PMC:549712 / 29676-47948 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T10788	5444-5445	.	denotes	.
T10789	5445-5650	sentence	denotes	The first, severely affected group develops anophthalmia that correlates with formation of ectopic retinal-pigmented epithelium and induction of proliferation of underlying mesenchyme in the nasal cavity.
T9791	12-17	NN	denotes	Ptdsr
T9792	21-29	VBN	denotes	required
T9793	18-20	VBZ	denotes	is
T9794	30-33	IN	denotes	for
T9795	34-37	DT	denotes	the
T9796	38-53	NN	denotes	differentiation
T9797	54-56	IN	denotes	of
T9798	57-65	JJ	denotes	multiple
T9799	72-79	NNS	denotes	systems
T9800	66-71	NN	denotes	organ
T9801	80-86	IN	denotes	during
T9802	87-98	NN	denotes	development
T9803	98-213	sentence	denotes	In this study, we have generated a null mutation in the phosphatidylserine receptor (Ptdsr) gene in C57BL/6J mice.
T9804	99-101	IN	denotes	In
T9805	122-131	VBN	denotes	generated
T9806	102-106	DT	denotes	this
T9807	107-112	NN	denotes	study
T9808	112-114	,	denotes	,
T9809	114-116	PRP	denotes	we
T9810	117-121	VBP	denotes	have
T9811	132-133	DT	denotes	a
T9812	139-147	NN	denotes	mutation
T9813	134-138	JJ	denotes	null
T9814	148-150	IN	denotes	in
T9815	151-154	DT	denotes	the
T9816	191-195	NN	denotes	gene
T9817	155-173	NN	denotes	phosphatidylserine
T9818	174-182	NN	denotes	receptor
T9819	183-184	-LRB-	denotes	(
T9820	184-189	NN	denotes	Ptdsr
T9821	189-190	-RRB-	denotes	)
T9822	196-198	IN	denotes	in
T9823	199-204	NN	denotes	C57BL
T9824	205-207	NN	denotes	6J
T9825	204-205	HYPH	denotes	/
T9826	208-212	NNS	denotes	mice
T9827	212-213	.	denotes	.
T9828	213-376	sentence	denotes	We show that ablation of Ptdsr results in profound differentiation defects in multiple organs and tissues during embryogenesis, although with variable penetrance.
T9829	214-216	PRP	denotes	We
T9830	217-221	VBP	denotes	show
T9831	222-226	IN	denotes	that
T9832	245-252	VBZ	denotes	results
T9833	227-235	NN	denotes	ablation
T9834	236-238	IN	denotes	of
T9835	239-244	NN	denotes	Ptdsr
T9836	253-255	IN	denotes	in
T9837	256-264	JJ	denotes	profound
T9838	281-288	NNS	denotes	defects
T9839	265-280	NN	denotes	differentiation
T9840	289-291	IN	denotes	in
T9841	292-300	JJ	denotes	multiple
T9842	301-307	NNS	denotes	organs
T9843	308-311	CC	denotes	and
T9844	312-319	NNS	denotes	tissues
T9845	320-326	IN	denotes	during
T9846	327-340	NN	denotes	embryogenesis
T9847	340-342	,	denotes	,
T9848	342-350	IN	denotes	although
T9849	351-355	IN	denotes	with
T9850	356-364	JJ	denotes	variable
T9851	365-375	NN	denotes	penetrance
T9852	375-376	.	denotes	.
T9853	376-483	sentence	denotes	While this work was in progress, two other groups reported the generation of Ptdsr-deficient mice [31,32].
T9854	377-382	IN	denotes	While
T9855	393-396	VBD	denotes	was
T9856	383-387	DT	denotes	this
T9857	388-392	NN	denotes	work
T9858	427-435	VBD	denotes	reported
T9859	397-399	IN	denotes	in
T9860	400-408	NN	denotes	progress
T9861	408-410	,	denotes	,
T9862	410-413	CD	denotes	two
T9863	420-426	NNS	denotes	groups
T9864	414-419	JJ	denotes	other
T9865	436-439	DT	denotes	the
T9866	440-450	NN	denotes	generation
T9867	451-453	IN	denotes	of
T9868	454-459	NN	denotes	Ptdsr
T9869	460-469	JJ	denotes	deficient
T9870	459-460	HYPH	denotes	-
T9871	470-474	NNS	denotes	mice
T9872	475-476	-LRB-	denotes	[
T9873	479-481	CD	denotes	32
T9874	476-478	CD	denotes	31
T9875	478-479	,	denotes	,
T9876	481-482	-RRB-	denotes	]
T9877	482-483	.	denotes	.
T9878	483-651	sentence	denotes	In all three knockout mouse lines, the first two exons ([31] and this study) or exons one to three [32] were deleted by replacement with a neomycin-selection cassette.
T9879	484-486	IN	denotes	In
T9880	593-600	VBN	denotes	deleted
T9881	487-490	DT	denotes	all
T9882	512-517	NNS	denotes	lines
T9883	491-496	CD	denotes	three
T9884	497-505	NN	denotes	knockout
T9885	506-511	NN	denotes	mouse
T9886	517-519	,	denotes	,
T9887	519-522	DT	denotes	the
T9888	533-538	NNS	denotes	exons
T9889	523-528	JJ	denotes	first
T9890	529-532	CD	denotes	two
T9891	539-540	-LRB-	denotes	(
T9892	541-543	CD	denotes	31
T9893	540-541	-LRB-	denotes	[
T9894	543-544	-RRB-	denotes	]
T9895	545-548	CC	denotes	and
T9896	549-553	DT	denotes	this
T9897	554-559	NN	denotes	study
T9898	559-560	-RRB-	denotes	)
T9899	561-563	CC	denotes	or
T9900	564-569	NNS	denotes	exons
T9901	570-573	CD	denotes	one
T9902	574-576	IN	denotes	to
T9903	577-582	CD	denotes	three
T9904	583-584	-LRB-	denotes	[
T9905	584-586	CD	denotes	32
T9906	586-587	-RRB-	denotes	]
T9907	588-592	VBD	denotes	were
T9908	601-603	IN	denotes	by
T9909	604-615	NN	denotes	replacement
T9910	616-620	IN	denotes	with
T9911	621-622	DT	denotes	a
T9912	642-650	NN	denotes	cassette
T9913	623-631	NN	denotes	neomycin
T9914	632-641	NN	denotes	selection
T9915	631-632	HYPH	denotes	-
T9916	650-651	.	denotes	.
T9917	651-776	sentence	denotes	The Ptdsr-knockout mouse lines differ in the genetic background in which the mutation was generated and maintained, however.
T9918	652-655	DT	denotes	The
T9919	677-682	NNS	denotes	lines
T9920	656-661	NN	denotes	Ptdsr
T9921	671-676	NN	denotes	mouse
T9922	661-662	HYPH	denotes	-
T9923	662-670	NN	denotes	knockout
T9924	683-689	VBP	denotes	differ
T9925	690-692	IN	denotes	in
T9926	693-696	DT	denotes	the
T9927	705-715	NN	denotes	background
T9928	697-704	JJ	denotes	genetic
T9929	716-718	IN	denotes	in
T9930	742-751	VBN	denotes	generated
T9931	719-724	WDT	denotes	which
T9932	725-728	DT	denotes	the
T9933	729-737	NN	denotes	mutation
T9934	738-741	VBD	denotes	was
T9935	752-755	CC	denotes	and
T9936	756-766	VBN	denotes	maintained
T9937	766-768	,	denotes	,
T9938	768-775	RB	denotes	however
T9939	775-776	.	denotes	.
T9940	776-1002	sentence	denotes	In our case, the Ptdsr-null allele was generated in an isogenic C57BL/6J background, whereas Li et al. [31] and Kunisaki et al. [32] investigated the phenotype of their Ptdsr-knockout mice in a mixed 129 × C57BL/6 background.
T9941	777-779	IN	denotes	In
T9942	816-825	VBN	denotes	generated
T9943	780-783	PRP$	denotes	our
T9944	784-788	NN	denotes	case
T9945	788-790	,	denotes	,
T9946	790-793	DT	denotes	the
T9947	805-811	NN	denotes	allele
T9948	794-799	NN	denotes	Ptdsr
T9949	800-804	JJ	denotes	null
T9950	799-800	HYPH	denotes	-
T9951	812-815	VBD	denotes	was
T9952	826-828	IN	denotes	in
T9953	829-831	DT	denotes	an
T9954	850-860	NN	denotes	background
T9955	832-840	JJ	denotes	isogenic
T9956	841-846	NN	denotes	C57BL
T9957	847-849	NN	denotes	6J
T9958	846-847	HYPH	denotes	/
T9959	860-862	,	denotes	,
T9960	862-869	IN	denotes	whereas
T9961	910-922	VBD	denotes	investigated
T9962	870-872	NNP	denotes	Li
T9963	873-875	FW	denotes	et
T9964	876-879	FW	denotes	al.
T9965	880-881	-LRB-	denotes	[
T9966	881-883	CD	denotes	31
T9967	883-884	-RRB-	denotes	]
T9968	885-888	CC	denotes	and
T9969	889-897	NNP	denotes	Kunisaki
T9970	898-900	FW	denotes	et
T9971	901-904	FW	denotes	al.
T9972	905-906	-LRB-	denotes	[
T9973	906-908	CD	denotes	32
T9974	908-909	-RRB-	denotes	]
T9975	923-926	DT	denotes	the
T9976	927-936	NN	denotes	phenotype
T9977	937-939	IN	denotes	of
T9978	940-945	PRP$	denotes	their
T9979	961-965	NNS	denotes	mice
T9980	946-951	NN	denotes	Ptdsr
T9981	952-960	NN	denotes	knockout
T9982	951-952	HYPH	denotes	-
T9983	966-968	IN	denotes	in
T9984	969-970	DT	denotes	a
T9985	991-1001	NN	denotes	background
T9986	971-976	VBN	denotes	mixed
T9987	977-980	CD	denotes	129
T9988	981-982	SYM	denotes	×
T9989	983-988	NN	denotes	C57BL
T9990	988-989	HYPH	denotes	/
T9991	989-990	CD	denotes	6
T9992	1001-1002	.	denotes	.
T9993	1002-1209	sentence	denotes	The ablation of Ptdsr function results in perinatal lethality in all cases, but there are interesting differences in severity or expressivities of phenotypes among the different Ptdsr-deficient mouse lines.
T9994	1003-1006	DT	denotes	The
T9995	1007-1015	NN	denotes	ablation
T9996	1034-1041	VBZ	denotes	results
T9997	1016-1018	IN	denotes	of
T9998	1019-1024	NN	denotes	Ptdsr
T9999	1025-1033	NN	denotes	function
T10000	1042-1044	IN	denotes	in
T10001	1045-1054	JJ	denotes	perinatal
T10002	1055-1064	NN	denotes	lethality
T10003	1065-1067	IN	denotes	in
T10004	1068-1071	DT	denotes	all
T10005	1072-1077	NNS	denotes	cases
T10006	1077-1079	,	denotes	,
T10007	1079-1082	CC	denotes	but
T10008	1083-1088	EX	denotes	there
T10009	1089-1092	VBP	denotes	are
T10010	1093-1104	JJ	denotes	interesting
T10011	1105-1116	NNS	denotes	differences
T10012	1117-1119	IN	denotes	in
T10013	1120-1128	NN	denotes	severity
T10014	1129-1131	CC	denotes	or
T10015	1132-1146	NNS	denotes	expressivities
T10016	1147-1149	IN	denotes	of
T10017	1150-1160	NNS	denotes	phenotypes
T10018	1161-1166	IN	denotes	among
T10019	1167-1170	DT	denotes	the
T10020	1203-1208	NNS	denotes	lines
T10021	1171-1180	JJ	denotes	different
T10022	1181-1186	NN	denotes	Ptdsr
T10023	1187-1196	JJ	denotes	deficient
T10024	1186-1187	HYPH	denotes	-
T10025	1197-1202	NN	denotes	mouse
T10026	1208-1209	.	denotes	.
T10027	1209-1385	sentence	denotes	This might be due either to differences in genetic background or because the phenotypes that have been investigated in this study have not been analyzed in such detail before.
T10028	1210-1214	DT	denotes	This
T10029	1221-1223	VB	denotes	be
T10030	1215-1220	MD	denotes	might
T10031	1224-1227	IN	denotes	due
T10032	1228-1234	CC	denotes	either
T10033	1235-1237	IN	denotes	to
T10034	1238-1249	NNS	denotes	differences
T10035	1250-1252	IN	denotes	in
T10036	1253-1260	JJ	denotes	genetic
T10037	1261-1271	NN	denotes	background
T10038	1272-1274	CC	denotes	or
T10039	1275-1282	IN	denotes	because
T10040	1354-1362	VBN	denotes	analyzed
T10041	1283-1286	DT	denotes	the
T10042	1287-1297	NNS	denotes	phenotypes
T10043	1298-1302	WDT	denotes	that
T10044	1313-1325	VBN	denotes	investigated
T10045	1303-1307	VBP	denotes	have
T10046	1308-1312	VBN	denotes	been
T10047	1326-1328	IN	denotes	in
T10048	1329-1333	DT	denotes	this
T10049	1334-1339	NN	denotes	study
T10050	1340-1344	VBP	denotes	have
T10051	1345-1348	RB	denotes	not
T10052	1349-1353	VBN	denotes	been
T10053	1363-1365	IN	denotes	in
T10054	1366-1370	JJ	denotes	such
T10055	1371-1377	NN	denotes	detail
T10056	1378-1384	RB	denotes	before
T10057	1384-1385	.	denotes	.
T10058	1385-1624	sentence	denotes	In the Ptdsr-knockout mouse line reported here, growth retardation started from E12.5 onwards and was associated with delayed differentiation in several organs in which Ptdsr is expressed either during embryogenesis or later in adulthood.
T10059	1386-1388	IN	denotes	In
T10060	1453-1460	VBD	denotes	started
T10061	1389-1392	DT	denotes	the
T10062	1414-1418	NN	denotes	line
T10063	1393-1398	NN	denotes	Ptdsr
T10064	1399-1407	NN	denotes	knockout
T10065	1398-1399	HYPH	denotes	-
T10066	1408-1413	NN	denotes	mouse
T10067	1419-1427	VBN	denotes	reported
T10068	1428-1432	RB	denotes	here
T10069	1432-1434	,	denotes	,
T10070	1434-1440	NN	denotes	growth
T10071	1441-1452	NN	denotes	retardation
T10072	1461-1465	IN	denotes	from
T10073	1466-1471	NN	denotes	E12.5
T10074	1472-1479	RB	denotes	onwards
T10075	1480-1483	CC	denotes	and
T10076	1484-1487	VBD	denotes	was
T10077	1488-1498	VBN	denotes	associated
T10078	1499-1503	IN	denotes	with
T10079	1504-1511	VBN	denotes	delayed
T10080	1512-1527	NN	denotes	differentiation
T10081	1528-1530	IN	denotes	in
T10082	1531-1538	JJ	denotes	several
T10083	1539-1545	NNS	denotes	organs
T10084	1546-1548	IN	denotes	in
T10085	1564-1573	VBN	denotes	expressed
T10086	1549-1554	WDT	denotes	which
T10087	1555-1560	NN	denotes	Ptdsr
T10088	1561-1563	VBZ	denotes	is
T10089	1574-1580	CC	denotes	either
T10090	1581-1587	IN	denotes	during
T10091	1588-1601	NN	denotes	embryogenesis
T10092	1602-1604	CC	denotes	or
T10093	1605-1610	RB	denotes	later
T10094	1611-1613	IN	denotes	in
T10095	1614-1623	NN	denotes	adulthood
T10096	1623-1624	.	denotes	.
T10097	1624-1723	sentence	denotes	At E16.5 almost no branching morphogenesis of the lung epithelium was observed in Ptdsr -/- lungs.
T10098	1625-1627	IN	denotes	At
T10099	1695-1703	VBN	denotes	observed
T10100	1628-1633	NN	denotes	E16.5
T10101	1634-1640	RB	denotes	almost
T10102	1654-1667	NN	denotes	morphogenesis
T10103	1641-1643	DT	denotes	no
T10104	1644-1653	NN	denotes	branching
T10105	1668-1670	IN	denotes	of
T10106	1671-1674	DT	denotes	the
T10107	1680-1690	NN	denotes	epithelium
T10108	1675-1679	NN	denotes	lung
T10109	1691-1694	VBD	denotes	was
T10110	1704-1706	IN	denotes	in
T10111	1707-1712	NN	denotes	Ptdsr
T10112	1717-1722	NNS	denotes	lungs
T10113	1713-1714	SYM	denotes	-
T10114	1714-1715	HYPH	denotes	/
T10115	1715-1716	SYM	denotes	-
T10116	1722-1723	.	denotes	.
T10117	1723-1938	sentence	denotes	Similarly, epithelial structures were only partially developed in mutant kidneys, without terminal differentiation of Bowman's capsule and with a severe reduction in the number of differentiated collecting tubules.
T10118	1724-1733	RB	denotes	Similarly
T10119	1777-1786	VBN	denotes	developed
T10120	1733-1735	,	denotes	,
T10121	1735-1745	JJ	denotes	epithelial
T10122	1746-1756	NNS	denotes	structures
T10123	1757-1761	VBD	denotes	were
T10124	1762-1766	RB	denotes	only
T10125	1767-1776	RB	denotes	partially
T10126	1787-1789	IN	denotes	in
T10127	1790-1796	JJ	denotes	mutant
T10128	1797-1804	NNS	denotes	kidneys
T10129	1804-1806	,	denotes	,
T10130	1806-1813	IN	denotes	without
T10131	1814-1822	JJ	denotes	terminal
T10132	1823-1838	NN	denotes	differentiation
T10133	1839-1841	IN	denotes	of
T10134	1842-1848	NNP	denotes	Bowman
T10135	1851-1858	NN	denotes	capsule
T10136	1848-1850	POS	denotes	's
T10137	1859-1862	CC	denotes	and
T10138	1863-1867	IN	denotes	with
T10139	1868-1869	DT	denotes	a
T10140	1877-1886	NN	denotes	reduction
T10141	1870-1876	JJ	denotes	severe
T10142	1887-1889	IN	denotes	in
T10143	1890-1893	DT	denotes	the
T10144	1894-1900	NN	denotes	number
T10145	1901-1903	IN	denotes	of
T10146	1904-1918	VBN	denotes	differentiated
T10147	1930-1937	NNS	denotes	tubules
T10148	1919-1929	NN	denotes	collecting
T10149	1937-1938	.	denotes	.
T10150	1938-2040	sentence	denotes	Likewise, the differentiation of the intestine was also severely delayed at this developmental stage.
T10151	1939-1947	RB	denotes	Likewise
T10152	2004-2011	VBN	denotes	delayed
T10153	1947-1949	,	denotes	,
T10154	1949-1952	DT	denotes	the
T10155	1953-1968	NN	denotes	differentiation
T10156	1969-1971	IN	denotes	of
T10157	1972-1975	DT	denotes	the
T10158	1976-1985	NN	denotes	intestine
T10159	1986-1989	VBD	denotes	was
T10160	1990-1994	RB	denotes	also
T10161	1995-2003	RB	denotes	severely
T10162	2012-2014	IN	denotes	at
T10163	2015-2019	DT	denotes	this
T10164	2034-2039	NN	denotes	stage
T10165	2020-2033	JJ	denotes	developmental
T10166	2039-2040	.	denotes	.
T10167	2040-2223	sentence	denotes	When compared with wild-type controls, intestinal tissues of Ptdsr knockout mice appeared unstructured, with an absence of enteric ganglia and of differentiated smooth muscle tissue.
T10168	2041-2045	WRB	denotes	When
T10169	2046-2054	VBN	denotes	compared
T10170	2122-2130	VBD	denotes	appeared
T10171	2055-2059	IN	denotes	with
T10172	2060-2064	JJ	denotes	wild
T10173	2065-2069	NN	denotes	type
T10174	2064-2065	HYPH	denotes	-
T10175	2070-2078	NNS	denotes	controls
T10176	2078-2080	,	denotes	,
T10177	2080-2090	JJ	denotes	intestinal
T10178	2091-2098	NNS	denotes	tissues
T10179	2099-2101	IN	denotes	of
T10180	2102-2107	NN	denotes	Ptdsr
T10181	2117-2121	NNS	denotes	mice
T10182	2108-2116	NN	denotes	knockout
T10183	2131-2143	JJ	denotes	unstructured
T10184	2143-2145	,	denotes	,
T10185	2145-2149	IN	denotes	with
T10186	2150-2152	DT	denotes	an
T10187	2153-2160	NN	denotes	absence
T10188	2161-2163	IN	denotes	of
T10189	2164-2171	JJ	denotes	enteric
T10190	2172-2179	NNS	denotes	ganglia
T10191	2180-2183	CC	denotes	and
T10192	2184-2186	IN	denotes	of
T10193	2187-2201	VBN	denotes	differentiated
T10194	2216-2222	NN	denotes	tissue
T10195	2202-2208	JJ	denotes	smooth
T10196	2209-2215	NN	denotes	muscle
T10197	2222-2223	.	denotes	.
T10198	2223-2382	sentence	denotes	Interestingly, defects in kidney and intestine differentiation were not described in the Ptdsr-knockouts generated by Li et al. [31] and Kunisaki et al. [32].
T10199	2224-2237	RB	denotes	Interestingly
T10200	2296-2305	VBN	denotes	described
T10201	2237-2239	,	denotes	,
T10202	2239-2246	NNS	denotes	defects
T10203	2247-2249	IN	denotes	in
T10204	2250-2256	NN	denotes	kidney
T10205	2271-2286	NN	denotes	differentiation
T10206	2257-2260	CC	denotes	and
T10207	2261-2270	NN	denotes	intestine
T10208	2287-2291	VBD	denotes	were
T10209	2292-2295	RB	denotes	not
T10210	2306-2308	IN	denotes	in
T10211	2309-2312	DT	denotes	the
T10212	2319-2328	NNS	denotes	knockouts
T10213	2313-2318	NN	denotes	Ptdsr
T10214	2318-2319	HYPH	denotes	-
T10215	2329-2338	VBN	denotes	generated
T10216	2339-2341	IN	denotes	by
T10217	2342-2344	NNP	denotes	Li
T10218	2345-2347	FW	denotes	et
T10219	2348-2351	FW	denotes	al.
T10220	2352-2353	-LRB-	denotes	[
T10221	2353-2355	CD	denotes	31
T10222	2355-2356	-RRB-	denotes	]
T10223	2357-2360	CC	denotes	and
T10224	2361-2369	NNP	denotes	Kunisaki
T10225	2370-2372	FW	denotes	et
T10226	2373-2376	FW	denotes	al.
T10227	2377-2378	-LRB-	denotes	[
T10228	2378-2380	CD	denotes	32
T10229	2380-2381	-RRB-	denotes	]
T10230	2381-2382	.	denotes	.
T10231	2382-2576	sentence	denotes	Surprisingly, when we examined Ptdsr-/- embryos shortly before birth (E18.5) or neonatally, we found only mild differentiation delays in organs that appeared severely affected at mid-gestation.
T10232	2383-2395	RB	denotes	Surprisingly
T10233	2478-2483	VBD	denotes	found
T10234	2395-2397	,	denotes	,
T10235	2397-2401	WRB	denotes	when
T10236	2405-2413	VBD	denotes	examined
T10237	2402-2404	PRP	denotes	we
T10238	2414-2419	NN	denotes	Ptdsr
T10239	2423-2430	NNS	denotes	embryos
T10240	2419-2420	SYM	denotes	-
T10241	2420-2421	HYPH	denotes	/
T10242	2421-2422	SYM	denotes	-
T10243	2431-2438	RB	denotes	shortly
T10244	2439-2445	IN	denotes	before
T10245	2446-2451	NN	denotes	birth
T10246	2452-2453	-LRB-	denotes	(
T10247	2453-2458	NN	denotes	E18.5
T10248	2458-2459	-RRB-	denotes	)
T10249	2460-2462	CC	denotes	or
T10250	2463-2473	RB	denotes	neonatally
T10251	2473-2475	,	denotes	,
T10252	2475-2477	PRP	denotes	we
T10253	2484-2488	RB	denotes	only
T10254	2489-2493	JJ	denotes	mild
T10255	2510-2516	NNS	denotes	delays
T10256	2494-2509	NN	denotes	differentiation
T10257	2517-2519	IN	denotes	in
T10258	2520-2526	NNS	denotes	organs
T10259	2527-2531	WDT	denotes	that
T10260	2532-2540	VBD	denotes	appeared
T10261	2541-2549	RB	denotes	severely
T10262	2550-2558	JJ	denotes	affected
T10263	2559-2561	IN	denotes	at
T10264	2562-2575	NN	denotes	mid-gestation
T10265	2575-2576	.	denotes	.
T10266	2576-2764	sentence	denotes	This 'recovery' was most visible in Ptdsr -/- lungs: at P0 we found expanded lungs in the knockout mice that showed normal branching patterns, with differentiated alveoli and bronchioles.
T10267	2577-2581	DT	denotes	This
T10268	2583-2591	NN	denotes	recovery
T10269	2582-2583	``	denotes	'
T10270	2593-2596	VBD	denotes	was
T10271	2591-2592	''	denotes	'
T10272	2639-2644	VBD	denotes	found
T10273	2597-2601	RBS	denotes	most
T10274	2602-2609	JJ	denotes	visible
T10275	2610-2612	IN	denotes	in
T10276	2613-2618	NN	denotes	Ptdsr
T10277	2623-2628	NNS	denotes	lungs
T10278	2619-2620	SYM	denotes	-
T10279	2620-2621	HYPH	denotes	/
T10280	2621-2622	SYM	denotes	-
T10281	2628-2630	:	denotes	:
T10282	2630-2632	IN	denotes	at
T10283	2633-2635	NN	denotes	P0
T10284	2636-2638	PRP	denotes	we
T10285	2645-2653	VBN	denotes	expanded
T10286	2654-2659	NNS	denotes	lungs
T10287	2660-2662	IN	denotes	in
T10288	2663-2666	DT	denotes	the
T10289	2676-2680	NNS	denotes	mice
T10290	2667-2675	NN	denotes	knockout
T10291	2681-2685	WDT	denotes	that
T10292	2686-2692	VBD	denotes	showed
T10293	2693-2699	JJ	denotes	normal
T10294	2710-2718	NNS	denotes	patterns
T10295	2700-2709	NN	denotes	branching
T10296	2718-2720	,	denotes	,
T10297	2720-2724	IN	denotes	with
T10298	2725-2739	VBN	denotes	differentiated
T10299	2740-2747	NNS	denotes	alveoli
T10300	2748-2751	CC	denotes	and
T10301	2752-2763	NNS	denotes	bronchioles
T10302	2763-2764	.	denotes	.
T10303	2764-2921	sentence	denotes	We investigated the occurrence of programmed cell death during lung development in wild-type and Ptdsr-knockout mice throughout embryogenesis (E16.5 to P0).
T10304	2765-2767	PRP	denotes	We
T10305	2768-2780	VBD	denotes	investigated
T10306	2781-2784	DT	denotes	the
T10307	2785-2795	NN	denotes	occurrence
T10308	2796-2798	IN	denotes	of
T10309	2799-2809	VBN	denotes	programmed
T10310	2815-2820	NN	denotes	death
T10311	2810-2814	NN	denotes	cell
T10312	2821-2827	IN	denotes	during
T10313	2828-2832	NN	denotes	lung
T10314	2833-2844	NN	denotes	development
T10315	2845-2847	IN	denotes	in
T10316	2848-2852	JJ	denotes	wild
T10317	2853-2857	NN	denotes	type
T10318	2852-2853	HYPH	denotes	-
T10319	2877-2881	NNS	denotes	mice
T10320	2858-2861	CC	denotes	and
T10321	2862-2867	NN	denotes	Ptdsr
T10322	2868-2876	NN	denotes	knockout
T10323	2867-2868	HYPH	denotes	-
T10324	2882-2892	IN	denotes	throughout
T10325	2893-2906	NN	denotes	embryogenesis
T10326	2907-2908	-LRB-	denotes	(
T10327	2908-2913	NN	denotes	E16.5
T10328	2914-2916	IN	denotes	to
T10329	2917-2919	NN	denotes	P0
T10330	2919-2920	-RRB-	denotes	)
T10331	2920-2921	.	denotes	.
T10332	2921-3032	sentence	denotes	Comparative immunohistochemistry for aCasp3 revealed that apoptosis is a rare event during lung morphogenesis.
T10333	2922-2933	JJ	denotes	Comparative
T10334	2934-2954	NN	denotes	immunohistochemistry
T10335	2966-2974	VBD	denotes	revealed
T10336	2955-2958	IN	denotes	for
T10337	2959-2965	NN	denotes	aCasp3
T10338	2975-2979	IN	denotes	that
T10339	2990-2992	VBZ	denotes	is
T10340	2980-2989	NN	denotes	apoptosis
T10341	2993-2994	DT	denotes	a
T10342	3000-3005	NN	denotes	event
T10343	2995-2999	JJ	denotes	rare
T10344	3006-3012	IN	denotes	during
T10345	3013-3017	NN	denotes	lung
T10346	3018-3031	NN	denotes	morphogenesis
T10347	3031-3032	.	denotes	.
T10348	3032-3231	sentence	denotes	Furthermore, we failed to detect any differences in the number of apoptotic cells in Ptdsr-knockout and wild-type animals in the rare cases where we could detect apoptotic cells within lung tissues.
T10349	3033-3044	RB	denotes	Furthermore
T10350	3049-3055	VBD	denotes	failed
T10351	3044-3046	,	denotes	,
T10352	3046-3048	PRP	denotes	we
T10353	3056-3058	TO	denotes	to
T10354	3059-3065	VB	denotes	detect
T10355	3066-3069	DT	denotes	any
T10356	3070-3081	NNS	denotes	differences
T10357	3082-3084	IN	denotes	in
T10358	3085-3088	DT	denotes	the
T10359	3089-3095	NN	denotes	number
T10360	3096-3098	IN	denotes	of
T10361	3099-3108	JJ	denotes	apoptotic
T10362	3109-3114	NNS	denotes	cells
T10363	3115-3117	IN	denotes	in
T10364	3118-3123	NN	denotes	Ptdsr
T10365	3124-3132	NN	denotes	knockout
T10366	3123-3124	HYPH	denotes	-
T10367	3147-3154	NNS	denotes	animals
T10368	3133-3136	CC	denotes	and
T10369	3137-3141	JJ	denotes	wild
T10370	3142-3146	NN	denotes	type
T10371	3141-3142	HYPH	denotes	-
T10372	3155-3157	IN	denotes	in
T10373	3158-3161	DT	denotes	the
T10374	3167-3172	NNS	denotes	cases
T10375	3162-3166	JJ	denotes	rare
T10376	3173-3178	WRB	denotes	where
T10377	3188-3194	VB	denotes	detect
T10378	3179-3181	PRP	denotes	we
T10379	3182-3187	MD	denotes	could
T10380	3195-3204	JJ	denotes	apoptotic
T10381	3205-3210	NNS	denotes	cells
T10382	3211-3217	IN	denotes	within
T10383	3218-3222	NN	denotes	lung
T10384	3223-3230	NNS	denotes	tissues
T10385	3230-3231	.	denotes	.
T10386	3231-3450	sentence	denotes	These findings are contrary to the results reported by Li et al. [31], who suggested that impaired clearance of apoptotic mesenchymal and epithelial cells causes a failure in lung morphogenesis in Ptdsr-deficient mice.
T10387	3232-3237	DT	denotes	These
T10388	3238-3246	NNS	denotes	findings
T10389	3247-3250	VBP	denotes	are
T10390	3251-3259	JJ	denotes	contrary
T10391	3260-3262	IN	denotes	to
T10392	3263-3266	DT	denotes	the
T10393	3267-3274	NNS	denotes	results
T10394	3275-3283	VBN	denotes	reported
T10395	3284-3286	IN	denotes	by
T10396	3287-3289	NNP	denotes	Li
T10397	3290-3292	FW	denotes	et
T10398	3293-3296	FW	denotes	al.
T10399	3297-3298	-LRB-	denotes	[
T10400	3298-3300	CD	denotes	31
T10401	3300-3301	-RRB-	denotes	]
T10402	3301-3303	,	denotes	,
T10403	3303-3306	WP	denotes	who
T10404	3307-3316	VBD	denotes	suggested
T10405	3317-3321	IN	denotes	that
T10406	3387-3393	VBZ	denotes	causes
T10407	3322-3330	JJ	denotes	impaired
T10408	3331-3340	NN	denotes	clearance
T10409	3341-3343	IN	denotes	of
T10410	3344-3353	JJ	denotes	apoptotic
T10411	3381-3386	NNS	denotes	cells
T10412	3354-3365	JJ	denotes	mesenchymal
T10413	3366-3369	CC	denotes	and
T10414	3370-3380	JJ	denotes	epithelial
T10415	3394-3395	DT	denotes	a
T10416	3396-3403	NN	denotes	failure
T10417	3404-3406	IN	denotes	in
T10418	3407-3411	NN	denotes	lung
T10419	3412-3425	NN	denotes	morphogenesis
T10420	3426-3428	IN	denotes	in
T10421	3429-3434	NN	denotes	Ptdsr
T10422	3435-3444	JJ	denotes	deficient
T10423	3434-3435	HYPH	denotes	-
T10424	3445-3449	NNS	denotes	mice
T10425	3449-3450	.	denotes	.
T10426	3450-3552	sentence	denotes	In contrast, our findings are in line with the current view on lung development during embryogenesis.
T10427	3451-3453	IN	denotes	In
T10428	3477-3480	VBP	denotes	are
T10429	3454-3462	NN	denotes	contrast
T10430	3462-3464	,	denotes	,
T10431	3464-3467	PRP$	denotes	our
T10432	3468-3476	NNS	denotes	findings
T10433	3481-3483	IN	denotes	in
T10434	3484-3488	NN	denotes	line
T10435	3489-3493	IN	denotes	with
T10436	3494-3497	DT	denotes	the
T10437	3506-3510	NN	denotes	view
T10438	3498-3505	JJ	denotes	current
T10439	3511-3513	IN	denotes	on
T10440	3514-3518	NN	denotes	lung
T10441	3519-3530	NN	denotes	development
T10442	3531-3537	IN	denotes	during
T10443	3538-3551	NN	denotes	embryogenesis
T10444	3551-3552	.	denotes	.
T10445	3552-4005	sentence	denotes	Accordingly, formation of the epithelial lung via branching morphogenesis can be subdivided into a series of sequential steps that involve: first, formation of the organ anlage in the form of a placode; second, primary bud formation by placode invagination; third, branch initiation and branch outgrowth; fourth, further reiteration of the branching process; and fifth, terminal differentiation of organ-specific proximal and distal structures [34,35].
T10446	3553-3564	RB	denotes	Accordingly
T10447	3634-3644	VBN	denotes	subdivided
T10448	3564-3566	,	denotes	,
T10449	3566-3575	NN	denotes	formation
T10450	3576-3578	IN	denotes	of
T10451	3579-3582	DT	denotes	the
T10452	3594-3598	NN	denotes	lung
T10453	3583-3593	JJ	denotes	epithelial
T10454	3599-3602	IN	denotes	via
T10455	3603-3612	NN	denotes	branching
T10456	3613-3626	NN	denotes	morphogenesis
T10457	3627-3630	MD	denotes	can
T10458	3631-3633	VB	denotes	be
T10459	3645-3649	IN	denotes	into
T10460	3650-3651	DT	denotes	a
T10461	3652-3658	NN	denotes	series
T10462	3659-3661	IN	denotes	of
T10463	3662-3672	JJ	denotes	sequential
T10464	3673-3678	NNS	denotes	steps
T10465	3679-3683	WDT	denotes	that
T10466	3684-3691	VBP	denotes	involve
T10467	3691-3693	:	denotes	:
T10468	3693-3698	RB	denotes	first
T10469	3700-3709	NN	denotes	formation
T10470	3698-3700	,	denotes	,
T10471	3710-3712	IN	denotes	of
T10472	3713-3716	DT	denotes	the
T10473	3723-3729	NN	denotes	anlage
T10474	3717-3722	NN	denotes	organ
T10475	3730-3732	IN	denotes	in
T10476	3733-3736	DT	denotes	the
T10477	3737-3741	NN	denotes	form
T10478	3742-3744	IN	denotes	of
T10479	3745-3746	DT	denotes	a
T10480	3747-3754	NN	denotes	placode
T10481	3754-3755	:	denotes	;
T10482	3756-3762	RB	denotes	second
T10483	3776-3785	NN	denotes	formation
T10484	3762-3764	,	denotes	,
T10485	3764-3771	JJ	denotes	primary
T10486	3772-3775	NN	denotes	bud
T10487	3786-3788	IN	denotes	by
T10488	3789-3796	NN	denotes	placode
T10489	3797-3809	NN	denotes	invagination
T10490	3809-3810	:	denotes	;
T10491	3811-3816	RB	denotes	third
T10492	3825-3835	NN	denotes	initiation
T10493	3816-3818	,	denotes	,
T10494	3818-3824	NN	denotes	branch
T10495	3836-3839	CC	denotes	and
T10496	3840-3846	NN	denotes	branch
T10497	3847-3856	NN	denotes	outgrowth
T10498	3856-3857	:	denotes	;
T10499	3858-3864	RB	denotes	fourth
T10500	3874-3885	NN	denotes	reiteration
T10501	3864-3866	,	denotes	,
T10502	3866-3873	JJ	denotes	further
T10503	3886-3888	IN	denotes	of
T10504	3889-3892	DT	denotes	the
T10505	3903-3910	NN	denotes	process
T10506	3893-3902	NN	denotes	branching
T10507	3910-3911	:	denotes	;
T10508	3912-3915	CC	denotes	and
T10509	3916-3921	RB	denotes	fifth
T10510	3932-3947	NN	denotes	differentiation
T10511	3921-3923	,	denotes	,
T10512	3923-3931	JJ	denotes	terminal
T10513	3948-3950	IN	denotes	of
T10514	3951-3956	NN	denotes	organ
T10515	3957-3965	JJ	denotes	specific
T10516	3956-3957	HYPH	denotes	-
T10517	3986-3996	NNS	denotes	structures
T10518	3966-3974	JJ	denotes	proximal
T10519	3975-3978	CC	denotes	and
T10520	3979-3985	JJ	denotes	distal
T10521	3997-3998	-LRB-	denotes	[
T10522	4001-4003	CD	denotes	35
T10523	3998-4000	CD	denotes	34
T10524	4000-4001	,	denotes	,
T10525	4003-4004	-RRB-	denotes	]
T10526	4004-4005	.	denotes	.
T10527	4005-4238	sentence	denotes	In contrast to other invagination processes during embryogenesis, such as mammary gland formation, the lumen of the lungs is expanded by successive branching events, branch outgrowth and elongation, rather than by apoptosis [34,36].
T10528	4006-4008	IN	denotes	In
T10529	4131-4139	VBN	denotes	expanded
T10530	4009-4017	NN	denotes	contrast
T10531	4018-4020	IN	denotes	to
T10532	4021-4026	JJ	denotes	other
T10533	4040-4049	NNS	denotes	processes
T10534	4027-4039	NN	denotes	invagination
T10535	4050-4056	IN	denotes	during
T10536	4057-4070	NN	denotes	embryogenesis
T10537	4070-4072	,	denotes	,
T10538	4072-4076	JJ	denotes	such
T10539	4077-4079	IN	denotes	as
T10540	4080-4087	JJ	denotes	mammary
T10541	4094-4103	NN	denotes	formation
T10542	4088-4093	NN	denotes	gland
T10543	4103-4105	,	denotes	,
T10544	4105-4108	DT	denotes	the
T10545	4109-4114	NN	denotes	lumen
T10546	4115-4117	IN	denotes	of
T10547	4118-4121	DT	denotes	the
T10548	4122-4127	NNS	denotes	lungs
T10549	4128-4130	VBZ	denotes	is
T10550	4140-4142	IN	denotes	by
T10551	4143-4153	JJ	denotes	successive
T10552	4164-4170	NNS	denotes	events
T10553	4154-4163	NN	denotes	branching
T10554	4170-4172	,	denotes	,
T10555	4172-4178	NN	denotes	branch
T10556	4179-4188	NN	denotes	outgrowth
T10557	4189-4192	CC	denotes	and
T10558	4193-4203	NN	denotes	elongation
T10559	4203-4205	,	denotes	,
T10560	4205-4211	RB	denotes	rather
T10561	4212-4216	IN	denotes	than
T10562	4217-4219	IN	denotes	by
T10563	4220-4229	NN	denotes	apoptosis
T10564	4230-4231	-LRB-	denotes	[
T10565	4234-4236	CD	denotes	36
T10566	4231-4233	CD	denotes	34
T10567	4233-4234	,	denotes	,
T10568	4236-4237	-RRB-	denotes	]
T10569	4237-4238	.	denotes	.
T10570	4238-4460	sentence	denotes	Finally, because the lungs of Ptdsr -/-neonates were almost fully expanded and appeared normal in structure in comparison to wild-type littermates, it is highly unlikely that Ptdsr mutants die of respiratory lung failure.
T10571	4239-4246	RB	denotes	Finally
T10572	4390-4392	VBZ	denotes	is
T10573	4246-4248	,	denotes	,
T10574	4248-4255	IN	denotes	because
T10575	4305-4313	VBN	denotes	expanded
T10576	4256-4259	DT	denotes	the
T10577	4260-4265	NNS	denotes	lungs
T10578	4266-4268	IN	denotes	of
T10579	4269-4274	NN	denotes	Ptdsr
T10580	4278-4286	NNS	denotes	neonates
T10581	4275-4276	SYM	denotes	-
T10582	4276-4277	HYPH	denotes	/
T10583	4277-4278	SYM	denotes	-
T10584	4287-4291	VBD	denotes	were
T10585	4292-4298	RB	denotes	almost
T10586	4299-4304	RB	denotes	fully
T10587	4314-4317	CC	denotes	and
T10588	4318-4326	VBD	denotes	appeared
T10589	4327-4333	JJ	denotes	normal
T10590	4334-4336	IN	denotes	in
T10591	4337-4346	NN	denotes	structure
T10592	4347-4349	IN	denotes	in
T10593	4350-4360	NN	denotes	comparison
T10594	4361-4363	IN	denotes	to
T10595	4364-4368	JJ	denotes	wild
T10596	4369-4373	NN	denotes	type
T10597	4368-4369	HYPH	denotes	-
T10598	4374-4385	NNS	denotes	littermates
T10599	4385-4387	,	denotes	,
T10600	4387-4389	PRP	denotes	it
T10601	4393-4399	RB	denotes	highly
T10602	4400-4408	JJ	denotes	unlikely
T10603	4409-4413	IN	denotes	that
T10604	4428-4431	VBP	denotes	die
T10605	4414-4419	NN	denotes	Ptdsr
T10606	4420-4427	NNS	denotes	mutants
T10607	4432-4434	IN	denotes	of
T10608	4435-4446	JJ	denotes	respiratory
T10609	4452-4459	NN	denotes	failure
T10610	4447-4451	NN	denotes	lung
T10611	4459-4460	.	denotes	.
T10612	4460-4692	sentence	denotes	In addition, Li and colleagues [31] demonstrated that surfactant expression is normal in Ptdsr-deficient animals, supporting the idea of normal maturation of surfactant-producing type II alveolar epithelial cells and lung function.
