530 |
T11114 |
T11107 |
ccomp |
explained,proposed |
R6531 |
T11115 |
T11116 |
det |
the,phenotype |
R6532 |
T11116 |
T11114 |
nsubjpass |
phenotype,explained |
R6533 |
T11117 |
T11116 |
compound |
eye,phenotype |
R6534 |
T11118 |
T11119 |
nsubj |
they,observed |
R6535 |
T11119 |
T11116 |
advcl |
observed,phenotype |
R6536 |
T11120 |
T11114 |
aux |
could,explained |
R6537 |
T11121 |
T11114 |
auxpass |
be,explained |
R6538 |
T11122 |
T11114 |
prep |
by,explained |
R6539 |
T11123 |
T11124 |
amod |
failed,removal |
R6540 |
T11153 |
T11151 |
amod |
comprehensive,analysis |
R6541 |
T11124 |
T11122 |
pobj |
removal,by |
R6542 |
T11125 |
T11124 |
prep |
of,removal |
R6543 |
T11154 |
T11151 |
amod |
kinetic,analysis |
R6544 |
T11126 |
T11127 |
amod |
apoptotic,cells |
R6545 |
T11156 |
T11151 |
prep |
of,analysis |
R6546 |
T11157 |
T11158 |
compound |
apoptosis,induction |
R6547 |
T11158 |
T11156 |
pobj |
induction,of |
R6548 |
T11127 |
T11125 |
pobj |
cells,of |
R6549 |
T11159 |
T11158 |
prep |
during,induction |
R6550 |
T11160 |
T11161 |
compound |
mouse,development |
R6551 |
T11128 |
T11124 |
prep |
during,removal |
R6552 |
T11161 |
T11159 |
pobj |
development,during |
R6553 |
T11162 |
T11161 |
compound |
retinal,development |
R6554 |
T11163 |
T11164 |
nummod |
four,peaks |
R6555 |
T11164 |
T11155 |
dobj |
peaks,described |
R6556 |
T11165 |
T11164 |
amod |
major,peaks |
R6557 |
T11166 |
T11164 |
prep |
of,peaks |
R6558 |
T11129 |
T11130 |
compound |
eye,development |
R6559 |
T11167 |
T11168 |
amod |
apoptotic,death |
R6560 |
T11168 |
T11166 |
pobj |
death,of |
R6561 |
T11169 |
T11168 |
compound |
cell,death |
R6562 |
T11130 |
T11128 |
pobj |
development,during |
R6563 |
T11170 |
T11171 |
punct |
[,42 |
R6564 |
T11171 |
T11155 |
parataxis |
42,described |
R6565 |
T11172 |
T11171 |
punct |
],42 |
R6566 |
T11131 |
T11107 |
punct |
", ",proposed |
R6567 |
T11173 |
T11155 |
punct |
.,described |
R6568 |
T11132 |
T11107 |
cc |
but,proposed |
R6569 |
T11175 |
T11176 |
det |
This,study |
R6570 |
T11176 |
T11177 |
nsubj |
study,demonstrated |
R6571 |
T11133 |
T11134 |
nsubj |
we,think |
R6572 |
T11178 |
T11179 |
mark |
that,is |
R6573 |
T11179 |
T11177 |
ccomp |
is,demonstrated |
R6574 |
T11134 |
T11107 |
conj |
think,proposed |
R6575 |
T11180 |
T11179 |
expl |
there,is |
R6576 |
T11181 |
T11182 |
det |
an,phase |
R6577 |
T11135 |
T11136 |
mark |
that,are |
R6578 |
T11182 |
T11179 |
attr |
phase,is |
R6579 |
T11183 |
T11182 |
amod |
initial,phase |
R6580 |
T11184 |
T11182 |
prep |
of,phase |
R6581 |
T11136 |
T11134 |
ccomp |
are,think |
R6582 |
T11185 |
T11186 |
compound |
cell,death |
R6583 |
T11137 |
T11138 |
det |
the,defects |
R6584 |
T11186 |
T11184 |
pobj |
death,of |
R6585 |
T11187 |
T11179 |
prep |
during,is |
R6586 |
T11188 |
T11189 |
det |
the,invagination |
R6587 |
T11189 |
T11187 |
pobj |
invagination,during |
R6588 |
T11138 |
T11136 |
nsubj |
defects,are |