T10613	4461-4463	IN	denotes	In
T10614	4497-4509	VBD	denotes	demonstrated
T10615	4464-4472	NN	denotes	addition
T10616	4472-4474	,	denotes	,
T10617	4474-4476	NNP	denotes	Li
T10618	4477-4480	CC	denotes	and
T10619	4481-4491	NNS	denotes	colleagues
T10620	4492-4493	-LRB-	denotes	[
T10621	4493-4495	CD	denotes	31
T10622	4495-4496	-RRB-	denotes	]
T10623	4510-4514	IN	denotes	that
T10624	4537-4539	VBZ	denotes	is
T10625	4515-4525	JJ	denotes	surfactant
T10626	4526-4536	NN	denotes	expression
T10627	4540-4546	JJ	denotes	normal
T10628	4547-4549	IN	denotes	in
T10629	4550-4555	NN	denotes	Ptdsr
T10630	4556-4565	JJ	denotes	deficient
T10631	4555-4556	HYPH	denotes	-
T10632	4566-4573	NNS	denotes	animals
T10633	4573-4575	,	denotes	,
T10634	4575-4585	VBG	denotes	supporting
T10635	4586-4589	DT	denotes	the
T10636	4590-4594	NN	denotes	idea
T10637	4595-4597	IN	denotes	of
T10638	4598-4604	JJ	denotes	normal
T10639	4605-4615	NN	denotes	maturation
T10640	4616-4618	IN	denotes	of
T10641	4619-4629	NN	denotes	surfactant
T10642	4630-4639	VBG	denotes	producing
T10643	4629-4630	HYPH	denotes	-
T10644	4668-4673	NNS	denotes	cells
T10645	4640-4644	NN	denotes	type
T10646	4645-4647	CD	denotes	II
T10647	4648-4656	JJ	denotes	alveolar
T10648	4657-4667	JJ	denotes	epithelial
T10649	4674-4677	CC	denotes	and
T10650	4678-4682	NN	denotes	lung
T10651	4683-4691	NN	denotes	function
T10652	4691-4692	.	denotes	.
T10653	4692-4772	sentence	denotes	Other defects must therefore be responsible for the death of Ptdsr-mutant mice.
T10654	4693-4698	JJ	denotes	Other
T10655	4699-4706	NNS	denotes	defects
T10656	4722-4724	VB	denotes	be
T10657	4707-4711	MD	denotes	must
T10658	4712-4721	RB	denotes	therefore
T10659	4725-4736	JJ	denotes	responsible
T10660	4737-4740	IN	denotes	for
T10661	4741-4744	DT	denotes	the
T10662	4745-4750	NN	denotes	death
T10663	4751-4753	IN	denotes	of
T10664	4754-4759	NN	denotes	Ptdsr
T10665	4760-4766	NN	denotes	mutant
T10666	4759-4760	HYPH	denotes	-
T10667	4767-4771	NNS	denotes	mice
T10668	4771-4772	.	denotes	.
T10669	4772-4966	sentence	denotes	The frequently observed subcutaneous edema of various extents in Ptdsr-deficient homozygotes gave us a hint that Ptdsr-deficiency and lethality might be associated with cardiovascular problems.
T10670	4773-4776	DT	denotes	The
T10671	4810-4815	NN	denotes	edema
T10672	4777-4787	RB	denotes	frequently
T10673	4788-4796	VBN	denotes	observed
T10674	4797-4809	JJ	denotes	subcutaneous
T10675	4866-4870	VBD	denotes	gave
T10676	4816-4818	IN	denotes	of
T10677	4819-4826	JJ	denotes	various
T10678	4827-4834	NNS	denotes	extents
T10679	4835-4837	IN	denotes	in
T10680	4838-4843	NN	denotes	Ptdsr
T10681	4844-4853	JJ	denotes	deficient
T10682	4843-4844	HYPH	denotes	-
T10683	4854-4865	NNS	denotes	homozygotes
T10684	4871-4873	PRP	denotes	us
T10685	4874-4875	DT	denotes	a
T10686	4876-4880	NN	denotes	hint
T10687	4881-4885	IN	denotes	that
T10688	4926-4936	VBN	denotes	associated
T10689	4886-4891	NN	denotes	Ptdsr
T10690	4892-4902	NN	denotes	deficiency
T10691	4891-4892	HYPH	denotes	-
T10692	4903-4906	CC	denotes	and
T10693	4907-4916	NN	denotes	lethality
T10694	4917-4922	MD	denotes	might
T10695	4923-4925	VB	denotes	be
T10696	4937-4941	IN	denotes	with
T10697	4942-4956	JJ	denotes	cardiovascular
T10698	4957-4965	NNS	denotes	problems
T10699	4965-4966	.	denotes	.
T10700	4966-5294	sentence	denotes	Indeed, very recently we have obtained strong evidence that Ptdsr-knockout mice die as a result of defects in heart development that are associated with specific cardiopulmonary malformations; (J.E. Schneider, J.B., S.D. Bamfort, A.D.G., C. Broadbent, K. Clarke, S. Neubauer, A.L. and S. Battacharya, unpublished observations).
T10701	4967-4973	RB	denotes	Indeed
T10702	4997-5005	VBN	denotes	obtained
T10703	4973-4975	,	denotes	,
T10704	4975-4979	RB	denotes	very
T10705	4980-4988	RB	denotes	recently
T10706	4989-4991	PRP	denotes	we
T10707	4992-4996	VBP	denotes	have
T10708	5006-5012	JJ	denotes	strong
T10709	5013-5021	NN	denotes	evidence
T10710	5022-5026	IN	denotes	that
T10711	5047-5050	VBP	denotes	die
T10712	5027-5032	NN	denotes	Ptdsr
T10713	5033-5041	NN	denotes	knockout
T10714	5032-5033	HYPH	denotes	-
T10715	5042-5046	NNS	denotes	mice
T10716	5051-5053	IN	denotes	as
T10717	5054-5055	DT	denotes	a
T10718	5056-5062	NN	denotes	result
T10719	5063-5065	IN	denotes	of
T10720	5066-5073	NNS	denotes	defects
T10721	5074-5076	IN	denotes	in
T10722	5077-5082	NN	denotes	heart
T10723	5083-5094	NN	denotes	development
T10724	5095-5099	WDT	denotes	that
T10725	5104-5114	VBN	denotes	associated
T10726	5100-5103	VBP	denotes	are
T10727	5115-5119	IN	denotes	with
T10728	5120-5128	JJ	denotes	specific
T10729	5145-5158	NNS	denotes	malformations
T10730	5129-5144	JJ	denotes	cardiopulmonary
T10731	5158-5159	:	denotes	;
T10732	5160-5161	-LRB-	denotes	(
T10733	5161-5165	NNP	denotes	J.E.
T10734	5166-5175	NNP	denotes	Schneider
T10735	5175-5177	,	denotes	,
T10736	5177-5181	NNP	denotes	J.B.
T10737	5181-5183	,	denotes	,
T10738	5183-5187	NNP	denotes	S.D.
T10739	5188-5195	NNP	denotes	Bamfort
T10740	5195-5197	,	denotes	,
T10741	5197-5203	NNP	denotes	A.D.G.
T10742	5203-5205	,	denotes	,
T10743	5205-5207	NNP	denotes	C.
T10744	5208-5217	NNP	denotes	Broadbent
T10745	5217-5219	,	denotes	,
T10746	5219-5221	NNP	denotes	K.
T10747	5222-5228	NNP	denotes	Clarke
T10748	5228-5230	,	denotes	,
T10749	5230-5232	NNP	denotes	S.
T10750	5233-5241	NNP	denotes	Neubauer
T10751	5241-5243	,	denotes	,
T10752	5243-5247	NNP	denotes	A.L.
T10753	5248-5251	CC	denotes	and
T10754	5252-5254	NNP	denotes	S.
T10755	5255-5266	NNP	denotes	Battacharya
T10756	5266-5268	,	denotes	,
T10757	5268-5279	JJ	denotes	unpublished
T10758	5280-5292	NNS	denotes	observations
T10759	5292-5293	-RRB-	denotes	)
T10760	5293-5294	.	denotes	.
T10761	5294-5377	sentence	denotes	In addition, we demonstrate that eye development requires a functional Ptdsr gene.
T10762	5295-5297	IN	denotes	In
T10763	5311-5322	VBP	denotes	demonstrate
T10764	5298-5306	NN	denotes	addition
T10765	5306-5308	,	denotes	,
T10766	5308-5310	PRP	denotes	we
T10767	5323-5327	IN	denotes	that
T10768	5344-5352	VBZ	denotes	requires
T10769	5328-5331	NN	denotes	eye
T10770	5332-5343	NN	denotes	development
T10771	5353-5354	DT	denotes	a
T10772	5372-5376	NN	denotes	gene
T10773	5355-5365	JJ	denotes	functional
T10774	5366-5371	NN	denotes	Ptdsr
T10775	5376-5377	.	denotes	.
T10776	5377-5445	sentence	denotes	Ptdsr-deficient embryos can be roughly divided into two categories.
T10777	5378-5383	NN	denotes	Ptdsr
T10778	5384-5393	JJ	denotes	deficient
T10779	5383-5384	HYPH	denotes	-
T10780	5394-5401	NNS	denotes	embryos
T10781	5417-5424	VBN	denotes	divided
T10782	5402-5405	MD	denotes	can
T10783	5406-5408	VB	denotes	be
T10784	5409-5416	RB	denotes	roughly
T10785	5425-5429	IN	denotes	into
T10786	5430-5433	CD	denotes	two
T10787	5434-5444	NNS	denotes	categories
T10790	5446-5449	DT	denotes	The
T10791	5475-5480	NN	denotes	group
T10792	5450-5455	JJ	denotes	first
T10793	5455-5457	,	denotes	,
T10794	5457-5465	RB	denotes	severely
T10795	5466-5474	VBN	denotes	affected
T10796	5481-5489	VBZ	denotes	develops
T10797	5490-5502	NN	denotes	anophthalmia
T10798	5503-5507	WDT	denotes	that
T10799	5508-5518	VBZ	denotes	correlates
T10800	5519-5523	IN	denotes	with
T10801	5524-5533	NN	denotes	formation
T10802	5534-5536	IN	denotes	of
T10803	5537-5544	JJ	denotes	ectopic
T10804	5563-5573	NN	denotes	epithelium
T10805	5545-5552	JJ	denotes	retinal
T10806	5553-5562	VBN	denotes	pigmented
T10807	5552-5553	HYPH	denotes	-
T10808	5574-5577	CC	denotes	and
T10809	5578-5587	NN	denotes	induction
T10810	5588-5590	IN	denotes	of
T10811	5591-5604	NN	denotes	proliferation
T10812	5605-5607	IN	denotes	of
T10813	5608-5618	VBG	denotes	underlying
T10814	5619-5629	NN	denotes	mesenchyme
T10815	5630-5632	IN	denotes	in
T10816	5633-5636	DT	denotes	the
T10817	5643-5649	NN	denotes	cavity
T10818	5637-5642	JJ	denotes	nasal
T10819	5649-5650	.	denotes	.
T10820	5650-5781	sentence	denotes	This phenotype represents a completely novel lesion that to our knowledge has not been described before in any other mouse mutant.
T10821	5651-5655	DT	denotes	This
T10822	5656-5665	NN	denotes	phenotype
T10823	5666-5676	VBZ	denotes	represents
T10824	5677-5678	DT	denotes	a
T10825	5696-5702	NN	denotes	lesion
T10826	5679-5689	RB	denotes	completely
T10827	5690-5695	JJ	denotes	novel
T10828	5703-5707	WDT	denotes	that
T10829	5738-5747	VBN	denotes	described
T10830	5708-5710	IN	denotes	to
T10831	5711-5714	PRP$	denotes	our
T10832	5715-5724	NN	denotes	knowledge
T10833	5725-5728	VBZ	denotes	has
T10834	5729-5732	RB	denotes	not
T10835	5733-5737	VBN	denotes	been
T10836	5748-5754	RB	denotes	before
T10837	5755-5757	IN	denotes	in
T10838	5758-5761	DT	denotes	any
T10839	5774-5780	NN	denotes	mutant
T10840	5762-5767	JJ	denotes	other
T10841	5768-5773	NN	denotes	mouse
T10842	5780-5781	.	denotes	.
T10843	5781-6032	sentence	denotes	The second group shows normal external eye structures, although in this case retinal development is temporally delayed during mid-gestation, with persistent, abnormal morphogenesis of the inner granular retinal layer at later stages of embryogenesis.
T10844	5782-5785	DT	denotes	The
T10845	5793-5798	NN	denotes	group
T10846	5786-5792	JJ	denotes	second
T10847	5799-5804	VBZ	denotes	shows
T10848	5805-5811	JJ	denotes	normal
T10849	5825-5835	NNS	denotes	structures
T10850	5812-5820	JJ	denotes	external
T10851	5821-5824	NN	denotes	eye
T10852	5835-5837	,	denotes	,
T10853	5837-5845	IN	denotes	although
T10854	5893-5900	VBN	denotes	delayed
T10855	5846-5848	IN	denotes	in
T10856	5849-5853	DT	denotes	this
T10857	5854-5858	NN	denotes	case
T10858	5859-5866	JJ	denotes	retinal
T10859	5867-5878	NN	denotes	development
T10860	5879-5881	VBZ	denotes	is
T10861	5882-5892	RB	denotes	temporally
T10862	5901-5907	IN	denotes	during
T10863	5908-5921	NN	denotes	mid-gestation
T10864	5921-5923	,	denotes	,
T10865	5923-5927	IN	denotes	with
T10866	5928-5938	JJ	denotes	persistent
T10867	5949-5962	NN	denotes	morphogenesis
T10868	5938-5940	,	denotes	,
T10869	5940-5948	JJ	denotes	abnormal
T10870	5963-5965	IN	denotes	of
T10871	5966-5969	DT	denotes	the
T10872	5993-5998	NN	denotes	layer
T10873	5970-5975	JJ	denotes	inner
T10874	5976-5984	JJ	denotes	granular
T10875	5985-5992	JJ	denotes	retinal
T10876	5999-6001	IN	denotes	at
T10877	6002-6007	JJ	denotes	later
T10878	6008-6014	NNS	denotes	stages
T10879	6015-6017	IN	denotes	of
T10880	6018-6031	NN	denotes	embryogenesis
T10881	6031-6032	.	denotes	.
T10882	6032-6138	sentence	denotes	A possible explanation for these two phenotypes can be found in the expression pattern of the Ptdsr gene.
T10883	6033-6034	DT	denotes	A
T10884	6044-6055	NN	denotes	explanation
T10885	6035-6043	JJ	denotes	possible
T10886	6088-6093	VBN	denotes	found
T10887	6056-6059	IN	denotes	for
T10888	6060-6065	DT	denotes	these
T10889	6070-6080	NNS	denotes	phenotypes
T10890	6066-6069	CD	denotes	two
T10891	6081-6084	MD	denotes	can
T10892	6085-6087	VB	denotes	be
T10893	6094-6096	IN	denotes	in
T10894	6097-6100	DT	denotes	the
T10895	6112-6119	NN	denotes	pattern
T10896	6101-6111	NN	denotes	expression
T10897	6120-6122	IN	denotes	of
T10898	6123-6126	DT	denotes	the
T10899	6133-6137	NN	denotes	gene
T10900	6127-6132	NN	denotes	Ptdsr
T10901	6137-6138	.	denotes	.
T10902	6138-6286	sentence	denotes	Initially, Ptdsr is expressed throughout the whole developing nervous system, with exceptionally high levels in the anterior part of the forebrain.
T10903	6139-6148	RB	denotes	Initially
T10904	6159-6168	VBN	denotes	expressed
T10905	6148-6150	,	denotes	,
T10906	6150-6155	NN	denotes	Ptdsr
T10907	6156-6158	VBZ	denotes	is
T10908	6169-6179	IN	denotes	throughout
T10909	6180-6183	DT	denotes	the
T10910	6209-6215	NN	denotes	system
T10911	6184-6189	JJ	denotes	whole
T10912	6190-6200	VBG	denotes	developing
T10913	6201-6208	JJ	denotes	nervous
T10914	6215-6217	,	denotes	,
T10915	6217-6221	IN	denotes	with
T10916	6222-6235	RB	denotes	exceptionally
T10917	6236-6240	JJ	denotes	high
T10918	6241-6247	NNS	denotes	levels
T10919	6248-6250	IN	denotes	in
T10920	6251-6254	DT	denotes	the
T10921	6264-6268	NN	denotes	part
T10922	6255-6263	JJ	denotes	anterior
T10923	6269-6271	IN	denotes	of
T10924	6272-6275	DT	denotes	the
T10925	6276-6285	NN	denotes	forebrain
T10926	6285-6286	.	denotes	.
T10927	6286-6362	sentence	denotes	Later expression becomes more restricted to the developing retina and lens.
T10928	6287-6292	JJ	denotes	Later
T10929	6293-6303	NN	denotes	expression
T10930	6304-6311	VBZ	denotes	becomes
T10931	6312-6316	RBR	denotes	more
T10932	6317-6327	JJ	denotes	restricted
T10933	6328-6330	IN	denotes	to
T10934	6331-6334	DT	denotes	the
T10935	6346-6352	NN	denotes	retina
T10936	6335-6345	VBG	denotes	developing
T10937	6353-6356	CC	denotes	and
T10938	6357-6361	NN	denotes	lens
T10939	6361-6362	.	denotes	.
T10940	6362-6523	sentence	denotes	Thus, Ptdsr might play an important role in early events of ocular morphogenesis, such as establishment and bisection of eye fields and formation of optic cups.
T10941	6363-6367	RB	denotes	Thus
T10942	6381-6385	VB	denotes	play
T10943	6367-6369	,	denotes	,
T10944	6369-6374	NN	denotes	Ptdsr
T10945	6375-6380	MD	denotes	might
T10946	6386-6388	DT	denotes	an
T10947	6399-6403	NN	denotes	role
T10948	6389-6398	JJ	denotes	important
T10949	6404-6406	IN	denotes	in
T10950	6407-6412	JJ	denotes	early
T10951	6413-6419	NNS	denotes	events
T10952	6420-6422	IN	denotes	of
T10953	6423-6429	JJ	denotes	ocular
T10954	6430-6443	NN	denotes	morphogenesis
T10955	6443-6445	,	denotes	,
T10956	6445-6449	JJ	denotes	such
T10957	6450-6452	IN	denotes	as
T10958	6453-6466	NN	denotes	establishment
T10959	6467-6470	CC	denotes	and
T10960	6471-6480	NN	denotes	bisection
T10961	6481-6483	IN	denotes	of
T10962	6484-6487	NN	denotes	eye
T10963	6488-6494	NNS	denotes	fields
T10964	6495-6498	CC	denotes	and
T10965	6499-6508	NN	denotes	formation
T10966	6509-6511	IN	denotes	of
T10967	6512-6517	JJ	denotes	optic
T10968	6518-6522	NNS	denotes	cups
T10969	6522-6523	.	denotes	.
T10970	6523-6646	sentence	denotes	These early eye-formation steps are closely interconnected with development of the forebrain [37,38] and the nose [39-41].
T10971	6524-6529	DT	denotes	These
T10972	6550-6555	NNS	denotes	steps
T10973	6530-6535	JJ	denotes	early
T10974	6536-6539	NN	denotes	eye
T10975	6540-6549	NN	denotes	formation
T10976	6539-6540	HYPH	denotes	-
T10977	6568-6582	VBN	denotes	interconnected
T10978	6556-6559	VBP	denotes	are
T10979	6560-6567	RB	denotes	closely
T10980	6583-6587	IN	denotes	with
T10981	6588-6599	NN	denotes	development
T10982	6600-6602	IN	denotes	of
T10983	6603-6606	DT	denotes	the
T10984	6607-6616	NN	denotes	forebrain
T10985	6617-6618	-LRB-	denotes	[
T10986	6621-6623	CD	denotes	38
T10987	6618-6620	CD	denotes	37
T10988	6620-6621	,	denotes	,
T10989	6623-6624	-RRB-	denotes	]
T10990	6625-6628	CC	denotes	and
T10991	6629-6632	DT	denotes	the
T10992	6633-6637	NN	denotes	nose
T10993	6638-6639	-LRB-	denotes	[
T10994	6639-6641	CD	denotes	39
T10995	6641-6642	SYM	denotes	-
T10996	6642-6644	CD	denotes	41
T10997	6644-6645	-RRB-	denotes	]
T10998	6645-6646	.	denotes	.
T10999	6646-6867	sentence	denotes	Interestingly, we occasionally observed serious malformations of forebrain and nasal structures in Ptdsr-knockout embryos that were associated with bilateral anophthalmia (see for example the mutant embryo in Figure 1g).
T11000	6647-6660	RB	denotes	Interestingly
T11001	6678-6686	VBD	denotes	observed
T11002	6660-6662	,	denotes	,
T11003	6662-6664	PRP	denotes	we
T11004	6665-6677	RB	denotes	occasionally
T11005	6687-6694	JJ	denotes	serious
T11006	6695-6708	NNS	denotes	malformations
T11007	6709-6711	IN	denotes	of
T11008	6712-6721	NN	denotes	forebrain
T11009	6722-6725	CC	denotes	and
T11010	6726-6731	JJ	denotes	nasal
T11011	6732-6742	NNS	denotes	structures
T11012	6743-6745	IN	denotes	in
T11013	6746-6751	NN	denotes	Ptdsr
T11014	6752-6760	NN	denotes	knockout
T11015	6751-6752	HYPH	denotes	-
T11016	6761-6768	NNS	denotes	embryos
T11017	6769-6773	WDT	denotes	that
T11018	6779-6789	VBN	denotes	associated
T11019	6774-6778	VBD	denotes	were
T11020	6790-6794	IN	denotes	with
T11021	6795-6804	JJ	denotes	bilateral
T11022	6805-6817	NN	denotes	anophthalmia
T11023	6818-6819	-LRB-	denotes	(
T11024	6819-6822	VB	denotes	see
T11025	6823-6826	IN	denotes	for
T11026	6827-6834	NN	denotes	example
T11027	6835-6838	DT	denotes	the
T11028	6846-6852	NN	denotes	embryo
T11029	6839-6845	NN	denotes	mutant
T11030	6853-6855	IN	denotes	in
T11031	6856-6862	NN	denotes	Figure
T11032	6863-6865	NN	denotes	1g
T11033	6865-6866	-RRB-	denotes	)
T11034	6866-6867	.	denotes	.
T11035	6867-7059	sentence	denotes	This suggests that Ptdsr is involved in the regulation of differentiation processes within forebrain regions, and that ablation of Ptdsr function might secondarily affect early eye formation.
T11036	6868-6872	DT	denotes	This
T11037	6873-6881	VBZ	denotes	suggests
T11038	6882-6886	IN	denotes	that
T11039	6896-6904	VBN	denotes	involved
T11040	6887-6892	NN	denotes	Ptdsr
T11041	6893-6895	VBZ	denotes	is
T11042	6905-6907	IN	denotes	in
T11043	6908-6911	DT	denotes	the
T11044	6912-6922	NN	denotes	regulation
T11045	6923-6925	IN	denotes	of
T11046	6926-6941	NN	denotes	differentiation
T11047	6942-6951	NNS	denotes	processes
T11048	6952-6958	IN	denotes	within
T11049	6959-6968	NN	denotes	forebrain
T11050	6969-6976	NNS	denotes	regions
T11051	6976-6978	,	denotes	,
T11052	6978-6981	CC	denotes	and
T11053	6982-6986	IN	denotes	that
T11054	7032-7038	VB	denotes	affect
T11055	6987-6995	NN	denotes	ablation
T11056	6996-6998	IN	denotes	of
T11057	6999-7004	NN	denotes	Ptdsr
T11058	7005-7013	NN	denotes	function
T11059	7014-7019	MD	denotes	might
T11060	7020-7031	RB	denotes	secondarily
T11061	7039-7044	JJ	denotes	early
T11062	7049-7058	NN	denotes	formation
T11063	7045-7048	NN	denotes	eye
T11064	7058-7059	.	denotes	.
T11065	7059-7286	sentence	denotes	Li et al. [31] found smaller lenses in Ptdsr-knockout mice and described the formation of retinal protrusions, although anophthalmia and specific differentiation defects of retinal cell layers were not reported in their study.
T11066	7060-7062	NNP	denotes	Li
T11067	7075-7080	VBD	denotes	found
T11068	7063-7065	FW	denotes	et
T11069	7066-7069	FW	denotes	al.
T11070	7070-7071	-LRB-	denotes	[
T11071	7071-7073	CD	denotes	31
T11072	7073-7074	-RRB-	denotes	]
T11073	7081-7088	JJR	denotes	smaller
T11074	7089-7095	NNS	denotes	lenses
T11075	7096-7098	IN	denotes	in
T11076	7099-7104	NN	denotes	Ptdsr
T11077	7105-7113	NN	denotes	knockout
T11078	7104-7105	HYPH	denotes	-
T11079	7114-7118	NNS	denotes	mice
T11080	7119-7122	CC	denotes	and
T11081	7123-7132	VBD	denotes	described
T11082	7133-7136	DT	denotes	the
T11083	7137-7146	NN	denotes	formation
T11084	7147-7149	IN	denotes	of
T11085	7150-7157	JJ	denotes	retinal
T11086	7158-7169	NNS	denotes	protrusions
T11087	7169-7171	,	denotes	,
T11088	7171-7179	IN	denotes	although
T11089	7262-7270	VBN	denotes	reported
T11090	7180-7192	NN	denotes	anophthalmia
T11091	7193-7196	CC	denotes	and
T11092	7197-7205	JJ	denotes	specific
T11093	7222-7229	NNS	denotes	defects
T11094	7206-7221	NN	denotes	differentiation
T11095	7230-7232	IN	denotes	of
T11096	7233-7240	JJ	denotes	retinal
T11097	7246-7252	NNS	denotes	layers
T11098	7241-7245	NN	denotes	cell
T11099	7253-7257	VBD	denotes	were
T11100	7258-7261	RB	denotes	not
T11101	7271-7273	IN	denotes	in
T11102	7274-7279	PRP$	denotes	their
T11103	7280-7285	NN	denotes	study
T11104	7285-7286	.	denotes	.
T11105	7286-7522	sentence	denotes	Li et al. proposed [31] that the eye phenotype they observed could be explained by failed removal of apoptotic cells during eye development, but we think that the observed defects are unrelated to a failure of apoptotic cell clearance.
T11106	7287-7289	NNP	denotes	Li
T11107	7297-7305	VBN	denotes	proposed
T11108	7290-7292	FW	denotes	et
T11109	7293-7296	FW	denotes	al.
T11110	7306-7307	-LRB-	denotes	[
T11111	7307-7309	CD	denotes	31
T11112	7309-7310	-RRB-	denotes	]
T11113	7311-7315	IN	denotes	that
T11114	7357-7366	VBN	denotes	explained
T11115	7316-7319	DT	denotes	the
T11116	7324-7333	NN	denotes	phenotype
T11117	7320-7323	NN	denotes	eye
T11118	7334-7338	PRP	denotes	they
T11119	7339-7347	VBD	denotes	observed
T11120	7348-7353	MD	denotes	could
T11121	7354-7356	VB	denotes	be
T11122	7367-7369	IN	denotes	by
T11123	7370-7376	JJ	denotes	failed
T11124	7377-7384	NN	denotes	removal
T11125	7385-7387	IN	denotes	of
T11126	7388-7397	JJ	denotes	apoptotic
T11127	7398-7403	NNS	denotes	cells
T11128	7404-7410	IN	denotes	during
T11129	7411-7414	NN	denotes	eye
T11130	7415-7426	NN	denotes	development
T11131	7426-7428	,	denotes	,
T11132	7428-7431	CC	denotes	but
T11133	7432-7434	PRP	denotes	we
T11134	7435-7440	VBP	denotes	think
T11135	7441-7445	IN	denotes	that
T11136	7467-7470	VBP	denotes	are
T11137	7446-7449	DT	denotes	the
T11138	7459-7466	NNS	denotes	defects
T11139	7450-7458	VBN	denotes	observed
T11140	7471-7480	JJ	denotes	unrelated
T11141	7481-7483	IN	denotes	to
T11142	7484-7485	DT	denotes	a
T11143	7486-7493	NN	denotes	failure
T11144	7494-7496	IN	denotes	of
T11145	7497-7506	JJ	denotes	apoptotic
T11146	7507-7511	NN	denotes	cell
T11147	7512-7521	NN	denotes	clearance
T11148	7521-7522	.	denotes	.
T11149	7522-7675	sentence	denotes	A recent comprehensive kinetic analysis of apoptosis induction during mouse retinal development described four major peaks of apoptotic cell death [42].
T11150	7523-7524	DT	denotes	A
T11151	7554-7562	NN	denotes	analysis
T11152	7525-7531	JJ	denotes	recent
T11153	7532-7545	JJ	denotes	comprehensive
T11154	7546-7553	JJ	denotes	kinetic
T11155	7619-7628	VBD	denotes	described
T11156	7563-7565	IN	denotes	of
T11157	7566-7575	NN	denotes	apoptosis
T11158	7576-7585	NN	denotes	induction
T11159	7586-7592	IN	denotes	during
T11160	7593-7598	NN	denotes	mouse
T11161	7607-7618	NN	denotes	development
T11162	7599-7606	NN	denotes	retinal
T11163	7629-7633	CD	denotes	four
T11164	7640-7645	NNS	denotes	peaks
T11165	7634-7639	JJ	denotes	major
T11166	7646-7648	IN	denotes	of
T11167	7649-7658	JJ	denotes	apoptotic
T11168	7664-7669	NN	denotes	death
T11169	7659-7663	NN	denotes	cell
T11170	7670-7671	-LRB-	denotes	[
T11171	7671-7673	CD	denotes	42
T11172	7673-7674	-RRB-	denotes	]
T11173	7674-7675	.	denotes	.
T11174	7675-7965	sentence	denotes	This study demonstrated that there is an initial phase of cell death during the invagination of the optic cup (E10.5), followed by subsequent waves of apoptosis induction immediately before and after birth (E18.5 to postnatal day P2), and from postnatal days P9 to P10 and P14 to P16 [42].
T11175	7676-7680	DT	denotes	This
T11176	7681-7686	NN	denotes	study
T11177	7687-7699	VBD	denotes	demonstrated
T11178	7700-7704	IN	denotes	that
T11179	7711-7713	VBZ	denotes	is
T11180	7705-7710	EX	denotes	there
T11181	7714-7716	DT	denotes	an
T11182	7725-7730	NN	denotes	phase
T11183	7717-7724	JJ	denotes	initial
T11184	7731-7733	IN	denotes	of
T11185	7734-7738	NN	denotes	cell
T11186	7739-7744	NN	denotes	death
T11187	7745-7751	IN	denotes	during
T11188	7752-7755	DT	denotes	the
T11189	7756-7768	NN	denotes	invagination
T11190	7769-7771	IN	denotes	of
T11191	7772-7775	DT	denotes	the
T11192	7782-7785	NN	denotes	cup
T11193	7776-7781	JJ	denotes	optic
T11194	7786-7787	-LRB-	denotes	(
T11195	7787-7792	NN	denotes	E10.5
T11196	7792-7793	-RRB-	denotes	)
T11197	7793-7795	,	denotes	,
T11198	7795-7803	VBN	denotes	followed
T11199	7804-7806	IN	denotes	by
T11200	7807-7817	JJ	denotes	subsequent
T11201	7818-7823	NNS	denotes	waves
T11202	7824-7826	IN	denotes	of
T11203	7827-7836	NN	denotes	apoptosis
T11204	7837-7846	NN	denotes	induction
T11205	7847-7858	RB	denotes	immediately
T11206	7859-7865	IN	denotes	before
T11207	7866-7869	CC	denotes	and
T11208	7870-7875	IN	denotes	after
T11209	7876-7881	NN	denotes	birth
T11210	7882-7883	-LRB-	denotes	(
T11211	7883-7888	NN	denotes	E18.5
T11212	7889-7891	IN	denotes	to
T11213	7892-7901	JJ	denotes	postnatal
T11214	7902-7905	NN	denotes	day
T11215	7906-7908	NN	denotes	P2
T11216	7908-7909	-RRB-	denotes	)
T11217	7909-7911	,	denotes	,
T11218	7911-7914	CC	denotes	and
T11219	7915-7919	IN	denotes	from
T11220	7920-7929	JJ	denotes	postnatal
T11221	7935-7937	NN	denotes	P9
T11222	7930-7934	NNS	denotes	days
T11223	7938-7940	IN	denotes	to
T11224	7941-7944	NN	denotes	P10
T11225	7945-7948	CC	denotes	and
T11226	7949-7952	NN	denotes	P14
T11227	7953-7955	IN	denotes	to
T11228	7956-7959	NN	denotes	P16
T11229	7960-7961	-LRB-	denotes	[
T11230	7961-7963	CD	denotes	42
T11231	7963-7964	-RRB-	denotes	]
T11232	7964-7965	.	denotes	.
T11233	7965-8221	sentence	denotes	Thus, besides the formation of the inner and outer layers of the optic cup in early eye development, other major phases of retinal cell apoptosis take place only postnatally and correspond to important periods in the establishment of neuronal connections.
T11234	7966-7970	RB	denotes	Thus
T11235	8112-8116	VBP	denotes	take
T11236	7970-7972	,	denotes	,
T11237	7972-7979	IN	denotes	besides
T11238	7980-7983	DT	denotes	the
T11239	7984-7993	NN	denotes	formation
T11240	7994-7996	IN	denotes	of
T11241	7997-8000	DT	denotes	the
T11242	8017-8023	NNS	denotes	layers
T11243	8001-8006	JJ	denotes	inner
T11244	8007-8010	CC	denotes	and
T11245	8011-8016	JJ	denotes	outer
T11246	8024-8026	IN	denotes	of
T11247	8027-8030	DT	denotes	the
T11248	8037-8040	NN	denotes	cup
T11249	8031-8036	JJ	denotes	optic
T11250	8041-8043	IN	denotes	in
T11251	8044-8049	JJ	denotes	early
T11252	8054-8065	NN	denotes	development
T11253	8050-8053	NN	denotes	eye
T11254	8065-8067	,	denotes	,
T11255	8067-8072	JJ	denotes	other
T11256	8079-8085	NNS	denotes	phases
T11257	8073-8078	JJ	denotes	major
T11258	8086-8088	IN	denotes	of
T11259	8089-8096	JJ	denotes	retinal
T11260	8102-8111	NN	denotes	apoptosis
T11261	8097-8101	NN	denotes	cell
T11262	8117-8122	NN	denotes	place
T11263	8123-8127	RB	denotes	only
T11264	8128-8139	RB	denotes	postnatally
T11265	8140-8143	CC	denotes	and
T11266	8144-8154	VBP	denotes	correspond
T11267	8155-8157	IN	denotes	to
T11268	8158-8167	JJ	denotes	important
T11269	8168-8175	NNS	denotes	periods
T11270	8176-8178	IN	denotes	in
T11271	8179-8182	DT	denotes	the
T11272	8183-8196	NN	denotes	establishment
T11273	8197-8199	IN	denotes	of
T11274	8200-8208	JJ	denotes	neuronal
T11275	8209-8220	NNS	denotes	connections
T11276	8220-8221	.	denotes	.
T11277	8221-8446	sentence	denotes	Furthermore, cell death during normal retinal development occurs in retinal layers distinct from the inner granular layer where we observed the most pronounced differentiation defects in the Ptdsr -/- mutants described here.
T11278	8222-8233	RB	denotes	Furthermore
T11279	8280-8286	VBZ	denotes	occurs
T11280	8233-8235	,	denotes	,
T11281	8235-8239	NN	denotes	cell
T11282	8240-8245	NN	denotes	death
T11283	8246-8252	IN	denotes	during
T11284	8253-8259	JJ	denotes	normal
T11285	8268-8279	NN	denotes	development
T11286	8260-8267	JJ	denotes	retinal
T11287	8287-8289	IN	denotes	in
T11288	8290-8297	JJ	denotes	retinal
T11289	8298-8304	NNS	denotes	layers
T11290	8305-8313	JJ	denotes	distinct
T11291	8314-8318	IN	denotes	from
T11292	8319-8322	DT	denotes	the
T11293	8338-8343	NN	denotes	layer
T11294	8323-8328	JJ	denotes	inner
T11295	8329-8337	JJ	denotes	granular
T11296	8344-8349	WRB	denotes	where
T11297	8353-8361	VBD	denotes	observed
T11298	8350-8352	PRP	denotes	we
T11299	8362-8365	DT	denotes	the
T11300	8398-8405	NNS	denotes	defects
T11301	8366-8370	RBS	denotes	most
T11302	8371-8381	JJ	denotes	pronounced
T11303	8382-8397	NN	denotes	differentiation
T11304	8406-8408	IN	denotes	in
T11305	8409-8412	DT	denotes	the
T11306	8423-8430	NNS	denotes	mutants
T11307	8413-8418	NN	denotes	Ptdsr
T11308	8419-8420	SYM	denotes	-
T11309	8420-8421	HYPH	denotes	/
T11310	8421-8422	SYM	denotes	-
T11311	8431-8440	VBN	denotes	described
T11312	8441-8445	RB	denotes	here
T11313	8445-8446	.	denotes	.
T11314	8446-8719	sentence	denotes	Other studies that connect the postnatal elimination of apoptotic photoreceptor cells to Ptdsr-mediated macrophage engulfment [43] should be interpreted with extreme caution as these studies were based on the monoclonal anti-Ptdsr antibody mAb 217G8E9 [26,43] (see below).
T11315	8447-8452	JJ	denotes	Other
T11316	8453-8460	NNS	denotes	studies
T11317	8588-8599	VBN	denotes	interpreted
T11318	8461-8465	WDT	denotes	that
T11319	8466-8473	VBP	denotes	connect
T11320	8474-8477	DT	denotes	the
T11321	8488-8499	NN	denotes	elimination
T11322	8478-8487	JJ	denotes	postnatal
T11323	8500-8502	IN	denotes	of
T11324	8503-8512	JJ	denotes	apoptotic
T11325	8527-8532	NNS	denotes	cells
T11326	8513-8526	NN	denotes	photoreceptor
T11327	8533-8535	IN	denotes	to
T11328	8536-8541	NN	denotes	Ptdsr
T11329	8542-8550	VBN	denotes	mediated
T11330	8541-8542	HYPH	denotes	-
T11331	8562-8572	NN	denotes	engulfment
T11332	8551-8561	NN	denotes	macrophage
T11333	8573-8574	-LRB-	denotes	[
T11334	8574-8576	CD	denotes	43
T11335	8576-8577	-RRB-	denotes	]
T11336	8578-8584	MD	denotes	should
T11337	8585-8587	VB	denotes	be
T11338	8600-8604	IN	denotes	with
T11339	8605-8612	JJ	denotes	extreme
T11340	8613-8620	NN	denotes	caution
T11341	8621-8623	IN	denotes	as
T11342	8643-8648	VBN	denotes	based
T11343	8624-8629	DT	denotes	these
T11344	8630-8637	NNS	denotes	studies
T11345	8638-8642	VBD	denotes	were
T11346	8649-8651	IN	denotes	on
T11347	8652-8655	DT	denotes	the
T11348	8678-8686	NN	denotes	antibody
T11349	8656-8666	JJ	denotes	monoclonal
T11350	8667-8677	JJ	denotes	anti-Ptdsr
T11351	8687-8690	NN	denotes	mAb
T11352	8691-8698	CD	denotes	217G8E9
T11353	8699-8700	-LRB-	denotes	[
T11354	8703-8705	CD	denotes	43
T11355	8700-8702	CD	denotes	26
T11356	8702-8703	,	denotes	,
T11357	8705-8706	-RRB-	denotes	]
T11358	8707-8708	-LRB-	denotes	(
T11359	8708-8711	VB	denotes	see
T11360	8712-8717	RB	denotes	below
T11361	8717-8718	-RRB-	denotes	)
T11362	8718-8719	.	denotes	.
T11363	8719-8829	sentence	denotes	Consistent with the results of Li et al. [31], we found particular brain malformations in our Ptdsr -/- mice.
T11364	8720-8730	JJ	denotes	Consistent
T11365	8770-8775	VBD	denotes	found
T11366	8731-8735	IN	denotes	with
T11367	8736-8739	DT	denotes	the
T11368	8740-8747	NNS	denotes	results
T11369	8748-8750	IN	denotes	of
T11370	8751-8753	NNP	denotes	Li
T11371	8754-8756	FW	denotes	et
T11372	8757-8760	FW	denotes	al.
T11373	8761-8762	-LRB-	denotes	[
T11374	8762-8764	CD	denotes	31
T11375	8764-8765	-RRB-	denotes	]
T11376	8765-8767	,	denotes	,
T11377	8767-8769	PRP	denotes	we
T11378	8776-8786	JJ	denotes	particular
T11379	8793-8806	NNS	denotes	malformations
T11380	8787-8792	NN	denotes	brain
T11381	8807-8809	IN	denotes	in
T11382	8810-8813	PRP$	denotes	our
T11383	8824-8828	NNS	denotes	mice
T11384	8814-8819	NN	denotes	Ptdsr
T11385	8820-8821	SYM	denotes	-
T11386	8821-8822	HYPH	denotes	/
T11387	8822-8823	SYM	denotes	-
T11388	8828-8829	.	denotes	.
T11389	8829-9277	sentence	denotes	Exencephaly and hyperplastic brain phenotypes were observed at a low penetrance in Ptdsr-mutant mice (less then 4.5% of homozygotes), but these do not resemble to any extent the brain-overgrowth phenotypes of caspase- or Apaf1-knockout mice ([44], and references therein) in that we failed to identify any differences in the number or distribution of apoptotic cells or pyknotic cell clusters in the neuroepithelium of Ptdsr -/- and Ptdsr+/+ mice.
T11390	8830-8841	NN	denotes	Exencephaly
T11391	8865-8875	NNS	denotes	phenotypes
T11392	8842-8845	CC	denotes	and
T11393	8846-8858	JJ	denotes	hyperplastic
T11394	8859-8864	NN	denotes	brain
T11395	8881-8889	VBN	denotes	observed
T11396	8876-8880	VBD	denotes	were
T11397	8890-8892	IN	denotes	at
T11398	8893-8894	DT	denotes	a
T11399	8899-8909	NN	denotes	penetrance
T11400	8895-8898	JJ	denotes	low
T11401	8910-8912	IN	denotes	in
T11402	8913-8918	NN	denotes	Ptdsr
T11403	8919-8925	NN	denotes	mutant
T11404	8918-8919	HYPH	denotes	-
T11405	8926-8930	NNS	denotes	mice
T11406	8931-8932	-LRB-	denotes	(
T11407	8945-8946	NN	denotes	%
T11408	8932-8936	RBR	denotes	less
T11409	8942-8945	CD	denotes	4.5
T11410	8937-8941	IN	denotes	then
T11411	8947-8949	IN	denotes	of
T11412	8950-8961	NNS	denotes	homozygotes
T11413	8961-8962	-RRB-	denotes	)
T11414	8962-8964	,	denotes	,
T11415	8964-8967	CC	denotes	but
T11416	8968-8973	DT	denotes	these
T11417	8981-8989	VB	denotes	resemble
T11418	8974-8976	VBP	denotes	do
T11419	8977-8980	RB	denotes	not
T11420	8990-8992	IN	denotes	to
T11421	8993-8996	DT	denotes	any
T11422	8997-9003	NN	denotes	extent
T11423	9004-9007	DT	denotes	the
T11424	9025-9035	NNS	denotes	phenotypes
T11425	9008-9013	NN	denotes	brain
T11426	9014-9024	NN	denotes	overgrowth
T11427	9013-9014	HYPH	denotes	-
T11428	9036-9038	IN	denotes	of
T11429	9039-9046	NN	denotes	caspase
T11430	9057-9065	NN	denotes	knockout
T11431	9046-9047	HYPH	denotes	-
T11432	9048-9050	CC	denotes	or
T11433	9051-9056	NN	denotes	Apaf1
T11434	9056-9057	HYPH	denotes	-
T11435	9066-9070	NNS	denotes	mice
T11436	9071-9072	-LRB-	denotes	(
T11437	9073-9075	CD	denotes	44
T11438	9072-9073	-LRB-	denotes	[
T11439	9075-9076	-RRB-	denotes	]
T11440	9076-9078	,	denotes	,
T11441	9078-9081	CC	denotes	and
T11442	9082-9092	NNS	denotes	references
T11443	9093-9100	RB	denotes	therein
T11444	9100-9101	-RRB-	denotes	)
T11445	9102-9104	IN	denotes	in
T11446	9113-9119	VBD	denotes	failed
T11447	9105-9109	IN	denotes	that
T11448	9110-9112	PRP	denotes	we
T11449	9120-9122	TO	denotes	to
T11450	9123-9131	VB	denotes	identify
T11451	9132-9135	DT	denotes	any
T11452	9136-9147	NNS	denotes	differences
T11453	9148-9150	IN	denotes	in
T11454	9151-9154	DT	denotes	the
T11455	9155-9161	NN	denotes	number
T11456	9162-9164	CC	denotes	or
T11457	9165-9177	NN	denotes	distribution
T11458	9178-9180	IN	denotes	of
T11459	9181-9190	JJ	denotes	apoptotic
T11460	9191-9196	NNS	denotes	cells
T11461	9197-9199	CC	denotes	or
T11462	9200-9208	JJ	denotes	pyknotic
T11463	9214-9222	NNS	denotes	clusters
T11464	9209-9213	NN	denotes	cell
T11465	9223-9225	IN	denotes	in
T11466	9226-9229	DT	denotes	the
T11467	9230-9245	NN	denotes	neuroepithelium
T11468	9246-9248	IN	denotes	of
T11469	9249-9254	NN	denotes	Ptdsr
T11470	9272-9276	NNS	denotes	mice
T11471	9255-9256	SYM	denotes	-
T11472	9256-9257	HYPH	denotes	/
T11473	9257-9258	SYM	denotes	-
T11474	9259-9262	CC	denotes	and
T11475	9263-9268	NN	denotes	Ptdsr
T11476	9268-9269	SYM	denotes	+
T11477	9269-9270	HYPH	denotes	/
T11478	9270-9271	SYM	denotes	+
T11479	9276-9277	.	denotes	.
T11480	9277-9417	sentence	denotes	Thus, reduced cell death or diminished clearance of apoptotic neural progenitor cells is unlikely to be the cause of the brain hyperplasia.
T11481	9278-9282	RB	denotes	Thus
T11482	9364-9366	VBZ	denotes	is
T11483	9282-9284	,	denotes	,
T11484	9284-9291	VBN	denotes	reduced
T11485	9297-9302	NN	denotes	death
T11486	9292-9296	NN	denotes	cell
T11487	9303-9305	CC	denotes	or
T11488	9306-9316	VBN	denotes	diminished
T11489	9317-9326	NN	denotes	clearance
T11490	9327-9329	IN	denotes	of
T11491	9330-9339	JJ	denotes	apoptotic
T11492	9358-9363	NNS	denotes	cells
T11493	9340-9346	JJ	denotes	neural
T11494	9347-9357	NN	denotes	progenitor
T11495	9367-9375	JJ	denotes	unlikely
T11496	9376-9378	TO	denotes	to
T11497	9379-9381	VB	denotes	be
T11498	9382-9385	DT	denotes	the
T11499	9386-9391	NN	denotes	cause
T11500	9392-9394	IN	denotes	of
T11501	9395-9398	DT	denotes	the
T11502	9405-9416	NN	denotes	hyperplasia
T11503	9399-9404	NN	denotes	brain
T11504	9416-9417	.	denotes	.
T11505	9417-9652	sentence	denotes	In summary, our studies demonstrate that Ptdsr is required for normal tissue differentiation, especially during the mid-gestation period when we observed the most severe differentiation delays in several organs of Ptdsr-knockout mice.
T11506	9418-9420	IN	denotes	In
T11507	9442-9453	VBP	denotes	demonstrate
T11508	9421-9428	NN	denotes	summary
T11509	9428-9430	,	denotes	,
T11510	9430-9433	PRP$	denotes	our
T11511	9434-9441	NNS	denotes	studies
T11512	9454-9458	IN	denotes	that
T11513	9468-9476	VBN	denotes	required
T11514	9459-9464	NN	denotes	Ptdsr
T11515	9465-9467	VBZ	denotes	is
T11516	9477-9480	IN	denotes	for
T11517	9481-9487	JJ	denotes	normal
T11518	9495-9510	NN	denotes	differentiation
T11519	9488-9494	NN	denotes	tissue
T11520	9510-9512	,	denotes	,
T11521	9512-9522	RB	denotes	especially
T11522	9523-9529	IN	denotes	during
T11523	9530-9533	DT	denotes	the
T11524	9548-9554	NN	denotes	period
T11525	9534-9547	NN	denotes	mid-gestation
T11526	9555-9559	WRB	denotes	when
T11527	9563-9571	VBD	denotes	observed
T11528	9560-9562	PRP	denotes	we
T11529	9572-9575	DT	denotes	the
T11530	9604-9610	NNS	denotes	delays
T11531	9576-9580	RBS	denotes	most
T11532	9581-9587	JJ	denotes	severe
T11533	9588-9603	NN	denotes	differentiation
T11534	9611-9613	IN	denotes	in
T11535	9614-9621	JJ	denotes	several
T11536	9622-9628	NNS	denotes	organs
T11537	9629-9631	IN	denotes	of
T11538	9632-9637	NN	denotes	Ptdsr
T11539	9638-9646	NN	denotes	knockout
T11540	9637-9638	HYPH	denotes	-
T11541	9647-9651	NNS	denotes	mice
T11542	9651-9652	.	denotes	.
T11543	9652-9813	sentence	denotes	The multiple defects in tissue differentiation cannot be explained by failure of apoptotic cell clearance, as this process is normal in our Ptdsr-knockout line.
T11544	9653-9656	DT	denotes	The
T11545	9666-9673	NNS	denotes	defects
T11546	9657-9665	JJ	denotes	multiple
T11547	9710-9719	VBN	denotes	explained
T11548	9674-9676	IN	denotes	in
T11549	9677-9683	NN	denotes	tissue
T11550	9684-9699	NN	denotes	differentiation
T11551	9700-9703	MD	denotes	can
T11552	9703-9706	RB	denotes	not
T11553	9707-9709	VB	denotes	be
T11554	9720-9722	IN	denotes	by
T11555	9723-9730	NN	denotes	failure
T11556	9731-9733	IN	denotes	of
T11557	9734-9743	JJ	denotes	apoptotic
T11558	9749-9758	NN	denotes	clearance
T11559	9744-9748	NN	denotes	cell
T11560	9758-9760	,	denotes	,
T11561	9760-9762	IN	denotes	as
T11562	9776-9778	VBZ	denotes	is
T11563	9763-9767	DT	denotes	this
T11564	9768-9775	NN	denotes	process
T11565	9779-9785	JJ	denotes	normal
T11566	9786-9788	IN	denotes	in
T11567	9789-9792	PRP$	denotes	our
T11568	9808-9812	NN	denotes	line
T11569	9793-9798	NN	denotes	Ptdsr
T11570	9799-9807	NN	denotes	knockout
T11571	9798-9799	HYPH	denotes	-
T11572	9812-9813	.	denotes	.
T11573	9813-9956	sentence	denotes	This result therefore indicates that Ptdsr has a novel, hitherto unexpected, role in promoting tissue maturation and terminal differentiation.
T11574	9814-9818	DT	denotes	This
T11575	9819-9825	NN	denotes	result
T11609	10041-10052	VB	denotes	investigate
T11610	10053-10056	DT	denotes	the
T11611	10057-10061	NN	denotes	role
T11612	10062-10064	IN	denotes	of
T11613	10065-10072	JJ	denotes	spatial
T11614	10092-10102	NN	denotes	expression
T11615	10073-10076	CC	denotes	and
T11616	10077-10085	JJ	denotes	temporal
T11617	10086-10091	NN	denotes	Ptdsr
T11618	10103-10106	CC	denotes	and
T11619	10107-10115	NN	denotes	function
T11620	10116-10122	IN	denotes	during
T11621	10123-10129	NN	denotes	tissue
T11622	10130-10145	NN	denotes	differentiation
T11623	10145-10146	.	denotes	.
T12455	10148-10153	NN	denotes	Ptdsr
T12456	10154-10156	VBZ	denotes	is
T12457	10157-10160	RB	denotes	not
T12458	10161-10170	JJ	denotes	essential
T12459	10171-10174	IN	denotes	for
T12460	10175-10178	DT	denotes	the
T12461	10179-10188	NN	denotes	clearance
T12462	10189-10191	IN	denotes	of
T12463	10192-10201	JJ	denotes	apoptotic
T12464	10202-10207	NNS	denotes	cells
T12465	10207-10303	sentence	denotes	Our studies demonstrate that Ptdsr is not a primary receptor for the uptake of apoptotic cells.
T12466	10208-10211	PRP$	denotes	Our
T12467	10212-10219	NNS	denotes	studies
T12468	10220-10231	VBP	denotes	demonstrate
T12469	10232-10236	IN	denotes	that
T12470	10243-10245	VBZ	denotes	is
T12471	10237-10242	NN	denotes	Ptdsr
T12472	10246-10249	RB	denotes	not
T12473	10250-10251	DT	denotes	a
T12474	10260-10268	NN	denotes	receptor
T12475	10252-10259	JJ	denotes	primary
T12476	10269-10272	IN	denotes	for
T12477	10273-10276	DT	denotes	the
T12478	10277-10283	NN	denotes	uptake
T12479	10284-10286	IN	denotes	of
T12480	10287-10296	JJ	denotes	apoptotic
T12481	10297-10302	NNS	denotes	cells
T12482	10302-10303	.	denotes	.
T12483	10303-10476	sentence	denotes	Investigation of apoptotic cell clearance in vivo in Ptdsr -/- embryos conclusively showed that removal of apoptotic cells is not compromised by ablation of Ptdsr function.
T12484	10304-10317	NN	denotes	Investigation
T12485	10388-10394	VBD	denotes	showed
T12486	10318-10320	IN	denotes	of
T12487	10321-10330	JJ	denotes	apoptotic
T12488	10336-10345	NN	denotes	clearance
T12489	10331-10335	NN	denotes	cell
T12490	10346-10348	FW	denotes	in
T12491	10349-10353	FW	denotes	vivo
T12492	10354-10356	IN	denotes	in
T12493	10357-10362	NN	denotes	Ptdsr
T12494	10367-10374	NNS	denotes	embryos
T12495	10363-10364	SYM	denotes	-
T12496	10364-10365	HYPH	denotes	/
T12497	10365-10366	SYM	denotes	-
T12498	10375-10387	RB	denotes	conclusively
T12499	10395-10399	IN	denotes	that
T12500	10434-10445	VBN	denotes	compromised
T12501	10400-10407	NN	denotes	removal
T12502	10408-10410	IN	denotes	of
T12503	10411-10420	JJ	denotes	apoptotic
T12504	10421-10426	NNS	denotes	cells
T12505	10427-10429	VBZ	denotes	is
T12506	10430-10433	RB	denotes	not
T12507	10446-10448	IN	denotes	by
T12508	10449-10457	NN	denotes	ablation
T12509	10458-10460	IN	denotes	of
T12510	10461-10466	NN	denotes	Ptdsr
T12511	10467-10475	NN	denotes	function
T12512	10475-10476	.	denotes	.
T12513	10476-10712	sentence	denotes	Comparative analysis of ten different tissues and organs in Ptdsr+/+ and Ptdsr -/- animals at several stages of embryonic development and in neonates failed to identify impaired uptake of apoptotic cells at any time during development.
T12514	10477-10488	JJ	denotes	Comparative
T12515	10489-10497	NN	denotes	analysis
T12516	10627-10633	VBD	denotes	failed
T12517	10498-10500	IN	denotes	of
T12518	10501-10504	CD	denotes	ten
T12519	10515-10522	NNS	denotes	tissues
T12520	10505-10514	JJ	denotes	different
T12521	10523-10526	CC	denotes	and
T12522	10527-10533	NNS	denotes	organs
T12523	10534-10536	IN	denotes	in
T12524	10537-10542	NN	denotes	Ptdsr
T12525	10560-10567	NNS	denotes	animals
T12526	10542-10543	SYM	denotes	+
T12527	10543-10544	HYPH	denotes	/
T12528	10544-10545	SYM	denotes	+
T12529	10546-10549	CC	denotes	and
T12530	10550-10555	NN	denotes	Ptdsr
T12531	10556-10557	SYM	denotes	-
T12532	10557-10558	HYPH	denotes	/
T12533	10558-10559	SYM	denotes	-
T12534	10568-10570	IN	denotes	at
T12535	10571-10578	JJ	denotes	several
T12536	10579-10585	NNS	denotes	stages
T12537	10586-10588	IN	denotes	of
T12538	10589-10598	JJ	denotes	embryonic
T12539	10599-10610	NN	denotes	development
T12540	10611-10614	CC	denotes	and
T12541	10615-10617	IN	denotes	in
T12542	10618-10626	NNS	denotes	neonates
T12543	10634-10636	TO	denotes	to
T12544	10637-10645	VB	denotes	identify
T12545	10646-10654	JJ	denotes	impaired
T12546	10655-10661	NN	denotes	uptake
T12547	10662-10664	IN	denotes	of
T12548	10665-10674	JJ	denotes	apoptotic
T12549	10675-10680	NNS	denotes	cells
T12550	10681-10683	IN	denotes	at
T12551	10684-10687	DT	denotes	any
T12552	10688-10692	NN	denotes	time
T12553	10693-10699	IN	denotes	during
T12554	10700-10711	NN	denotes	development
T12555	10711-10712	.	denotes	.
T12556	10712-10935	sentence	denotes	Furthermore, phagocytosis assays in vitro demonstrated a completely normal uptake of apoptotic cells by Ptdsr -/- macrophages, with some knockout macrophages showing loads even higher than wild-type of engulfed dead cells.
T12557	10713-10724	RB	denotes	Furthermore
T12558	10755-10767	VBD	denotes	demonstrated
T12559	10724-10726	,	denotes	,
T12560	10726-10738	NN	denotes	phagocytosis
T12561	10739-10745	NNS	denotes	assays
T12562	10746-10748	FW	denotes	in
T12563	10749-10754	FW	denotes	vitro
T12564	10768-10769	DT	denotes	a
T12565	10788-10794	NN	denotes	uptake
T12566	10770-10780	RB	denotes	completely
T12567	10781-10787	JJ	denotes	normal
T12568	10795-10797	IN	denotes	of
T12569	10798-10807	JJ	denotes	apoptotic
T12570	10808-10813	NNS	denotes	cells
T12571	10814-10816	IN	denotes	by
T12572	10817-10822	NN	denotes	Ptdsr
T12573	10827-10838	NNS	denotes	macrophages
T12574	10823-10824	SYM	denotes	-
T12575	10824-10825	HYPH	denotes	/
T12576	10825-10826	SYM	denotes	-
T12577	10838-10840	,	denotes	,
T12578	10840-10844	IN	denotes	with
T12579	10845-10849	DT	denotes	some
T12580	10859-10870	NNS	denotes	macrophages
T12581	10850-10858	JJ	denotes	knockout
T12582	10871-10878	VBG	denotes	showing
T12583	10879-10884	NNS	denotes	loads
T12584	10885-10889	RB	denotes	even
T12585	10890-10896	JJR	denotes	higher
T12586	10897-10901	IN	denotes	than
T12587	10902-10906	JJ	denotes	wild
T12588	10907-10911	NN	denotes	type
T12589	10906-10907	HYPH	denotes	-
T12590	10912-10914	IN	denotes	of
T12591	10915-10923	VBN	denotes	engulfed
T12592	10929-10934	NNS	denotes	cells
T12593	10924-10928	JJ	denotes	dead
T12594	10934-10935	.	denotes	.
T12595	10935-11187	sentence	denotes	These results are contrary to the expected role of Ptdsr in apoptotic cell clearance and to the reported findings of Li et al. [31] and Kunisaki et al. [32], as well as to a study done with a phosphatidylserine receptor null allele in C. elegans [45].
T12596	10936-10941	DT	denotes	These
T12597	10942-10949	NNS	denotes	results
T12598	10950-10953	VBP	denotes	are
T12599	10954-10962	JJ	denotes	contrary
T12600	10963-10965	IN	denotes	to
T12601	10966-10969	DT	denotes	the
T12602	10979-10983	NN	denotes	role
T12603	10970-10978	VBN	denotes	expected
T12604	10984-10986	IN	denotes	of
T12605	10987-10992	NN	denotes	Ptdsr
T12606	10993-10995	IN	denotes	in
T12607	10996-11005	JJ	denotes	apoptotic
T12608	11006-11010	NN	denotes	cell
T12609	11011-11020	NN	denotes	clearance
T12610	11021-11024	CC	denotes	and
T12611	11025-11027	IN	denotes	to
T12612	11028-11031	DT	denotes	the
T12613	11041-11049	NNS	denotes	findings
T12614	11032-11040	VBN	denotes	reported
T12615	11050-11052	IN	denotes	of
T12616	11053-11055	NNP	denotes	Li
T12617	11056-11058	FW	denotes	et
T12618	11059-11062	FW	denotes	al.
T12619	11063-11064	-LRB-	denotes	[
T12620	11064-11066	CD	denotes	31
T12621	11066-11067	-RRB-	denotes	]
T12622	11068-11071	CC	denotes	and
T12623	11072-11080	NNP	denotes	Kunisaki
T12624	11081-11083	FW	denotes	et
T12625	11084-11087	FW	denotes	al.
T12626	11088-11089	-LRB-	denotes	[
T12627	11089-11091	CD	denotes	32
T12628	11091-11092	-RRB-	denotes	]
T12629	11092-11094	,	denotes	,
T12630	11094-11096	RB	denotes	as
T12631	11102-11104	IN	denotes	as
T12632	11097-11101	RB	denotes	well
T12633	11105-11107	IN	denotes	to
T12634	11108-11109	DT	denotes	a
T12635	11110-11115	NN	denotes	study
T12636	11116-11120	VBN	denotes	done
T12637	11121-11125	IN	denotes	with
T12638	11126-11127	DT	denotes	a
T12639	11161-11167	NN	denotes	allele
T12640	11128-11146	NN	denotes	phosphatidylserine
T12641	11147-11155	NN	denotes	receptor
T12642	11156-11160	JJ	denotes	null
T12643	11168-11170	IN	denotes	in
T12644	11171-11173	NNP	denotes	C.
T12645	11174-11181	NNP	denotes	elegans
T12646	11182-11183	-LRB-	denotes	[
T12647	11183-11185	CD	denotes	45
T12648	11185-11186	-RRB-	denotes	]
T12649	11186-11187	.	denotes	.
T12650	11187-11396	sentence	denotes	In previous studies in the mouse, the distribution and amount of apoptotic cells in Ptdsr-knockout and control animals were investigated in only a few tissues and at one [31] or two [32] developmental stages.
T12651	11188-11190	IN	denotes	In
T12652	11312-11324	VBN	denotes	investigated
T12653	11191-11199	JJ	denotes	previous
T12654	11200-11207	NNS	denotes	studies
T12655	11208-11210	IN	denotes	in
T12656	11211-11214	DT	denotes	the
T12657	11215-11220	NN	denotes	mouse
T12658	11220-11222	,	denotes	,
T12659	11222-11225	DT	denotes	the
T12660	11226-11238	NN	denotes	distribution
T12661	11239-11242	CC	denotes	and
T12662	11243-11249	NN	denotes	amount
T12663	11250-11252	IN	denotes	of
T12664	11253-11262	JJ	denotes	apoptotic
T12665	11263-11268	NNS	denotes	cells
T12666	11269-11271	IN	denotes	in
T12667	11272-11277	NN	denotes	Ptdsr
T12668	11278-11286	NN	denotes	knockout
T12669	11277-11278	HYPH	denotes	-
T12670	11299-11306	NNS	denotes	animals
T12671	11287-11290	CC	denotes	and
T12672	11291-11298	NN	denotes	control
T12673	11307-11311	VBD	denotes	were
T12674	11325-11327	IN	denotes	in
T12675	11328-11332	RB	denotes	only
T12676	11339-11346	NNS	denotes	tissues
T12677	11333-11334	DT	denotes	a
T12678	11335-11338	JJ	denotes	few
T12679	11347-11350	CC	denotes	and
T12680	11351-11353	IN	denotes	at
T12681	11354-11357	CD	denotes	one
T12682	11389-11395	NNS	denotes	stages
T12683	11358-11359	-LRB-	denotes	[
T12684	11359-11361	CD	denotes	31
T12685	11361-11362	-RRB-	denotes	]
T12686	11363-11365	CC	denotes	or
T12687	11366-11369	CD	denotes	two
T12688	11370-11371	-LRB-	denotes	[
T12689	11371-11373	CD	denotes	32
T12690	11373-11374	-RRB-	denotes	]
T12691	11375-11388	JJ	denotes	developmental
T12692	11395-11396	.	denotes	.
T12693	11396-11522	sentence	denotes	Li et al. [31] examined lung, midbrain and retina at day E17.5 of gestation and identified apoptotic cells by TUNEL staining.
T12694	11397-11399	NNP	denotes	Li
T12695	11412-11420	VBN	denotes	examined
T12696	11400-11402	FW	denotes	et
T12697	11403-11406	FW	denotes	al.
T12698	11407-11408	-LRB-	denotes	[
T12699	11408-11410	CD	denotes	31
T12700	11410-11411	-RRB-	denotes	]
T12701	11421-11425	NN	denotes	lung
T12702	11425-11427	,	denotes	,
T12703	11427-11435	NN	denotes	midbrain
T12704	11436-11439	CC	denotes	and
T12705	11440-11446	NN	denotes	retina
T12706	11447-11449	IN	denotes	at
T12707	11450-11453	NN	denotes	day
T12708	11454-11459	NN	denotes	E17.5
T12709	11460-11462	IN	denotes	of
T12710	11463-11472	NN	denotes	gestation
T12711	11473-11476	CC	denotes	and
T12712	11477-11487	VBD	denotes	identified
T12713	11488-11497	JJ	denotes	apoptotic
T12714	11498-11503	NNS	denotes	cells
T12715	11504-11506	IN	denotes	by
T12716	11507-11512	NN	denotes	TUNEL
T12717	11513-11521	NN	denotes	staining
T12718	11521-11522	.	denotes	.
T12719	11522-11913	sentence	denotes	Their findings must be interpreted with caution because remodeling of cellular structures by apoptosis in specific retina layers is known to occur mainly postnatally [42], and apoptosis plays an important physiological role in the maintenance and homeostasis of lung epithelium after birth or in pathological conditions involving pulmonary inflammation and not during lung development [46].
T12720	11523-11528	PRP$	denotes	Their
T12721	11529-11537	NNS	denotes	findings
T12722	11546-11557	VBN	denotes	interpreted
T12723	11538-11542	MD	denotes	must
T12724	11543-11545	VB	denotes	be
T12725	11558-11562	IN	denotes	with
T12726	11563-11570	NN	denotes	caution
T12727	11571-11578	IN	denotes	because
T12728	11655-11660	VBN	denotes	known
T12729	11579-11589	NN	denotes	remodeling
T12730	11590-11592	IN	denotes	of
T12731	11593-11601	JJ	denotes	cellular
T12732	11602-11612	NNS	denotes	structures
T12733	11613-11615	IN	denotes	by
T12734	11616-11625	NN	denotes	apoptosis
T12735	11626-11628	IN	denotes	in
T12736	11629-11637	JJ	denotes	specific
T12737	11645-11651	NNS	denotes	layers
T12738	11638-11644	NN	denotes	retina
T12739	11652-11654	VBZ	denotes	is
T12740	11661-11663	TO	denotes	to
T12741	11664-11669	VB	denotes	occur
T12742	11670-11676	RB	denotes	mainly
T12743	11677-11688	RB	denotes	postnatally
T12744	11689-11690	-LRB-	denotes	[
T12745	11690-11692	CD	denotes	42
T12746	11692-11693	-RRB-	denotes	]
T12747	11693-11695	,	denotes	,
T12748	11695-11698	CC	denotes	and
T12749	11699-11708	NN	denotes	apoptosis
T12750	11709-11714	VBZ	denotes	plays
T12751	11715-11717	DT	denotes	an
T12752	11742-11746	NN	denotes	role
T12753	11718-11727	JJ	denotes	important
T12754	11728-11741	JJ	denotes	physiological
T12755	11747-11749	IN	denotes	in
T12756	11750-11753	DT	denotes	the
T12757	11754-11765	NN	denotes	maintenance
T12758	11766-11769	CC	denotes	and
T12759	11770-11781	NN	denotes	homeostasis
T12760	11782-11784	IN	denotes	of
T12761	11785-11789	NN	denotes	lung
T12762	11790-11800	NN	denotes	epithelium
T12763	11801-11806	IN	denotes	after
T12764	11807-11812	NN	denotes	birth
T12765	11813-11815	CC	denotes	or
T12766	11816-11818	IN	denotes	in
T12767	11819-11831	JJ	denotes	pathological
T12768	11832-11842	NNS	denotes	conditions
T12769	11843-11852	VBG	denotes	involving
T12770	11853-11862	JJ	denotes	pulmonary
T12771	11863-11875	NN	denotes	inflammation
T12772	11876-11879	CC	denotes	and
T12773	11880-11883	RB	denotes	not
T12774	11884-11890	IN	denotes	during
T12775	11891-11895	NN	denotes	lung
T12776	11896-11907	NN	denotes	development
T12777	11908-11909	-LRB-	denotes	[
T12778	11909-11911	CD	denotes	46
T12779	11911-11912	-RRB-	denotes	]
T12780	11912-11913	.	denotes	.
T12781	11913-12099	sentence	denotes	This postnatal role for apoptosis is in accordance with our data, as we rarely observed apoptotic cells in retina or lung tissue throughout embryogenesis in Ptdsr+/+ and Ptdsr -/- mice.
T12782	11914-11918	DT	denotes	This
T12783	11929-11933	NN	denotes	role
T12784	11919-11928	JJ	denotes	postnatal
T12785	11948-11950	VBZ	denotes	is
T12786	11934-11937	IN	denotes	for
T12787	11938-11947	NN	denotes	apoptosis
T12788	11951-11953	IN	denotes	in
T12789	11954-11964	NN	denotes	accordance
T12790	11965-11969	IN	denotes	with
T12791	11970-11973	PRP$	denotes	our
T12792	11974-11978	NNS	denotes	data
T12793	11978-11980	,	denotes	,
T12794	11980-11982	IN	denotes	as
T12795	11993-12001	VBD	denotes	observed
T12796	11983-11985	PRP	denotes	we
T12797	11986-11992	RB	denotes	rarely
T12798	12002-12011	JJ	denotes	apoptotic
T12799	12012-12017	NNS	denotes	cells
T12800	12018-12020	IN	denotes	in
T12801	12021-12027	NN	denotes	retina
T12802	12036-12042	NN	denotes	tissue
T12803	12028-12030	CC	denotes	or
T12804	12031-12035	NN	denotes	lung
T12805	12043-12053	IN	denotes	throughout
T12806	12054-12067	NN	denotes	embryogenesis
T12807	12068-12070	IN	denotes	in
T12808	12071-12076	NN	denotes	Ptdsr
T12809	12094-12098	NNS	denotes	mice
T12810	12076-12077	SYM	denotes	+
T12811	12077-12078	HYPH	denotes	/
T12812	12078-12079	SYM	denotes	+
T12813	12080-12083	CC	denotes	and
T12814	12084-12089	NN	denotes	Ptdsr
T12815	12090-12091	SYM	denotes	-
T12816	12091-12092	HYPH	denotes	/
T12817	12092-12093	SYM	denotes	-
T12818	12098-12099	.	denotes	.
T12819	12099-12345	sentence	denotes	Kunisaki et al. [32] analyzed TUNEL-stained sections of liver and thymus at days E13.5 and E16.5 of development in Ptdsr+/- and Ptdsr -/- embryos and found reduced rather than increased numbers of TUNEL-positive cells in Ptdsr-deficient embryos.
T12820	12100-12108	NNP	denotes	Kunisaki
T12821	12121-12129	VBN	denotes	analyzed
T12822	12109-12111	FW	denotes	et
T12823	12112-12115	FW	denotes	al.
T12824	12116-12117	-LRB-	denotes	[
T12825	12117-12119	CD	denotes	32
T12826	12119-12120	-RRB-	denotes	]
T12827	12130-12135	NN	denotes	TUNEL
T12828	12136-12143	VBN	denotes	stained
T12829	12135-12136	HYPH	denotes	-
T12830	12144-12152	NNS	denotes	sections
T12831	12153-12155	IN	denotes	of
T12832	12156-12161	NN	denotes	liver
T12833	12162-12165	CC	denotes	and
T12834	12166-12172	NN	denotes	thymus
T12835	12173-12175	IN	denotes	at
T12836	12176-12180	NNS	denotes	days
T12837	12181-12186	NN	denotes	E13.5
T12838	12187-12190	CC	denotes	and
T12839	12191-12196	NN	denotes	E16.5
T12840	12197-12199	IN	denotes	of
T12841	12200-12211	NN	denotes	development
T12842	12212-12214	IN	denotes	in
T12843	12215-12220	NN	denotes	Ptdsr
T12844	12238-12245	NNS	denotes	embryos
T12845	12220-12221	SYM	denotes	+
T12846	12221-12222	HYPH	denotes	/
T12847	12222-12223	SYM	denotes	-
T12848	12224-12227	CC	denotes	and
T12849	12228-12233	NN	denotes	Ptdsr
T12850	12234-12235	SYM	denotes	-
T12851	12235-12236	HYPH	denotes	/
T12852	12236-12237	SYM	denotes	-
T12853	12246-12249	CC	denotes	and
T12854	12250-12255	VBN	denotes	found
T12855	12256-12263	VBN	denotes	reduced
T12856	12286-12293	NNS	denotes	numbers
T12857	12264-12270	RB	denotes	rather
T12858	12271-12275	IN	denotes	than
T12859	12276-12285	VBN	denotes	increased
T12860	12294-12296	IN	denotes	of
T12861	12297-12302	NN	denotes	TUNEL
T12862	12303-12311	JJ	denotes	positive
T12863	12302-12303	HYPH	denotes	-
T12864	12312-12317	NNS	denotes	cells
T12865	12318-12320	IN	denotes	in
T12866	12321-12326	NN	denotes	Ptdsr
T12867	12327-12336	JJ	denotes	deficient
T12868	12326-12327	HYPH	denotes	-
T12869	12337-12344	NNS	denotes	embryos
T12870	12344-12345	.	denotes	.
T12871	12345-12614	sentence	denotes	Using co-localization of TUNEL-positive cells with F4/80-positive macrophages they suggested that Ptdsr -/- embryos exhibited a three-fold increase in the frequency of unphagocytosed TUNEL-positive cells together with a severely reduced number of F4/80-positive cells.
T12872	12346-12351	VBG	denotes	Using
T12873	12429-12438	VBD	denotes	suggested
T12874	12352-12367	NN	denotes	co-localization
T12875	12368-12370	IN	denotes	of
T12876	12371-12376	NN	denotes	TUNEL
T12877	12377-12385	JJ	denotes	positive
T12878	12376-12377	HYPH	denotes	-
T12879	12386-12391	NNS	denotes	cells
T12880	12392-12396	IN	denotes	with
T12881	12397-12399	NN	denotes	F4
T12882	12403-12411	JJ	denotes	positive
T12883	12399-12400	HYPH	denotes	/
T12884	12400-12402	CD	denotes	80
T12885	12402-12403	HYPH	denotes	-
T12886	12412-12423	NNS	denotes	macrophages
T12887	12424-12428	PRP	denotes	they
T12888	12439-12443	IN	denotes	that
T12889	12462-12471	VBD	denotes	exhibited
T12890	12444-12449	NN	denotes	Ptdsr
T12891	12454-12461	NNS	denotes	embryos
T12892	12450-12451	SYM	denotes	-
T12893	12451-12452	HYPH	denotes	/
T12894	12452-12453	SYM	denotes	-
T12895	12472-12473	DT	denotes	a
T12896	12485-12493	NN	denotes	increase
T12897	12474-12484	JJ	denotes	three-fold
T12898	12494-12496	IN	denotes	in
T12899	12497-12500	DT	denotes	the
T12900	12501-12510	NN	denotes	frequency
T12901	12511-12513	IN	denotes	of
T12902	12514-12528	JJ	denotes	unphagocytosed
T12903	12544-12549	NNS	denotes	cells
T12904	12529-12534	NN	denotes	TUNEL
T12905	12535-12543	JJ	denotes	positive
T12906	12534-12535	HYPH	denotes	-
T12907	12550-12558	RB	denotes	together
T12908	12559-12563	IN	denotes	with
T12909	12564-12565	DT	denotes	a
T12910	12583-12589	NN	denotes	number
T12911	12566-12574	RB	denotes	severely
T12912	12575-12582	VBN	denotes	reduced
T12913	12590-12592	IN	denotes	of
T12914	12593-12595	NN	denotes	F4
T12915	12599-12607	JJ	denotes	positive
T12916	12595-12596	HYPH	denotes	/
T12917	12596-12598	CD	denotes	80
T12918	12598-12599	HYPH	denotes	-
T12919	12608-12613	NNS	denotes	cells
T12920	12613-12614	.	denotes	.
T12921	12614-12823	sentence	denotes	These results must be interpreted very carefully, however, as it is technically difficult to unambiguously identify engulfed target cells in individual macrophages in solid tissues by fluorescence microscopy.
T12922	12615-12620	DT	denotes	These
T12923	12621-12628	NNS	denotes	results
T12924	12637-12648	VBN	denotes	interpreted
T12925	12629-12633	MD	denotes	must
T12926	12634-12636	VB	denotes	be
T12927	12649-12653	RB	denotes	very
T12928	12654-12663	RB	denotes	carefully
T12929	12663-12665	,	denotes	,
T12930	12665-12672	RB	denotes	however
T12931	12672-12674	,	denotes	,
T12932	12674-12676	IN	denotes	as
T12933	12680-12682	VBZ	denotes	is
T12934	12677-12679	PRP	denotes	it
T12935	12683-12694	RB	denotes	technically
T12936	12695-12704	JJ	denotes	difficult
T12937	12705-12707	TO	denotes	to
T12938	12722-12730	VB	denotes	identify
T12939	12708-12721	RB	denotes	unambiguously
T12940	12731-12739	VBN	denotes	engulfed
T12941	12747-12752	NNS	denotes	cells
T12942	12740-12746	NN	denotes	target
T12943	12753-12755	IN	denotes	in
T12944	12756-12766	JJ	denotes	individual
T12945	12767-12778	NNS	denotes	macrophages
T12946	12779-12781	IN	denotes	in
T12947	12782-12787	JJ	denotes	solid
T12948	12788-12795	NNS	denotes	tissues
T12949	12796-12798	IN	denotes	by
T12950	12799-12811	NN	denotes	fluorescence
T12951	12812-12822	NN	denotes	microscopy
T12952	12822-12823	.	denotes	.
T12953	12823-13015	sentence	denotes	In addition, our data suggest that during embryogenesis, macrophage-mediated clearance of apoptotic cells is not the only - or even the primary - mechanism for the removal of apoptotic cells.
T12954	12824-12826	IN	denotes	In
T12955	12846-12853	VBP	denotes	suggest
T12956	12827-12835	NN	denotes	addition
T12957	12835-12837	,	denotes	,
T12958	12837-12840	PRP$	denotes	our
T12959	12841-12845	NNS	denotes	data
T12960	12854-12858	IN	denotes	that
T12961	12930-12932	VBZ	denotes	is
T12962	12859-12865	IN	denotes	during
T12963	12866-12879	NN	denotes	embryogenesis
T12964	12879-12881	,	denotes	,
T12965	12881-12891	NN	denotes	macrophage
T12966	12892-12900	VBN	denotes	mediated
T12967	12891-12892	HYPH	denotes	-
T12968	12901-12910	NN	denotes	clearance
T12969	12911-12913	IN	denotes	of
T12970	12914-12923	JJ	denotes	apoptotic
T12971	12924-12929	NNS	denotes	cells
T12972	12933-12936	RB	denotes	not
T12973	12937-12940	DT	denotes	the
T12974	12941-12945	JJ	denotes	only
T12975	12946-12947	,	denotes	-
T12976	12948-12950	CC	denotes	or
T12977	12951-12955	RB	denotes	even
T12978	12960-12967	JJ	denotes	primary
T12979	12956-12959	DT	denotes	the
T12980	12968-12969	,	denotes	-
T12981	12970-12979	NN	denotes	mechanism
T12982	12980-12983	IN	denotes	for
T12983	12984-12987	DT	denotes	the
T12984	12988-12995	NN	denotes	removal
T12985	12996-12998	IN	denotes	of
T12986	12999-13008	JJ	denotes	apoptotic
T12987	13009-13014	NNS	denotes	cells
T12988	13014-13015	.	denotes	.
T12989	13015-13287	sentence	denotes	In many tissues where programmed cell death occurs as a prominent event during embryogenesis, such as remodeling of the genital ridge during gonad morphogenesis and differentiation of the neural tube, we found almost no co-localization of apoptotic cells and macrophages.
T12990	13016-13018	IN	denotes	In
T12991	13220-13225	VBD	denotes	found
T12992	13019-13023	JJ	denotes	many
T12993	13024-13031	NNS	denotes	tissues
T12994	13032-13037	WRB	denotes	where
T12995	13060-13066	VBZ	denotes	occurs
T12996	13038-13048	VBN	denotes	programmed
T12997	13054-13059	NN	denotes	death
T12998	13049-13053	NN	denotes	cell
T12999	13067-13069	IN	denotes	as
T13000	13070-13071	DT	denotes	a
T13001	13082-13087	NN	denotes	event
T13002	13072-13081	JJ	denotes	prominent
T13003	13088-13094	IN	denotes	during
T13004	13095-13108	NN	denotes	embryogenesis
T13005	13108-13110	,	denotes	,
T13006	13110-13114	JJ	denotes	such
T13007	13115-13117	IN	denotes	as
T13008	13118-13128	VBG	denotes	remodeling
T13009	13129-13131	IN	denotes	of
T13010	13132-13135	DT	denotes	the
T13011	13144-13149	NN	denotes	ridge
T13012	13136-13143	JJ	denotes	genital
T13013	13150-13156	IN	denotes	during
T13014	13157-13162	NN	denotes	gonad
T13015	13163-13176	NN	denotes	morphogenesis
T13016	13177-13180	CC	denotes	and
T13017	13181-13196	NN	denotes	differentiation
T13018	13197-13199	IN	denotes	of
T13019	13200-13203	DT	denotes	the
T13020	13211-13215	NN	denotes	tube
T13021	13204-13210	JJ	denotes	neural
T13022	13215-13217	,	denotes	,
T13023	13217-13219	PRP	denotes	we
T13024	13226-13232	RB	denotes	almost
T13025	13236-13251	NN	denotes	co-localization
T13026	13233-13235	DT	denotes	no
T13027	13252-13254	IN	denotes	of
T13028	13255-13264	JJ	denotes	apoptotic
T13029	13265-13270	NNS	denotes	cells
T13030	13271-13274	CC	denotes	and
T13031	13275-13286	NNS	denotes	macrophages
T13032	13286-13287	.	denotes	.
T13033	13287-13492	sentence	denotes	This indicates that in these cases clearance of apoptotic cells is directly mediated by neighboring 'bystander' cells rather than by macrophages that have been recruited into areas where apoptosis occurs.
T13034	13288-13292	DT	denotes	This
T13035	13293-13302	VBZ	denotes	indicates
T13036	13303-13307	IN	denotes	that
T13037	13364-13372	VBN	denotes	mediated
T13038	13308-13310	IN	denotes	in
T13039	13311-13316	DT	denotes	these
T13040	13317-13322	NNS	denotes	cases
T13041	13323-13332	NN	denotes	clearance
T13042	13333-13335	IN	denotes	of
T13043	13336-13345	JJ	denotes	apoptotic
T13044	13346-13351	NNS	denotes	cells
T13045	13352-13354	VBZ	denotes	is
T13046	13355-13363	RB	denotes	directly
T13047	13373-13375	IN	denotes	by
T13048	13376-13387	VBG	denotes	neighboring
T13049	13400-13405	NNS	denotes	cells
T13050	13388-13389	``	denotes	'
T13051	13389-13398	NN	denotes	bystander
T13052	13398-13399	''	denotes	'
T13053	13406-13412	RB	denotes	rather
T13054	13413-13417	IN	denotes	than
T13055	13418-13420	IN	denotes	by
T13056	13421-13432	NNS	denotes	macrophages
T13057	13433-13437	WDT	denotes	that
T13058	13448-13457	VBN	denotes	recruited
T13059	13438-13442	VBP	denotes	have
T13060	13443-13447	VBN	denotes	been
T13061	13458-13462	IN	denotes	into
T13062	13463-13468	NNS	denotes	areas
T13063	13469-13474	WRB	denotes	where
T13064	13485-13491	VBZ	denotes	occurs
T13065	13475-13484	NN	denotes	apoptosis
T13066	13491-13492	.	denotes	.
T13067	13492-13601	sentence	denotes	Obviously these in vivo clearance mechanisms are not compromised by Ptdsr-deficiency in our knockout mutant.
T13068	13493-13502	RB	denotes	Obviously
T13069	13546-13557	VBN	denotes	compromised
T13070	13503-13508	DT	denotes	these
T13071	13527-13537	NNS	denotes	mechanisms
T13072	13509-13511	FW	denotes	in
T13073	13512-13516	FW	denotes	vivo
T13074	13517-13526	NN	denotes	clearance
T13075	13538-13541	VBP	denotes	are
T13076	13542-13545	RB	denotes	not
T13077	13558-13560	IN	denotes	by
T13078	13561-13566	NN	denotes	Ptdsr
T13079	13567-13577	NN	denotes	deficiency
T13080	13566-13567	HYPH	denotes	-
T13081	13578-13580	IN	denotes	in
T13082	13581-13584	PRP$	denotes	our
T13083	13594-13600	NN	denotes	mutant
T13084	13585-13593	NN	denotes	knockout
T13085	13600-13601	.	denotes	.
T13086	13601-13764	sentence	denotes	This finding is in line with studies in macrophageless Sfpi1-knockout embryos that are deficient for the hematopoietic-lineage-specific transcription factor PU.1.
T13087	13602-13606	DT	denotes	This
T13088	13607-13614	NN	denotes	finding
T13089	13615-13617	VBZ	denotes	is
T13090	13618-13620	IN	denotes	in
T13091	13621-13625	NN	denotes	line
T13092	13626-13630	IN	denotes	with
T13093	13631-13638	NNS	denotes	studies
T13094	13639-13641	IN	denotes	in
T13095	13642-13656	JJ	denotes	macrophageless
T13096	13672-13679	NNS	denotes	embryos
T13097	13657-13662	NN	denotes	Sfpi1
T13098	13663-13671	NN	denotes	knockout
T13099	13662-13663	HYPH	denotes	-
T13100	13680-13684	WDT	denotes	that
T13101	13685-13688	VBP	denotes	are
T13102	13689-13698	JJ	denotes	deficient
T13103	13699-13702	IN	denotes	for
T13104	13703-13706	DT	denotes	the
T13105	13752-13758	NN	denotes	factor
T13106	13707-13720	JJ	denotes	hematopoietic
T13107	13721-13728	NN	denotes	lineage
T13108	13720-13721	HYPH	denotes	-
T13109	13729-13737	JJ	denotes	specific
T13110	13728-13729	HYPH	denotes	-
T13111	13738-13751	NN	denotes	transcription
T13112	13759-13763	NN	denotes	PU.1
T13113	13763-13764	.	denotes	.
T13114	13764-13883	sentence	denotes	Here, the phagocytosis of apoptotic cells during embryogenesis is taken over by 'stand-in' mesenchymal neighbors [47].
T13115	13765-13769	RB	denotes	Here
T13116	13831-13836	VBN	denotes	taken
T13117	13769-13771	,	denotes	,
T13118	13771-13774	DT	denotes	the
T13119	13775-13787	NN	denotes	phagocytosis
T13120	13788-13790	IN	denotes	of
T13121	13791-13800	JJ	denotes	apoptotic
T13122	13801-13806	NNS	denotes	cells
T13123	13807-13813	IN	denotes	during
T13124	13814-13827	NN	denotes	embryogenesis
T13125	13828-13830	VBZ	denotes	is
T13126	13837-13841	RP	denotes	over
T13127	13842-13844	IN	denotes	by
T13128	13845-13846	``	denotes	'
T13129	13868-13877	NNS	denotes	neighbors
T13130	13846-13851	VB	denotes	stand
T13131	13851-13852	HYPH	denotes	-
T13132	13852-13854	RP	denotes	in
T13133	13854-13855	''	denotes	'
T13134	13856-13867	JJ	denotes	mesenchymal
T13135	13878-13879	-LRB-	denotes	[
T13136	13879-13881	CD	denotes	47
T13137	13881-13882	-RRB-	denotes	]
T13138	13882-13883	.	denotes	.