R6589 |
T11190 |
T11189 |
prep |
of,invagination |
R6590 |
T11191 |
T11192 |
det |
the,cup |
R6591 |
T11139 |
T11138 |
amod |
observed,defects |
R6592 |
T11192 |
T11190 |
pobj |
cup,of |
R6593 |
T11193 |
T11192 |
amod |
optic,cup |
R6594 |
T11194 |
T11195 |
punct |
(,E10.5 |
R6595 |
T11140 |
T11136 |
acomp |
unrelated,are |
R6596 |
T11195 |
T11189 |
parataxis |
E10.5,invagination |
R6597 |
T11196 |
T11195 |
punct |
),E10.5 |
R6598 |
T11197 |
T11179 |
punct |
", ",is |
R6599 |
T11141 |
T11140 |
prep |
to,unrelated |
R6600 |
T11198 |
T11179 |
advcl |
followed,is |
R6601 |
T11199 |
T11198 |
agent |
by,followed |
R6602 |
T11200 |
T11201 |
amod |
subsequent,waves |
R6603 |
T11142 |
T11143 |
det |
a,failure |
R6604 |
T11201 |
T11199 |
pobj |
waves,by |
R6605 |
T11202 |
T11201 |
prep |
of,waves |
R6606 |
T11143 |
T11141 |
pobj |
failure,to |
R6607 |
T11203 |
T11204 |
compound |
apoptosis,induction |
R6608 |
T11204 |
T11202 |
pobj |
induction,of |
R6609 |
T11205 |
T11206 |
advmod |
immediately,before |
R6610 |
T11206 |
T11201 |
prep |
before,waves |
R6611 |
T11207 |
T11206 |
cc |
and,before |
R6612 |
T11208 |
T11206 |
conj |
after,before |
R6613 |
T11144 |
T11143 |
prep |
of,failure |
R6614 |
T11209 |
T11208 |
pobj |
birth,after |
R6615 |
T11210 |
T11211 |
punct |
(,E18.5 |
R6616 |
T11211 |
T11209 |
parataxis |
E18.5,birth |
R6617 |
T11145 |
T11146 |
amod |
apoptotic,cell |
R6618 |
T11212 |
T11211 |
prep |
to,E18.5 |
R6619 |
T11213 |
T11214 |
amod |
postnatal,day |
R6620 |
T11214 |
T11212 |
pobj |
day,to |
R6621 |
T11146 |
T11147 |
compound |
cell,clearance |
R6622 |
T11215 |
T11214 |
appos |
P2,day |
R6623 |
T11216 |
T11211 |
punct |
),E18.5 |
R6624 |
T11147 |
T11144 |
pobj |
clearance,of |
R6625 |
T11217 |
T11206 |
punct |
", ",before |
R6626 |
T11218 |
T11206 |
cc |
and,before |
R6627 |
T11219 |
T11206 |
conj |
from,before |
R6628 |
T11148 |
T11134 |
punct |
.,think |
R6629 |
T11220 |
T11221 |
amod |
postnatal,P9 |
R6630 |
T11221 |
T11219 |
pobj |
P9,from |
R6631 |
T11150 |
T11151 |
det |
A,analysis |
R6632 |
T11222 |
T11221 |
compound |
days,P9 |
R6633 |
T11223 |
T11221 |
prep |
to,P9 |
R6634 |
T11151 |
T11155 |
nsubj |
analysis,described |
R6635 |
T11224 |
T11223 |
pobj |
P10,to |
R6636 |
T11152 |
T11151 |
amod |
recent,analysis |
R6637 |
T11259 |
T11260 |
amod |
retinal,apoptosis |
R6638 |
T11225 |
T11221 |
cc |
and,P9 |
R6639 |
T11226 |
T11221 |
conj |
P14,P9 |
R6640 |
T11260 |
T11258 |
pobj |
apoptosis,of |
R6641 |
T11227 |
T11226 |
prep |
to,P14 |
R6642 |
T11228 |
T11227 |
pobj |
P16,to |
R6643 |
T11229 |
T11230 |
punct |
[,42 |
R6644 |
T11261 |
T11260 |
compound |
cell,apoptosis |
R6645 |
T11230 |
T11177 |
parataxis |
42,demonstrated |
R6646 |
T11231 |
T11230 |
punct |
],42 |
R6647 |
T11262 |
T11235 |
dobj |
place,take |
R6648 |
T11232 |
T11177 |
punct |
.,demonstrated |
R6649 |
T11263 |
T11235 |
advmod |
only,take |
R6650 |
T11234 |
T11235 |