T13139	13883-14170	sentence	denotes	As recognition of phosphatidylserine is thought to be a universal engulfment mechanism for all cells that are able to phagocytose apoptotic cells, it is very striking that apoptotic cell clearance mediated by non-professional bystander cells is also not compromised by Ptdsr-deficiency.
T13140	13884-13886	IN	denotes	As
T13141	13924-13931	VBN	denotes	thought
T13142	13887-13898	NN	denotes	recognition
T13143	13899-13901	IN	denotes	of
T13144	13902-13920	NN	denotes	phosphatidylserine
T13145	13921-13923	VBZ	denotes	is
T13146	14034-14036	VBZ	denotes	is
T13147	13932-13934	TO	denotes	to
T13148	13935-13937	VB	denotes	be
T13149	13938-13939	DT	denotes	a
T13150	13961-13970	NN	denotes	mechanism
T13151	13940-13949	JJ	denotes	universal
T13152	13950-13960	NN	denotes	engulfment
T13153	13971-13974	IN	denotes	for
T13154	13975-13978	DT	denotes	all
T13155	13979-13984	NNS	denotes	cells
T13156	13985-13989	WDT	denotes	that
T13157	13990-13993	VBP	denotes	are
T13158	13994-13998	JJ	denotes	able
T13159	13999-14001	TO	denotes	to
T13160	14002-14013	VB	denotes	phagocytose
T13161	14014-14023	JJ	denotes	apoptotic
T13162	14024-14029	NNS	denotes	cells
T13163	14029-14031	,	denotes	,
T13164	14031-14033	PRP	denotes	it
T13165	14037-14041	RB	denotes	very
T13166	14042-14050	JJ	denotes	striking
T13167	14051-14055	IN	denotes	that
T13168	14138-14149	VBN	denotes	compromised
T13169	14056-14065	JJ	denotes	apoptotic
T13170	14071-14080	NN	denotes	clearance
T13171	14066-14070	NN	denotes	cell
T13172	14081-14089	VBN	denotes	mediated
T13173	14090-14092	IN	denotes	by
T13174	14093-14109	JJ	denotes	non-professional
T13175	14120-14125	NNS	denotes	cells
T13176	14110-14119	NN	denotes	bystander
T13177	14126-14128	VBZ	denotes	is
T13178	14129-14133	RB	denotes	also
T13179	14134-14137	RB	denotes	not
T13180	14150-14152	IN	denotes	by
T13181	14153-14158	NN	denotes	Ptdsr
T13182	14159-14169	NN	denotes	deficiency
T13183	14158-14159	HYPH	denotes	-
T13184	14169-14170	.	denotes	.
T13185	14170-14303	sentence	denotes	In contrast to Li et al. [31], we did not observe any impairment in the uptake of apoptotic cells by Ptdsr -/- macrophages in vitro.
T13186	14171-14173	IN	denotes	In
T13187	14213-14220	VB	denotes	observe
T13188	14174-14182	NN	denotes	contrast
T13189	14183-14185	IN	denotes	to
T13190	14186-14188	NNP	denotes	Li
T13191	14189-14191	FW	denotes	et
T13192	14192-14195	FW	denotes	al.
T13193	14196-14197	-LRB-	denotes	[
T13194	14197-14199	CD	denotes	31
T13195	14199-14200	-RRB-	denotes	]
T13196	14200-14202	,	denotes	,
T13197	14202-14204	PRP	denotes	we
T13198	14205-14208	VBD	denotes	did
T13199	14209-14212	RB	denotes	not
T13200	14221-14224	DT	denotes	any
T13201	14225-14235	NN	denotes	impairment
T13202	14236-14238	IN	denotes	in
T13203	14239-14242	DT	denotes	the
T13204	14243-14249	NN	denotes	uptake
T13205	14250-14252	IN	denotes	of
T13206	14253-14262	JJ	denotes	apoptotic
T13207	14263-14268	NNS	denotes	cells
T13208	14269-14271	IN	denotes	by
T13209	14272-14277	NN	denotes	Ptdsr
T13210	14282-14293	NNS	denotes	macrophages
T13211	14278-14279	SYM	denotes	-
T13212	14279-14280	HYPH	denotes	/
T13213	14280-14281	SYM	denotes	-
T13214	14294-14296	FW	denotes	in
T13215	14297-14302	FW	denotes	vitro
T13216	14302-14303	.	denotes	.
T13217	14303-14539	sentence	denotes	We performed phagocytosis assays in vitro with fetal-liver-derived macrophages, while in their assays, Li and colleagues used thioglycollate-elicited peritoneal macrophages after adoptive transfer of Ptdsr -/- hematopoietic stem cells.
T13218	14304-14306	PRP	denotes	We
T13219	14307-14316	VBD	denotes	performed
T13220	14317-14329	NN	denotes	phagocytosis
T13221	14330-14336	NNS	denotes	assays
T13222	14337-14339	FW	denotes	in
T13223	14340-14345	FW	denotes	vitro
T13224	14346-14350	IN	denotes	with
T13225	14351-14356	JJ	denotes	fetal
T13226	14357-14362	NN	denotes	liver
T13227	14356-14357	HYPH	denotes	-
T13228	14363-14370	VBN	denotes	derived
T13229	14362-14363	HYPH	denotes	-
T13230	14371-14382	NNS	denotes	macrophages
T13231	14382-14384	,	denotes	,
T13232	14384-14389	IN	denotes	while
T13233	14425-14429	VBD	denotes	used
T13234	14390-14392	IN	denotes	in
T13235	14393-14398	PRP$	denotes	their
T13236	14399-14405	NNS	denotes	assays
T13237	14405-14407	,	denotes	,
T13238	14407-14409	NNP	denotes	Li
T13239	14410-14413	CC	denotes	and
T13240	14414-14424	NNS	denotes	colleagues
T13241	14430-14444	NN	denotes	thioglycollate
T13242	14445-14453	VBN	denotes	elicited
T13243	14444-14445	HYPH	denotes	-
T13244	14465-14476	NNS	denotes	macrophages
T13245	14454-14464	JJ	denotes	peritoneal
T13246	14477-14482	IN	denotes	after
T13247	14483-14491	JJ	denotes	adoptive
T13248	14492-14500	NN	denotes	transfer
T13249	14501-14503	IN	denotes	of
T13250	14504-14509	NN	denotes	Ptdsr
T13251	14533-14538	NNS	denotes	cells
T13252	14510-14511	SYM	denotes	-
T13253	14511-14512	HYPH	denotes	/
T13254	14512-14513	SYM	denotes	-
T13255	14514-14527	JJ	denotes	hematopoietic
T13256	14528-14532	NN	denotes	stem
T13257	14538-14539	.	denotes	.
T13258	14539-14677	sentence	denotes	The different results obtained in the two studies are puzzling; they might be due to the use of different macrophage or cell populations.
T13259	14540-14543	DT	denotes	The
T13260	14554-14561	NNS	denotes	results
T13261	14544-14553	JJ	denotes	different
T13262	14590-14593	VBP	denotes	are
T13263	14562-14570	VBN	denotes	obtained
T13264	14571-14573	IN	denotes	in
T13265	14574-14577	DT	denotes	the
T13266	14582-14589	NNS	denotes	studies
T13267	14578-14581	CD	denotes	two
T13268	14615-14617	VB	denotes	be
T13269	14594-14602	JJ	denotes	puzzling
T13270	14602-14603	:	denotes	;
T13271	14604-14608	PRP	denotes	they
T13272	14609-14614	MD	denotes	might
T13273	14618-14621	IN	denotes	due
T13274	14622-14624	IN	denotes	to
T13275	14625-14628	DT	denotes	the
T13276	14629-14632	NN	denotes	use
T13277	14633-14635	IN	denotes	of
T13278	14636-14645	JJ	denotes	different
T13279	14665-14676	NNS	denotes	populations
T13280	14646-14656	NN	denotes	macrophage
T13281	14657-14659	CC	denotes	or
T13282	14660-14664	NN	denotes	cell
T13283	14676-14677	.	denotes	.
T13284	14677-14793	sentence	denotes	We and Kunisaki et al. [32] found that Ptdsr-deficiency is to some extent associated with defects in hematopoiesis.
T13285	14678-14680	PRP	denotes	We
T13286	14706-14711	VBD	denotes	found
T13287	14681-14684	CC	denotes	and
T13288	14685-14693	NNP	denotes	Kunisaki
T13289	14694-14696	FW	denotes	et
T13290	14697-14700	FW	denotes	al.
T13291	14701-14702	-LRB-	denotes	[
T13292	14702-14704	CD	denotes	32
T13293	14704-14705	-RRB-	denotes	]
T13294	14712-14716	IN	denotes	that
T13295	14752-14762	VBN	denotes	associated
T13296	14717-14722	NN	denotes	Ptdsr
T13297	14723-14733	NN	denotes	deficiency
T13298	14722-14723	HYPH	denotes	-
T13299	14734-14736	VBZ	denotes	is
T13300	14737-14739	IN	denotes	to
T13301	14740-14744	DT	denotes	some
T13302	14745-14751	NN	denotes	extent
T13303	14763-14767	IN	denotes	with
T13304	14768-14775	NNS	denotes	defects
T13305	14776-14778	IN	denotes	in
T13306	14779-14792	NN	denotes	hematopoiesis
T13307	14792-14793	.	denotes	.
T13308	14793-14969	sentence	denotes	Thus, it seems possible that recruitment and activation/differentiation of macrophages after adoptive transfer and thioglycollate elicitation are affected by Ptdsr-deficiency.
T13309	14794-14798	RB	denotes	Thus
T13310	14803-14808	VBZ	denotes	seems
T13311	14798-14800	,	denotes	,
T13312	14800-14802	PRP	denotes	it
T13313	14809-14817	JJ	denotes	possible
T13314	14818-14822	IN	denotes	that
T13315	14940-14948	VBN	denotes	affected
T13316	14823-14834	NN	denotes	recruitment
T13317	14835-14838	CC	denotes	and
T13318	14839-14849	NN	denotes	activation
T13319	14850-14865	NN	denotes	differentiation
T13320	14849-14850	HYPH	denotes	/
T13321	14866-14868	IN	denotes	of
T13322	14869-14880	NNS	denotes	macrophages
T13323	14881-14886	IN	denotes	after
T13324	14887-14895	JJ	denotes	adoptive
T13325	14896-14904	NN	denotes	transfer
T13326	14905-14908	CC	denotes	and
T13327	14909-14923	NN	denotes	thioglycollate
T13328	14924-14935	NN	denotes	elicitation
T13329	14936-14939	VBP	denotes	are
T13330	14949-14951	IN	denotes	by
T13331	14952-14957	NN	denotes	Ptdsr
T13332	14958-14968	NN	denotes	deficiency
T13333	14957-14958	HYPH	denotes	-
T13334	14968-14969	.	denotes	.
T13335	14969-15386	sentence	denotes	We do not think that the different results observed in Ptdsr-knockout mice in a mixed C57BL/6 × 129 background and in a pure C57BL/6J background can be attributed to genetic background effects: comparison of apoptotic cell engulfment efficacies of thioglycollate-elicited macrophages from 129P2/OlaHsd and C57BL/6J mice did not show any differences in apoptotic cell uptake (J.B. and A.L., unpublished observations).
T13336	14970-14972	PRP	denotes	We
T13337	14980-14985	VB	denotes	think
T13338	14973-14975	VBP	denotes	do
T13339	14976-14979	RB	denotes	not
T13340	15298-15302	VB	denotes	show
T13341	14986-14990	IN	denotes	that
T13342	15122-15132	VBN	denotes	attributed
T13343	14991-14994	DT	denotes	the
T13344	15005-15012	NNS	denotes	results
T13345	14995-15004	JJ	denotes	different
T13346	15013-15021	VBN	denotes	observed
T13347	15022-15024	IN	denotes	in
T13348	15025-15030	NN	denotes	Ptdsr
T13349	15031-15039	NN	denotes	knockout
T13350	15030-15031	HYPH	denotes	-
T13351	15040-15044	NNS	denotes	mice
T13352	15045-15047	IN	denotes	in
T13353	15048-15049	DT	denotes	a
T13354	15070-15080	NN	denotes	background
T13355	15050-15055	JJ	denotes	mixed
T13356	15056-15061	NN	denotes	C57BL
T13357	15061-15062	HYPH	denotes	/
T13358	15062-15063	CD	denotes	6
T13359	15064-15065	SYM	denotes	×
T13360	15066-15069	CD	denotes	129
T13361	15081-15084	CC	denotes	and
T13362	15085-15087	IN	denotes	in
T13363	15088-15089	DT	denotes	a
T13364	15104-15114	NN	denotes	background
T13365	15090-15094	JJ	denotes	pure
T13366	15095-15100	NN	denotes	C57BL
T13367	15101-15103	NN	denotes	6J
T13368	15100-15101	HYPH	denotes	/
T13369	15115-15118	MD	denotes	can
T13370	15119-15121	VB	denotes	be
T13371	15133-15135	IN	denotes	to
T13372	15136-15143	JJ	denotes	genetic
T13373	15155-15162	NNS	denotes	effects
T13374	15144-15154	NN	denotes	background
T13375	15162-15164	:	denotes	:
T13376	15164-15174	NN	denotes	comparison
T13377	15175-15177	IN	denotes	of
T13378	15178-15187	JJ	denotes	apoptotic
T13379	15204-15214	NNS	denotes	efficacies
T13380	15188-15192	NN	denotes	cell
T13381	15193-15203	NN	denotes	engulfment
T13382	15215-15217	IN	denotes	of
T13383	15218-15232	NN	denotes	thioglycollate
T13384	15233-15241	VBN	denotes	elicited
T13385	15232-15233	HYPH	denotes	-
T13386	15242-15253	NNS	denotes	macrophages
T13387	15254-15258	IN	denotes	from
T13388	15259-15264	NN	denotes	129P2
T13389	15265-15271	NN	denotes	OlaHsd
T13390	15264-15265	HYPH	denotes	/
T13391	15285-15289	NNS	denotes	mice
T13392	15272-15275	CC	denotes	and
T13393	15276-15281	NN	denotes	C57BL
T13394	15282-15284	NN	denotes	6J
T13395	15281-15282	HYPH	denotes	/
T13396	15290-15293	VBD	denotes	did
T13397	15294-15297	RB	denotes	not
T13398	15303-15306	DT	denotes	any
T13399	15307-15318	NNS	denotes	differences
T13400	15319-15321	IN	denotes	in
T13401	15322-15331	JJ	denotes	apoptotic
T13402	15337-15343	NN	denotes	uptake
T13403	15332-15336	NN	denotes	cell
T13404	15344-15345	-LRB-	denotes	(
T13405	15345-15349	NNP	denotes	J.B.
T13406	15350-15353	CC	denotes	and
T13407	15354-15358	NNP	denotes	A.L.
T13408	15358-15360	,	denotes	,
T13409	15360-15371	JJ	denotes	unpublished
T13410	15372-15384	NNS	denotes	observations
T13411	15384-15385	-RRB-	denotes	)
T13412	15385-15386	.	denotes	.
T13413	15386-15548	sentence	denotes	Moreover, in contrast to our studies, neither Li et al. [31] nor Kunisaki et al. [32] determined phagocytotic engulfment indexes for Ptdsr-deficient macrophages.
T13414	15387-15395	RB	denotes	Moreover
T13415	15473-15483	VBD	denotes	determined
T13416	15395-15397	,	denotes	,
T13417	15397-15399	IN	denotes	in
T13418	15400-15408	NN	denotes	contrast
T13419	15409-15411	IN	denotes	to
T13420	15412-15415	PRP$	denotes	our
T13421	15416-15423	NNS	denotes	studies
T13422	15423-15425	,	denotes	,
T13423	15425-15432	CC	denotes	neither
T13424	15433-15435	NNP	denotes	Li
T13425	15436-15438	FW	denotes	et
T13426	15439-15442	FW	denotes	al.
T13427	15443-15444	-LRB-	denotes	[
T13428	15444-15446	CD	denotes	31
T13429	15446-15447	-RRB-	denotes	]
T13430	15448-15451	CC	denotes	nor
T13431	15452-15460	NNP	denotes	Kunisaki
T13432	15461-15463	FW	denotes	et
T13433	15464-15467	FW	denotes	al.
T13434	15468-15469	-LRB-	denotes	[
T13435	15469-15471	CD	denotes	32
T13436	15471-15472	-RRB-	denotes	]
T13437	15484-15496	JJ	denotes	phagocytotic
T13438	15508-15515	NNS	denotes	indexes
T13439	15497-15507	NN	denotes	engulfment
T13440	15516-15519	IN	denotes	for
T13441	15520-15525	NN	denotes	Ptdsr
T13442	15526-15535	JJ	denotes	deficient
T13443	15525-15526	HYPH	denotes	-
T13444	15536-15547	NNS	denotes	macrophages
T13445	15547-15548	.	denotes	.
T13446	15548-15735	sentence	denotes	Interestingly, we observed differences between Ptdsr+/+ and Ptdsr -/- macrophages in the secretion of pro- and anti-inflammatory cytokines after stimulation with LPS and apoptotic cells.
T13447	15549-15562	RB	denotes	Interestingly
T13448	15567-15575	VBD	denotes	observed
T13449	15562-15564	,	denotes	,
T13450	15564-15566	PRP	denotes	we
T13451	15576-15587	NNS	denotes	differences
T13452	15588-15595	IN	denotes	between
T13453	15596-15601	NN	denotes	Ptdsr
T13454	15619-15630	NNS	denotes	macrophages
T13455	15601-15602	SYM	denotes	+
T13456	15602-15603	HYPH	denotes	/
T13457	15603-15604	SYM	denotes	+
T13458	15605-15608	CC	denotes	and
T13459	15609-15614	NN	denotes	Ptdsr
T13460	15615-15616	SYM	denotes	-
T13461	15616-15617	HYPH	denotes	/
T13462	15617-15618	SYM	denotes	-
T13463	15631-15633	IN	denotes	in
T13464	15634-15637	DT	denotes	the
T13465	15638-15647	NN	denotes	secretion
T13466	15648-15650	IN	denotes	of
T13467	15651-15654	AFX	denotes	pro
T13468	15660-15677	JJ	denotes	anti-inflammatory
T13469	15654-15655	HYPH	denotes	-
T13470	15656-15659	CC	denotes	and
T13471	15678-15687	NNS	denotes	cytokines
T13472	15688-15693	IN	denotes	after
T13473	15694-15705	NN	denotes	stimulation
T13474	15706-15710	IN	denotes	with
T13475	15711-15714	NN	denotes	LPS
T13476	15715-15718	CC	denotes	and
T13477	15719-15728	JJ	denotes	apoptotic
T13478	15729-15734	NNS	denotes	cells
T13479	15734-15735	.	denotes	.
T13480	15735-15850	sentence	denotes	This provides evidence that cellular activation and effector mechanisms are impaired in Ptdsr-deleted macrophages.
T13481	15736-15740	DT	denotes	This
T13482	15741-15749	VBZ	denotes	provides
T13483	15750-15758	NN	denotes	evidence
T13484	15759-15763	IN	denotes	that
T13485	15812-15820	VBN	denotes	impaired
T13486	15764-15772	JJ	denotes	cellular
T13487	15773-15783	NN	denotes	activation
T13488	15784-15787	CC	denotes	and
T13489	15788-15796	NN	denotes	effector
T13490	15797-15807	NNS	denotes	mechanisms
T13491	15808-15811	VBP	denotes	are
T13492	15821-15823	IN	denotes	in
T13493	15824-15829	NN	denotes	Ptdsr
T13494	15830-15837	VBN	denotes	deleted
T13495	15829-15830	HYPH	denotes	-
T13496	15838-15849	NNS	denotes	macrophages
T13497	15849-15850	.	denotes	.
T13498	15850-15956	sentence	denotes	It remains to be determined which classical pathways of macrophage activation and function involve Ptdsr.
T13499	15851-15853	PRP	denotes	It
T13500	15854-15861	VBZ	denotes	remains
T13501	15862-15864	TO	denotes	to
T13502	15868-15878	VBN	denotes	determined
T13503	15865-15867	VB	denotes	be
T13504	15879-15884	WDT	denotes	which
T13505	15895-15903	NNS	denotes	pathways
T13506	15885-15894	JJ	denotes	classical
T13507	15942-15949	VBP	denotes	involve
T13508	15904-15906	IN	denotes	of
T13509	15907-15917	NN	denotes	macrophage
T13510	15918-15928	NN	denotes	activation
T13511	15929-15932	CC	denotes	and
T13512	15933-15941	NN	denotes	function
T13513	15950-15955	NN	denotes	Ptdsr
T13514	15955-15956	.	denotes	.
T13515	15956-16079	sentence	denotes	This is especially important in light of recent findings that demonstrated nuclear localization of the Ptdsr protein [29].
T13516	15957-15961	DT	denotes	This
T13517	15962-15964	VBZ	denotes	is
T13518	15965-15975	RB	denotes	especially
T13519	15976-15985	JJ	denotes	important
T13520	15986-15988	IN	denotes	in
T13521	15989-15994	NN	denotes	light
T13522	15995-15997	IN	denotes	of
T13523	15998-16004	JJ	denotes	recent
T13524	16005-16013	NNS	denotes	findings
T13525	16014-16018	WDT	denotes	that
T13526	16019-16031	VBD	denotes	demonstrated
T13527	16032-16039	JJ	denotes	nuclear
T13528	16040-16052	NN	denotes	localization
T13529	16053-16055	IN	denotes	of
T13530	16056-16059	DT	denotes	the
T13531	16066-16073	NN	denotes	protein
T13532	16060-16065	NN	denotes	Ptdsr
T13533	16074-16075	-LRB-	denotes	[
T13534	16075-16077	CD	denotes	29
T13535	16077-16078	-RRB-	denotes	]
T13536	16078-16079	.	denotes	.
T13537	16079-16249	sentence	denotes	Most strikingly, the recently published data regarding the genetic ablation or perturbation of phosphatidylserine receptor function in C. elegans are also contradictory.
T13538	16080-16084	RBS	denotes	Most
T13539	16085-16095	RB	denotes	strikingly
T13540	16226-16229	VBP	denotes	are
T13541	16095-16097	,	denotes	,
T13542	16097-16100	DT	denotes	the
T13543	16120-16124	NNS	denotes	data
T13544	16101-16109	RB	denotes	recently
T13545	16110-16119	VBN	denotes	published
T13546	16125-16134	VBG	denotes	regarding
T13547	16135-16138	DT	denotes	the
T13548	16147-16155	NN	denotes	ablation
T13549	16139-16146	JJ	denotes	genetic
T13550	16156-16158	CC	denotes	or
T13551	16159-16171	NN	denotes	perturbation
T13552	16172-16174	IN	denotes	of
T13553	16175-16193	NN	denotes	phosphatidylserine
T13554	16203-16211	NN	denotes	function
T13555	16194-16202	NN	denotes	receptor
T13556	16212-16214	IN	denotes	in
T13557	16215-16217	NNP	denotes	C.
T13558	16218-16225	NNP	denotes	elegans
T13559	16230-16234	RB	denotes	also
T13560	16235-16248	JJ	denotes	contradictory
T13561	16248-16249	.	denotes	.
T13562	16249-16458	sentence	denotes	Wang et al. [45] reported that psr-1, the C. elegans homolog of Ptdsr, is important for cell-corpse engulfment, whereas psr-1 RNAi studies performed by Arur et al. [25] yielded, in this respect, no phenotype.
T13563	16250-16254	NNP	denotes	Wang
T13564	16267-16275	VBD	denotes	reported
T13565	16255-16257	FW	denotes	et
T13566	16258-16261	FW	denotes	al.
T13567	16262-16263	-LRB-	denotes	[
T13568	16263-16265	CD	denotes	45
T13569	16265-16266	-RRB-	denotes	]
T13570	16276-16280	IN	denotes	that
T13571	16321-16323	VBZ	denotes	is
T13572	16281-16284	NN	denotes	psr
T13573	16284-16285	HYPH	denotes	-
T13574	16285-16286	CD	denotes	1
T13575	16286-16288	,	denotes	,
T13576	16288-16291	DT	denotes	the
T13577	16303-16310	NN	denotes	homolog
T13578	16292-16294	NNP	denotes	C.
T13579	16295-16302	NNP	denotes	elegans
T13580	16311-16313	IN	denotes	of
T13581	16314-16319	NN	denotes	Ptdsr
T13582	16319-16321	,	denotes	,
T13583	16324-16333	JJ	denotes	important
T13584	16334-16337	IN	denotes	for
T13585	16338-16342	NN	denotes	cell
T13586	16343-16349	NN	denotes	corpse
T13587	16342-16343	HYPH	denotes	-
T13588	16350-16360	NN	denotes	engulfment
T13589	16360-16362	,	denotes	,
T13590	16362-16369	IN	denotes	whereas
T13591	16419-16426	VBD	denotes	yielded
T13592	16370-16373	NN	denotes	psr
T13593	16381-16388	NNS	denotes	studies
T13594	16373-16374	HYPH	denotes	-
T13595	16374-16375	CD	denotes	1
T13596	16376-16380	NN	denotes	RNAi
T13597	16389-16398	VBN	denotes	performed
T13598	16399-16401	IN	denotes	by
T13599	16402-16406	NNP	denotes	Arur
T13600	16407-16409	FW	denotes	et
T13601	16410-16413	FW	denotes	al.
T13602	16414-16415	-LRB-	denotes	[
T13603	16415-16417	CD	denotes	25
T13604	16417-16418	-RRB-	denotes	]
T13605	16426-16428	,	denotes	,
T13606	16428-16430	IN	denotes	in
T13607	16431-16435	DT	denotes	this
T13608	16436-16443	NN	denotes	respect
T13609	16443-16445	,	denotes	,
T13610	16445-16447	DT	denotes	no
T13611	16448-16457	NN	denotes	phenotype
T13612	16457-16458	.	denotes	.
T13613	16458-16730	sentence	denotes	Moreover, Wang and colleagues hypothesized on the basis of their data that psr-1 might act to transduce an engulfment signal upstream of Ced-2 (Crk II), Ced-5 (Dock 180), Ced-10 (Rac 1) and Ced-12 (Elmo) in one of the two cell-corpse engulfment pathways in the worm [45].
T13614	16459-16467	RB	denotes	Moreover
T13615	16489-16501	VBN	denotes	hypothesized
T13616	16467-16469	,	denotes	,
T13617	16469-16473	NNP	denotes	Wang
T13618	16474-16477	CC	denotes	and
T13619	16478-16488	NNS	denotes	colleagues
T13620	16502-16504	IN	denotes	on
T13621	16505-16508	DT	denotes	the
T13622	16509-16514	NN	denotes	basis
T13623	16515-16517	IN	denotes	of
T13624	16518-16523	PRP$	denotes	their
T13625	16524-16528	NNS	denotes	data
T13626	16529-16533	IN	denotes	that
T13627	16546-16549	VB	denotes	act
T13628	16534-16537	NN	denotes	psr
T13629	16537-16538	HYPH	denotes	-
T13630	16538-16539	CD	denotes	1
T13631	16540-16545	MD	denotes	might
T13632	16550-16552	TO	denotes	to
T13633	16553-16562	VB	denotes	transduce
T13634	16563-16565	DT	denotes	an
T13635	16577-16583	NN	denotes	signal
T13636	16566-16576	NN	denotes	engulfment
T13637	16584-16592	RB	denotes	upstream
T13638	16593-16595	IN	denotes	of
T13639	16596-16599	NN	denotes	Ced
T13640	16599-16600	HYPH	denotes	-
T13641	16600-16601	CD	denotes	2
T13642	16602-16603	-LRB-	denotes	(
T13643	16603-16606	NN	denotes	Crk
T13644	16607-16609	CD	denotes	II
T13645	16609-16610	-RRB-	denotes	)
T13646	16610-16612	,	denotes	,
T13647	16612-16615	NN	denotes	Ced
T13648	16615-16616	HYPH	denotes	-
T13649	16616-16617	CD	denotes	5
T13650	16618-16619	-LRB-	denotes	(
T13651	16619-16623	NN	denotes	Dock
T13652	16624-16627	CD	denotes	180
T13653	16627-16628	-RRB-	denotes	)
T13654	16628-16630	,	denotes	,
T13655	16630-16633	NN	denotes	Ced
T13656	16633-16634	HYPH	denotes	-
T13657	16634-16636	CD	denotes	10
T13658	16637-16638	-LRB-	denotes	(
T13659	16638-16641	NN	denotes	Rac
T13660	16642-16643	CD	denotes	1
T13661	16643-16644	-RRB-	denotes	)
T13662	16645-16648	CC	denotes	and
T13663	16649-16652	NN	denotes	Ced
T13664	16652-16653	HYPH	denotes	-
T13665	16653-16655	CD	denotes	12
T13666	16656-16657	-LRB-	denotes	(
T13667	16657-16661	NN	denotes	Elmo
T13668	16661-16662	-RRB-	denotes	)
T13669	16663-16665	IN	denotes	in
T13670	16666-16669	CD	denotes	one
T13671	16670-16672	IN	denotes	of
T13672	16673-16676	DT	denotes	the
T13673	16704-16712	NNS	denotes	pathways
T13674	16677-16680	CD	denotes	two
T13675	16681-16685	NN	denotes	cell
T13676	16686-16692	NN	denotes	corpse
T13677	16685-16686	HYPH	denotes	-
T13678	16693-16703	NN	denotes	engulfment
T13679	16713-16715	IN	denotes	in
T13680	16716-16719	DT	denotes	the
T13681	16720-16724	NN	denotes	worm
T13682	16725-16726	-LRB-	denotes	[
T13683	16726-16728	CD	denotes	45
T13684	16728-16729	-RRB-	denotes	]
T13685	16729-16730	.	denotes	.
T13686	16730-16958	sentence	denotes	But the loss-of-function phenotype of psr-1 mutants and the complementation phenotypes in overexpressing transgenic worms shown by Wang et al. [45] are rather weak as compared to the classical C. elegans engulfment mutants [8].
T13687	16731-16734	CC	denotes	But
T13688	16879-16882	VBP	denotes	are
T13689	16735-16738	DT	denotes	the
T13690	16756-16765	NN	denotes	phenotype
T13691	16739-16743	NN	denotes	loss
T13692	16743-16744	HYPH	denotes	-
T13693	16744-16746	IN	denotes	of
T13694	16746-16747	HYPH	denotes	-
T13695	16747-16755	NN	denotes	function
T13696	16766-16768	IN	denotes	of
T13697	16769-16772	NN	denotes	psr
T13698	16775-16782	NNS	denotes	mutants
T13699	16772-16773	HYPH	denotes	-
T13700	16773-16774	CD	denotes	1
T13701	16783-16786	CC	denotes	and
T13702	16787-16790	DT	denotes	the
T13703	16807-16817	NNS	denotes	phenotypes
T13704	16791-16806	NN	denotes	complementation
T13705	16818-16820	IN	denotes	in
T13706	16821-16835	VBG	denotes	overexpressing
T13707	16847-16852	NNS	denotes	worms
T13708	16836-16846	JJ	denotes	transgenic
T13709	16853-16858	VBN	denotes	shown
T13710	16859-16861	IN	denotes	by
T13711	16862-16866	NNP	denotes	Wang
T13712	16867-16869	FW	denotes	et
T13713	16870-16873	FW	denotes	al.
T13714	16874-16875	-LRB-	denotes	[
T13715	16875-16877	CD	denotes	45
T13716	16877-16878	-RRB-	denotes	]
T13717	16883-16889	RB	denotes	rather
T13718	16890-16894	JJ	denotes	weak
T13719	16895-16897	IN	denotes	as
T13720	16898-16906	VBN	denotes	compared
T13721	16907-16909	IN	denotes	to
T13722	16910-16913	DT	denotes	the
T13723	16946-16953	NNS	denotes	mutants
T13724	16914-16923	JJ	denotes	classical
T13725	16924-16926	NNP	denotes	C.
T13726	16927-16934	NNP	denotes	elegans
T13727	16935-16945	NN	denotes	engulfment
T13728	16954-16955	-LRB-	denotes	[
T13729	16955-16956	CD	denotes	8
T13730	16956-16957	-RRB-	denotes	]
T13731	16957-16958	.	denotes	.
T13732	16958-17127	sentence	denotes	Many previous functional studies that reported a requirement for Ptdsr for the phagocytosis of apoptotic cells used the monoclonal anti-Ptdsr antibody mAb 217G8E9 [26].
T13733	16959-16963	JJ	denotes	Many
T13734	16984-16991	NNS	denotes	studies
T13735	16964-16972	JJ	denotes	previous
T13736	16973-16983	JJ	denotes	functional
T13737	17070-17074	VBD	denotes	used
T13738	16992-16996	WDT	denotes	that
T13739	16997-17005	VBD	denotes	reported
T13740	17006-17007	DT	denotes	a
T13741	17008-17019	NN	denotes	requirement
T13742	17020-17023	IN	denotes	for
T13743	17024-17029	NN	denotes	Ptdsr
T13744	17030-17033	IN	denotes	for
T13745	17034-17037	DT	denotes	the
T13746	17038-17050	NN	denotes	phagocytosis
T13747	17051-17053	IN	denotes	of
T13748	17054-17063	JJ	denotes	apoptotic
T13749	17064-17069	NNS	denotes	cells
T13750	17075-17078	DT	denotes	the
T13751	17101-17109	NN	denotes	antibody
T13752	17079-17089	JJ	denotes	monoclonal
T13753	17090-17100	JJ	denotes	anti-Ptdsr
T13754	17110-17113	NN	denotes	mAb
T13755	17114-17121	NN	denotes	217G8E9
T13756	17122-17123	-LRB-	denotes	[
T13757	17123-17125	CD	denotes	26
T13758	17125-17126	-RRB-	denotes	]
T13759	17126-17127	.	denotes	.
T13760	17127-17370	sentence	denotes	This antibody was used in Ptdsr binding and blocking experiments, as well as in subcellular localization studies, which led to the conclusion that Ptdsr is a transmembrane receptor critical for signal transduction at the engulfment interface.
T13761	17128-17132	DT	denotes	This
T13762	17133-17141	NN	denotes	antibody
T13763	17146-17150	VBN	denotes	used
T13764	17142-17145	VBD	denotes	was
T13765	17151-17153	IN	denotes	in
T13766	17154-17159	NN	denotes	Ptdsr
T13767	17181-17192	NNS	denotes	experiments
T13768	17160-17167	NN	denotes	binding
T13769	17168-17171	CC	denotes	and
T13770	17172-17180	NN	denotes	blocking
T13771	17192-17194	,	denotes	,
T13772	17194-17196	RB	denotes	as
T13773	17202-17204	IN	denotes	as
T13774	17197-17201	RB	denotes	well
T13775	17205-17207	IN	denotes	in
T13776	17208-17219	JJ	denotes	subcellular
T13777	17233-17240	NNS	denotes	studies
T13778	17220-17232	NN	denotes	localization
T13779	17240-17242	,	denotes	,
T13780	17242-17247	WDT	denotes	which
T13781	17248-17251	VBD	denotes	led
T13782	17252-17254	IN	denotes	to
T13783	17255-17258	DT	denotes	the
T13784	17259-17269	NN	denotes	conclusion
T13785	17270-17274	IN	denotes	that
T13786	17281-17283	VBZ	denotes	is
T13787	17275-17280	NN	denotes	Ptdsr
T13788	17284-17285	DT	denotes	a
T13789	17300-17308	NN	denotes	receptor
T13790	17286-17299	NN	denotes	transmembrane
T13791	17309-17317	JJ	denotes	critical
T13792	17318-17321	IN	denotes	for
T13793	17322-17328	NN	denotes	signal
T13794	17329-17341	NN	denotes	transduction
T13795	17342-17344	IN	denotes	at
T13796	17345-17348	DT	denotes	the
T13797	17360-17369	NN	denotes	interface
T13798	17349-17359	NN	denotes	engulfment
T13799	17369-17370	.	denotes	.
T13800	17370-17501	sentence	denotes	More recently it was used in binding assays to show that the human and worm Ptdsr molecules can recognize phosphatidylserine [45].
T13801	17371-17375	RBR	denotes	More
T13802	17376-17384	RB	denotes	recently
T13803	17392-17396	VBN	denotes	used
T13804	17385-17387	PRP	denotes	it
T13805	17388-17391	VBD	denotes	was
T13806	17397-17399	IN	denotes	in
T13807	17400-17407	NN	denotes	binding
T13808	17408-17414	NNS	denotes	assays
T13809	17415-17417	TO	denotes	to
T13810	17418-17422	VB	denotes	show
T13811	17423-17427	IN	denotes	that
T13812	17467-17476	VB	denotes	recognize
T13813	17428-17431	DT	denotes	the
T13814	17453-17462	NNS	denotes	molecules
T13815	17432-17437	JJ	denotes	human
T13816	17438-17441	CC	denotes	and
T13817	17442-17446	NN	denotes	worm
T13818	17447-17452	NN	denotes	Ptdsr
T13819	17463-17466	MD	denotes	can
T13820	17477-17495	NN	denotes	phosphatidylserine
T13821	17496-17497	-LRB-	denotes	[
T13822	17497-17499	CD	denotes	45
T13823	17499-17500	-RRB-	denotes	]
T13824	17500-17501	.	denotes	.
T13825	17501-17725	sentence	denotes	In the course of the study presented here, we stained immunohistochemically for Ptdsr with mAb 217G8E9 on wild-type and Ptdsr-deficient macrophages and fibroblasts (see Additional data file 1, Figure S2 and data not shown).
T13826	17502-17504	IN	denotes	In
T13827	17548-17555	VBD	denotes	stained
T13828	17505-17508	DT	denotes	the
T13829	17509-17515	NN	denotes	course
T13830	17516-17518	IN	denotes	of
T13831	17519-17522	DT	denotes	the
T13832	17523-17528	NN	denotes	study
T13833	17529-17538	VBN	denotes	presented
T13834	17539-17543	RB	denotes	here
T13835	17543-17545	,	denotes	,
T13836	17545-17547	PRP	denotes	we
T13837	17556-17577	RB	denotes	immunohistochemically
T13838	17578-17581	IN	denotes	for
T13839	17582-17587	NN	denotes	Ptdsr
T13840	17588-17592	IN	denotes	with
T13841	17593-17596	NN	denotes	mAb
T13842	17597-17604	NN	denotes	217G8E9
T13843	17605-17607	IN	denotes	on
T13844	17608-17612	JJ	denotes	wild
T13845	17613-17617	NN	denotes	type
T13846	17612-17613	HYPH	denotes	-
T13847	17638-17649	NNS	denotes	macrophages
T13848	17618-17621	CC	denotes	and
T13849	17622-17627	NN	denotes	Ptdsr
T13850	17628-17637	JJ	denotes	deficient
T13851	17627-17628	HYPH	denotes	-
T13852	17650-17653	CC	denotes	and
T13853	17654-17665	NNS	denotes	fibroblasts
T13854	17666-17667	-LRB-	denotes	(
T13855	17667-17670	VB	denotes	see
T13856	17671-17681	JJ	denotes	Additional
T13857	17682-17686	NNS	denotes	data
T13858	17687-17691	NN	denotes	file
T13859	17692-17693	CD	denotes	1
T13860	17693-17695	,	denotes	,
T13861	17695-17701	NN	denotes	Figure
T13862	17702-17704	NN	denotes	S2
T13863	17705-17708	CC	denotes	and
T13864	17709-17713	NNS	denotes	data
T13865	17714-17717	RB	denotes	not
T13866	17718-17723	VBN	denotes	shown
T13867	17723-17724	-RRB-	denotes	)
T13868	17724-17725	.	denotes	.
T13869	17725-17810	sentence	denotes	To our surprise, we observed similar staining patterns with cells of both genotypes.
T13870	17726-17728	IN	denotes	To
T13871	17746-17754	VBD	denotes	observed
T13872	17729-17732	PRP$	denotes	our
T13873	17733-17741	NN	denotes	surprise
T13874	17741-17743	,	denotes	,
T13875	17743-17745	PRP	denotes	we
T13876	17755-17762	JJ	denotes	similar
T13877	17772-17780	NNS	denotes	patterns
T13878	17763-17771	NN	denotes	staining
T13879	17781-17785	IN	denotes	with
T13880	17786-17791	NNS	denotes	cells
T13881	17792-17794	IN	denotes	of
T13882	17795-17799	DT	denotes	both
T13883	17800-17809	NNS	denotes	genotypes
T13884	17809-17810	.	denotes	.
T13885	17810-18126	sentence	denotes	Furthermore, using a Ptdsr-peptide array we found that mAb 217G8E9 can bind weakly to a Ptdsr peptide, explaining the original isolation of Ptdsr cDNA clones by phage display [26]; but the antibody mainly recognizes additional, as-yet unknown, membrane-associated protein(s) (see Additional data file 1, Figure S2).
T13886	17811-17822	RB	denotes	Furthermore
T13887	17855-17860	VBD	denotes	found
T13888	17822-17824	,	denotes	,
T13889	17824-17829	VBG	denotes	using
T13890	17830-17831	DT	denotes	a
T13891	17846-17851	NN	denotes	array
T13892	17832-17837	NN	denotes	Ptdsr
T13893	17838-17845	NN	denotes	peptide
T13894	17837-17838	HYPH	denotes	-
T13895	17852-17854	PRP	denotes	we
T13896	17861-17865	IN	denotes	that
T13897	17882-17886	VB	denotes	bind
T13898	17866-17869	NN	denotes	mAb
T13899	17870-17877	NN	denotes	217G8E9
T13900	17878-17881	MD	denotes	can
T13901	17887-17893	RB	denotes	weakly
T13902	17894-17896	IN	denotes	to
T13903	17897-17898	DT	denotes	a
T13904	17905-17912	NN	denotes	peptide
T13905	17899-17904	NN	denotes	Ptdsr
T13906	17912-17914	,	denotes	,
T13907	17914-17924	VBG	denotes	explaining
T13908	17925-17928	DT	denotes	the
T13909	17938-17947	NN	denotes	isolation
T13910	17929-17937	JJ	denotes	original
T13911	17948-17950	IN	denotes	of
T13912	17951-17956	NN	denotes	Ptdsr
T13913	17962-17968	NNS	denotes	clones
T13914	17957-17961	NN	denotes	cDNA
T13915	17969-17971	IN	denotes	by
T13916	17972-17977	NN	denotes	phage
T13917	17978-17985	NN	denotes	display
T13918	17986-17987	-LRB-	denotes	[
T13919	17987-17989	CD	denotes	26
T13920	17989-17990	-RRB-	denotes	]
T13921	17990-17991	:	denotes	;
T13922	17992-17995	CC	denotes	but
T13923	17996-17999	DT	denotes	the
T13924	18000-18008	NN	denotes	antibody
T13925	18016-18026	VBZ	denotes	recognizes
T13926	18009-18015	RB	denotes	mainly
T13927	18027-18037	JJ	denotes	additional
T13928	18075-18082	NN	denotes	protein
T13929	18037-18039	,	denotes	,
T13930	18039-18041	RB	denotes	as
T13931	18042-18045	RB	denotes	yet
T13932	18041-18042	HYPH	denotes	-
T13933	18046-18053	JJ	denotes	unknown
T13934	18053-18055	,	denotes	,
T13935	18055-18063	NN	denotes	membrane
T13936	18064-18074	VBN	denotes	associated
T13937	18063-18064	HYPH	denotes	-
T13938	18082-18083	-LRB-	denotes	(
T13939	18083-18084	AFX	denotes	s
T13940	18084-18085	-RRB-	denotes	)
T13941	18086-18087	-LRB-	denotes	(
T13942	18122-18124	NN	denotes	S2
T13943	18087-18090	VB	denotes	see
T13944	18091-18101	JJ	denotes	Additional
T13945	18102-18106	NNS	denotes	data
T13946	18107-18111	NN	denotes	file
T13947	18112-18113	CD	denotes	1
T13948	18113-18115	,	denotes	,
T13949	18115-18121	NN	denotes	Figure
T13950	18124-18125	-RRB-	denotes	)
T13951	18125-18126	.	denotes	.