advmod |
Thus,take |
R6651 |
T11264 |
T11235 |
advmod |
postnatally,take |
R6652 |
T11236 |
T11235 |
punct |
", ",take |
R6653 |
T11237 |
T11235 |
prep |
besides,take |
R6654 |
T11238 |
T11239 |
det |
the,formation |
R6655 |
T11265 |
T11235 |
cc |
and,take |
R6656 |
T11239 |
T11237 |
pobj |
formation,besides |
R6657 |
T11240 |
T11239 |
prep |
of,formation |
R6658 |
T11266 |
T11235 |
conj |
correspond,take |
R6659 |
T11241 |
T11242 |
det |
the,layers |
R6660 |
T11242 |
T11240 |
pobj |
layers,of |
R6661 |
T11243 |
T11242 |
amod |
inner,layers |
R6662 |
T11244 |
T11243 |
cc |
and,inner |
R6663 |
T11245 |
T11243 |
conj |
outer,inner |
R6664 |
T11246 |
T11242 |
prep |
of,layers |
R6665 |
T11267 |
T11266 |
prep |
to,correspond |
R6666 |
T11247 |
T11248 |
det |
the,cup |
R6667 |
T11248 |
T11246 |
pobj |
cup,of |
R6668 |
T11249 |
T11248 |
amod |
optic,cup |
R6669 |
T11268 |
T11269 |
amod |
important,periods |
R6670 |
T11250 |
T11242 |
prep |
in,layers |
R6671 |
T11251 |
T11252 |
amod |
early,development |
R6672 |
T11252 |
T11250 |
pobj |
development,in |
R6673 |
T11269 |
T11267 |
pobj |
periods,to |
R6674 |
T11253 |
T11252 |
compound |
eye,development |
R6675 |
T11254 |
T11235 |
punct |
", ",take |
R6676 |
T11270 |
T11269 |
prep |
in,periods |
R6677 |
T11255 |
T11256 |
amod |
other,phases |
R6678 |
T11256 |
T11235 |
nsubj |
phases,take |
R6679 |
T11257 |
T11256 |
amod |
major,phases |
R6680 |
T11271 |
T11272 |
det |
the,establishment |
R6681 |
T11258 |
T11256 |
prep |
of,phases |
R6682 |
T11272 |
T11270 |
pobj |
establishment,in |
R6683 |
T11273 |
T11272 |
prep |
of,establishment |
R6684 |
T11274 |
T11275 |
amod |
neuronal,connections |
R6685 |
T11275 |
T11273 |
pobj |
connections,of |
R6687 |
T11276 |
T11235 |
punct |
.,take |
R6691 |
T11278 |
T11279 |
advmod |
Furthermore,occurs |
R6695 |
T11280 |
T11279 |
punct |
", ",occurs |
R6700 |
T11281 |
T11282 |
compound |
cell,death |
R6703 |
T11282 |
T11279 |
nsubj |
death,occurs |
R6707 |
T11283 |
T11282 |
prep |
during,death |
R6714 |
T11284 |
T11285 |
amod |
normal,development |
R6717 |
T11285 |
T11283 |
pobj |
development,during |
R6721 |
T11286 |
T11285 |
amod |
retinal,development |
R6724 |
T11287 |
T11279 |
prep |
in,occurs |
R6726 |
T11288 |
T11289 |
amod |
retinal,layers |
R6729 |
T11289 |
T11287 |
pobj |
layers,in |
R6733 |
T11290 |
T11289 |
amod |
distinct,layers |
R6737 |
T11291 |
T11290 |
prep |
from,distinct |
R6739 |
T11292 |
T11293 |
det |
the,layer |
R6744 |
T11293 |
T11291 |
pobj |
layer,from |
R6747 |
T11294 |
T11293 |
amod |
inner,layer |
R6750 |
T11295 |
T11293 |
amod |
granular,layer |
R6754 |
T11296 |
T11297 |
advmod |
where,observed |
R6758 |
T11297 |
T11293 |
relcl |
observed,layer |
R6762 |
T11298 |
T11297 |
nsubj |
we,observed |
R6770 |
T11299 |
T11300 |
det |
the,defects |
R6774 |
T11300 |
T11297 |
dobj |
defects,observed |
R6778 |
T11301 |
T11302 |
advmod |
most,pronounced |
R6782 |