T13952	18126-18272	sentence	denotes	Experiments that have used this antibody should therefore be interpreted with great caution as they might come to be viewed in a different light.
T13953	18127-18138	NNS	denotes	Experiments
T13954	18188-18199	VBN	denotes	interpreted
T13955	18139-18143	WDT	denotes	that
T13956	18149-18153	VBN	denotes	used
T13957	18144-18148	VBP	denotes	have
T13958	18154-18158	DT	denotes	this
T13959	18159-18167	NN	denotes	antibody
T13960	18168-18174	MD	denotes	should
T13961	18175-18184	RB	denotes	therefore
T13962	18185-18187	VB	denotes	be
T13963	18200-18204	IN	denotes	with
T13964	18205-18210	JJ	denotes	great
T13965	18211-18218	NN	denotes	caution
T13966	18219-18221	IN	denotes	as
T13967	18233-18237	VB	denotes	come
T13968	18222-18226	PRP	denotes	they
T13969	18227-18232	MD	denotes	might
T13970	18238-18240	TO	denotes	to
T13971	18244-18250	VBN	denotes	viewed
T13972	18241-18243	VB	denotes	be
T13973	18251-18253	IN	denotes	in
T13974	18254-18255	DT	denotes	a
T13975	18266-18271	NN	denotes	light
T13976	18256-18265	JJ	denotes	different
T13977	18271-18272	.	denotes	.
T11576	9836-9845	VBZ	denotes	indicates
T11577	9826-9835	RB	denotes	therefore
T11578	9846-9850	IN	denotes	that
T11579	9857-9860	VBZ	denotes	has
T11580	9851-9856	NN	denotes	Ptdsr
T11581	9861-9862	DT	denotes	a
T11582	9891-9895	NN	denotes	role
T11583	9863-9868	JJ	denotes	novel
T11584	9868-9870	,	denotes	,
T11585	9870-9878	RB	denotes	hitherto
T11586	9879-9889	JJ	denotes	unexpected
T11587	9889-9891	,	denotes	,
T11588	9896-9898	IN	denotes	in
T11589	9899-9908	VBG	denotes	promoting
T11590	9909-9915	NN	denotes	tissue
T11591	9916-9926	NN	denotes	maturation
T11592	9927-9930	CC	denotes	and
T11593	9931-9939	JJ	denotes	terminal
T11594	9940-9955	NN	denotes	differentiation
T11595	9955-9956	.	denotes	.
T11596	9956-10146	sentence	denotes	Additional studies with conditionally targeted Ptdsr-deficient mice are required to investigate the role of spatial and temporal Ptdsr expression and function during tissue differentiation.
T11597	9957-9967	JJ	denotes	Additional
T11598	9968-9975	NNS	denotes	studies
T11599	10029-10037	VBN	denotes	required
T11600	9976-9980	IN	denotes	with
T11601	9981-9994	RB	denotes	conditionally
T11602	9995-10003	VBN	denotes	targeted
T11603	10020-10024	NNS	denotes	mice
T11604	10004-10009	NN	denotes	Ptdsr
T11605	10010-10019	JJ	denotes	deficient
T11606	10009-10010	HYPH	denotes	-
T11607	10025-10028	VBP	denotes	are
T11608	10038-10040	TO	denotes	to
R5292	T9791	T9792	nsubjpass	Ptdsr,required
R5293	T9793	T9792	auxpass	is,required
R5294	T9794	T9792	prep	for,required
R5295	T9795	T9796	det	the,differentiation
R5296	T9796	T9794	pobj	differentiation,for
R5297	T9797	T9796	prep	of,differentiation
R5298	T9798	T9799	amod	multiple,systems
R5299	T9799	T9797	pobj	systems,of
R5300	T9800	T9799	compound	organ,systems
R5301	T9801	T9792	prep	during,required
R5302	T9802	T9801	pobj	development,during
R5303	T9804	T9805	prep	In,generated
R5304	T9806	T9807	det	this,study
R5305	T9807	T9804	pobj	study,In
R5306	T9808	T9805	punct	", ",generated
R5307	T9809	T9805	nsubj	we,generated
R5308	T9810	T9805	aux	have,generated
R5309	T9811	T9812	det	a,mutation
R5310	T9812	T9805	dobj	mutation,generated
R5311	T9813	T9812	amod	null,mutation
R5312	T9814	T9812	prep	in,mutation
R5313	T9815	T9816	det	the,gene
R5314	T9816	T9814	pobj	gene,in
R5315	T9817	T9816	nmod	phosphatidylserine,gene
R5316	T9818	T9816	nmod	receptor,gene
R5317	T9819	T9820	punct	(,Ptdsr
R5318	T9820	T9816	parataxis	Ptdsr,gene
R5319	T9821	T9820	punct	),Ptdsr
R5320	T9822	T9812	prep	in,mutation
R5321	T9823	T9824	compound	C57BL,6J
R5322	T9824	T9826	compound	6J,mice
R5323	T9825	T9824	punct	/,6J
R5324	T9826	T9822	pobj	mice,in
R5325	T9827	T9805	punct	.,generated
R5326	T9829	T9830	nsubj	We,show
R5327	T9831	T9832	mark	that,results
R5328	T9832	T9830	ccomp	results,show
R5329	T9833	T9832	nsubj	ablation,results
R5330	T9834	T9833	prep	of,ablation
R5331	T9835	T9834	pobj	Ptdsr,of
R5332	T9836	T9832	prep	in,results
R5333	T9837	T9838	amod	profound,defects
R5334	T9838	T9836	pobj	defects,in
R5335	T9839	T9838	compound	differentiation,defects
R5336	T9840	T9832	prep	in,results
R5337	T9841	T9842	amod	multiple,organs
R5338	T9842	T9840	pobj	organs,in
R5339	T9843	T9842	cc	and,organs
R5340	T9844	T9842	conj	tissues,organs
R5341	T9845	T9832	prep	during,results
R5342	T9846	T9845	pobj	embryogenesis,during
R5343	T9847	T9832	punct	", ",results
R5344	T9848	T9849	mark	although,with
R5345	T9849	T9832	advcl	with,results
R5346	T9850	T9851	amod	variable,penetrance
R5347	T9851	T9849	pobj	penetrance,with
R5348	T9852	T9830	punct	.,show
R5349	T9854	T9855	mark	While,was
R5350	T9855	T9858	advcl	was,reported
R5351	T9856	T9857	det	this,work
R5352	T9857	T9855	nsubj	work,was
R5353	T9859	T9855	prep	in,was
R5354	T9860	T9859	pobj	progress,in
R5355	T9861	T9858	punct	", ",reported
R5356	T9862	T9863	nummod	two,groups
R5357	T9863	T9858	nsubj	groups,reported
R5358	T9864	T9863	amod	other,groups
R5359	T9865	T9866	det	the,generation
R5360	T9866	T9858	dobj	generation,reported
R5361	T9867	T9866	prep	of,generation
R5362	T9868	T9869	npadvmod	Ptdsr,deficient
R5363	T9869	T9871	amod	deficient,mice
R5364	T9870	T9869	punct	-,deficient
R5365	T9871	T9867	pobj	mice,of
R5366	T9872	T9873	punct	[,32
R5367	T9873	T9858	parataxis	32,reported
R5368	T9874	T9873	nummod	31,32
R5369	T9875	T9873	punct	",",32
R5370	T9876	T9873	punct	],32
R5371	T9877	T9858	punct	.,reported
R5372	T9879	T9880	prep	In,deleted
R5373	T9881	T9882	det	all,lines
R5374	T9882	T9879	pobj	lines,In
R5375	T9883	T9882	nummod	three,lines
R5376	T9884	T9885	compound	knockout,mouse
R5377	T9885	T9882	compound	mouse,lines
R5378	T9886	T9880	punct	", ",deleted
R5379	T9887	T9888	det	the,exons
R5380	T9888	T9880	nsubjpass	exons,deleted
R5381	T9889	T9888	amod	first,exons
R5382	T9890	T9888	nummod	two,exons
R5383	T9891	T9892	punct	(,31
R5384	T9892	T9888	parataxis	31,exons
R5385	T9893	T9892	punct	[,31
R5386	T9894	T9892	punct	],31
R5387	T9895	T9892	cc	and,31
R5388	T9896	T9897	det	this,study
R5389	T9897	T9892	conj	study,31
R5390	T9898	T9892	punct	),31
R5391	T9899	T9888	cc	or,exons
R5392	T9900	T9901	nmod	exons,one
R5393	T9901	T9888	conj	one,exons
R5394	T9902	T9901	prep	to,one
R5395	T9903	T9902	pobj	three,to
R5396	T9904	T9905	punct	[,32
R5397	T9905	T9901	parataxis	32,one
R5398	T9906	T9905	punct	],32
R5399	T9907	T9880	auxpass	were,deleted
R5400	T9908	T9880	prep	by,deleted
R5401	T9909	T9908	pobj	replacement,by
R5402	T9910	T9909	prep	with,replacement
R5403	T9911	T9912	det	a,cassette
R5404	T9912	T9910	pobj	cassette,with
R5405	T9913	T9914	compound	neomycin,selection
R5406	T9914	T9912	compound	selection,cassette
R5407	T9915	T9914	punct	-,selection
R5408	T9916	T9880	punct	.,deleted
R5409	T9918	T9919	det	The,lines
R5410	T9919	T9924	nsubj	lines,differ
R5411	T9920	T9921	compound	Ptdsr,mouse
R5412	T9921	T9919	compound	mouse,lines
R5413	T9922	T9921	punct	-,mouse
R5414	T9923	T9921	compound	knockout,mouse
R5415	T9925	T9924	prep	in,differ
R5416	T9926	T9927	det	the,background
R5417	T9927	T9925	pobj	background,in
R5418	T9928	T9927	amod	genetic,background
R5419	T9929	T9930	prep	in,generated
R5420	T9930	T9927	relcl	generated,background
R5421	T9931	T9929	pobj	which,in
R5422	T9932	T9933	det	the,mutation
R5423	T9933	T9930	nsubjpass	mutation,generated
R5424	T9934	T9930	auxpass	was,generated
R5425	T9935	T9930	cc	and,generated
R5426	T9936	T9930	conj	maintained,generated
R5427	T9937	T9924	punct	", ",differ
R5428	T9938	T9924	advmod	however,differ
R5429	T9939	T9924	punct	.,differ
R5430	T9941	T9942	prep	In,generated
R5431	T9943	T9944	poss	our,case
R5432	T9944	T9941	pobj	case,In
R5433	T9945	T9942	punct	", ",generated
R5434	T9946	T9947	det	the,allele
R5435	T9947	T9942	nsubjpass	allele,generated
R5436	T9948	T9949	npadvmod	Ptdsr,null
R5437	T9949	T9947	amod	null,allele
R5438	T9950	T9949	punct	-,null
R5439	T9951	T9942	auxpass	was,generated
R5440	T9952	T9942	prep	in,generated
R5441	T9953	T9954	det	an,background
R5442	T9954	T9952	pobj	background,in
R5443	T9955	T9954	amod	isogenic,background
R5444	T9956	T9957	compound	C57BL,6J
R5445	T9957	T9954	compound	6J,background
R5446	T9958	T9957	punct	/,6J
R5447	T9959	T9942	punct	", ",generated
R5448	T9960	T9961	mark	whereas,investigated
R5449	T9961	T9942	advcl	investigated,generated
R5450	T9962	T9961	nsubj	Li,investigated
R5451	T9963	T9964	advmod	et,al.
R5452	T9964	T9962	advmod	al.,Li
R5453	T9965	T9966	punct	[,31
R5454	T9966	T9962	parataxis	31,Li
R5455	T9967	T9966	punct	],31
R5456	T9968	T9962	cc	and,Li
R5457	T9969	T9962	conj	Kunisaki,Li
R5458	T9970	T9971	advmod	et,al.
R5459	T9971	T9969	advmod	al.,Kunisaki
R5460	T9972	T9973	punct	[,32
R5461	T9973	T9969	parataxis	32,Kunisaki
R5462	T9974	T9973	punct	],32
R5463	T9975	T9976	det	the,phenotype
R5464	T9976	T9961	dobj	phenotype,investigated
R5465	T9977	T9976	prep	of,phenotype
R5466	T9978	T9979	poss	their,mice
R5467	T9979	T9977	pobj	mice,of
R5468	T9980	T9981	compound	Ptdsr,knockout
R5469	T9981	T9979	compound	knockout,mice
R5470	T9982	T9981	punct	-,knockout
R5471	T9983	T9961	prep	in,investigated
R5472	T9984	T9985	det	a,background
R5473	T9985	T9983	pobj	background,in
R5474	T9986	T9985	amod	mixed,background
R5475	T9987	T9985	nummod	129,background
R5476	T9988	T9989	punct	×,C57BL
R5477	T9989	T9987	prep	C57BL,129
R5478	T9990	T9989	punct	/,C57BL
R5479	T9991	T9989	nummod	6,C57BL
R5480	T9992	T9942	punct	.,generated
R5481	T9994	T9995	det	The,ablation
R5482	T9995	T9996	nsubj	ablation,results
R5483	T9997	T9995	prep	of,ablation
R5484	T9998	T9999	compound	Ptdsr,function
R5485	T9999	T9997	pobj	function,of
R5486	T10000	T9996	prep	in,results
R5487	T10001	T10002	amod	perinatal,lethality
R5488	T10002	T10000	pobj	lethality,in
R5489	T10003	T9996	prep	in,results
R5490	T10004	T10005	det	all,cases
R5491	T10005	T10003	pobj	cases,in
R5492	T10006	T9996	punct	", ",results
R5493	T10007	T9996	cc	but,results
R5494	T10008	T10009	expl	there,are
R5495	T10009	T9996	conj	are,results
R5496	T10010	T10011	amod	interesting,differences
R5497	T10011	T10009	attr	differences,are
R5498	T10012	T10011	prep	in,differences
R5499	T10013	T10012	pobj	severity,in
R5500	T10014	T10013	cc	or,severity
R5501	T10015	T10013	conj	expressivities,severity
R5502	T10016	T10013	prep	of,severity
R5503	T10017	T10016	pobj	phenotypes,of
R5504	T10018	T10011	prep	among,differences
R5505	T10019	T10020	det	the,lines
R5506	T10020	T10018	pobj	lines,among
R5507	T10021	T10020	amod	different,lines
R5508	T10022	T10023	npadvmod	Ptdsr,deficient
R5509	T10023	T10020	amod	deficient,lines
R5510	T10024	T10023	punct	-,deficient
R5511	T10025	T10020	compound	mouse,lines
R5512	T10026	T10009	punct	.,are
R5513	T10028	T10029	nsubj	This,be
R5514	T10030	T10029	aux	might,be
R5515	T10031	T10029	prep	due,be
R5516	T10032	T10031	preconj	either,due
R5517	T10033	T10031	conj	to,due
R5518	T10034	T10033	pobj	differences,to
R5519	T10035	T10034	prep	in,differences
R5520	T10036	T10037	amod	genetic,background
R5521	T10037	T10035	pobj	background,in
R5522	T10038	T10031	cc	or,due
R5523	T10039	T10040	mark	because,analyzed
R5524	T10040	T10031	conj	analyzed,due
R5525	T10041	T10042	det	the,phenotypes
R5526	T10042	T10040	nsubjpass	phenotypes,analyzed
R5527	T10043	T10044	dep	that,investigated
R5528	T10044	T10042	relcl	investigated,phenotypes
R5529	T10045	T10044	aux	have,investigated
R5530	T10046	T10044	auxpass	been,investigated
R5531	T10047	T10044	prep	in,investigated
R5532	T10048	T10049	det	this,study
R5533	T10049	T10047	pobj	study,in
R5534	T10050	T10040	aux	have,analyzed
R5535	T10051	T10040	neg	not,analyzed
R5536	T10052	T10040	auxpass	been,analyzed
R5537	T10053	T10040	prep	in,analyzed
R5538	T10054	T10055	amod	such,detail
R5539	T10055	T10053	pobj	detail,in
R5540	T10056	T10040	advmod	before,analyzed
R5541	T10057	T10029	punct	.,be
R5542	T10059	T10060	prep	In,started
R5543	T10061	T10062	det	the,line
R5544	T10062	T10059	pobj	line,In
R5545	T10063	T10064	compound	Ptdsr,knockout
R5546	T10064	T10062	compound	knockout,line
R5547	T10065	T10064	punct	-,knockout
R5548	T10066	T10062	compound	mouse,line
R5549	T10067	T10062	acl	reported,line
R5550	T10068	T10067	advmod	here,reported
R5551	T10069	T10060	punct	", ",started
R5552	T10070	T10071	compound	growth,retardation
R5553	T10071	T10060	nsubj	retardation,started
R5554	T10072	T10060	prep	from,started
R5555	T10073	T10072	pobj	E12.5,from
R5556	T10074	T10073	advmod	onwards,E12.5
R5557	T10075	T10060	cc	and,started
R5558	T10076	T10077	auxpass	was,associated
R5559	T10077	T10060	conj	associated,started
R5560	T10078	T10077	prep	with,associated
R5561	T10079	T10080	amod	delayed,differentiation
R5562	T10080	T10078	pobj	differentiation,with
R5563	T10081	T10080	prep	in,differentiation
R5564	T10082	T10083	amod	several,organs
R5565	T10083	T10081	pobj	organs,in
R5566	T10084	T10085	prep	in,expressed
R5567	T10085	T10083	relcl	expressed,organs
R5568	T10086	T10084	pobj	which,in
R5569	T10087	T10085	nsubjpass	Ptdsr,expressed
R5570	T10088	T10085	auxpass	is,expressed
R5571	T10089	T10090	preconj	either,during
R5572	T10090	T10085	prep	during,expressed
R5573	T10091	T10090	pobj	embryogenesis,during
R5574	T10092	T10090	cc	or,during
R5575	T10093	T10094	advmod	later,in
R5576	T10094	T10090	conj	in,during
R5577	T10095	T10094	pobj	adulthood,in
R5578	T10096	T10060	punct	.,started
R5579	T10098	T10099	prep	At,observed
R5580	T10100	T10098	pobj	E16.5,At
R5581	T10101	T10102	advmod	almost,morphogenesis
R5582	T10102	T10099	nsubjpass	morphogenesis,observed
R5583	T10103	T10102	det	no,morphogenesis
R5584	T10104	T10102	compound	branching,morphogenesis
R5585	T10105	T10102	prep	of,morphogenesis
R5586	T10106	T10107	det	the,epithelium
R5587	T10107	T10105	pobj	epithelium,of
R5588	T10108	T10107	compound	lung,epithelium
R5589	T10109	T10099	auxpass	was,observed
R5590	T10110	T10099	prep	in,observed
R5591	T10111	T10112	nmod	Ptdsr,lungs
R5592	T10112	T10110	pobj	lungs,in
R5593	T10113	T10111	punct	-,Ptdsr
R5594	T10114	T10111	punct	/,Ptdsr
R5595	T10115	T10111	punct	-,Ptdsr
R5596	T10116	T10099	punct	.,observed
R5597	T10118	T10119	advmod	Similarly,developed
R5598	T10120	T10119	punct	", ",developed
R5599	T10121	T10122	amod	epithelial,structures
R5600	T10122	T10119	nsubjpass	structures,developed
R5601	T10123	T10119	auxpass	were,developed
R5602	T10124	T10119	advmod	only,developed
R5603	T10125	T10119	advmod	partially,developed
R5604	T10126	T10119	prep	in,developed
R5605	T10127	T10128	amod	mutant,kidneys
R5606	T10128	T10126	pobj	kidneys,in
R5607	T10129	T10119	punct	", ",developed
R5608	T10130	T10119	prep	without,developed
R5609	T10131	T10132	amod	terminal,differentiation
R5610	T10132	T10130	pobj	differentiation,without
R5611	T10133	T10132	prep	of,differentiation
R5612	T10134	T10135	poss	Bowman,capsule
R5613	T10135	T10133	pobj	capsule,of
R5614	T10136	T10134	case	's,Bowman
R5615	T10137	T10130	cc	and,without
R5616	T10138	T10130	conj	with,without
R5617	T10139	T10140	det	a,reduction
R5618	T10140	T10138	pobj	reduction,with
R5619	T10141	T10140	amod	severe,reduction
R5620	T10142	T10140	prep	in,reduction
R5621	T10143	T10144	det	the,number
R5622	T10144	T10142	pobj	number,in
R5623	T10145	T10144	prep	of,number
R5624	T10146	T10147	amod	differentiated,tubules
R5625	T10147	T10145	pobj	tubules,of
R5626	T10148	T10147	compound	collecting,tubules
R5627	T10149	T10119	punct	.,developed
R5628	T10151	T10152	advmod	Likewise,delayed
R5629	T10153	T10152	punct	", ",delayed
R5630	T10154	T10155	det	the,differentiation
R5631	T10155	T10152	nsubjpass	differentiation,delayed
R5632	T10156	T10155	prep	of,differentiation
R5633	T10157	T10158	det	the,intestine
R5634	T10158	T10156	pobj	intestine,of
R5635	T10159	T10152	auxpass	was,delayed
R5636	T10160	T10152	advmod	also,delayed
R5637	T10161	T10152	advmod	severely,delayed
R5638	T10162	T10152	prep	at,delayed
R5639	T10163	T10164	det	this,stage
R5640	T10164	T10162	pobj	stage,at
R5641	T10165	T10164	amod	developmental,stage
R5642	T10166	T10152	punct	.,delayed
R5643	T10168	T10169	advmod	When,compared
R5644	T10169	T10170	advcl	compared,appeared
R5645	T10171	T10169	prep	with,compared
R5646	T10172	T10173	amod	wild,type
R5647	T10173	T10175	compound	type,controls
R5648	T10174	T10173	punct	-,type
R5649	T10175	T10171	pobj	controls,with
R5650	T10176	T10170	punct	", ",appeared
R5651	T10177	T10178	amod	intestinal,tissues
R5652	T10178	T10170	nsubj	tissues,appeared
R5653	T10179	T10178	prep	of,tissues
R5654	T10180	T10181	compound	Ptdsr,mice
R5655	T10181	T10179	pobj	mice,of
R5656	T10182	T10181	compound	knockout,mice
R5657	T10183	T10170	oprd	unstructured,appeared
R5658	T10184	T10170	punct	", ",appeared
R5659	T10185	T10170	prep	with,appeared
R5660	T10186	T10187	det	an,absence
R5661	T10187	T10185	pobj	absence,with
R5662	T10188	T10187	prep	of,absence
R5663	T10189	T10190	amod	enteric,ganglia
R5664	T10190	T10188	pobj	ganglia,of
R5665	T10191	T10188	cc	and,of
R5666	T10192	T10188	conj	of,of
R5667	T10193	T10194	amod	differentiated,tissue
R5668	T10194	T10192	pobj	tissue,of
R5669	T10195	T10196	amod	smooth,muscle
R5670	T10196	T10194	compound	muscle,tissue
R5671	T10197	T10170	punct	.,appeared
R5672	T10199	T10200	advmod	Interestingly,described
R5673	T10201	T10200	punct	", ",described
R5674	T10202	T10200	nsubjpass	defects,described
R5675	T10203	T10202	prep	in,defects
R5676	T10204	T10205	nmod	kidney,differentiation
R5677	T10205	T10203	pobj	differentiation,in
R5678	T10206	T10204	cc	and,kidney
R5679	T10207	T10204	conj	intestine,kidney
R5680	T10208	T10200	auxpass	were,described
R5681	T10209	T10200	neg	not,described
R5682	T10210	T10200	prep	in,described
R5683	T10211	T10212	det	the,knockouts
R5684	T10212	T10210	pobj	knockouts,in
R5685	T10213	T10212	compound	Ptdsr,knockouts
R5686	T10214	T10212	punct	-,knockouts
R5687	T10215	T10212	acl	generated,knockouts
R5688	T10216	T10215	agent	by,generated
R5689	T10217	T10216	pobj	Li,by
R5690	T10218	T10219	advmod	et,al.
R5691	T10219	T10217	advmod	al.,Li
R5692	T10220	T10221	punct	[,31
R5693	T10221	T10217	parataxis	31,Li
R5694	T10222	T10221	punct	],31
R5695	T10223	T10217	cc	and,Li
R5696	T10224	T10217	conj	Kunisaki,Li
R5697	T10225	T10226	advmod	et,al.
R5698	T10226	T10224	advmod	al.,Kunisaki
R5699	T10227	T10228	punct	[,32
R5700	T10228	T10224	parataxis	32,Kunisaki
R5701	T10229	T10228	punct	],32
R5702	T10230	T10200	punct	.,described
R5703	T10232	T10233	advmod	Surprisingly,found
R5704	T10234	T10233	punct	", ",found
R5705	T10235	T10236	advmod	when,examined
R5706	T10236	T10233	advcl	examined,found
R5707	T10237	T10236	nsubj	we,examined
R5708	T10238	T10239	nmod	Ptdsr,embryos
R5709	T10239	T10236	dobj	embryos,examined
R5710	T10240	T10238	punct	-,Ptdsr
R5711	T10241	T10238	punct	/,Ptdsr
R5712	T10242	T10238	punct	-,Ptdsr
R5713	T10243	T10244	advmod	shortly,before
R5714	T10244	T10236	prep	before,examined
R5715	T10245	T10244	pobj	birth,before
R5716	T10246	T10247	punct	(,E18.5
R5717	T10247	T10245	parataxis	E18.5,birth
R5718	T10248	T10247	punct	),E18.5
R5719	T10249	T10244	cc	or,before
R5720	T10250	T10244	conj	neonatally,before
R5721	T10251	T10233	punct	", ",found
R5722	T10252	T10233	nsubj	we,found
R5723	T10253	T10233	advmod	only,found
R5724	T10254	T10255	amod	mild,delays
R5725	T10255	T10233	dobj	delays,found
R5726	T10256	T10255	compound	differentiation,delays
R5727	T10257	T10233	prep	in,found
R5728	T10258	T10257	pobj	organs,in
R5729	T10259	T10260	dep	that,appeared
R5730	T10260	T10258	relcl	appeared,organs
R5731	T10261	T10262	advmod	severely,affected
R5732	T10262	T10260	oprd	affected,appeared
R5733	T10263	T10260	prep	at,appeared
R5734	T10264	T10263	pobj	mid-gestation,at
R5735	T10265	T10233	punct	.,found
R5736	T10267	T10268	det	This,recovery
R5737	T10268	T10270	nsubj	recovery,was
R5738	T10269	T10268	punct	',recovery
R5739	T10270	T10272	ccomp	was,found
R5740	T10271	T10270	punct	',was
R5741	T10273	T10274	advmod	most,visible
R5742	T10274	T10270	acomp	visible,was
R5743	T10275	T10270	prep	in,was
R5744	T10276	T10277	nmod	Ptdsr,lungs
R5745	T10277	T10275	pobj	lungs,in
R5746	T10278	T10276	punct	-,Ptdsr
R5747	T10279	T10276	punct	/,Ptdsr
R5748	T10280	T10276	punct	-,Ptdsr
R5749	T10281	T10272	punct	: ,found
R5750	T10282	T10272	prep	at,found
R5751	T10283	T10282	pobj	P0,at
R5752	T10284	T10272	nsubj	we,found
R5753	T10285	T10286	amod	expanded,lungs
R5754	T10286	T10272	dobj	lungs,found
R5755	T10287	T10286	prep	in,lungs
R5756	T10288	T10289	det	the,mice
R5757	T10289	T10287	pobj	mice,in
R5758	T10290	T10289	compound	knockout,mice
R5759	T10291	T10292	dep	that,showed
R5760	T10292	T10286	relcl	showed,lungs
R5761	T10293	T10294	amod	normal,patterns
R5762	T10294	T10292	dobj	patterns,showed
R5763	T10295	T10294	compound	branching,patterns
R5764	T10296	T10294	punct	", ",patterns
R5765	T10297	T10294	prep	with,patterns
R5766	T10298	T10299	amod	differentiated,alveoli
R5767	T10299	T10297	pobj	alveoli,with
R5768	T10300	T10299	cc	and,alveoli
R5769	T10301	T10299	conj	bronchioles,alveoli
R5770	T10302	T10272	punct	.,found
R5771	T10304	T10305	nsubj	We,investigated
R5772	T10306	T10307	det	the,occurrence
R5773	T10307	T10305	dobj	occurrence,investigated
R5774	T10308	T10305	prep	of,investigated
R5775	T10309	T10310	amod	programmed,death
R5776	T10310	T10308	pobj	death,of
R5777	T10311	T10310	compound	cell,death
R5778	T10312	T10305	prep	during,investigated
R5779	T10313	T10314	compound	lung,development
R5780	T10314	T10312	pobj	development,during
R5781	T10315	T10305	prep	in,investigated
R5782	T10316	T10317	amod	wild,type
R5783	T10317	T10319	nmod	type,mice
R5784	T10318	T10317	punct	-,type
R5785	T10319	T10315	pobj	mice,in
R5786	T10320	T10317	cc	and,type
R5787	T10321	T10322	compound	Ptdsr,knockout
R5788	T10322	T10317	conj	knockout,type
R5789	T10323	T10322	punct	-,knockout
R5790	T10324	T10305	prep	throughout,investigated
R5791	T10325	T10324	pobj	embryogenesis,throughout
R5792	T10326	T10327	punct	(,E16.5
R5793	T10327	T10305	parataxis	E16.5,investigated
R5794	T10328	T10327	prep	to,E16.5
R5795	T10329	T10328	pobj	P0,to
R5796	T10330	T10327	punct	),E16.5
R5797	T10331	T10305	punct	.,investigated
R5798	T10333	T10334	amod	Comparative,immunohistochemistry
R5799	T10334	T10335	nsubj	immunohistochemistry,revealed
R5800	T10336	T10334	prep	for,immunohistochemistry
R5801	T10337	T10336	pobj	aCasp3,for
R5802	T10338	T10339	mark	that,is
R5803	T10339	T10335	ccomp	is,revealed
R5804	T10340	T10339	nsubj	apoptosis,is
R5805	T10341	T10342	det	a,event
R5806	T10342	T10339	attr	event,is
R5807	T10343	T10342	amod	rare,event
R5808	T10344	T10339	prep	during,is
R5809	T10345	T10346	compound	lung,morphogenesis
R5810	T10346	T10344	pobj	morphogenesis,during
R5811	T10347	T10335	punct	.,revealed
R5812	T10349	T10350	advmod	Furthermore,failed
R5813	T10351	T10350	punct	", ",failed
R5814	T10352	T10350	nsubj	we,failed
R5815	T10353	T10354	aux	to,detect
R5816	T10354	T10350	xcomp	detect,failed
R5817	T10355	T10356	det	any,differences
R5818	T10356	T10354	dobj	differences,detect
R5819	T10357	T10356	prep	in,differences
R5820	T10358	T10359	det	the,number
R5821	T10359	T10357	pobj	number,in
R5822	T10360	T10359	prep	of,number
R5823	T10361	T10362	amod	apoptotic,cells
R5824	T10362	T10360	pobj	cells,of
R5825	T10363	T10356	prep	in,differences
R5826	T10364	T10365	nmod	Ptdsr,knockout
R5827	T10365	T10367	nmod	knockout,animals
R5828	T10366	T10365	punct	-,knockout
R5829	T10367	T10363	pobj	animals,in
R5830	T10368	T10365	cc	and,knockout
R5831	T10369	T10370	amod	wild,type
R5832	T10370	T10365	conj	type,knockout
R5833	T10371	T10370	punct	-,type
R5834	T10372	T10354	prep	in,detect
R5835	T10373	T10374	det	the,cases
R5836	T10374	T10372	pobj	cases,in
R5837	T10375	T10374	amod	rare,cases
R5838	T10376	T10377	advmod	where,detect
R5839	T10377	T10374	relcl	detect,cases
R5840	T10378	T10377	nsubj	we,detect
R5841	T10379	T10377	aux	could,detect
R5842	T10380	T10381	amod	apoptotic,cells
R5843	T10381	T10377	dobj	cells,detect
R5844	T10382	T10377	prep	within,detect
R5845	T10383	T10384	compound	lung,tissues
R5846	T10384	T10382	pobj	tissues,within
R5847	T10385	T10350	punct	.,failed
R5848	T10387	T10388	det	These,findings
R5849	T10388	T10389	nsubj	findings,are
R5850	T10390	T10389	acomp	contrary,are
R5851	T10391	T10390	prep	to,contrary
R5852	T10392	T10393	det	the,results
R5853	T10393	T10391	pobj	results,to
R5854	T10394	T10393	acl	reported,results
R5855	T10395	T10394	agent	by,reported
R5856	T10396	T10395	pobj	Li,by
R5857	T10397	T10398	advmod	et,al.
R5858	T10398	T10396	advmod	al.,Li
R5859	T10399	T10400	punct	[,31
R5860	T10400	T10396	parataxis	31,Li
R5861	T10401	T10400	punct	],31
R5862	T10402	T10396	punct	", ",Li
R5863	T10403	T10404	dep	who,suggested
R5864	T10404	T10396	relcl	suggested,Li
R5865	T10405	T10406	mark	that,causes
R5866	T10406	T10404	ccomp	causes,suggested
R5867	T10407	T10408	amod	impaired,clearance
R5868	T10408	T10406	nsubj	clearance,causes
R5869	T10409	T10408	prep	of,clearance
R5870	T10410	T10411	amod	apoptotic,cells
R5871	T10411	T10409	pobj	cells,of
R5872	T10412	T10411	amod	mesenchymal,cells
R5873	T10413	T10412	cc	and,mesenchymal
R5874	T10414	T10412	conj	epithelial,mesenchymal
R5875	T10415	T10416	det	a,failure
R5876	T10416	T10406	dobj	failure,causes
R5877	T10417	T10416	prep	in,failure
R5878	T10418	T10419	compound	lung,morphogenesis
R5879	T10419	T10417	pobj	morphogenesis,in
R5880	T10420	T10416	prep	in,failure
R5881	T10421	T10422	npadvmod	Ptdsr,deficient
R5882	T10422	T10424	amod	deficient,mice
R5883	T10423	T10422	punct	-,deficient
R5884	T10424	T10420	pobj	mice,in
R5885	T10425	T10389	punct	.,are
R5886	T10427	T10428	prep	In,are
R5887	T10429	T10427	pobj	contrast,In
R5888	T10430	T10428	punct	", ",are
R5889	T10431	T10432	poss	our,findings
R5890	T10432	T10428	nsubj	findings,are
R5891	T10433	T10428	prep	in,are
R5892	T10434	T10433	pobj	line,in
R5893	T10435	T10434	prep	with,line
R5894	T10436	T10437	det	the,view
R5895	T10437	T10435	pobj	view,with
R5896	T10438	T10437	amod	current,view
R5897	T10439	T10437	prep	on,view
R5898	T10440	T10441	compound	lung,development
R5899	T10441	T10439	pobj	development,on
R5900	T10442	T10441	prep	during,development
R5901	T10443	T10442	pobj	embryogenesis,during
R5902	T10444	T10428	punct	.,are
R5903	T10446	T10447	advmod	Accordingly,subdivided
R5904	T10448	T10447	punct	", ",subdivided
R5905	T10449	T10447	nsubjpass	formation,subdivided
R5906	T10450	T10449	prep	of,formation
R5907	T10451	T10452	det	the,lung
R5908	T10452	T10450	pobj	lung,of
R5909	T10453	T10452	amod	epithelial,lung
R5910	T10454	T10449	prep	via,formation
R5911	T10455	T10456	compound	branching,morphogenesis
R5912	T10456	T10454	pobj	morphogenesis,via
R5913	T10457	T10447	aux	can,subdivided
R5914	T10458	T10447	auxpass	be,subdivided
R5915	T10459	T10447	prep	into,subdivided
R5916	T10460	T10461	det	a,series
R5917	T10461	T10459	pobj	series,into
R5918	T10462	T10461	prep	of,series
R5919	T10463	T10464	amod	sequential,steps
R5920	T10464	T10462	pobj	steps,of
R5921	T10465	T10466	dep	that,involve
R5922	T10466	T10464	relcl	involve,steps
R5923	T10467	T10466	punct	: ,involve
R5924	T10468	T10469	advmod	first,formation
R5925	T10469	T10466	dobj	formation,involve
R5926	T10470	T10469	punct	", ",formation
R5927	T10471	T10469	prep	of,formation
R5928	T10472	T10473	det	the,anlage
R5929	T10473	T10471	pobj	anlage,of
R5930	T10474	T10473	compound	organ,anlage
R5931	T10475	T10469	prep	in,formation
R5932	T10476	T10477	det	the,form
R5933	T10477	T10475	pobj	form,in
R5934	T10478	T10477	prep	of,form
R5935	T10479	T10480	det	a,placode
R5936	T10480	T10478	pobj	placode,of
R5937	T10481	T10469	punct	;,formation
R5938	T10482	T10483	advmod	second,formation
R5939	T10483	T10469	conj	formation,formation
R5940	T10484	T10483	punct	", ",formation
R5941	T10485	T10483	amod	primary,formation
R5942	T10486	T10483	compound	bud,formation
R5943	T10487	T10483	prep	by,formation
R5944	T10488	T10489	compound	placode,invagination
R5945	T10489	T10487	pobj	invagination,by
R5946	T10490	T10483	punct	;,formation
R5947	T10491	T10492	advmod	third,initiation
R5948	T10492	T10483	conj	initiation,formation
R5949	T10493	T10492	punct	", ",initiation
R5950	T10494	T10492	compound	branch,initiation
R5951	T10495	T10492	cc	and,initiation
R5952	T10496	T10497	compound	branch,outgrowth
R5953	T10497	T10492	conj	outgrowth,initiation
R5954	T10498	T10492	punct	;,initiation
R5955	T10499	T10500	advmod	fourth,reiteration
R5956	T10500	T10492	conj	reiteration,initiation
R5957	T10501	T10500	punct	", ",reiteration
R5958	T10502	T10500	amod	further,reiteration
R5959	T10503	T10500	prep	of,reiteration
R5960	T10504	T10505	det	the,process
R5961	T10505	T10503	pobj	process,of
R5962	T10506	T10505	compound	branching,process
R5963	T10507	T10500	punct	;,reiteration
R5964	T10508	T10500	cc	and,reiteration
R5965	T10509	T10510	advmod	fifth,differentiation
R5966	T10510	T10500	conj	differentiation,reiteration
R5967	T10511	T10510	punct	", ",differentiation
R5968	T10512	T10510	amod	terminal,differentiation
R5969	T10513	T10510	prep	of,differentiation
R5970	T10514	T10515	npadvmod	organ,specific
R5971	T10515	T10517	amod	specific,structures
R5972	T10516	T10515	punct	-,specific
R5973	T10517	T10513	pobj	structures,of
R5974	T10518	T10517	amod	proximal,structures
R5975	T10519	T10518	cc	and,proximal
R5976	T10520	T10518	conj	distal,proximal
R5977	T10521	T10522	punct	[,35
R5978	T10522	T10466	parataxis	35,involve
R5979	T10523	T10522	nummod	34,35
R5980	T10524	T10522	punct	",",35
R5981	T10525	T10522	punct	],35
R5982	T10526	T10447	punct	.,subdivided
R5983	T10528	T10529	prep	In,expanded
R5984	T10530	T10528	pobj	contrast,In
R5985	T10531	T10530	prep	to,contrast
R5986	T10532	T10533	amod	other,processes
R5987	T10533	T10531	pobj	processes,to
R5988	T10534	T10533	compound	invagination,processes
R5989	T10535	T10533	prep	during,processes
R5990	T10536	T10535	pobj	embryogenesis,during
R5991	T10537	T10533	punct	", ",processes
R5992	T10538	T10539	amod	such,as
R5993	T10539	T10533	prep	as,processes
R5994	T10540	T10541	amod	mammary,formation
R5995	T10541	T10539	pobj	formation,as
R5996	T10542	T10541	compound	gland,formation
R5997	T10543	T10529	punct	", ",expanded
R5998	T10544	T10545	det	the,lumen
R5999	T10545	T10529	nsubjpass	lumen,expanded
R6000	T10546	T10545	prep	of,lumen
R6001	T10547	T10548	det	the,lungs
R6002	T10548	T10546	pobj	lungs,of
R6003	T10549	T10529	auxpass	is,expanded
R6004	T10550	T10529	prep	by,expanded
R6005	T10551	T10552	amod	successive,events
R6006	T10552	T10550	pobj	events,by
R6007	T10553	T10552	compound	branching,events
R6008	T10554	T10552	punct	", ",events
R6009	T10555	T10556	compound	branch,outgrowth
R6010	T10556	T10552	conj	outgrowth,events
R6011	T10557	T10556	cc	and,outgrowth
R6012	T10558	T10556	conj	elongation,outgrowth
R6013	T10559	T10550	punct	", ",by
R6014	T10560	T10561	advmod	rather,than
R6015	T10561	T10550	cc	than,by
R6016	T10562	T10550	conj	by,by
R6017	T10563	T10562	pobj	apoptosis,by
R6018	T10564	T10565	punct	[,36
R6019	T10565	T10529	parataxis	36,expanded
R6020	T10566	T10565	nummod	34,36
R6021	T10567	T10565	punct	",",36
R6022	T10568	T10565	punct	],36
R6023	T10569	T10529	punct	.,expanded
R6024	T10571	T10572	advmod	Finally,is
R6025	T10573	T10572	punct	", ",is
R6026	T10574	T10575	mark	because,expanded
R6027	T10575	T10572	advcl	expanded,is
R6028	T10576	T10577	det	the,lungs
R6029	T10577	T10575	nsubjpass	lungs,expanded
R6030	T10578	T10577	prep	of,lungs
R6031	T10579	T10580	nmod	Ptdsr,neonates
R6032	T10580	T10578	pobj	neonates,of
R6033	T10581	T10579	punct	-,Ptdsr
R6034	T10582	T10579	punct	/,Ptdsr
R6035	T10583	T10579	punct	-,Ptdsr
R6036	T10584	T10575	auxpass	were,expanded
R6037	T10585	T10575	advmod	almost,expanded
R6038	T10586	T10575	advmod	fully,expanded
R6039	T10587	T10575	cc	and,expanded
R6040	T10588	T10575	conj	appeared,expanded
R6041	T10589	T10588	oprd	normal,appeared
R6042	T10590	T10588	prep	in,appeared
R6043	T10591	T10590	pobj	structure,in
R6044	T10592	T10588	prep	in,appeared
R6045	T10593	T10592	pobj	comparison,in
R6046	T10594	T10593	prep	to,comparison
R6047	T10595	T10596	amod	wild,type
R6048	T10596	T10598	compound	type,littermates
R6049	T10597	T10596	punct	-,type
R6050	T10598	T10594	pobj	littermates,to
R6051	T10599	T10572	punct	", ",is
R6052	T10600	T10572	nsubj	it,is
R6053	T10601	T10602	advmod	highly,unlikely
R6054	T10602	T10572	acomp	unlikely,is
R6055	T10603	T10604	mark	that,die
R6056	T10604	T10572	ccomp	die,is
R6057	T10605	T10606	compound	Ptdsr,mutants
R6058	T10606	T10604	nsubj	mutants,die
R6059	T10607	T10604	prep	of,die
R6060	T10608	T10609	amod	respiratory,failure
R6061	T10609	T10607	pobj	failure,of
R6062	T10610	T10609	compound	lung,failure
R6063	T10611	T10572	punct	.,is
R6064	T10613	T10614	prep	In,demonstrated
R6065	T10615	T10613	pobj	addition,In
R6066	T10616	T10614	punct	", ",demonstrated
R6067	T10617	T10614	nsubj	Li,demonstrated
R6068	T10618	T10617	cc	and,Li
R6069	T10619	T10617	conj	colleagues,Li
R6070	T10620	T10621	punct	[,31
R6071	T10621	T10619	parataxis	31,colleagues
R6072	T10622	T10621	punct	],31
R6073	T10623	T10624	mark	that,is
R6074	T10624	T10614	ccomp	is,demonstrated
R6075	T10625	T10626	amod	surfactant,expression
R6076	T10626	T10624	nsubj	expression,is
R6077	T10627	T10624	acomp	normal,is
R6078	T10628	T10624	prep	in,is
R6079	T10629	T10630	npadvmod	Ptdsr,deficient
R6080	T10630	T10632	amod	deficient,animals
R6081	T10631	T10630	punct	-,deficient
R6082	T10632	T10628	pobj	animals,in
R6083	T10633	T10624	punct	", ",is
R6084	T10634	T10624	advcl	supporting,is
R6085	T10635	T10636	det	the,idea
R6086	T10636	T10634	dobj	idea,supporting
R6087	T10637	T10636	prep	of,idea
R6088	T10638	T10639	amod	normal,maturation
R6089	T10639	T10637	pobj	maturation,of
R6090	T10640	T10639	prep	of,maturation
R6091	T10641	T10642	npadvmod	surfactant,producing
R6092	T10642	T10644	amod	producing,cells
R6093	T10643	T10642	punct	-,producing
R6094	T10644	T10640	pobj	cells,of
R6095	T10645	T10644	nmod	type,cells
R6096	T10646	T10645	nummod	II,type
R6097	T10647	T10644	amod	alveolar,cells
R6098	T10648	T10644	amod	epithelial,cells
R6099	T10649	T10644	cc	and,cells
R6100	T10650	T10651	compound	lung,function
R6101	T10651	T10644	conj	function,cells
R6102	T10652	T10614	punct	.,demonstrated
R6103	T10654	T10655	amod	Other,defects
R6104	T10655	T10656	nsubj	defects,be
R6105	T10657	T10656	aux	must,be
R6106	T10658	T10656	advmod	therefore,be
R6107	T10659	T10656	acomp	responsible,be
R6108	T10660	T10659	prep	for,responsible
R6109	T10661	T10662	det	the,death
R6110	T10662	T10660	pobj	death,for
R6111	T10663	T10662	prep	of,death
R6112	T10664	T10665	compound	Ptdsr,mutant
R6113	T10665	T10667	compound	mutant,mice
R6114	T10666	T10665	punct	-,mutant
R6115	T10667	T10663	pobj	mice,of
R6116	T10668	T10656	punct	.,be
R6117	T10670	T10671	det	The,edema
R6118	T10671	T10675	nsubj	edema,gave
R6119	T10672	T10673	advmod	frequently,observed
R6120	T10673	T10671	amod	observed,edema
R6121	T10674	T10671	amod	subcutaneous,edema
R6122	T10676	T10671	prep	of,edema
R6123	T10677	T10678	amod	various,extents
R6124	T10678	T10676	pobj	extents,of
R6125	T10679	T10671	prep	in,edema
R6126	T10680	T10681	npadvmod	Ptdsr,deficient
R6127	T10681	T10683	amod	deficient,homozygotes
R6128	T10682	T10681	punct	-,deficient
R6129	T10683	T10679	pobj	homozygotes,in
R6130	T10684	T10675	dative	us,gave
R6131	T10685	T10686	det	a,hint
R6132	T10686	T10675	dobj	hint,gave
R6133	T10687	T10688	mark	that,associated
R6134	T10688	T10686	acl	associated,hint
R6135	T10689	T10690	compound	Ptdsr,deficiency
R6136	T10690	T10688	nsubjpass	deficiency,associated
R6137	T10691	T10690	punct	-,deficiency
R6138	T10692	T10690	cc	and,deficiency
R6139	T10693	T10690	conj	lethality,deficiency
R6140	T10694	T10688	aux	might,associated
R6141	T10695	T10688	auxpass	be,associated
R6142	T10696	T10688	prep	with,associated
R6143	T10697	T10698	amod	cardiovascular,problems
R6144	T10698	T10696	pobj	problems,with
R6145	T10699	T10675	punct	.,gave
R6146	T10701	T10702	advmod	Indeed,obtained
R6147	T10703	T10702	punct	", ",obtained
R6148	T10704	T10705	advmod	very,recently
R6149	T10705	T10702	advmod	recently,obtained
R6150	T10706	T10702	nsubj	we,obtained
R6151	T10707	T10702	aux	have,obtained
R6152	T10708	T10709	amod	strong,evidence
R6153	T10709	T10702	dobj	evidence,obtained
R6154	T10710	T10711	mark	that,die
R6155	T10711	T10709	acl	die,evidence
R6156	T10712	T10713	compound	Ptdsr,knockout
R6157	T10713	T10715	compound	knockout,mice
R6158	T10714	T10713	punct	-,knockout
R6159	T10715	T10711	nsubj	mice,die
R6160	T10716	T10711	prep	as,die
R6161	T10717	T10718	det	a,result
R6162	T10718	T10716	pobj	result,as
R6163	T10719	T10718	prep	of,result
R6164	T10720	T10719	pobj	defects,of
R6165	T10721	T10720	prep	in,defects
R6166	T10722	T10723	compound	heart,development
R6167	T10723	T10721	pobj	development,in
R6168	T10724	T10725	dep	that,associated
R6169	T10725	T10720	relcl	associated,defects
R6170	T10726	T10725	auxpass	are,associated
R6171	T10727	T10725	prep	with,associated
R6172	T10728	T10729	amod	specific,malformations
R6173	T10729	T10727	pobj	malformations,with
R6174	T10730	T10729	amod	cardiopulmonary,malformations
R6175	T10731	T10702	punct	;,obtained
R6176	T10732	T10733	punct	(,J.E.
R6177	T10733	T10702	meta	J.E.,obtained
R6178	T10734	T10733	nmod	Schneider,J.E.
R6179	T10735	T10733	punct	", ",J.E.
R6180	T10736	T10733	conj	J.B.,J.E.
R6181	T10737	T10736	punct	", ",J.B.
R6182	T10738	T10736	conj	S.D.,J.B.
R6183	T10739	T10738	nmod	Bamfort,S.D.
R6184	T10740	T10738	punct	", ",S.D.
R6185	T10741	T10738	conj	A.D.G.,S.D.
R6186	T10742	T10741	punct	", ",A.D.G.
R6187	T10743	T10741	conj	C.,A.D.G.
R6188	T10744	T10743	nmod	Broadbent,C.
R6189	T10745	T10743	punct	", ",C.
R6190	T10746	T10743	conj	K.,C.
R6191	T10747	T10746	nmod	Clarke,K.
R6192	T10748	T10746	punct	", ",K.
R6193	T10749	T10746	conj	S.,K.
R6194	T10750	T10749	nmod	Neubauer,S.
R6195	T10751	T10749	punct	", ",S.
R6196	T10752	T10749	conj	A.L.,S.
R6197	T10753	T10752	cc	and,A.L.
R6198	T10754	T10752	conj	S.,A.L.
R6199	T10755	T10754	nmod	Battacharya,S.
R6200	T10756	T10754	punct	", ",S.
R6201	T10757	T10758	amod	unpublished,observations
R6202	T10758	T10754	conj	observations,S.
R6203	T10759	T10758	punct	),observations
R6204	T10760	T10702	punct	.,obtained
R6205	T10762	T10763	prep	In,demonstrate
R6206	T10764	T10762	pobj	addition,In
R6207	T10765	T10763	punct	", ",demonstrate
R6208	T10766	T10763	nsubj	we,demonstrate
R6209	T10767	T10768	mark	that,requires
R6210	T10768	T10763	ccomp	requires,demonstrate
R6211	T10769	T10770	compound	eye,development
R6212	T10770	T10768	nsubj	development,requires
R6213	T10771	T10772	det	a,gene
R6214	T10772	T10768	dobj	gene,requires
R6215	T10773	T10772	amod	functional,gene
R6216	T10774	T10772	compound	Ptdsr,gene
R6217	T10775	T10763	punct	.,demonstrate
R6218	T10777	T10778	npadvmod	Ptdsr,deficient
R6219	T10778	T10780	amod	deficient,embryos
R6220	T10779	T10778	punct	-,deficient
R6221	T10780	T10781	nsubjpass	embryos,divided
R6222	T10782	T10781	aux	can,divided
R6223	T10783	T10781	auxpass	be,divided
R6224	T10784	T10781	advmod	roughly,divided
R6225	T10785	T10781	prep	into,divided
R6226	T10786	T10787	nummod	two,categories
R6227	T10787	T10785	pobj	categories,into
R6228	T10788	T10781	punct	.,divided
R6229	T10790	T10791	det	The,group
R6230	T10791	T10796	nsubj	group,develops
R6231	T10792	T10791	amod	first,group
R6232	T10793	T10791	punct	", ",group
R6233	T10794	T10795	advmod	severely,affected
R6234	T10795	T10791	amod	affected,group
R6235	T10797	T10796	dobj	anophthalmia,develops
R6236	T10798	T10799	dep	that,correlates
R6237	T10799	T10797	relcl	correlates,anophthalmia
R6238	T10800	T10799	prep	with,correlates
R6239	T10801	T10800	pobj	formation,with
R6240	T10802	T10801	prep	of,formation
R6241	T10803	T10804	amod	ectopic,epithelium
R6242	T10804	T10802	pobj	epithelium,of
R6243	T10805	T10806	amod	retinal,pigmented
R6244	T10806	T10804	amod	pigmented,epithelium
R6245	T10807	T10806	punct	-,pigmented
R6246	T10808	T10804	cc	and,epithelium
R6247	T10809	T10804	conj	induction,epithelium
R6248	T10810	T10809	prep	of,induction
R6249	T10811	T10810	pobj	proliferation,of
R6250	T10812	T10811	prep	of,proliferation
R6251	T10813	T10814	amod	underlying,mesenchyme
R6252	T10814	T10812	pobj	mesenchyme,of
R6253	T10815	T10801	prep	in,formation
R6254	T10816	T10817	det	the,cavity
R6255	T10817	T10815	pobj	cavity,in
R6256	T10818	T10817	amod	nasal,cavity
R6257	T10819	T10796	punct	.,develops
R6258	T10821	T10822	det	This,phenotype
R6259	T10822	T10823	nsubj	phenotype,represents
R6260	T10824	T10825	det	a,lesion
R6261	T10825	T10823	dobj	lesion,represents
R6262	T10826	T10827	advmod	completely,novel
R6263	T10827	T10825	amod	novel,lesion
R6264	T10828	T10829	dep	that,described
R6265	T10829	T10825	relcl	described,lesion
R6266	T10830	T10829	prep	to,described
R6267	T10831	T10832	poss	our,knowledge
R6268	T10832	T10830	pobj	knowledge,to
R6269	T10833	T10829	aux	has,described
R6270	T10834	T10829	neg	not,described
R6271	T10835	T10829	auxpass	been,described
R6272	T10836	T10829	advmod	before,described
R6273	T10837	T10829	prep	in,described
R6274	T10838	T10839	det	any,mutant
R6275	T10839	T10837	pobj	mutant,in
R6276	T10840	T10839	amod	other,mutant
R6277	T10841	T10839	compound	mouse,mutant
R6278	T10842	T10823	punct	.,represents
R6279	T10844	T10845	det	The,group
R6280	T10845	T10847	nsubj	group,shows
R6281	T10846	T10845	amod	second,group
R6282	T10848	T10849	amod	normal,structures
R6283	T10849	T10847	dobj	structures,shows
R6284	T10850	T10849	amod	external,structures
R6285	T10851	T10849	compound	eye,structures
R6286	T10852	T10847	punct	", ",shows
R6287	T10853	T10854	mark	although,delayed
R6288	T10854	T10847	advcl	delayed,shows
R6289	T10855	T10854	prep	in,delayed
R6290	T10856	T10857	det	this,case
R6291	T10857	T10855	pobj	case,in
R6292	T10858	T10859	amod	retinal,development
R6293	T10859	T10854	nsubjpass	development,delayed
R6294	T10860	T10854	auxpass	is,delayed
R6295	T10861	T10854	advmod	temporally,delayed
R6296	T10862	T10854	prep	during,delayed
R6297	T10863	T10862	pobj	mid-gestation,during
R6298	T10864	T10854	punct	", ",delayed
R6299	T10865	T10854	prep	with,delayed
R6300	T10866	T10867	amod	persistent,morphogenesis
R6301	T10867	T10865	pobj	morphogenesis,with
R6302	T10868	T10867	punct	", ",morphogenesis
R6303	T10869	T10867	amod	abnormal,morphogenesis
R6304	T10870	T10867	prep	of,morphogenesis
R6305	T10871	T10872	det	the,layer
R6306	T10872	T10870	pobj	layer,of
R6307	T10873	T10872	amod	inner,layer
R6308	T10874	T10872	amod	granular,layer
R6309	T10875	T10872	amod	retinal,layer
R6310	T10876	T10867	prep	at,morphogenesis
R6311	T10877	T10878	amod	later,stages
R6312	T10878	T10876	pobj	stages,at
R6313	T10879	T10878	prep	of,stages
R6314	T10880	T10879	pobj	embryogenesis,of
R6315	T10881	T10847	punct	.,shows
R6316	T10883	T10884	det	A,explanation
R6317	T10884	T10886	nsubjpass	explanation,found
R6318	T10885	T10884	amod	possible,explanation
R6319	T10887	T10884	prep	for,explanation
R6320	T10888	T10889	det	these,phenotypes
R6321	T10889	T10887	pobj	phenotypes,for
R6322	T10890	T10889	nummod	two,phenotypes
R6323	T10891	T10886	aux	can,found
R6324	T10892	T10886	auxpass	be,found
R6325	T10893	T10886	prep	in,found
R6326	T10894	T10895	det	the,pattern
R6327	T10895	T10893	pobj	pattern,in
R6328	T10896	T10895	compound	expression,pattern
R6329	T10897	T10895	prep	of,pattern
R6330	T10898	T10899	det	the,gene
R6331	T10899	T10897	pobj	gene,of
R6332	T10900	T10899	compound	Ptdsr,gene
R6333	T10901	T10886	punct	.,found
R6334	T10903	T10904	advmod	Initially,expressed
R6335	T10905	T10904	punct	", ",expressed
R6336	T10906	T10904	nsubjpass	Ptdsr,expressed
R6337	T10907	T10904	auxpass	is,expressed
R6338	T10908	T10904	prep	throughout,expressed
R6339	T10909	T10910	det	the,system
R6340	T10910	T10908	pobj	system,throughout
R6341	T10911	T10910	amod	whole,system
R6342	T10912	T10910	amod	developing,system
R6343	T10913	T10910	amod	nervous,system
R6344	T10914	T10904	punct	", ",expressed
R6345	T10915	T10904	prep	with,expressed
R6346	T10916	T10917	advmod	exceptionally,high
R6347	T10917	T10918	amod	high,levels
R6348	T10918	T10915	pobj	levels,with
R6349	T10919	T10918	prep	in,levels
R6350	T10920	T10921	det	the,part
R6351	T10921	T10919	pobj	part,in
R6352	T10922	T10921	amod	anterior,part
R6353	T10923	T10921	prep	of,part
R6354	T10924	T10925	det	the,forebrain
R6355	T10925	T10923	pobj	forebrain,of
R6356	T10926	T10904	punct	.,expressed
R6357	T10928	T10929	amod	Later,expression
R6358	T10929	T10930	nsubj	expression,becomes
R6359	T10931	T10932	advmod	more,restricted
R6360	T10932	T10930	acomp	restricted,becomes
R6361	T10933	T10932	prep	to,restricted
R6362	T10934	T10935	det	the,retina
R6363	T10935	T10933	pobj	retina,to
R6364	T10936	T10935	amod	developing,retina
R6365	T10937	T10935	cc	and,retina
R6366	T10938	T10935	conj	lens,retina
R6367	T10939	T10930	punct	.,becomes
R6368	T10941	T10942	advmod	Thus,play
R6369	T10943	T10942	punct	", ",play
R6370	T10944	T10942	nsubj	Ptdsr,play
R6371	T10945	T10942	aux	might,play
R6372	T10946	T10947	det	an,role
R6373	T10947	T10942	dobj	role,play
R6374	T10948	T10947	amod	important,role
R6375	T10949	T10942	prep	in,play
R6376	T10950	T10951	amod	early,events
R6377	T10951	T10949	pobj	events,in
R6378	T10952	T10951	prep	of,events
R6379	T10953	T10954	amod	ocular,morphogenesis
R6380	T10954	T10952	pobj	morphogenesis,of
R6381	T10955	T10951	punct	", ",events
R6382	T10956	T10957	amod	such,as
R6383	T10957	T10951	prep	as,events
R6384	T10958	T10957	pobj	establishment,as
R6385	T10959	T10958	cc	and,establishment
R6386	T10960	T10958	conj	bisection,establishment
R6387	T10961	T10958	prep	of,establishment
R6388	T10962	T10963	compound	eye,fields
R6389	T10963	T10961	pobj	fields,of
R6390	T10964	T10958	cc	and,establishment
R6391	T10965	T10958	conj	formation,establishment
R6392	T10966	T10965	prep	of,formation
R6393	T10967	T10968	amod	optic,cups
R6394	T10968	T10966	pobj	cups,of
R6395	T10969	T10942	punct	.,play
R6396	T10971	T10972	det	These,steps
R6397	T10972	T10977	nsubjpass	steps,interconnected
R6398	T10973	T10972	amod	early,steps
R6399	T10974	T10975	compound	eye,formation
R6400	T10975	T10972	compound	formation,steps
R6401	T10976	T10975	punct	-,formation
R6402	T10978	T10977	auxpass	are,interconnected
R6403	T10979	T10977	advmod	closely,interconnected
R6404	T10980	T10977	prep	with,interconnected
R6405	T10981	T10980	pobj	development,with
R6406	T10982	T10981	prep	of,development
R6407	T10983	T10984	det	the,forebrain
R6408	T10984	T10982	pobj	forebrain,of
R6409	T10985	T10986	punct	[,38
R6410	T10986	T10984	parataxis	38,forebrain
R6411	T10987	T10986	nummod	37,38
R6412	T10988	T10986	punct	",",38
R6413	T10989	T10986	punct	],38
R6414	T10990	T10984	cc	and,forebrain
R6415	T10991	T10992	det	the,nose
R6416	T10992	T10984	conj	nose,forebrain
R6417	T10993	T10994	punct	[,39
R6418	T10994	T10992	parataxis	39,nose
R6419	T10995	T10996	punct	-,41
R6420	T10996	T10994	prep	41,39
R6421	T10997	T10994	punct	],39
R6422	T10998	T10977	punct	.,interconnected
R6423	T11000	T11001	advmod	Interestingly,observed
R6424	T11002	T11001	punct	", ",observed
R6425	T11003	T11001	nsubj	we,observed
R6426	T11004	T11001	advmod	occasionally,observed
R6427	T11005	T11006	amod	serious,malformations
R6428	T11006	T11001	dobj	malformations,observed
R6429	T11007	T11006	prep	of,malformations
R6430	T11008	T11007	pobj	forebrain,of
R6431	T11009	T11008	cc	and,forebrain
R6432	T11010	T11011	amod	nasal,structures
R6433	T11011	T11008	conj	structures,forebrain
R6434	T11012	T11006	prep	in,malformations
R6435	T11013	T11014	compound	Ptdsr,knockout
R6436	T11014	T11016	compound	knockout,embryos
R6437	T11015	T11014	punct	-,knockout
R6438	T11016	T11012	pobj	embryos,in
R6439	T11017	T11018	dep	that,associated
R6440	T11018	T11006	relcl	associated,malformations
R6441	T11019	T11018	auxpass	were,associated
R6442	T11020	T11018	prep	with,associated
R6443	T11021	T11022	amod	bilateral,anophthalmia
R6444	T11022	T11020	pobj	anophthalmia,with
R6445	T11023	T11024	punct	(,see
R6446	T11024	T11001	parataxis	see,observed
R6447	T11025	T11024	prep	for,see
R6448	T11026	T11025	pobj	example,for
R6449	T11027	T11028	det	the,embryo
R6450	T11028	T11024	dobj	embryo,see
R6451	T11029	T11028	compound	mutant,embryo
R6452	T11030	T11028	prep	in,embryo
R6453	T11031	T11032	compound	Figure,1g
R6454	T11032	T11030	pobj	1g,in
R6455	T11033	T11024	punct	),see
R6456	T11034	T11001	punct	.,observed
R6457	T11036	T11037	nsubj	This,suggests
R6458	T11038	T11039	mark	that,involved
R6459	T11039	T11037	advcl	involved,suggests
R6460	T11040	T11039	nsubjpass	Ptdsr,involved
R6461	T11041	T11039	auxpass	is,involved
R6462	T11042	T11039	prep	in,involved
R6463	T11043	T11044	det	the,regulation
R6464	T11044	T11042	pobj	regulation,in
R6465	T11045	T11044	prep	of,regulation
R6466	T11046	T11047	compound	differentiation,processes
R6467	T11047	T11045	pobj	processes,of
R6468	T11048	T11044	prep	within,regulation
R6469	T11049	T11050	compound	forebrain,regions
R6470	T11050	T11048	pobj	regions,within
R6471	T11051	T11039	punct	", ",involved
R6472	T11052	T11039	cc	and,involved
R6473	T11053	T11054	mark	that,affect
R6474	T11054	T11039	conj	affect,involved
R6475	T11055	T11054	nsubj	ablation,affect
R6476	T11056	T11055	prep	of,ablation
R6477	T11057	T11058	compound	Ptdsr,function
R6478	T11058	T11056	pobj	function,of
R6479	T11059	T11054	aux	might,affect
R6480	T11060	T11054	advmod	secondarily,affect
R6481	T11061	T11062	amod	early,formation
R6482	T11062	T11054	dobj	formation,affect
R6483	T11063	T11062	compound	eye,formation
R6484	T11064	T11037	punct	.,suggests
R6485	T11066	T11067	nsubj	Li,found
R6486	T11068	T11069	advmod	et,al.
R6487	T11069	T11066	advmod	al.,Li
R6488	T11070	T11071	punct	[,31
R6489	T11071	T11066	parataxis	31,Li
R6490	T11072	T11071	punct	],31
R6491	T11073	T11074	amod	smaller,lenses
R6492	T11074	T11067	dobj	lenses,found
R6493	T11075	T11074	prep	in,lenses
R6494	T11076	T11077	compound	Ptdsr,knockout
R6495	T11077	T11079	compound	knockout,mice
R6496	T11078	T11077	punct	-,knockout
R6497	T11079	T11075	pobj	mice,in
R6498	T11080	T11067	cc	and,found
R6499	T11081	T11067	conj	described,found
R6500	T11082	T11083	det	the,formation
R6501	T11083	T11081	dobj	formation,described
R6502	T11084	T11083	prep	of,formation
R6503	T11085	T11086	amod	retinal,protrusions
R6504	T11086	T11084	pobj	protrusions,of
R6505	T11087	T11067	punct	", ",found
R6506	T11088	T11089	mark	although,reported
R6507	T11089	T11067	advcl	reported,found
R6508	T11090	T11089	nsubjpass	anophthalmia,reported
R6509	T11091	T11090	cc	and,anophthalmia
R6510	T11092	T11093	amod	specific,defects
R6511	T11093	T11090	conj	defects,anophthalmia
R6512	T11094	T11093	compound	differentiation,defects
R6513	T11095	T11093	prep	of,defects
R6514	T11096	T11097	amod	retinal,layers
R6515	T11097	T11095	pobj	layers,of
R6516	T11098	T11097	compound	cell,layers
R6517	T11099	T11089	auxpass	were,reported
R6518	T11100	T11089	neg	not,reported
R6519	T11101	T11089	prep	in,reported
R6520	T11102	T11103	poss	their,study
R6521	T11103	T11101	pobj	study,in
R6522	T11104	T11067	punct	.,found
R6523	T11106	T11107	nsubj	Li,proposed
R6524	T11108	T11109	advmod	et,al.
R6525	T11109	T11106	advmod	al.,Li
R6526	T11110	T11111	punct	[,31
R6527	T11111	T11107	parataxis	31,proposed
R6528	T11112	T11111	punct	],31
R6529	T11113	T11114	mark	that,explained
R6530	T11114	T11107	ccomp	explained,proposed
R6531	T11115	T11116	det	the,phenotype
R6532	T11116	T11114	nsubjpass	phenotype,explained
R6533	T11117	T11116	compound	eye,phenotype
R6534	T11118	T11119	nsubj	they,observed
R6535	T11119	T11116	advcl	observed,phenotype
R6536	T11120	T11114	aux	could,explained
R6537	T11121	T11114	auxpass	be,explained
R6538	T11122	T11114	prep	by,explained
R6539	T11123	T11124	amod	failed,removal
R6540	T11153	T11151	amod	comprehensive,analysis
R6541	T11124	T11122	pobj	removal,by
R6542	T11125	T11124	prep	of,removal
R6543	T11154	T11151	amod	kinetic,analysis
R6544	T11126	T11127	amod	apoptotic,cells
R6545	T11156	T11151	prep	of,analysis
R6546	T11157	T11158	compound	apoptosis,induction
R6547	T11158	T11156	pobj	induction,of
R6548	T11127	T11125	pobj	cells,of
R6549	T11159	T11158	prep	during,induction
R6550	T11160	T11161	compound	mouse,development
R6551	T11128	T11124	prep	during,removal
R6552	T11161	T11159	pobj	development,during
R6553	T11162	T11161	compound	retinal,development
R6554	T11163	T11164	nummod	four,peaks
R6555	T11164	T11155	dobj	peaks,described
R6556	T11165	T11164	amod	major,peaks
R6557	T11166	T11164	prep	of,peaks
R6558	T11129	T11130	compound	eye,development
R6559	T11167	T11168	amod	apoptotic,death
R6560	T11168	T11166	pobj	death,of
R6561	T11169	T11168	compound	cell,death
R6562	T11130	T11128	pobj	development,during
R6563	T11170	T11171	punct	[,42
R6564	T11171	T11155	parataxis	42,described
R6565	T11172	T11171	punct	],42
R6566	T11131	T11107	punct	", ",proposed
R6567	T11173	T11155	punct	.,described
R6568	T11132	T11107	cc	but,proposed
R6569	T11175	T11176	det	This,study
R6570	T11176	T11177	nsubj	study,demonstrated
R6571	T11133	T11134	nsubj	we,think
R6572	T11178	T11179	mark	that,is
R6573	T11179	T11177	ccomp	is,demonstrated
R6574	T11134	T11107	conj	think,proposed
R6575	T11180	T11179	expl	there,is
R6576	T11181	T11182	det	an,phase
R6577	T11135	T11136	mark	that,are
R6578	T11182	T11179	attr	phase,is
R6579	T11183	T11182	amod	initial,phase
R6580	T11184	T11182	prep	of,phase
R6581	T11136	T11134	ccomp	are,think
R6582	T11185	T11186	compound	cell,death
R6583	T11137	T11138	det	the,defects
R6584	T11186	T11184	pobj	death,of
R6585	T11187	T11179	prep	during,is
R6586	T11188	T11189	det	the,invagination
R6587	T11189	T11187	pobj	invagination,during
R6588	T11138	T11136	nsubj	defects,are
R6589	T11190	T11189	prep	of,invagination
R6590	T11191	T11192	det	the,cup
R6591	T11139	T11138	amod	observed,defects
R6592	T11192	T11190	pobj	cup,of
R6593	T11193	T11192	amod	optic,cup
R6594	T11194	T11195	punct	(,E10.5
R6595	T11140	T11136	acomp	unrelated,are
R6596	T11195	T11189	parataxis	E10.5,invagination
R6597	T11196	T11195	punct	),E10.5
R6598	T11197	T11179	punct	", ",is
R6599	T11141	T11140	prep	to,unrelated
R6600	T11198	T11179	advcl	followed,is
R6601	T11199	T11198	agent	by,followed
R6602	T11200	T11201	amod	subsequent,waves
R6603	T11142	T11143	det	a,failure
R6604	T11201	T11199	pobj	waves,by
R6605	T11202	T11201	prep	of,waves
R6606	T11143	T11141	pobj	failure,to
R6607	T11203	T11204	compound	apoptosis,induction
R6608	T11204	T11202	pobj	induction,of
R6609	T11205	T11206	advmod	immediately,before
R6610	T11206	T11201	prep	before,waves
R6611	T11207	T11206	cc	and,before
R6612	T11208	T11206	conj	after,before
R6613	T11144	T11143	prep	of,failure
R6614	T11209	T11208	pobj	birth,after
R6615	T11210	T11211	punct	(,E18.5
R6616	T11211	T11209	parataxis	E18.5,birth
R6617	T11145	T11146	amod	apoptotic,cell
R6618	T11212	T11211	prep	to,E18.5
R6619	T11213	T11214	amod	postnatal,day
R6620	T11214	T11212	pobj	day,to
R6621	T11146	T11147	compound	cell,clearance
R6622	T11215	T11214	appos	P2,day
R6623	T11216	T11211	punct	),E18.5
R6624	T11147	T11144	pobj	clearance,of
R6625	T11217	T11206	punct	", ",before
R6626	T11218	T11206	cc	and,before
R6627	T11219	T11206	conj	from,before
R6628	T11148	T11134	punct	.,think
R6629	T11220	T11221	amod	postnatal,P9
R6630	T11221	T11219	pobj	P9,from
R6631	T11150	T11151	det	A,analysis
R6632	T11222	T11221	compound	days,P9
R6633	T11223	T11221	prep	to,P9
R6634	T11151	T11155	nsubj	analysis,described
R6635	T11224	T11223	pobj	P10,to
R6636	T11152	T11151	amod	recent,analysis
R6637	T11259	T11260	amod	retinal,apoptosis
R6638	T11225	T11221	cc	and,P9
R6639	T11226	T11221	conj	P14,P9
R6640	T11260	T11258	pobj	apoptosis,of
R6641	T11227	T11226	prep	to,P14
R6642	T11228	T11227	pobj	P16,to
R6643	T11229	T11230	punct	[,42
R6644	T11261	T11260	compound	cell,apoptosis
R6645	T11230	T11177	parataxis	42,demonstrated
R6646	T11231	T11230	punct	],42
R6647	T11262	T11235	dobj	place,take
R6648	T11232	T11177	punct	.,demonstrated
R6649	T11263	T11235	advmod	only,take
R6650	T11234	T11235	advmod	Thus,take
R6651	T11264	T11235	advmod	postnatally,take
R6652	T11236	T11235	punct	", ",take
R6653	T11237	T11235	prep	besides,take
R6654	T11238	T11239	det	the,formation
R6655	T11265	T11235	cc	and,take
R6656	T11239	T11237	pobj	formation,besides
R6657	T11240	T11239	prep	of,formation
R6658	T11266	T11235	conj	correspond,take
R6659	T11241	T11242	det	the,layers
R6660	T11242	T11240	pobj	layers,of
R6661	T11243	T11242	amod	inner,layers
R6662	T11244	T11243	cc	and,inner
R6663	T11245	T11243	conj	outer,inner
R6664	T11246	T11242	prep	of,layers
R6665	T11267	T11266	prep	to,correspond
R6666	T11247	T11248	det	the,cup
R6667	T11248	T11246	pobj	cup,of
R6668	T11249	T11248	amod	optic,cup
R6669	T11268	T11269	amod	important,periods
R6670	T11250	T11242	prep	in,layers
R6671	T11251	T11252	amod	early,development
R6672	T11252	T11250	pobj	development,in
R6673	T11269	T11267	pobj	periods,to
R6674	T11253	T11252	compound	eye,development
R6675	T11254	T11235	punct	", ",take
R6676	T11270	T11269	prep	in,periods
R6677	T11255	T11256	amod	other,phases
R6678	T11256	T11235	nsubj	phases,take
R6679	T11257	T11256	amod	major,phases
R6680	T11271	T11272	det	the,establishment
R6681	T11258	T11256	prep	of,phases
R6682	T11272	T11270	pobj	establishment,in
R6683	T11273	T11272	prep	of,establishment
R6684	T11274	T11275	amod	neuronal,connections
R6685	T11275	T11273	pobj	connections,of
R6686	T11366	T11364	prep	with,Consistent
R6687	T11276	T11235	punct	.,take
R6688	T11367	T11368	det	the,results
R6689	T11368	T11366	pobj	results,with
R6690	T11369	T11368	prep	of,results
R6691	T11278	T11279	advmod	Furthermore,occurs
R6692	T11370	T11369	pobj	Li,of
R6693	T11371	T11372	advmod	et,al.