T11302 |
T11300 |
amod |
pronounced,defects |
R6785 |
T11303 |
T11300 |
compound |
differentiation,defects |
R6789 |
T11304 |
T11300 |
prep |
in,defects |
R6793 |
T11305 |
T11306 |
det |
the,mutants |
R6796 |
T11306 |
T11304 |
pobj |
mutants,in |
R6800 |
T11307 |
T11306 |
nmod |
Ptdsr,mutants |
R6804 |
T11308 |
T11307 |
punct |
-,Ptdsr |
R6808 |
T11309 |
T11307 |
punct |
/,Ptdsr |
R6812 |
T11310 |
T11307 |
punct |
-,Ptdsr |
R6819 |
T11311 |
T11306 |
acl |
described,mutants |
R6822 |
T11312 |
T11311 |
advmod |
here,described |
R6823 |
T11313 |
T11279 |
punct |
.,occurs |
R6824 |
T11315 |
T11316 |
amod |
Other,studies |
R6825 |
T11316 |
T11317 |
nsubjpass |
studies,interpreted |
R6828 |
T11318 |
T11319 |
dep |
that,connect |
R6833 |
T11319 |
T11316 |
relcl |
connect,studies |
R6837 |
T11320 |
T11321 |
det |
the,elimination |
R6839 |
T11321 |
T11319 |
dobj |
elimination,connect |
R6842 |
T11322 |
T11321 |
amod |
postnatal,elimination |
R6846 |
T11323 |
T11321 |
prep |
of,elimination |
R6849 |
T11324 |
T11325 |
amod |
apoptotic,cells |
R6853 |
T11325 |
T11323 |
pobj |
cells,of |
R6857 |
T11326 |
T11325 |
compound |
photoreceptor,cells |
R6860 |
T11327 |
T11319 |
prep |
to,connect |
R6864 |
T11328 |
T11329 |
npadvmod |
Ptdsr,mediated |
R6870 |
T11329 |
T11331 |
amod |
mediated,engulfment |
R6873 |
T11330 |
T11329 |
punct |
-,mediated |
R6877 |
T11331 |
T11327 |
pobj |
engulfment,to |
R6881 |
T11332 |
T11331 |
compound |
macrophage,engulfment |
R6885 |
T11333 |
T11334 |
punct |
[,43 |
R6888 |
T11334 |
T11316 |
parataxis |
43,studies |
R6892 |
T11335 |
T11334 |
punct |
],43 |
R6896 |
T11336 |
T11317 |
aux |
should,interpreted |
R6900 |
T11337 |
T11317 |
auxpass |
be,interpreted |
R6904 |
T11338 |
T11317 |
prep |
with,interpreted |
R6907 |
T11339 |
T11340 |
amod |
extreme,caution |
R6911 |
T11340 |
T11338 |
pobj |
caution,with |
R6914 |
T11341 |
T11342 |
mark |
as,based |
R6919 |
T11342 |
T11317 |
advcl |
based,interpreted |
R6923 |
T11343 |
T11344 |
det |
these,studies |
R6926 |
T11344 |
T11342 |
nsubjpass |
studies,based |
R6930 |
T11345 |
T11342 |
auxpass |
were,based |
R6933 |
T11346 |
T11342 |
prep |
on,based |
R6937 |
T11347 |
T11348 |
det |
the,antibody |
R6940 |
T11348 |
T11346 |
pobj |
antibody,on |
R6944 |
T11349 |
T11348 |
amod |
monoclonal,antibody |
R6947 |
T11350 |
T11348 |
amod |
anti-Ptdsr,antibody |
R6948 |
T11351 |
T11348 |
appos |
mAb,antibody |
R6950 |
T11352 |
T11351 |
nummod |
217G8E9,mAb |
R6954 |
T11353 |
T11354 |
punct |
[,43 |
R6957 |
T11354 |
T11342 |
parataxis |
43,based |
R6960 |
T11355 |
T11354 |
nummod |
26,43 |
R6963 |
T11356 |
T11354 |
punct |
",",43 |
R6964 |
T11357 |
T11354 |
punct |
],43 |
R6965 |
T11358 |
T11359 |
punct |
(,see |
R6966 |
T11359 |
T11317 |
parataxis |
see,interpreted |
R6967 |
T11360 |
T11359 |
advmod |
below,see |
R6971 |
T11361 |
T11359 |
punct |
),see |
R6976 |
T11362 |
T11317 |
punct |
.,interpreted |