R6694	T11372	T11370	advmod	al.,Li
R6695	T11280	T11279	punct	", ",occurs
R6696	T11373	T11374	punct	[,31
R6697	T11374	T11364	parataxis	31,Consistent
R6698	T11375	T11374	punct	],31
R6699	T11376	T11365	punct	", ",found
R6700	T11281	T11282	compound	cell,death
R6701	T11377	T11365	nsubj	we,found
R6702	T11378	T11379	amod	particular,malformations
R6703	T11282	T11279	nsubj	death,occurs
R6704	T11379	T11365	dobj	malformations,found
R6705	T11380	T11379	compound	brain,malformations
R6706	T11381	T11365	prep	in,found
R6707	T11283	T11282	prep	during,death
R6708	T11382	T11383	poss	our,mice
R6709	T11383	T11381	pobj	mice,in
R6710	T11384	T11383	nmod	Ptdsr,mice
R6711	T11385	T11384	punct	-,Ptdsr
R6712	T11386	T11384	punct	/,Ptdsr
R6713	T11387	T11384	punct	-,Ptdsr
R6714	T11284	T11285	amod	normal,development
R6715	T11388	T11365	punct	.,found
R6716	T11390	T11391	nmod	Exencephaly,phenotypes
R6717	T11285	T11283	pobj	development,during
R6718	T11391	T11395	nsubjpass	phenotypes,observed
R6719	T11392	T11390	cc	and,Exencephaly
R6720	T11393	T11394	amod	hyperplastic,brain
R6721	T11286	T11285	amod	retinal,development
R6722	T11394	T11390	conj	brain,Exencephaly
R6723	T11396	T11395	auxpass	were,observed
R6724	T11287	T11279	prep	in,occurs
R6725	T11397	T11395	prep	at,observed
R6726	T11288	T11289	amod	retinal,layers
R6727	T11398	T11399	det	a,penetrance
R6728	T11399	T11397	pobj	penetrance,at
R6729	T11289	T11287	pobj	layers,in
R6730	T11400	T11399	amod	low,penetrance
R6731	T11401	T11395	prep	in,observed
R6732	T11402	T11403	compound	Ptdsr,mutant
R6733	T11290	T11289	amod	distinct,layers
R6734	T11403	T11405	compound	mutant,mice
R6735	T11404	T11403	punct	-,mutant
R6736	T11405	T11401	pobj	mice,in
R6737	T11291	T11290	prep	from,distinct
R6738	T11406	T11407	punct	(,%
R6739	T11292	T11293	det	the,layer
R6740	T11407	T11395	parataxis	%,observed
R6741	T11408	T11409	advmod	less,4.5
R6742	T11409	T11407	nummod	4.5,%
R6743	T11410	T11409	quantmod	then,4.5
R6744	T11293	T11291	pobj	layer,from
R6745	T11411	T11407	prep	of,%
R6746	T11412	T11411	pobj	homozygotes,of
R6747	T11294	T11293	amod	inner,layer
R6748	T11413	T11407	punct	),%
R6749	T11414	T11395	punct	", ",observed
R6750	T11295	T11293	amod	granular,layer
R6751	T11415	T11395	cc	but,observed
R6752	T11416	T11417	nsubj	these,resemble
R6753	T11417	T11395	conj	resemble,observed
R6754	T11296	T11297	advmod	where,observed
R6755	T11418	T11417	aux	do,resemble
R6756	T11419	T11417	neg	not,resemble
R6757	T11420	T11417	prep	to,resemble
R6758	T11297	T11293	relcl	observed,layer
R6759	T11421	T11422	det	any,extent
R6760	T11422	T11420	pobj	extent,to
R6761	T11423	T11424	det	the,phenotypes
R6762	T11298	T11297	nsubj	we,observed
R6763	T11424	T11417	dobj	phenotypes,resemble
R6764	T11425	T11426	compound	brain,overgrowth
R6765	T11426	T11424	compound	overgrowth,phenotypes
R6766	T11427	T11426	punct	-,overgrowth
R6767	T11428	T11424	prep	of,phenotypes
R6768	T11429	T11430	nmod	caspase,knockout
R6769	T11430	T11435	compound	knockout,mice
R6770	T11299	T11300	det	the,defects
R6771	T11431	T11429	punct	-,caspase
R6772	T11432	T11429	cc	or,caspase
R6773	T11433	T11429	conj	Apaf1,caspase
R6774	T11300	T11297	dobj	defects,observed
R6775	T11434	T11430	punct	-,knockout
R6776	T11435	T11428	pobj	mice,of
R6777	T11436	T11437	punct	(,44
R6778	T11301	T11302	advmod	most,pronounced
R6779	T11437	T11424	parataxis	44,phenotypes
R6780	T11438	T11437	punct	[,44
R6781	T11439	T11437	punct	],44
R6782	T11302	T11300	amod	pronounced,defects
R6783	T11440	T11437	punct	", ",44
R6784	T11441	T11437	cc	and,44
R6785	T11303	T11300	compound	differentiation,defects
R6786	T11442	T11437	conj	references,44
R6787	T11443	T11442	advmod	therein,references
R6788	T11444	T11437	punct	),44
R6789	T11304	T11300	prep	in,defects
R6790	T11445	T11446	mark	in,failed
R6791	T11446	T11417	advcl	failed,resemble
R6792	T11447	T11446	mark	that,failed
R6793	T11305	T11306	det	the,mutants
R6794	T11448	T11446	nsubj	we,failed
R6795	T11449	T11450	aux	to,identify
R6796	T11306	T11304	pobj	mutants,in
R6797	T11450	T11446	xcomp	identify,failed
R6798	T11451	T11452	det	any,differences
R6799	T11452	T11450	dobj	differences,identify
R6800	T11307	T11306	nmod	Ptdsr,mutants
R6801	T11453	T11452	prep	in,differences
R6802	T11454	T11455	det	the,number
R6803	T11455	T11453	pobj	number,in
R6804	T11308	T11307	punct	-,Ptdsr
R6805	T11456	T11455	cc	or,number
R6806	T11457	T11455	conj	distribution,number
R6807	T11458	T11455	prep	of,number
R6808	T11309	T11307	punct	/,Ptdsr
R6809	T11459	T11460	amod	apoptotic,cells
R6810	T11460	T11458	pobj	cells,of
R6811	T11461	T11460	cc	or,cells
R6812	T11310	T11307	punct	-,Ptdsr
R6813	T11462	T11463	amod	pyknotic,clusters
R6814	T11463	T11460	conj	clusters,cells
R6815	T11464	T11463	compound	cell,clusters
R6816	T11465	T11450	prep	in,identify
R6817	T11466	T11467	det	the,neuroepithelium
R6818	T11467	T11465	pobj	neuroepithelium,in
R6819	T11311	T11306	acl	described,mutants
R6820	T11468	T11467	prep	of,neuroepithelium
R6821	T11469	T11470	nmod	Ptdsr,mice
R6822	T11312	T11311	advmod	here,described
R6823	T11313	T11279	punct	.,occurs
R6824	T11315	T11316	amod	Other,studies
R6825	T11316	T11317	nsubjpass	studies,interpreted
R6826	T11470	T11468	pobj	mice,of
R6827	T11471	T11469	punct	-,Ptdsr
R6828	T11318	T11319	dep	that,connect
R6829	T11472	T11469	punct	/,Ptdsr
R6830	T11473	T11469	punct	-,Ptdsr
R6831	T11474	T11469	cc	and,Ptdsr
R6832	T11475	T11469	conj	Ptdsr,Ptdsr
R6833	T11319	T11316	relcl	connect,studies
R6834	T11476	T11475	punct	+,Ptdsr
R6835	T11477	T11475	punct	/,Ptdsr
R6836	T11478	T11475	punct	+,Ptdsr
R6837	T11320	T11321	det	the,elimination
R6838	T11479	T11417	punct	.,resemble
R6839	T11321	T11319	dobj	elimination,connect
R6840	T11481	T11482	advmod	Thus,is
R6841	T11483	T11482	punct	", ",is
R6842	T11322	T11321	amod	postnatal,elimination
R6843	T11484	T11485	amod	reduced,death
R6844	T11485	T11482	nsubj	death,is
R6845	T11486	T11485	compound	cell,death
R6846	T11323	T11321	prep	of,elimination
R6847	T11487	T11485	cc	or,death
R6848	T11488	T11489	amod	diminished,clearance
R6849	T11324	T11325	amod	apoptotic,cells
R6850	T11489	T11485	conj	clearance,death
R6851	T11490	T11489	prep	of,clearance
R6852	T11491	T11492	amod	apoptotic,cells
R6853	T11325	T11323	pobj	cells,of
R6854	T11492	T11490	pobj	cells,of
R6855	T11493	T11492	amod	neural,cells
R6856	T11494	T11492	compound	progenitor,cells
R6857	T11326	T11325	compound	photoreceptor,cells
R6858	T11495	T11482	acomp	unlikely,is
R6859	T11496	T11497	aux	to,be
R6860	T11327	T11319	prep	to,connect
R6861	T11497	T11495	xcomp	be,unlikely
R6862	T11498	T11499	det	the,cause
R6863	T11499	T11497	attr	cause,be
R6864	T11328	T11329	npadvmod	Ptdsr,mediated
R6865	T11500	T11499	prep	of,cause
R6866	T11501	T11502	det	the,hyperplasia
R6867	T11502	T11500	pobj	hyperplasia,of
R6868	T11503	T11502	compound	brain,hyperplasia
R6869	T11504	T11482	punct	.,is
R6870	T11329	T11331	amod	mediated,engulfment
R6871	T11506	T11507	prep	In,demonstrate
R6872	T11508	T11506	pobj	summary,In
R6873	T11330	T11329	punct	-,mediated
R6874	T11509	T11507	punct	", ",demonstrate
R6875	T11510	T11511	poss	our,studies
R6876	T11511	T11507	nsubj	studies,demonstrate
R6877	T11331	T11327	pobj	engulfment,to
R6878	T11512	T11513	mark	that,required
R6879	T11513	T11507	ccomp	required,demonstrate
R6880	T11514	T11513	nsubjpass	Ptdsr,required
R6881	T11332	T11331	compound	macrophage,engulfment
R6882	T11515	T11513	auxpass	is,required
R6883	T11516	T11513	prep	for,required
R6884	T11517	T11518	amod	normal,differentiation
R6885	T11333	T11334	punct	[,43
R6886	T11518	T11516	pobj	differentiation,for
R6887	T11519	T11518	compound	tissue,differentiation
R6888	T11334	T11316	parataxis	43,studies
R6889	T11520	T11513	punct	", ",required
R6890	T11521	T11522	advmod	especially,during
R6891	T11522	T11513	prep	during,required
R6892	T11335	T11334	punct	],43
R6893	T11523	T11524	det	the,period
R6894	T11524	T11522	pobj	period,during
R6895	T11525	T11524	compound	mid-gestation,period
R6896	T11336	T11317	aux	should,interpreted
R6897	T11526	T11527	advmod	when,observed
R6898	T11527	T11524	relcl	observed,period
R6899	T11528	T11527	nsubj	we,observed
R6900	T11337	T11317	auxpass	be,interpreted
R6901	T11529	T11530	det	the,delays
R6902	T11530	T11527	dobj	delays,observed
R6903	T11531	T11532	advmod	most,severe
R6904	T11338	T11317	prep	with,interpreted
R6905	T11532	T11530	amod	severe,delays
R6906	T11533	T11530	compound	differentiation,delays
R6907	T11339	T11340	amod	extreme,caution
R6908	T11534	T11527	prep	in,observed
R6909	T11535	T11536	amod	several,organs
R6910	T11536	T11534	pobj	organs,in
R6911	T11340	T11338	pobj	caution,with
R6912	T11537	T11536	prep	of,organs
R6913	T11538	T11539	compound	Ptdsr,knockout
R6914	T11341	T11342	mark	as,based
R6915	T11539	T11541	compound	knockout,mice
R6916	T11540	T11539	punct	-,knockout
R6917	T11541	T11537	pobj	mice,of
R6918	T11542	T11507	punct	.,demonstrate
R6919	T11342	T11317	advcl	based,interpreted
R6920	T11544	T11545	det	The,defects
R6921	T11545	T11547	nsubjpass	defects,explained
R6922	T11546	T11545	amod	multiple,defects
R6923	T11343	T11344	det	these,studies
R6924	T11548	T11545	prep	in,defects
R6925	T11549	T11550	compound	tissue,differentiation
R6926	T11344	T11342	nsubjpass	studies,based
R6927	T11550	T11548	pobj	differentiation,in
R6928	T11551	T11547	aux	can,explained
R6929	T11552	T11547	neg	not,explained
R6930	T11345	T11342	auxpass	were,based
R6931	T11553	T11547	auxpass	be,explained
R6932	T11554	T11547	agent	by,explained
R6933	T11346	T11342	prep	on,based
R6934	T11555	T11554	pobj	failure,by
R6935	T11556	T11555	prep	of,failure
R6936	T11557	T11558	amod	apoptotic,clearance
R6937	T11347	T11348	det	the,antibody
R6938	T11558	T11556	pobj	clearance,of
R6939	T11559	T11558	compound	cell,clearance
R6940	T11348	T11346	pobj	antibody,on
R6941	T11560	T11547	punct	", ",explained
R6942	T11561	T11562	mark	as,is
R6943	T11562	T11547	advcl	is,explained
R6944	T11349	T11348	amod	monoclonal,antibody
R6945	T11563	T11564	det	this,process
R6946	T11564	T11562	nsubj	process,is
R6947	T11350	T11348	amod	anti-Ptdsr,antibody
R6948	T11351	T11348	appos	mAb,antibody
R6950	T11352	T11351	nummod	217G8E9,mAb
R6954	T11353	T11354	punct	[,43
R6957	T11354	T11342	parataxis	43,based
R6960	T11355	T11354	nummod	26,43
R6963	T11356	T11354	punct	",",43
R6964	T11357	T11354	punct	],43
R6965	T11358	T11359	punct	(,see
R6966	T11359	T11317	parataxis	see,interpreted
R6967	T11360	T11359	advmod	below,see
R6971	T11361	T11359	punct	),see
R6976	T11362	T11317	punct	.,interpreted
R6979	T11364	T11365	advcl	Consistent,found
R6986	T11592	T11591	cc	and,maturation
R6987	T11593	T11594	amod	terminal,differentiation
R6988	T11594	T11591	conj	differentiation,maturation
R6989	T11595	T11576	punct	.,indicates
R6990	T11597	T11598	amod	Additional,studies
R6991	T11598	T11599	nsubjpass	studies,required
R6992	T11600	T11598	prep	with,studies
R6993	T11601	T11602	advmod	conditionally,targeted
R6994	T11602	T11603	amod	targeted,mice
R6995	T11603	T11600	pobj	mice,with
R6996	T11604	T11605	npadvmod	Ptdsr,deficient
R6997	T11605	T11603	amod	deficient,mice
R6998	T11606	T11605	punct	-,deficient
R6999	T11607	T11599	auxpass	are,required
R7000	T11608	T11609	aux	to,investigate
R7001	T11609	T11599	advcl	investigate,required
R7002	T11610	T11611	det	the,role
R7003	T11611	T11609	dobj	role,investigate
R7004	T11612	T11611	prep	of,role
R7005	T11613	T11614	amod	spatial,expression
R7006	T11614	T11612	pobj	expression,of
R7007	T11615	T11613	cc	and,spatial
R7008	T11616	T11613	conj	temporal,spatial
R7009	T11617	T11614	compound	Ptdsr,expression
R7010	T11618	T11614	cc	and,expression
R7011	T11619	T11614	conj	function,expression
R7012	T11620	T11611	prep	during,role
R7013	T11621	T11622	compound	tissue,differentiation
R7014	T11622	T11620	pobj	differentiation,during
R7015	T11623	T11599	punct	.,required
R7020	T12455	T12456	nsubj	Ptdsr,is
R7021	T12457	T12456	neg	not,is
R7022	T12458	T12456	acomp	essential,is
R7023	T12459	T12458	prep	for,essential
R7024	T12460	T12461	det	the,clearance
R7025	T12461	T12459	pobj	clearance,for
R7026	T12462	T12461	prep	of,clearance
R7027	T12463	T12464	amod	apoptotic,cells
R7028	T12464	T12462	pobj	cells,of
R7029	T12466	T12467	poss	Our,studies
R7030	T12467	T12468	nsubj	studies,demonstrate
R7031	T12469	T12470	mark	that,is
R7032	T12470	T12468	ccomp	is,demonstrate
R7033	T12471	T12470	nsubj	Ptdsr,is
R7034	T12472	T12470	neg	not,is
R7035	T12473	T12474	det	a,receptor
R7036	T12474	T12470	attr	receptor,is
R7037	T12475	T12474	amod	primary,receptor
R7038	T12476	T12474	prep	for,receptor
R7039	T12477	T12478	det	the,uptake
R7040	T12478	T12476	pobj	uptake,for
R7041	T12479	T12478	prep	of,uptake
R7042	T12480	T12481	amod	apoptotic,cells
R7043	T12481	T12479	pobj	cells,of
R7044	T12482	T12468	punct	.,demonstrate
R7045	T12484	T12485	nsubj	Investigation,showed
R7046	T12486	T12484	prep	of,Investigation
R7047	T12487	T12488	amod	apoptotic,clearance
R7048	T12488	T12486	pobj	clearance,of
R7049	T12489	T12488	compound	cell,clearance
R7050	T12490	T12491	advmod	in,vivo
R7051	T12491	T12484	advmod	vivo,Investigation
R7052	T12492	T12484	prep	in,Investigation
R7053	T12493	T12494	nmod	Ptdsr,embryos
R7054	T12494	T12492	pobj	embryos,in
R7055	T12495	T12493	punct	-,Ptdsr
R7056	T12496	T12493	punct	/,Ptdsr
R7057	T12497	T12493	punct	-,Ptdsr
R7058	T12498	T12485	advmod	conclusively,showed
R7059	T12499	T12500	mark	that,compromised
R7060	T12500	T12485	ccomp	compromised,showed
R7061	T12501	T12500	nsubjpass	removal,compromised
R7062	T12502	T12501	prep	of,removal
R7063	T12503	T12504	amod	apoptotic,cells
R7064	T12504	T12502	pobj	cells,of
R7065	T12505	T12500	auxpass	is,compromised
R7066	T12506	T12500	neg	not,compromised
R7067	T12507	T12500	agent	by,compromised
R7068	T12508	T12507	pobj	ablation,by
R7069	T12509	T12508	prep	of,ablation
R7070	T12510	T12511	compound	Ptdsr,function
R7071	T12511	T12509	pobj	function,of
R7072	T12512	T12485	punct	.,showed
R7073	T12514	T12515	amod	Comparative,analysis
R7074	T12515	T12516	nsubj	analysis,failed
R7075	T12517	T12515	prep	of,analysis
R7076	T12518	T12519	nummod	ten,tissues
R7077	T12519	T12517	pobj	tissues,of
R7078	T12520	T12519	amod	different,tissues
R7079	T12521	T12519	cc	and,tissues
R7080	T12522	T12519	conj	organs,tissues
R7081	T12523	T12515	prep	in,analysis
R7082	T12524	T12525	nmod	Ptdsr,animals
R7083	T12525	T12523	pobj	animals,in
R7084	T12526	T12524	punct	+,Ptdsr
R7085	T12527	T12524	punct	/,Ptdsr
R7086	T12528	T12524	punct	+,Ptdsr
R7087	T12529	T12524	cc	and,Ptdsr
R7088	T12530	T12524	conj	Ptdsr,Ptdsr
R7089	T12531	T12530	punct	-,Ptdsr
R7090	T12532	T12530	punct	/,Ptdsr
R7091	T12533	T12530	punct	-,Ptdsr
R7092	T12534	T12515	prep	at,analysis
R7093	T12535	T12536	amod	several,stages
R7094	T12536	T12534	pobj	stages,at
R7095	T12537	T12536	prep	of,stages
R7096	T12538	T12539	amod	embryonic,development
R7097	T12539	T12537	pobj	development,of
R7098	T12540	T12534	cc	and,at
R7099	T12541	T12534	conj	in,at
R7100	T12542	T12541	pobj	neonates,in
R7101	T12543	T12544	aux	to,identify
R7102	T12544	T12516	xcomp	identify,failed
R7103	T12545	T12546	amod	impaired,uptake
R7104	T12546	T12544	dobj	uptake,identify
R7105	T12547	T12546	prep	of,uptake
R7106	T12548	T12549	amod	apoptotic,cells
R7107	T12549	T12547	pobj	cells,of
R7108	T12550	T12544	prep	at,identify
R7109	T12551	T12552	det	any,time
R7110	T12552	T12550	pobj	time,at
R7111	T12553	T12552	prep	during,time
R7112	T12554	T12553	pobj	development,during
R7113	T12555	T12516	punct	.,failed
R7114	T12557	T12558	advmod	Furthermore,demonstrated
R7115	T12559	T12558	punct	", ",demonstrated
R7116	T12560	T12561	compound	phagocytosis,assays
R7117	T12561	T12558	nsubj	assays,demonstrated
R7118	T12562	T12563	advmod	in,vitro
R7119	T12563	T12561	advmod	vitro,assays
R7120	T12564	T12565	det	a,uptake
R7121	T12565	T12558	dobj	uptake,demonstrated
R7122	T12566	T12567	advmod	completely,normal
R7123	T12567	T12565	amod	normal,uptake
R7124	T12568	T12565	prep	of,uptake
R7125	T12569	T12570	amod	apoptotic,cells
R7126	T12570	T12568	pobj	cells,of
R7127	T12571	T12565	prep	by,uptake
R7128	T12572	T12573	nmod	Ptdsr,macrophages
R7129	T12573	T12571	pobj	macrophages,by
R7130	T12574	T12572	punct	-,Ptdsr
R7131	T12575	T12572	punct	/,Ptdsr
R7132	T12576	T12572	punct	-,Ptdsr
R7133	T12577	T12558	punct	", ",demonstrated
R7134	T12578	T12558	prep	with,demonstrated
R7135	T12579	T12580	det	some,macrophages
R7136	T12580	T12582	nsubj	macrophages,showing
R7137	T12581	T12580	amod	knockout,macrophages
R7138	T12582	T12578	pcomp	showing,with
R7139	T12583	T12582	dobj	loads,showing
R7140	T12584	T12585	advmod	even,higher
R7141	T12585	T12583	amod	higher,loads
R7142	T12586	T12585	prep	than,higher
R7143	T12587	T12588	amod	wild,type
R7144	T12588	T12586	pobj	type,than
R7145	T12589	T12588	punct	-,type
R7146	T12590	T12583	prep	of,loads
R7147	T12591	T12592	amod	engulfed,cells
R7148	T12592	T12590	pobj	cells,of
R7149	T12593	T12592	amod	dead,cells
R7150	T12594	T12558	punct	.,demonstrated
R7151	T12596	T12597	det	These,results
R7152	T12597	T12598	nsubj	results,are
R7153	T12599	T12598	acomp	contrary,are
R7154	T12600	T12599	prep	to,contrary
R7155	T12601	T12602	det	the,role
R7156	T12602	T12600	pobj	role,to
R7157	T12603	T12602	amod	expected,role
R7158	T12604	T12602	prep	of,role
R7159	T12605	T12604	pobj	Ptdsr,of
R7160	T12606	T12602	prep	in,role
R7161	T12607	T12608	amod	apoptotic,cell
R7162	T12608	T12609	compound	cell,clearance
R7163	T12609	T12606	pobj	clearance,in
R7164	T12610	T12600	cc	and,to
R7165	T12611	T12600	conj	to,to
R7166	T12612	T12613	det	the,findings
R7167	T12613	T12611	pobj	findings,to
R7168	T12614	T12613	amod	reported,findings
R7169	T12615	T12613	prep	of,findings
R7170	T12616	T12615	pobj	Li,of
R7171	T12617	T12618	advmod	et,al.
R7172	T12618	T12616	advmod	al.,Li
R7173	T12619	T12620	punct	[,31
R7174	T12620	T12616	parataxis	31,Li
R7175	T12621	T12620	punct	],31
R7176	T12622	T12616	cc	and,Li
R7177	T12623	T12616	conj	Kunisaki,Li
R7178	T12624	T12625	advmod	et,al.
R7179	T12625	T12623	advmod	al.,Kunisaki
R7180	T12626	T12627	punct	[,32
R7181	T12627	T12623	parataxis	32,Kunisaki
R7182	T12628	T12627	punct	],32
R7183	T12629	T12611	punct	", ",to
R7184	T12630	T12631	advmod	as,as
R7185	T12631	T12611	cc	as,to
R7186	T12632	T12631	advmod	well,as
R7187	T12633	T12611	conj	to,to
R7188	T12634	T12635	det	a,study
R7189	T12635	T12633	pobj	study,to
R7190	T12636	T12635	acl	done,study
R7191	T12637	T12636	prep	with,done
R7192	T12638	T12639	det	a,allele
R7193	T12639	T12637	pobj	allele,with
R7194	T12640	T12641	nmod	phosphatidylserine,receptor
R7195	T12641	T12639	nmod	receptor,allele
R7196	T12642	T12639	amod	null,allele
R7197	T12643	T12636	prep	in,done
R7198	T12644	T12645	compound	C.,elegans
R7199	T12645	T12643	pobj	elegans,in
R7200	T12646	T12647	punct	[,45
R7201	T12647	T12599	parataxis	45,contrary
R7202	T12648	T12647	punct	],45
R7203	T12649	T12598	punct	.,are
R7204	T12651	T12652	prep	In,investigated
R7205	T12653	T12654	amod	previous,studies
R7206	T12654	T12651	pobj	studies,In
R7207	T12655	T12654	prep	in,studies
R7208	T12656	T12657	det	the,mouse
R7209	T12657	T12655	pobj	mouse,in
R7210	T12658	T12652	punct	", ",investigated
R7211	T12659	T12660	det	the,distribution
R7212	T12660	T12652	nsubjpass	distribution,investigated
R7213	T12661	T12660	cc	and,distribution
R7214	T12662	T12660	conj	amount,distribution
R7215	T12663	T12660	prep	of,distribution
R7216	T12664	T12665	amod	apoptotic,cells
R7217	T12665	T12663	pobj	cells,of
R7218	T12666	T12660	prep	in,distribution
R7219	T12667	T12668	nmod	Ptdsr,knockout
R7220	T12668	T12670	nmod	knockout,animals
R7221	T12669	T12668	punct	-,knockout
R7222	T12670	T12666	pobj	animals,in
R7223	T12671	T12668	cc	and,knockout
R7224	T12672	T12668	conj	control,knockout
R7225	T12673	T12652	auxpass	were,investigated
R7226	T12674	T12652	prep	in,investigated
R7227	T12675	T12676	advmod	only,tissues
R7228	T12676	T12674	pobj	tissues,in
R7229	T12677	T12676	det	a,tissues
R7230	T12678	T12676	amod	few,tissues
R7231	T12679	T12674	cc	and,in
R7232	T12680	T12674	conj	at,in
R7233	T12681	T12682	nummod	one,stages
R7234	T12682	T12680	pobj	stages,at
R7235	T12683	T12684	punct	[,31
R7236	T12684	T12681	parataxis	31,one
R7237	T12685	T12684	punct	],31
R7238	T12686	T12681	cc	or,one
R7239	T12687	T12681	conj	two,one
R7240	T12688	T12689	punct	[,32
R7241	T12689	T12687	parataxis	32,two
R7242	T12690	T12689	punct	],32
R7243	T12691	T12682	amod	developmental,stages
R7244	T12692	T12652	punct	.,investigated
R7245	T12694	T12695	nsubj	Li,examined
R7246	T12696	T12697	advmod	et,al.
R7247	T12697	T12694	advmod	al.,Li
R7248	T12698	T12699	punct	[,31
R7249	T12699	T12694	parataxis	31,Li
R7250	T12700	T12699	punct	],31
R7251	T12701	T12695	dobj	lung,examined
R7252	T12702	T12701	punct	", ",lung
R7253	T12703	T12701	conj	midbrain,lung
R7254	T12704	T12703	cc	and,midbrain
R7255	T12705	T12703	conj	retina,midbrain
R7256	T12706	T12695	prep	at,examined
R7257	T12707	T12708	compound	day,E17.5
R7258	T12708	T12706	pobj	E17.5,at
R7259	T12709	T12708	prep	of,E17.5
R7260	T12710	T12709	pobj	gestation,of
R7261	T12711	T12695	cc	and,examined
R7262	T12712	T12695	conj	identified,examined
R7263	T12713	T12714	amod	apoptotic,cells
R7264	T12714	T12712	dobj	cells,identified
R7265	T12715	T12712	prep	by,identified
R7266	T12716	T12717	compound	TUNEL,staining
R7267	T12717	T12715	pobj	staining,by
R7268	T12718	T12695	punct	.,examined
R7269	T12720	T12721	poss	Their,findings
R7270	T12721	T12722	nsubjpass	findings,interpreted
R7271	T12723	T12722	aux	must,interpreted
R7272	T12724	T12722	auxpass	be,interpreted
R7273	T12725	T12722	prep	with,interpreted
R7274	T12726	T12725	pobj	caution,with
R7275	T12727	T12728	mark	because,known
R7276	T12728	T12722	advcl	known,interpreted
R7277	T12729	T12728	nsubjpass	remodeling,known
R7278	T12730	T12729	prep	of,remodeling
R7279	T12731	T12732	amod	cellular,structures
R7280	T12732	T12730	pobj	structures,of
R7281	T12733	T12729	prep	by,remodeling
R7282	T12734	T12733	pobj	apoptosis,by
R7283	T12735	T12729	prep	in,remodeling
R7284	T12736	T12737	amod	specific,layers
R7285	T12737	T12735	pobj	layers,in
R7286	T12738	T12737	compound	retina,layers
R7287	T12739	T12728	auxpass	is,known
R7288	T12740	T12741	aux	to,occur
R7289	T12741	T12728	xcomp	occur,known
R7290	T12742	T12743	advmod	mainly,postnatally
R7291	T12743	T12741	advmod	postnatally,occur
R7292	T12744	T12745	punct	[,42
R7293	T12745	T12728	parataxis	42,known
R7294	T12746	T12745	punct	],42
R7295	T12747	T12728	punct	", ",known
R7296	T12748	T12728	cc	and,known
R7297	T12749	T12750	nsubj	apoptosis,plays
R7298	T12750	T12728	conj	plays,known
R7299	T12751	T12752	det	an,role
R7300	T12752	T12750	dobj	role,plays
R7301	T12753	T12752	amod	important,role
R7302	T12754	T12752	amod	physiological,role
R7303	T12755	T12750	prep	in,plays
R7304	T12756	T12757	det	the,maintenance
R7305	T12757	T12755	pobj	maintenance,in
R7306	T12758	T12757	cc	and,maintenance
R7307	T12759	T12757	conj	homeostasis,maintenance
R7308	T12760	T12757	prep	of,maintenance
R7309	T12761	T12762	compound	lung,epithelium
R7310	T12762	T12760	pobj	epithelium,of
R7311	T12763	T12757	prep	after,maintenance
R7312	T12764	T12763	pobj	birth,after
R7313	T12765	T12755	cc	or,in
R7314	T12766	T12755	conj	in,in
R7315	T12767	T12768	amod	pathological,conditions
R7316	T12768	T12766	pobj	conditions,in
R7317	T12769	T12768	acl	involving,conditions
R7318	T12770	T12771	amod	pulmonary,inflammation
R7319	T12771	T12769	dobj	inflammation,involving
R7320	T12772	T12755	cc	and,in
R7321	T12773	T12772	neg	not,and
R7322	T12774	T12755	conj	during,in
R7323	T12775	T12776	compound	lung,development
R7324	T12776	T12774	pobj	development,during
R7325	T12777	T12778	punct	[,46
R7326	T12778	T12750	parataxis	46,plays
R7327	T12779	T12778	punct	],46
R7328	T12780	T12722	punct	.,interpreted
R7329	T12782	T12783	det	This,role
R7330	T12783	T12785	nsubj	role,is
R7331	T12784	T12783	amod	postnatal,role
R7332	T12786	T12783	prep	for,role
R7333	T12787	T12786	pobj	apoptosis,for
R7334	T12788	T12785	prep	in,is
R7335	T12789	T12788	pobj	accordance,in
R7336	T12790	T12789	prep	with,accordance
R7337	T12791	T12792	poss	our,data
R7338	T12792	T12790	pobj	data,with
R7339	T12793	T12785	punct	", ",is
R7340	T12794	T12795	mark	as,observed
R7341	T12795	T12785	advcl	observed,is
R7342	T12796	T12795	nsubj	we,observed
R7343	T12797	T12795	advmod	rarely,observed
R7344	T12798	T12799	amod	apoptotic,cells
R7345	T12799	T12795	dobj	cells,observed
R7346	T12800	T12795	prep	in,observed
R7347	T12801	T12802	nmod	retina,tissue
R7348	T12802	T12800	pobj	tissue,in
R7349	T12803	T12801	cc	or,retina
R7350	T12804	T12801	conj	lung,retina
R7351	T12805	T12795	prep	throughout,observed
R7352	T12806	T12805	pobj	embryogenesis,throughout
R7353	T12807	T12795	prep	in,observed
R7354	T12808	T12809	nmod	Ptdsr,mice
R7355	T12809	T12807	pobj	mice,in
R7356	T12810	T12808	punct	+,Ptdsr
R7357	T12811	T12808	punct	/,Ptdsr
R7358	T12812	T12808	punct	+,Ptdsr
R7359	T12813	T12808	cc	and,Ptdsr
R7360	T12814	T12808	conj	Ptdsr,Ptdsr
R7361	T12815	T12814	punct	-,Ptdsr
R7362	T12816	T12814	punct	/,Ptdsr
R7363	T12817	T12814	punct	-,Ptdsr
R7364	T12818	T12785	punct	.,is
R7365	T12820	T12821	nsubj	Kunisaki,analyzed
R7366	T12822	T12823	advmod	et,al.
R7367	T12823	T12820	advmod	al.,Kunisaki
R7368	T12824	T12825	punct	[,32
R7369	T12825	T12820	parataxis	32,Kunisaki
R7370	T12826	T12825	punct	],32
R7371	T12827	T12828	npadvmod	TUNEL,stained
R7372	T12828	T12830	amod	stained,sections
R7373	T12829	T12828	punct	-,stained
R7374	T12830	T12821	dobj	sections,analyzed
R7375	T12831	T12830	prep	of,sections
R7376	T12832	T12831	pobj	liver,of
R7377	T12833	T12832	cc	and,liver
R7378	T12834	T12832	conj	thymus,liver
R7379	T12835	T12830	prep	at,sections
R7380	T12836	T12837	compound	days,E13.5
R7381	T12837	T12835	pobj	E13.5,at
R7382	T12838	T12837	cc	and,E13.5
R7383	T12839	T12837	conj	E16.5,E13.5
R7384	T12840	T12837	prep	of,E13.5
R7385	T12841	T12840	pobj	development,of
R7386	T12842	T12830	prep	in,sections
R7387	T12843	T12844	nmod	Ptdsr,embryos
R7388	T12844	T12842	pobj	embryos,in
R7389	T12845	T12843	punct	+,Ptdsr
R7390	T12846	T12843	punct	/,Ptdsr
R7391	T12847	T12843	punct	-,Ptdsr
R7392	T12848	T12843	cc	and,Ptdsr
R7393	T12849	T12843	conj	Ptdsr,Ptdsr
R7394	T12850	T12849	punct	-,Ptdsr
R7395	T12851	T12849	punct	/,Ptdsr
R7396	T12852	T12849	punct	-,Ptdsr
R7397	T12853	T12821	cc	and,analyzed
R7398	T12854	T12821	conj	found,analyzed
R7399	T12855	T12856	amod	reduced,numbers
R7400	T12856	T12854	dobj	numbers,found
R7401	T12857	T12858	advmod	rather,than
R7402	T12858	T12855	cc	than,reduced
R7403	T12859	T12855	conj	increased,reduced
R7404	T12860	T12856	prep	of,numbers
R7405	T12861	T12862	npadvmod	TUNEL,positive
R7406	T12862	T12864	amod	positive,cells
R7407	T12863	T12862	punct	-,positive
R7408	T12864	T12860	pobj	cells,of
R7409	T12865	T12854	prep	in,found
R7410	T12866	T12867	npadvmod	Ptdsr,deficient
R7411	T12867	T12869	amod	deficient,embryos
R7412	T12868	T12867	punct	-,deficient
R7413	T12869	T12865	pobj	embryos,in
R7414	T12870	T12821	punct	.,analyzed
R7415	T12872	T12873	advcl	Using,suggested
R7416	T12874	T12872	dobj	co-localization,Using
R7417	T12875	T12874	prep	of,co-localization
R7418	T12876	T12877	npadvmod	TUNEL,positive
R7419	T12877	T12879	amod	positive,cells
R7420	T12878	T12877	punct	-,positive
R7421	T12879	T12875	pobj	cells,of
R7422	T12880	T12874	prep	with,co-localization
R7423	T12881	T12882	npadvmod	F4,positive
R7424	T12882	T12886	amod	positive,macrophages
R7425	T12883	T12881	punct	/,F4
R7426	T12884	T12881	nummod	80,F4
R7427	T12885	T12882	punct	-,positive
R7428	T12886	T12880	pobj	macrophages,with
R7429	T12887	T12873	nsubj	they,suggested
R7430	T12888	T12889	mark	that,exhibited
R7431	T12889	T12873	ccomp	exhibited,suggested
R7432	T12890	T12891	nmod	Ptdsr,embryos
R7433	T12891	T12889	nsubj	embryos,exhibited
R7434	T12892	T12890	punct	-,Ptdsr
R7435	T12893	T12890	punct	/,Ptdsr
R7436	T12894	T12890	punct	-,Ptdsr
R7437	T12895	T12896	det	a,increase
R7438	T12896	T12889	dobj	increase,exhibited
R7439	T12897	T12896	amod	three-fold,increase
R7440	T12898	T12896	prep	in,increase
R7441	T12899	T12900	det	the,frequency
R7442	T12900	T12898	pobj	frequency,in
R7443	T12901	T12900	prep	of,frequency
R7444	T12902	T12903	amod	unphagocytosed,cells
R7445	T12903	T12901	pobj	cells,of
R7446	T12904	T12905	npadvmod	TUNEL,positive
R7447	T12905	T12903	amod	positive,cells
R7448	T12906	T12905	punct	-,positive
R7449	T12907	T12889	advmod	together,exhibited
R7450	T12908	T12907	prep	with,together
R7451	T12909	T12910	det	a,number
R7452	T12910	T12908	pobj	number,with
R7453	T12911	T12912	advmod	severely,reduced
R7454	T12912	T12910	amod	reduced,number
R7455	T12913	T12910	prep	of,number
R7456	T12914	T12915	npadvmod	F4,positive
R7457	T12915	T12919	amod	positive,cells
R7458	T12916	T12914	punct	/,F4
R7459	T12917	T12914	nummod	80,F4
R7460	T12918	T12915	punct	-,positive
R7461	T12919	T12913	pobj	cells,of
R7462	T12920	T12873	punct	.,suggested
R7463	T12922	T12923	det	These,results
R7464	T12923	T12924	nsubjpass	results,interpreted
R7465	T12925	T12924	aux	must,interpreted
R7466	T12926	T12924	auxpass	be,interpreted
R7467	T12927	T12928	advmod	very,carefully
R7468	T12928	T12924	advmod	carefully,interpreted
R7469	T12929	T12924	punct	", ",interpreted
R7470	T12930	T12924	advmod	however,interpreted
R7471	T12931	T12924	punct	", ",interpreted
R7472	T12932	T12933	mark	as,is
R7473	T12933	T12924	advcl	is,interpreted
R7474	T12934	T12933	nsubj	it,is
R7475	T12935	T12936	advmod	technically,difficult
R7476	T12936	T12933	acomp	difficult,is
R7477	T12937	T12938	aux	to,identify
R7478	T12938	T12933	xcomp	identify,is
R7479	T12939	T12938	advmod	unambiguously,identify
R7480	T12940	T12941	amod	engulfed,cells
R7481	T12941	T12938	dobj	cells,identify
R7482	T12942	T12941	compound	target,cells
R7483	T12943	T12938	prep	in,identify
R7484	T12944	T12945	amod	individual,macrophages
R7485	T12945	T12943	pobj	macrophages,in
R7486	T12946	T12938	prep	in,identify
R7487	T12947	T12948	amod	solid,tissues
R7488	T12948	T12946	pobj	tissues,in
R7489	T12949	T12938	prep	by,identify
R7490	T12950	T12951	compound	fluorescence,microscopy
R7491	T12951	T12949	pobj	microscopy,by
R7492	T12952	T12924	punct	.,interpreted
R7493	T12954	T12955	prep	In,suggest
R7494	T12956	T12954	pobj	addition,In
R7495	T12957	T12955	punct	", ",suggest
R7496	T12958	T12959	poss	our,data
R7497	T12959	T12955	nsubj	data,suggest
R7498	T12960	T12961	mark	that,is
R7499	T12961	T12955	ccomp	is,suggest
R7500	T12962	T12961	prep	during,is
R7501	T12963	T12962	pobj	embryogenesis,during
R7502	T12964	T12961	punct	", ",is
R7503	T12965	T12966	npadvmod	macrophage,mediated
R7504	T12966	T12968	amod	mediated,clearance
R7505	T12967	T12966	punct	-,mediated
R7506	T12968	T12961	nsubj	clearance,is
R7507	T12969	T12968	prep	of,clearance
R7508	T12970	T12971	amod	apoptotic,cells
R7509	T12971	T12969	pobj	cells,of
R7510	T12972	T12961	neg	not,is
R7511	T12973	T12974	det	the,only
R7512	T12974	T12961	attr	only,is
R7513	T12975	T12974	punct	-,only
R7514	T12976	T12974	cc	or,only
R7515	T12977	T12978	advmod	even,primary
R7516	T12978	T12974	conj	primary,only
R7517	T12979	T12978	det	the,primary
R7518	T12980	T12978	punct	-,primary
R7519	T12981	T12978	conj	mechanism,primary
R7520	T12982	T12974	prep	for,only
R7521	T12983	T12984	det	the,removal
R7522	T12984	T12982	pobj	removal,for
R7523	T12985	T12984	prep	of,removal
R7524	T12986	T12987	amod	apoptotic,cells
R7525	T12987	T12985	pobj	cells,of
R7526	T12988	T12955	punct	.,suggest
R7527	T12990	T12991	prep	In,found
R7528	T12992	T12993	amod	many,tissues
R7529	T12993	T12990	pobj	tissues,In
R7530	T12994	T12995	advmod	where,occurs
R7531	T12995	T12993	relcl	occurs,tissues
R7532	T12996	T12997	amod	programmed,death
R7533	T12997	T12995	nsubj	death,occurs
R7534	T12998	T12997	compound	cell,death
R7535	T12999	T12995	prep	as,occurs
R7536	T13000	T13001	det	a,event
R7537	T13001	T12999	pobj	event,as
R7538	T13002	T13001	amod	prominent,event
R7539	T13003	T13001	prep	during,event
R7540	T13004	T13003	pobj	embryogenesis,during
R7541	T13005	T13001	punct	", ",event
R7542	T13006	T13007	amod	such,as
R7543	T13007	T13001	prep	as,event
R7544	T13008	T13007	pobj	remodeling,as
R7545	T13009	T13008	prep	of,remodeling
R7546	T13010	T13011	det	the,ridge
R7547	T13011	T13009	pobj	ridge,of
R7548	T13012	T13011	amod	genital,ridge
R7549	T13013	T13008	prep	during,remodeling
R7550	T13014	T13015	compound	gonad,morphogenesis
R7551	T13015	T13013	pobj	morphogenesis,during
R7552	T13016	T13015	cc	and,morphogenesis
R7553	T13017	T13015	conj	differentiation,morphogenesis
R7554	T13018	T13015	prep	of,morphogenesis
R7555	T13019	T13020	det	the,tube
R7556	T13020	T13018	pobj	tube,of
R7557	T13021	T13020	amod	neural,tube
R7558	T13022	T12991	punct	", ",found
R7559	T13023	T12991	nsubj	we,found
R7560	T13024	T13025	advmod	almost,co-localization
R7561	T13025	T12991	dobj	co-localization,found
R7562	T13026	T13025	det	no,co-localization
R7563	T13027	T13025	prep	of,co-localization
R7564	T13028	T13029	amod	apoptotic,cells
R7565	T13029	T13027	pobj	cells,of
R7566	T13030	T13029	cc	and,cells
R7567	T13031	T13029	conj	macrophages,cells
R7568	T13032	T12991	punct	.,found
R7569	T13034	T13035	nsubj	This,indicates
R7570	T13036	T13037	mark	that,mediated
R7571	T13037	T13035	ccomp	mediated,indicates
R7572	T13038	T13037	prep	in,mediated
R7573	T13039	T13040	det	these,cases
R7574	T13040	T13038	pobj	cases,in
R7575	T13041	T13037	nsubjpass	clearance,mediated
R7576	T13042	T13041	prep	of,clearance
R7577	T13043	T13044	amod	apoptotic,cells
R7578	T13044	T13042	pobj	cells,of
R7579	T13045	T13037	auxpass	is,mediated
R7580	T13046	T13037	advmod	directly,mediated
R7581	T13047	T13037	prep	by,mediated
R7582	T13048	T13049	amod	neighboring,cells
R7583	T13049	T13047	pobj	cells,by
R7584	T13050	T13049	punct	',cells
R7585	T13051	T13049	nmod	bystander,cells
R7586	T13052	T13049	punct	',cells
R7587	T13053	T13054	advmod	rather,than
R7588	T13054	T13047	cc	than,by
R7589	T13055	T13047	conj	by,by
R7590	T13056	T13055	pobj	macrophages,by
R7591	T13057	T13058	dep	that,recruited
R7592	T13058	T13056	relcl	recruited,macrophages
R7593	T13059	T13058	aux	have,recruited
R7594	T13060	T13058	auxpass	been,recruited
R7595	T13061	T13058	prep	into,recruited
R7596	T13062	T13061	pobj	areas,into
R7597	T13063	T13064	advmod	where,occurs
R7598	T13064	T13062	relcl	occurs,areas
R7599	T13065	T13064	nsubj	apoptosis,occurs
R7600	T13066	T13035	punct	.,indicates
R7601	T13068	T13069	advmod	Obviously,compromised
R7602	T13070	T13071	det	these,mechanisms
R7603	T13071	T13069	nsubjpass	mechanisms,compromised
R7604	T13072	T13073	advmod	in,vivo
R7605	T13073	T13071	amod	vivo,mechanisms
R7606	T13074	T13071	compound	clearance,mechanisms
R7607	T13075	T13069	auxpass	are,compromised
R7608	T13076	T13069	neg	not,compromised
R7609	T13077	T13069	agent	by,compromised
R7610	T13078	T13079	compound	Ptdsr,deficiency
R7611	T13079	T13077	pobj	deficiency,by
R7612	T13080	T13079	punct	-,deficiency
R7613	T13081	T13069	prep	in,compromised
R7614	T13082	T13083	poss	our,mutant
R7615	T13083	T13081	pobj	mutant,in
R7616	T13084	T13083	compound	knockout,mutant
R7617	T13085	T13069	punct	.,compromised
R7618	T13087	T13088	det	This,finding
R7619	T13088	T13089	nsubj	finding,is
R7620	T13090	T13089	prep	in,is
R7621	T13091	T13090	pobj	line,in
R7622	T13092	T13091	prep	with,line
R7623	T13093	T13092	pobj	studies,with
R7624	T13094	T13093	prep	in,studies
R7625	T13095	T13096	amod	macrophageless,embryos
R7626	T13096	T13094	pobj	embryos,in
R7627	T13097	T13098	compound	Sfpi1,knockout
R7628	T13098	T13096	compound	knockout,embryos
R7629	T13099	T13098	punct	-,knockout
R7630	T13100	T13101	dep	that,are
R7631	T13101	T13096	relcl	are,embryos
R7632	T13102	T13101	acomp	deficient,are
R7633	T13103	T13102	prep	for,deficient
R7634	T13104	T13105	det	the,factor
R7635	T13105	T13103	pobj	factor,for
R7636	T13106	T13107	amod	hematopoietic,lineage
R7637	T13107	T13109	npadvmod	lineage,specific
R7638	T13108	T13107	punct	-,lineage
R7639	T13109	T13105	amod	specific,factor
R7640	T13110	T13109	punct	-,specific
R7641	T13111	T13105	compound	transcription,factor
R7642	T13112	T13105	appos	PU.1,factor
R7643	T13113	T13089	punct	.,is
R7644	T13115	T13116	advmod	Here,taken
R7645	T13117	T13116	punct	", ",taken
R7646	T13118	T13119	det	the,phagocytosis
R7647	T13119	T13116	nsubjpass	phagocytosis,taken
R7648	T13120	T13119	prep	of,phagocytosis
R7649	T13121	T13122	amod	apoptotic,cells
R7650	T13122	T13120	pobj	cells,of
R7651	T13123	T13119	prep	during,phagocytosis
R7652	T13124	T13123	pobj	embryogenesis,during
R7653	T13125	T13116	auxpass	is,taken
R7654	T13126	T13116	prt	over,taken
R7655	T13127	T13116	prep	by,taken
R7656	T13128	T13129	punct	',neighbors
R7657	T13129	T13127	pobj	neighbors,by
R7658	T13130	T13129	amod	stand,neighbors
R7659	T13131	T13130	punct	-,stand
R7660	T13132	T13130	prt	in,stand
R7661	T13133	T13129	punct	',neighbors
R7662	T13134	T13129	amod	mesenchymal,neighbors
R7663	T13135	T13136	punct	[,47
R7664	T13136	T13116	parataxis	47,taken
R7665	T13137	T13136	punct	],47
R7666	T13138	T13116	punct	.,taken
R7667	T13140	T13141	mark	As,thought
R7668	T13141	T13146	advcl	thought,is
R7669	T13142	T13141	nsubjpass	recognition,thought
R7670	T13143	T13142	prep	of,recognition
R7671	T13144	T13143	pobj	phosphatidylserine,of
R7672	T13145	T13141	auxpass	is,thought
R7673	T13147	T13148	aux	to,be
R7674	T13148	T13141	xcomp	be,thought
R7675	T13149	T13150	det	a,mechanism
R7676	T13150	T13148	attr	mechanism,be
R7677	T13151	T13150	amod	universal,mechanism
R7678	T13152	T13150	compound	engulfment,mechanism
R7679	T13153	T13150	prep	for,mechanism
R7680	T13154	T13155	det	all,cells
R7681	T13155	T13153	pobj	cells,for
R7682	T13156	T13157	dep	that,are
R7683	T13157	T13155	relcl	are,cells
R7684	T13158	T13157	acomp	able,are
R7685	T13159	T13160	aux	to,phagocytose
R7686	T13160	T13158	xcomp	phagocytose,able
R7687	T13161	T13162	amod	apoptotic,cells
R7688	T13162	T13160	dobj	cells,phagocytose
R7689	T13163	T13146	punct	", ",is
R7690	T13164	T13146	nsubj	it,is
R7691	T13165	T13166	advmod	very,striking
R7692	T13166	T13146	acomp	striking,is
R7693	T13167	T13168	mark	that,compromised
R7694	T13168	T13146	ccomp	compromised,is
R7695	T13169	T13170	amod	apoptotic,clearance
R7696	T13170	T13168	nsubjpass	clearance,compromised
R7697	T13171	T13170	compound	cell,clearance
R7698	T13172	T13170	acl	mediated,clearance
R7699	T13173	T13172	agent	by,mediated
R7700	T13174	T13175	amod	non-professional,cells
R7701	T13175	T13173	pobj	cells,by
R7702	T13176	T13175	compound	bystander,cells
R7703	T13177	T13168	auxpass	is,compromised
R7704	T13178	T13168	advmod	also,compromised
R7705	T13179	T13168	neg	not,compromised
R7706	T13180	T13168	agent	by,compromised
R7707	T13181	T13182	compound	Ptdsr,deficiency
R7708	T13182	T13180	pobj	deficiency,by
R7709	T13183	T13182	punct	-,deficiency
R7710	T13184	T13146	punct	.,is
R7711	T13186	T13187	prep	In,observe
R7712	T13188	T13186	pobj	contrast,In
R7713	T13189	T13188	prep	to,contrast
R7714	T13190	T13189	pobj	Li,to
R7715	T13191	T13192	advmod	et,al.
R7716	T13192	T13190	advmod	al.,Li
R7717	T13193	T13194	punct	[,31
R7718	T13194	T13190	parataxis	31,Li
R7719	T13195	T13194	punct	],31
R7720	T13196	T13187	punct	", ",observe
R7721	T13197	T13187	nsubj	we,observe
R7722	T13198	T13187	aux	did,observe
R7723	T13199	T13187	neg	not,observe
R7724	T13200	T13201	det	any,impairment
R7725	T13201	T13187	dobj	impairment,observe
R7726	T13202	T13201	prep	in,impairment
R7727	T13203	T13204	det	the,uptake
R7728	T13204	T13202	pobj	uptake,in
R7729	T13205	T13204	prep	of,uptake
R7730	T13206	T13207	amod	apoptotic,cells
R7731	T13207	T13205	pobj	cells,of
R7732	T13208	T13204	prep	by,uptake
R7733	T13209	T13210	nmod	Ptdsr,macrophages
R7734	T13210	T13208	pobj	macrophages,by
R7735	T13211	T13209	punct	-,Ptdsr
R7736	T13212	T13209	punct	/,Ptdsr
R7737	T13213	T13209	punct	-,Ptdsr
R7738	T13214	T13215	advmod	in,vitro
R7739	T13215	T13204	advmod	vitro,uptake
R7740	T13216	T13187	punct	.,observe
R7741	T13218	T13219	nsubj	We,performed
R7742	T13220	T13221	compound	phagocytosis,assays
R7743	T13221	T13219	dobj	assays,performed
R7744	T13222	T13223	advmod	in,vitro
R7745	T13223	T13219	advmod	vitro,performed
R7746	T13224	T13219	prep	with,performed
R7747	T13225	T13226	amod	fetal,liver
R7748	T13226	T13228	npadvmod	liver,derived
R7749	T13227	T13226	punct	-,liver
R7750	T13228	T13230	amod	derived,macrophages
R7751	T13229	T13228	punct	-,derived
R7752	T13230	T13224	pobj	macrophages,with
R7753	T13231	T13219	punct	", ",performed
R7754	T13232	T13233	mark	while,used
R7755	T13233	T13219	advcl	used,performed
R7756	T13234	T13233	prep	in,used
R7757	T13235	T13236	poss	their,assays
R7758	T13236	T13234	pobj	assays,in
R7759	T13237	T13233	punct	", ",used
R7760	T13238	T13233	nsubj	Li,used
R7761	T13239	T13238	cc	and,Li
R7762	T13240	T13238	conj	colleagues,Li
R7763	T13241	T13242	npadvmod	thioglycollate,elicited
R7764	T13242	T13244	amod	elicited,macrophages
R7765	T13243	T13242	punct	-,elicited
R7766	T13244	T13233	dobj	macrophages,used
R7767	T13245	T13244	amod	peritoneal,macrophages
R7768	T13246	T13233	prep	after,used
R7769	T13247	T13248	amod	adoptive,transfer
R7770	T13248	T13246	pobj	transfer,after
R7771	T13249	T13248	prep	of,transfer
R7772	T13250	T13251	nmod	Ptdsr,cells
R7773	T13251	T13249	pobj	cells,of
R7774	T13252	T13250	punct	-,Ptdsr
R7775	T13253	T13250	punct	/,Ptdsr
R7776	T13254	T13250	punct	-,Ptdsr
R7777	T13255	T13251	amod	hematopoietic,cells
R7778	T13256	T13251	compound	stem,cells
R7779	T13257	T13219	punct	.,performed
R7780	T13259	T13260	det	The,results
R7781	T13260	T13262	nsubj	results,are
R7782	T13261	T13260	amod	different,results
R7783	T13262	T13268	ccomp	are,be
R7784	T13263	T13260	acl	obtained,results
R7785	T13264	T13263	prep	in,obtained
R7786	T13265	T13266	det	the,studies
R7787	T13266	T13264	pobj	studies,in
R7788	T13267	T13266	nummod	two,studies
R7789	T13269	T13262	acomp	puzzling,are
R7790	T13270	T13268	punct	;,be
R7791	T13271	T13268	nsubj	they,be
R7792	T13272	T13268	aux	might,be
R7793	T13273	T13268	prep	due,be
R7794	T13274	T13273	pcomp	to,due
R7795	T13275	T13276	det	the,use
R7796	T13276	T13273	pobj	use,due
R7797	T13277	T13276	prep	of,use
R7798	T13278	T13279	amod	different,populations
R7799	T13279	T13277	pobj	populations,of
R7800	T13280	T13279	nmod	macrophage,populations
R7801	T13281	T13280	cc	or,macrophage
R7802	T13282	T13280	conj	cell,macrophage
R7803	T13283	T13268	punct	.,be
R7804	T13285	T13286	nsubj	We,found
R7805	T13287	T13285	cc	and,We
R7806	T13288	T13285	conj	Kunisaki,We
R7807	T13289	T13290	advmod	et,al.
R7808	T13290	T13288	advmod	al.,Kunisaki
R7809	T13291	T13292	punct	[,32
R7810	T13292	T13288	parataxis	32,Kunisaki
R7811	T13293	T13292	punct	],32
R7812	T13294	T13295	mark	that,associated
R7813	T13295	T13286	ccomp	associated,found
R7814	T13296	T13297	compound	Ptdsr,deficiency
R7815	T13297	T13295	nsubjpass	deficiency,associated
R7816	T13298	T13297	punct	-,deficiency
R7817	T13299	T13295	auxpass	is,associated
R7818	T13300	T13295	prep	to,associated
R7819	T13301	T13302	det	some,extent
R7820	T13302	T13300	pobj	extent,to
R7821	T13303	T13295	prep	with,associated
R7822	T13304	T13303	pobj	defects,with
R7823	T13305	T13304	prep	in,defects
R7824	T13306	T13305	pobj	hematopoiesis,in
R7825	T13307	T13286	punct	.,found
R7826	T13309	T13310	advmod	Thus,seems
R7827	T13311	T13310	punct	", ",seems
R7828	T13312	T13310	nsubj	it,seems
R7829	T13313	T13310	oprd	possible,seems
R7830	T13314	T13315	mark	that,affected
R7831	T13315	T13310	ccomp	affected,seems
R7832	T13316	T13315	nsubjpass	recruitment,affected
R7833	T13317	T13316	cc	and,recruitment
R7834	T13318	T13319	compound	activation,differentiation
R7835	T13319	T13316	conj	differentiation,recruitment
R7836	T13320	T13319	punct	/,differentiation
R7837	T13321	T13316	prep	of,recruitment
R7838	T13322	T13321	pobj	macrophages,of
R7839	T13323	T13316	prep	after,recruitment
R7840	T13324	T13325	amod	adoptive,transfer
R7841	T13325	T13323	pobj	transfer,after
R7842	T13326	T13325	cc	and,transfer
R7843	T13327	T13328	compound	thioglycollate,elicitation
R7844	T13328	T13325	conj	elicitation,transfer
R7845	T13329	T13315	auxpass	are,affected
R7846	T13330	T13315	agent	by,affected
R7847	T13331	T13332	compound	Ptdsr,deficiency
R7848	T13332	T13330	pobj	deficiency,by
R7849	T13333	T13332	punct	-,deficiency
R7850	T13334	T13310	punct	.,seems
R7851	T13336	T13337	nsubj	We,think
R7852	T13337	T13340	ccomp	think,show
R7853	T13338	T13337	aux	do,think
R7854	T13339	T13337	neg	not,think
R7855	T13341	T13342	mark	that,attributed
R7856	T13342	T13337	ccomp	attributed,think
R7857	T13343	T13344	det	the,results
R7858	T13344	T13342	nsubjpass	results,attributed
R7859	T13345	T13344	amod	different,results
R7860	T13346	T13344	acl	observed,results
R7861	T13347	T13346	prep	in,observed
R7862	T13348	T13349	compound	Ptdsr,knockout
R7863	T13349	T13351	compound	knockout,mice
R7864	T13350	T13349	punct	-,knockout
R7865	T13351	T13347	pobj	mice,in
R7866	T13352	T13346	prep	in,observed
R7867	T13353	T13354	det	a,background
R7868	T13354	T13352	pobj	background,in
R7869	T13355	T13354	amod	mixed,background
R7870	T13356	T13354	nmod	C57BL,background
R7871	T13357	T13356	punct	/,C57BL
R7872	T13358	T13356	nummod	6,C57BL
R7873	T13359	T13360	punct	×,129
R7874	T13360	T13356	prep	129,C57BL
R7875	T13361	T13352	cc	and,in
R7876	T13362	T13352	conj	in,in
R7877	T13363	T13364	det	a,background
R7878	T13364	T13362	pobj	background,in
R7879	T13365	T13364	amod	pure,background
R7880	T13366	T13367	compound	C57BL,6J
R7881	T13367	T13364	compound	6J,background
R7882	T13368	T13367	punct	/,6J
R7883	T13369	T13342	aux	can,attributed
R7884	T13370	T13342	auxpass	be,attributed
R7885	T13371	T13342	prep	to,attributed
R7886	T13372	T13373	amod	genetic,effects
R7887	T13373	T13371	pobj	effects,to
R7888	T13374	T13373	compound	background,effects
R7889	T13375	T13340	punct	: ,show
R7890	T13376	T13340	nsubj	comparison,show
R7891	T13377	T13376	prep	of,comparison
R7892	T13378	T13379	amod	apoptotic,efficacies
R7893	T13379	T13377	pobj	efficacies,of
R7894	T13380	T13379	compound	cell,efficacies
R7895	T13381	T13379	compound	engulfment,efficacies
R7896	T13382	T13379	prep	of,efficacies
R7897	T13383	T13384	npadvmod	thioglycollate,elicited
R7898	T13384	T13386	amod	elicited,macrophages
R7899	T13385	T13384	punct	-,elicited
R7900	T13386	T13382	pobj	macrophages,of
R7901	T13387	T13376	prep	from,comparison
R7902	T13388	T13389	nmod	129P2,OlaHsd
R7903	T13389	T13391	nmod	OlaHsd,mice
R7904	T13390	T13389	punct	/,OlaHsd
R7905	T13391	T13387	pobj	mice,from
R7906	T13392	T13389	cc	and,OlaHsd
R7907	T13393	T13394	compound	C57BL,6J
R7908	T13394	T13389	conj	6J,OlaHsd
R7909	T13395	T13394	punct	/,6J
R7910	T13396	T13340	aux	did,show
R7911	T13397	T13340	neg	not,show
R7912	T13398	T13399	det	any,differences
R7913	T13399	T13340	dobj	differences,show
R7914	T13400	T13399	prep	in,differences
R7915	T13401	T13402	amod	apoptotic,uptake
R7916	T13402	T13400	pobj	uptake,in
R7917	T13403	T13402	compound	cell,uptake
R7918	T13404	T13405	punct	(,J.B.
R7919	T13405	T13340	meta	J.B.,show
R7920	T13406	T13405	cc	and,J.B.
R7921	T13407	T13405	conj	A.L.,J.B.
R7922	T13408	T13407	punct	", ",A.L.
R7923	T13409	T13410	amod	unpublished,observations
R7924	T13410	T13407	conj	observations,A.L.
R7925	T13411	T13410	punct	),observations
R7926	T13412	T13340	punct	.,show
R7927	T13414	T13415	advmod	Moreover,determined
R7928	T13416	T13415	punct	", ",determined
R7929	T13417	T13415	prep	in,determined
R7930	T13418	T13417	pobj	contrast,in
R7931	T13419	T13418	prep	to,contrast
R7932	T13420	T13421	poss	our,studies
R7933	T13421	T13419	pobj	studies,to
R7934	T13422	T13415	punct	", ",determined
R7935	T13423	T13424	preconj	neither,Li
R7936	T13424	T13415	nsubj	Li,determined
R7937	T13425	T13426	advmod	et,al.
R7938	T13426	T13424	advmod	al.,Li
R7939	T13427	T13428	punct	[,31
R7940	T13428	T13424	parataxis	31,Li
R7941	T13429	T13428	punct	],31
R7942	T13430	T13424	cc	nor,Li
R7943	T13431	T13424	conj	Kunisaki,Li
R7944	T13432	T13433	advmod	et,al.
R7945	T13433	T13431	advmod	al.,Kunisaki
R7946	T13434	T13435	punct	[,32
R7947	T13435	T13431	parataxis	32,Kunisaki
R7948	T13436	T13435	punct	],32
R7949	T13437	T13438	amod	phagocytotic,indexes
R7950	T13438	T13415	dobj	indexes,determined
R7951	T13439	T13438	compound	engulfment,indexes
R7952	T13440	T13438	prep	for,indexes
R7953	T13441	T13442	npadvmod	Ptdsr,deficient
R7954	T13442	T13444	amod	deficient,macrophages
R7955	T13443	T13442	punct	-,deficient
R7956	T13444	T13440	pobj	macrophages,for
R7957	T13445	T13415	punct	.,determined
R7958	T13447	T13448	advmod	Interestingly,observed
R7959	T13449	T13448	punct	", ",observed
R7960	T13450	T13448	nsubj	we,observed
R7961	T13451	T13448	dobj	differences,observed
R7962	T13452	T13451	prep	between,differences
R7963	T13453	T13454	nmod	Ptdsr,macrophages
R7964	T13454	T13452	pobj	macrophages,between
R7965	T13455	T13453	punct	+,Ptdsr
R7966	T13456	T13453	punct	/,Ptdsr
R7967	T13457	T13453	punct	+,Ptdsr
R7968	T13458	T13453	cc	and,Ptdsr
R7969	T13459	T13453	conj	Ptdsr,Ptdsr
R7970	T13460	T13459	punct	-,Ptdsr
R7971	T13461	T13459	punct	/,Ptdsr
R7972	T13462	T13459	punct	-,Ptdsr
R7973	T13463	T13451	prep	in,differences
R7974	T13464	T13465	det	the,secretion
R7975	T13465	T13463	pobj	secretion,in
R7976	T13466	T13465	prep	of,secretion
R7977	T13467	T13468	advmod	pro,anti-inflammatory
R7978	T13468	T13471	amod	anti-inflammatory,cytokines
R7979	T13469	T13468	punct	-,anti-inflammatory
R7980	T13470	T13468	cc	and,anti-inflammatory
R7981	T13471	T13466	pobj	cytokines,of
R7982	T13472	T13451	prep	after,differences
R7983	T13473	T13472	pobj	stimulation,after
R7984	T13474	T13473	prep	with,stimulation
R7985	T13475	T13474	pobj	LPS,with
R7986	T13476	T13475	cc	and,LPS
R7987	T13477	T13478	amod	apoptotic,cells
R7988	T13478	T13475	conj	cells,LPS
R7989	T13479	T13448	punct	.,observed
R7990	T13481	T13482	nsubj	This,provides
R7991	T13483	T13482	dobj	evidence,provides
R7992	T13484	T13485	mark	that,impaired
R7993	T13485	T13483	acl	impaired,evidence
R7994	T13486	T13487	amod	cellular,activation
R7995	T13487	T13485	nsubjpass	activation,impaired
R7996	T13488	T13487	cc	and,activation
R7997	T13489	T13490	compound	effector,mechanisms
R7998	T13490	T13487	conj	mechanisms,activation
R7999	T13491	T13485	auxpass	are,impaired
R8000	T13492	T13485	prep	in,impaired
R8001	T13493	T13494	npadvmod	Ptdsr,deleted
R8002	T13494	T13496	amod	deleted,macrophages
R8003	T13495	T13494	punct	-,deleted
R8004	T13496	T13492	pobj	macrophages,in
R8005	T13497	T13482	punct	.,provides
R8006	T13499	T13500	nsubj	It,remains
R8007	T13501	T13502	aux	to,determined
R8008	T13502	T13500	xcomp	determined,remains
R8009	T13503	T13502	auxpass	be,determined
R8010	T13504	T13505	det	which,pathways
R8011	T13505	T13507	dep	pathways,involve
R8012	T13506	T13505	amod	classical,pathways
R8013	T13507	T13500	ccomp	involve,remains
R8014	T13508	T13505	prep	of,pathways
R8015	T13509	T13510	compound	macrophage,activation
R8016	T13510	T13508	pobj	activation,of
R8017	T13511	T13510	cc	and,activation
R8018	T13512	T13510	conj	function,activation
R8019	T13513	T13507	dobj	Ptdsr,involve
R8020	T13514	T13500	punct	.,remains
R8021	T13516	T13517	nsubj	This,is
R8022	T13518	T13519	advmod	especially,important
R8023	T13519	T13517	acomp	important,is
R8024	T13520	T13517	prep	in,is
R8025	T13521	T13520	pobj	light,in
R8026	T13522	T13521	prep	of,light
R8027	T13523	T13524	amod	recent,findings
R8028	T13524	T13522	pobj	findings,of
R8029	T13525	T13526	dep	that,demonstrated
R8030	T13526	T13524	relcl	demonstrated,findings
R8031	T13527	T13528	amod	nuclear,localization
R8032	T13528	T13526	dobj	localization,demonstrated
R8033	T13529	T13528	prep	of,localization
R8034	T13530	T13531	det	the,protein
R8035	T13531	T13529	pobj	protein,of
R8036	T13532	T13531	compound	Ptdsr,protein
R8037	T13533	T13534	punct	[,29
R8038	T13534	T13517	parataxis	29,is
R8039	T13535	T13534	punct	],29
R8040	T13536	T13517	punct	.,is
R8041	T13538	T13539	advmod	Most,strikingly
R8042	T13539	T13540	advmod	strikingly,are
R8043	T13541	T13540	punct	", ",are
R8044	T13542	T13543	det	the,data
R8045	T13543	T13540	nsubj	data,are
R8046	T13544	T13545	advmod	recently,published
R8047	T13545	T13543	amod	published,data
R8048	T13546	T13543	acl	regarding,data
R8049	T13547	T13548	det	the,ablation
R8050	T13548	T13546	dobj	ablation,regarding
R8051	T13549	T13548	amod	genetic,ablation
R8052	T13550	T13548	cc	or,ablation
R8053	T13551	T13548	conj	perturbation,ablation
R8054	T13552	T13548	prep	of,ablation
R8055	T13553	T13554	compound	phosphatidylserine,function
R8056	T13554	T13552	pobj	function,of
R8057	T13555	T13554	compound	receptor,function
R8058	T13556	T13548	prep	in,ablation
R8059	T13557	T13558	compound	C.,elegans
R8060	T13558	T13556	pobj	elegans,in
R8061	T13559	T13540	advmod	also,are
R8062	T13560	T13540	acomp	contradictory,are
R8063	T13561	T13540	punct	.,are
R8064	T13563	T13564	nsubj	Wang,reported
R8065	T13565	T13566	advmod	et,al.
R8066	T13566	T13563	advmod	al.,Wang
R8067	T13567	T13568	punct	[,45
R8068	T13568	T13563	parataxis	45,Wang
R8069	T13569	T13568	punct	],45
R8070	T13570	T13571	mark	that,is
R8071	T13571	T13564	ccomp	is,reported
R8072	T13572	T13571	nsubj	psr,is
R8073	T13573	T13572	punct	-,psr
R8074	T13574	T13572	nummod	1,psr
R8075	T13575	T13572	punct	", ",psr
R8076	T13576	T13577	det	the,homolog
R8077	T13577	T13572	appos	homolog,psr
R8078	T13578	T13579	compound	C.,elegans
R8079	T13579	T13577	compound	elegans,homolog
R8080	T13580	T13577	prep	of,homolog
R8081	T13581	T13580	pobj	Ptdsr,of
R8082	T13582	T13571	punct	", ",is
R8083	T13583	T13571	acomp	important,is
R8084	T13584	T13583	prep	for,important
R8085	T13585	T13586	compound	cell,corpse
R8086	T13586	T13588	compound	corpse,engulfment
R8087	T13587	T13586	punct	-,corpse
R8088	T13588	T13584	pobj	engulfment,for
R8089	T13589	T13564	punct	", ",reported
R8090	T13590	T13591	mark	whereas,yielded
R8091	T13591	T13564	advcl	yielded,reported
R8092	T13592	T13593	nmod	psr,studies
R8093	T13593	T13591	nsubj	studies,yielded
R8094	T13594	T13592	punct	-,psr
R8095	T13595	T13592	nummod	1,psr
R8096	T13596	T13593	compound	RNAi,studies
R8097	T13597	T13593	acl	performed,studies
R8098	T13598	T13597	agent	by,performed
R8099	T13599	T13598	pobj	Arur,by
R8100	T13600	T13601	advmod	et,al.
R8101	T13601	T13599	advmod	al.,Arur
R8102	T13602	T13603	punct	[,25
R8103	T13603	T13599	parataxis	25,Arur
R8104	T13604	T13603	punct	],25
R8105	T13605	T13591	punct	", ",yielded
R8106	T13606	T13591	prep	in,yielded
R8107	T13607	T13608	det	this,respect
R8108	T13608	T13606	pobj	respect,in
R8109	T13609	T13591	punct	", ",yielded
R8110	T13610	T13611	det	no,phenotype
R8111	T13611	T13591	dobj	phenotype,yielded
R8112	T13612	T13564	punct	.,reported
R8113	T13614	T13615	advmod	Moreover,hypothesized
R8114	T13616	T13615	punct	", ",hypothesized
R8115	T13617	T13615	nsubj	Wang,hypothesized
R8116	T13618	T13617	cc	and,Wang
R8117	T13619	T13617	conj	colleagues,Wang
R8118	T13620	T13615	prep	on,hypothesized
R8119	T13621	T13622	det	the,basis
R8120	T13622	T13620	pobj	basis,on
R8121	T13623	T13622	prep	of,basis
R8122	T13624	T13625	poss	their,data
R8123	T13625	T13623	pobj	data,of
R8124	T13626	T13627	mark	that,act
R8125	T13627	T13615	ccomp	act,hypothesized
R8126	T13628	T13627	nsubj	psr,act
R8127	T13629	T13628	punct	-,psr
R8128	T13630	T13628	nummod	1,psr
R8129	T13631	T13627	aux	might,act
R8130	T13632	T13633	aux	to,transduce
R8131	T13633	T13627	advcl	transduce,act
R8132	T13634	T13635	det	an,signal
R8133	T13635	T13633	dobj	signal,transduce
R8134	T13636	T13635	compound	engulfment,signal
R8135	T13637	T13633	advmod	upstream,transduce
R8136	T13638	T13637	prep	of,upstream
R8137	T13639	T13638	pobj	Ced,of
R8138	T13640	T13639	punct	-,Ced
R8139	T13641	T13639	nummod	2,Ced
R8140	T13642	T13643	punct	(,Crk
R8141	T13643	T13639	parataxis	Crk,Ced
R8142	T13644	T13643	nummod	II,Crk
R8143	T13645	T13643	punct	),Crk
R8144	T13646	T13639	punct	", ",Ced
R8145	T13647	T13639	conj	Ced,Ced
R8146	T13648	T13647	punct	-,Ced
R8147	T13649	T13647	nummod	5,Ced
R8148	T13650	T13651	punct	(,Dock
R8149	T13651	T13647	parataxis	Dock,Ced
R8150	T13652	T13651	nummod	180,Dock
R8151	T13653	T13651	punct	),Dock
R8152	T13654	T13647	punct	", ",Ced
R8153	T13655	T13647	conj	Ced,Ced
R8154	T13656	T13655	punct	-,Ced
R8155	T13657	T13655	nummod	10,Ced
R8156	T13658	T13659	punct	(,Rac
R8157	T13659	T13655	parataxis	Rac,Ced
R8158	T13660	T13659	nummod	1,Rac
R8159	T13661	T13659	punct	),Rac
R8160	T13662	T13655	cc	and,Ced
R8161	T13663	T13655	conj	Ced,Ced
R8162	T13664	T13663	punct	-,Ced
R8163	T13665	T13663	nummod	12,Ced
R8164	T13666	T13667	punct	(,Elmo
R8165	T13667	T13663	parataxis	Elmo,Ced
R8166	T13668	T13667	punct	),Elmo
R8167	T13669	T13633	prep	in,transduce
R8168	T13670	T13669	pobj	one,in
R8169	T13671	T13670	prep	of,one
R8170	T13672	T13673	det	the,pathways
R8171	T13673	T13671	pobj	pathways,of
R8172	T13674	T13673	nummod	two,pathways
R8173	T13675	T13676	compound	cell,corpse
R8174	T13676	T13678	compound	corpse,engulfment
R8175	T13677	T13676	punct	-,corpse
R8176	T13678	T13673	compound	engulfment,pathways
R8177	T13679	T13673	prep	in,pathways
R8178	T13680	T13681	det	the,worm
R8179	T13681	T13679	pobj	worm,in
R8180	T13682	T13683	punct	[,45
R8181	T13683	T13615	parataxis	45,hypothesized
R8182	T13684	T13683	punct	],45
R8183	T13685	T13615	punct	.,hypothesized
R8184	T13687	T13688	cc	But,are
R8185	T13689	T13690	det	the,phenotype
R8186	T13690	T13688	nsubj	phenotype,are
R8187	T13691	T13690	nmod	loss,phenotype
R8188	T13692	T13691	punct	-,loss
R8189	T13693	T13691	prep	of,loss
R8190	T13694	T13693	punct	-,of
R8191	T13695	T13693	pobj	function,of
R8192	T13696	T13690	prep	of,phenotype
R8193	T13697	T13698	nmod	psr,mutants
R8194	T13698	T13696	pobj	mutants,of
R8195	T13699	T13697	punct	-,psr
R8196	T13700	T13697	nummod	1,psr
R8197	T13701	T13690	cc	and,phenotype
R8198	T13702	T13703	det	the,phenotypes
R8199	T13703	T13690	conj	phenotypes,phenotype
R8200	T13704	T13703	compound	complementation,phenotypes
R8201	T13705	T13703	prep	in,phenotypes
R8202	T13706	T13707	amod	overexpressing,worms
R8203	T13707	T13705	pobj	worms,in
R8204	T13708	T13707	amod	transgenic,worms
R8205	T13709	T13703	acl	shown,phenotypes
R8206	T13710	T13709	agent	by,shown
R8207	T13711	T13710	pobj	Wang,by
R8208	T13712	T13713	advmod	et,al.
R8209	T13713	T13711	advmod	al.,Wang
R8210	T13714	T13715	punct	[,45
R8211	T13715	T13711	parataxis	45,Wang
R8212	T13716	T13715	punct	],45
R8213	T13717	T13718	advmod	rather,weak
R8214	T13718	T13688	acomp	weak,are
R8215	T13719	T13720	mark	as,compared
R8216	T13720	T13688	advcl	compared,are
R8217	T13721	T13720	prep	to,compared
R8218	T13722	T13723	det	the,mutants
R8219	T13723	T13721	pobj	mutants,to
R8220	T13724	T13723	amod	classical,mutants
R8221	T13725	T13726	compound	C.,elegans
R8222	T13726	T13723	compound	elegans,mutants
R8223	T13727	T13723	compound	engulfment,mutants
R8224	T13728	T13729	punct	[,8
R8225	T13729	T13688	parataxis	8,are
R8226	T13730	T13729	punct	],8
R8227	T13731	T13688	punct	.,are
R8228	T13733	T13734	amod	Many,studies
R8229	T13734	T13737	nsubj	studies,used
R8230	T13735	T13734	amod	previous,studies
R8231	T13736	T13734	amod	functional,studies
R8232	T13738	T13739	dep	that,reported
R8233	T13739	T13734	relcl	reported,studies
R8234	T13740	T13741	det	a,requirement
R8235	T13741	T13739	dobj	requirement,reported
R8236	T13742	T13741	prep	for,requirement
R8237	T13743	T13742	pobj	Ptdsr,for
R8238	T13744	T13741	prep	for,requirement
R8239	T13745	T13746	det	the,phagocytosis
R8240	T13746	T13744	pobj	phagocytosis,for
R8241	T13747	T13746	prep	of,phagocytosis
R8242	T13748	T13749	amod	apoptotic,cells
R8243	T13749	T13747	pobj	cells,of
R8244	T13750	T13751	det	the,antibody
R8245	T13751	T13737	dobj	antibody,used
R8246	T13752	T13751	amod	monoclonal,antibody
R8247	T13753	T13751	amod	anti-Ptdsr,antibody
R8248	T13754	T13755	compound	mAb,217G8E9
R8249	T13755	T13751	appos	217G8E9,antibody
R8250	T13756	T13757	punct	[,26
R8251	T13757	T13737	parataxis	26,used
R8252	T13758	T13757	punct	],26
R8253	T13759	T13737	punct	.,used
R8254	T13761	T13762	det	This,antibody
R8255	T13762	T13763	nsubjpass	antibody,used
R8256	T13764	T13763	auxpass	was,used
R8257	T13765	T13763	prep	in,used
R8258	T13766	T13767	nmod	Ptdsr,experiments
R8259	T13767	T13765	pobj	experiments,in
R8260	T13768	T13767	nmod	binding,experiments
R8261	T13769	T13768	cc	and,binding
R8262	T13770	T13768	conj	blocking,binding
R8263	T13771	T13765	punct	", ",in
R8264	T13772	T13773	advmod	as,as
R8265	T13773	T13765	cc	as,in
R8266	T13774	T13773	advmod	well,as
R8267	T13775	T13765	conj	in,in
R8268	T13776	T13777	amod	subcellular,studies
R8269	T13777	T13775	pobj	studies,in
R8270	T13778	T13777	compound	localization,studies
R8271	T13779	T13777	punct	", ",studies
R8272	T13780	T13781	dep	which,led
R8273	T13781	T13777	relcl	led,studies
R8274	T13782	T13781	prep	to,led
R8275	T13783	T13784	det	the,conclusion
R8276	T13784	T13782	pobj	conclusion,to
R8277	T13785	T13786	mark	that,is
R8278	T13786	T13784	acl	is,conclusion
R8279	T13787	T13786	nsubj	Ptdsr,is
R8280	T13788	T13789	det	a,receptor
R8281	T13789	T13786	attr	receptor,is
R8282	T13790	T13789	compound	transmembrane,receptor
R8283	T13791	T13789	amod	critical,receptor
R8284	T13792	T13791	prep	for,critical
R8285	T13793	T13794	compound	signal,transduction
R8286	T13794	T13792	pobj	transduction,for
R8287	T13795	T13794	prep	at,transduction
R8288	T13796	T13797	det	the,interface
R8289	T13797	T13795	pobj	interface,at
R8290	T13798	T13797	compound	engulfment,interface
R8291	T13799	T13763	punct	.,used
R8292	T13801	T13802	advmod	More,recently
R8293	T13802	T13803	advmod	recently,used
R8294	T13804	T13803	nsubjpass	it,used
R8295	T13805	T13803	auxpass	was,used
R8296	T13806	T13803	prep	in,used
R8297	T13807	T13808	compound	binding,assays
R8298	T13808	T13806	pobj	assays,in
R8299	T13809	T13810	aux	to,show
R8300	T13810	T13803	advcl	show,used
R8301	T13811	T13812	mark	that,recognize
R8302	T13812	T13810	ccomp	recognize,show
R8303	T13813	T13814	det	the,molecules
R8304	T13814	T13812	nsubj	molecules,recognize
R8305	T13815	T13814	amod	human,molecules
R8306	T13816	T13815	cc	and,human
R8307	T13817	T13815	conj	worm,human
R8308	T13818	T13814	compound	Ptdsr,molecules
R8309	T13819	T13812	aux	can,recognize
R8310	T13820	T13812	dobj	phosphatidylserine,recognize
R8311	T13821	T13822	punct	[,45
R8312	T13822	T13803	parataxis	45,used
R8313	T13823	T13822	punct	],45
R8314	T13824	T13803	punct	.,used
R8315	T13826	T13827	prep	In,stained
R8316	T13828	T13829	det	the,course
R8317	T13829	T13826	pobj	course,In
R8318	T13830	T13829	prep	of,course
R8319	T13831	T13832	det	the,study
R8320	T13832	T13830	pobj	study,of
R8321	T13833	T13832	acl	presented,study
R8322	T13834	T13833	advmod	here,presented
R8323	T13835	T13827	punct	", ",stained
R8324	T13836	T13827	nsubj	we,stained
R8325	T13837	T13827	advmod	immunohistochemically,stained
R8326	T13838	T13827	prep	for,stained
R8327	T13839	T13838	pobj	Ptdsr,for
R8328	T13840	T13827	prep	with,stained
R8329	T13841	T13842	compound	mAb,217G8E9
R8330	T13842	T13840	pobj	217G8E9,with
R8331	T13843	T13827	prep	on,stained
R8332	T13844	T13845	amod	wild,type
R8333	T13845	T13847	nmod	type,macrophages
R8334	T13846	T13845	punct	-,type
R8335	T13847	T13843	pobj	macrophages,on
R8336	T13848	T13845	cc	and,type
R8337	T13849	T13850	npadvmod	Ptdsr,deficient
R8338	T13850	T13845	conj	deficient,type
R8339	T13851	T13850	punct	-,deficient
R8340	T13852	T13847	cc	and,macrophages
R8341	T13853	T13847	conj	fibroblasts,macrophages
R8342	T13854	T13855	punct	(,see
R8343	T13855	T13827	parataxis	see,stained
R8344	T13856	T13857	amod	Additional,data
R8345	T13857	T13858	compound	data,file
R8346	T13858	T13855	dobj	file,see
R8347	T13859	T13858	nummod	1,file
R8348	T13860	T13858	punct	", ",file
R8349	T13861	T13862	compound	Figure,S2
R8350	T13862	T13858	conj	S2,file
R8351	T13863	T13862	cc	and,S2
R8352	T13864	T13862	conj	data,S2
R8353	T13865	T13866	neg	not,shown
R8354	T13866	T13864	acl	shown,data
R8355	T13867	T13855	punct	),see
R8356	T13868	T13827	punct	.,stained
R8357	T13870	T13871	prep	To,observed
R8358	T13872	T13873	poss	our,surprise
R8359	T13873	T13870	pobj	surprise,To
R8360	T13874	T13871	punct	", ",observed
R8361	T13875	T13871	nsubj	we,observed
R8362	T13876	T13877	amod	similar,patterns
R8363	T13877	T13871	dobj	patterns,observed
R8364	T13878	T13877	compound	staining,patterns
R8365	T13879	T13871	prep	with,observed
R8366	T13880	T13879	pobj	cells,with
R8367	T13881	T13880	prep	of,cells
R8368	T13882	T13883	det	both,genotypes
R8369	T13883	T13881	pobj	genotypes,of
R8370	T13884	T13871	punct	.,observed
R8371	T13886	T13887	advmod	Furthermore,found
R8372	T13888	T13887	punct	", ",found
R8373	T13889	T13887	advcl	using,found
R8374	T13890	T13891	det	a,array
R8375	T13891	T13889	dobj	array,using
R8376	T13892	T13893	compound	Ptdsr,peptide
R8377	T13893	T13891	compound	peptide,array
R8378	T13894	T13893	punct	-,peptide
R8379	T13895	T13887	nsubj	we,found
R8380	T13896	T13897	mark	that,bind
R8381	T13897	T13887	ccomp	bind,found
R8382	T13898	T13899	compound	mAb,217G8E9
R8383	T13899	T13897	nsubj	217G8E9,bind
R8384	T13900	T13897	aux	can,bind
R8385	T13901	T13897	advmod	weakly,bind
R8386	T13902	T13897	prep	to,bind
R8387	T13903	T13904	det	a,peptide
R8388	T13904	T13902	pobj	peptide,to
R8389	T13905	T13904	compound	Ptdsr,peptide
R8390	T13906	T13897	punct	", ",bind
R8391	T13907	T13897	advcl	explaining,bind
R8392	T13908	T13909	det	the,isolation
R8393	T13909	T13907	dobj	isolation,explaining
R8394	T13910	T13909	amod	original,isolation
R8395	T13911	T13909	prep	of,isolation
R8396	T13912	T13913	compound	Ptdsr,clones
R8397	T13913	T13911	pobj	clones,of
R8398	T13914	T13913	compound	cDNA,clones
R8399	T13915	T13909	prep	by,isolation
R8400	T13916	T13917	compound	phage,display
R8401	T13917	T13915	pobj	display,by
R8402	T13918	T13919	punct	[,26
R8403	T13919	T13887	parataxis	26,found
R8404	T13920	T13919	punct	],26
R8405	T13921	T13887	punct	;,found
R8406	T13922	T13887	cc	but,found
R8407	T13923	T13924	det	the,antibody
R8408	T13924	T13925	nsubj	antibody,recognizes
R8409	T13925	T13887	conj	recognizes,found
R8410	T13926	T13925	advmod	mainly,recognizes
R8411	T13927	T13928	amod	additional,protein
R8412	T13928	T13925	dobj	protein,recognizes
R8413	T13929	T13928	punct	", ",protein
R8414	T13930	T13931	advmod	as,yet
R8415	T13931	T13933	advmod	yet,unknown
R8416	T13932	T13931	punct	-,yet
R8417	T13933	T13928	amod	unknown,protein
R8418	T13934	T13928	punct	", ",protein
R8419	T13935	T13936	npadvmod	membrane,associated
R8420	T13936	T13928	amod	associated,protein
R8421	T13937	T13936	punct	-,associated
R8422	T13938	T13928	punct	(,protein
R8423	T13939	T13928	nmod	s,protein
R8424	T13940	T13928	punct	),protein
R8425	T13941	T13942	punct	(,S2
R8426	T13942	T13925	parataxis	S2,recognizes
R8427	T13943	T13942	advcl	see,S2
R8428	T13944	T13945	amod	Additional,data
R8429	T13945	T13946	compound	data,file
R8430	T13946	T13943	dobj	file,see
R8431	T13947	T13946	nummod	1,file
R8432	T13948	T13942	punct	", ",S2
R8433	T13949	T13942	compound	Figure,S2
R8434	T13950	T13942	punct	),S2
R8435	T13951	T13925	punct	.,recognizes
R8436	T13953	T13954	nsubjpass	Experiments,interpreted
R8437	T13955	T13956	dep	that,used
R8438	T13956	T13953	relcl	used,Experiments
R8439	T13957	T13956	aux	have,used
R8440	T13958	T13959	det	this,antibody
R8441	T13959	T13956	dobj	antibody,used
R8442	T13960	T13954	aux	should,interpreted
R8443	T13961	T13954	advmod	therefore,interpreted
R8444	T13962	T13954	auxpass	be,interpreted
R8445	T13963	T13954	prep	with,interpreted
R8446	T13964	T13965	amod	great,caution
R8447	T13965	T13963	pobj	caution,with
R8448	T13966	T13967	mark	as,come
R8449	T13967	T13954	advcl	come,interpreted
R8450	T13968	T13967	nsubj	they,come
R8451	T13969	T13967	aux	might,come
R8452	T13970	T13971	aux	to,viewed
R8453	T13971	T13967	xcomp	viewed,come
R8454	T13972	T13971	auxpass	be,viewed
R8455	T13973	T13971	prep	in,viewed
R8456	T13974	T13975	det	a,light
R8457	T13975	T13973	pobj	light,in
R8458	T13976	T13975	amod	different,light
R8459	T13977	T13954	punct	.,interpreted
R6949	T11565	T11562	acomp	normal,is
R6951	T11566	T11562	prep	in,is
R6952	T11567	T11568	poss	our,line
R6953	T11568	T11566	pobj	line,in
R6955	T11569	T11570	compound	Ptdsr,knockout
R6956	T11570	T11568	compound	knockout,line
R6958	T11571	T11570	punct	-,knockout
R6959	T11572	T11547	punct	.,explained
R6961	T11574	T11575	det	This,result
R6962	T11575	T11576	nsubj	result,indicates
R6968	T11577	T11576	advmod	therefore,indicates
R6969	T11578	T11579	mark	that,has
R6970	T11579	T11576	ccomp	has,indicates
R6972	T11580	T11579	nsubj	Ptdsr,has
R6973	T11581	T11582	det	a,role
R6974	T11582	T11579	dobj	role,has
R6975	T11583	T11582	amod	novel,role
R6977	T11584	T11582	punct	", ",role
R6978	T11585	T11586	advmod	hitherto,unexpected
R6980	T11586	T11582	amod	unexpected,role
R6981	T11587	T11582	punct	", ",role
R6982	T11588	T11582	prep	in,role
R6983	T11589	T11588	pcomp	promoting,in
R6984	T11590	T11591	compound	tissue,maturation
R6985	T11591	T11589	dobj	maturation,promoting

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T9416	12-17	PR_EXT:000009218	denotes	Ptdsr
T9417	38-53	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9418	66-79	UBERON:0000467	denotes	organ systems
T9419	134-138	SO_EXT:sequence_nullness	denotes	null
T9420	139-147	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T9421	155-173	CHEBI:18303	denotes	phosphatidylserine
T9422	155-182	PR_EXT:000009218	denotes	phosphatidylserine receptor
T9423	174-182	GO_EXT:0004872	denotes	receptor
T9424	184-189	PR_EXT:000009218	denotes	Ptdsr
T9425	191-195	SO_EXT:0000704	denotes	gene
T9426	208-212	NCBITaxon:10088	denotes	mice
T9427	239-244	PR_EXT:000009218	denotes	Ptdsr
T9428	265-280	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9429	301-307	UBERON:0000062	denotes	organs
T9430	312-319	UBERON:0000479	denotes	tissues
T9431	327-340	GO:0009790	denotes	embryogenesis
T9432	454-459	PR_EXT:000009218	denotes	Ptdsr
T9433	470-474	NCBITaxon:10088	denotes	mice
T9434	506-511	NCBITaxon:10088	denotes	mouse
T9435	533-538	SO_EXT:0000147	denotes	exons
T9436	564-569	SO_EXT:0000147	denotes	exons
T9437	593-600	SO_EXT:sequence_deletion_process	denotes	deleted
T9438	604-615	SO_EXT:sequence_substitution_entity_or_process	denotes	replacement
T9439	623-631	CHEBI:7507	denotes	neomycin
T9440	642-650	SO_EXT:0005853	denotes	cassette
T9441	656-661	PR_EXT:000009218	denotes	Ptdsr
T9442	671-676	NCBITaxon:10088	denotes	mouse
T9443	697-704	SO_EXT:0000704	denotes	genetic
T9444	729-737	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T9445	794-799	PR_EXT:000009218	denotes	Ptdsr
T9446	800-804	SO_EXT:sequence_nullness	denotes	null
T9447	805-811	SO_EXT:0001023	denotes	allele
T9448	946-951	PR_EXT:000009218	denotes	Ptdsr
T9449	961-965	NCBITaxon:10088	denotes	mice
T9450	1019-1024	PR_EXT:000009218	denotes	Ptdsr
T9451	1045-1054	UBERON:0012101	denotes	perinatal
T9452	1049-1054	GO:0007567	denotes	natal
T9453	1055-1064	GO_EXT:fatality_or_lethality	denotes	lethality
T9454	1181-1186	PR_EXT:000009218	denotes	Ptdsr
T9455	1197-1202	NCBITaxon:10088	denotes	mouse
T9456	1253-1260	SO_EXT:0000704	denotes	genetic
T9457	1393-1398	PR_EXT:000009218	denotes	Ptdsr
T9458	1408-1413	NCBITaxon:10088	denotes	mouse
T9459	1434-1440	GO_EXT:biological_growth_entity_or_process	denotes	growth
T9460	1512-1527	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9461	1539-1545	UBERON:0000062	denotes	organs
T9462	1555-1560	PR_EXT:000009218	denotes	Ptdsr
T9463	1564-1573	GO:0010467	denotes	expressed
T9464	1588-1601	GO:0009790	denotes	embryogenesis
T9465	1614-1623	UBERON:0000113	denotes	adulthood
T9466	1644-1670	_FRAGMENT	denotes	branching morphogenesis of
T9467	1675-1690	GO:0060441	denotes	lung epithelium
T9468	1675-1690	UBERON:0000115	denotes	lung epithelium
T9469	1707-1712	PR_EXT:000009218	denotes	Ptdsr
T9470	1713-1714	SO_EXT:sequence_nullness_or_absence	denotes	-
T9471	1715-1716	SO_EXT:sequence_nullness_or_absence	denotes	-
T9472	1717-1722	UBERON:0002048	denotes	lungs
T9473	1735-1745	UBERON:0000483	denotes	epithelial
T9474	1790-1796	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9475	1797-1804	UBERON:0002113	denotes	kidneys
T9476	1823-1838	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9477	1842-1858	UBERON:0001230	denotes	Bowman's capsule
T9478	1904-1918	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T9479	1919-1937	UBERON:0001232	denotes	collecting tubules
T9480	1953-1968	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9481	1976-1985	UBERON:0000160	denotes	intestine
T9482	2060-2069	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9483	2080-2090	UBERON:0000160	denotes	intestinal
T9484	2091-2098	UBERON:0000479	denotes	tissues
T9485	2102-2107	PR_EXT:000009218	denotes	Ptdsr
T9486	2117-2121	NCBITaxon:10088	denotes	mice
T9487	2164-2179	UBERON:0001809	denotes	enteric ganglia
T9488	2187-2201	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T9489	2202-2222	UBERON:0001135	denotes	smooth muscle tissue
T9490	2250-2256	UBERON:0002113	denotes	kidney
T9491	2261-2270	UBERON:0000160	denotes	intestine
T9492	2271-2286	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9493	2313-2318	PR_EXT:000009218	denotes	Ptdsr
T9494	2414-2419	PR_EXT:000009218	denotes	Ptdsr
T9495	2419-2420	SO_EXT:sequence_nullness_or_absence	denotes	-
T9496	2421-2422	SO_EXT:sequence_nullness_or_absence	denotes	-
T9497	2423-2430	UBERON:0000922	denotes	embryos
T9498	2446-2451	GO:0007567	denotes	birth
T9499	2463-2473	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatally
T9500	2494-2509	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9501	2520-2526	UBERON:0000062	denotes	organs
T9502	2566-2575	GO:0007565	denotes	gestation
T9503	2613-2618	PR_EXT:000009218	denotes	Ptdsr
T9504	2619-2620	SO_EXT:sequence_nullness_or_absence	denotes	-
T9505	2621-2622	SO_EXT:sequence_nullness_or_absence	denotes	-
T9506	2623-2628	UBERON:0002048	denotes	lungs
T9507	2654-2659	UBERON:0002048	denotes	lungs
T9508	2676-2680	NCBITaxon:10088	denotes	mice
T9509	2725-2739	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T9510	2740-2747	UBERON:0003215	denotes	alveoli
T9511	2752-2763	UBERON:0002186	denotes	bronchioles
T9512	2799-2820	GO:0012501	denotes	programmed cell death
T9513	2810-2814	CL_GO_EXT:cell	denotes	cell
T9514	2828-2832	UBERON:0002048	denotes	lung
T9515	2828-2844	GO:0030324	denotes	lung development
T9516	2848-2857	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9517	2862-2867	PR_EXT:000009218	denotes	Ptdsr
T9518	2877-2881	NCBITaxon:10088	denotes	mice
T9519	2893-2906	GO:0009790	denotes	embryogenesis
T9520	2959-2965	PR:000026878	denotes	aCasp3
T9521	2980-2989	GO:0006915	denotes	apoptosis
T9522	3013-3017	UBERON:0002048	denotes	lung
T9523	3013-3031	GO:0060425	denotes	lung morphogenesis
T9524	3099-3108	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9525	3099-3114	CL:0000445	denotes	apoptotic cells
T9526	3109-3114	CL_GO_EXT:cell	denotes	cells
T9527	3118-3123	PR_EXT:000009218	denotes	Ptdsr
T9528	3137-3146	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9529	3147-3154	NCBITaxon:33208	denotes	animals
T9530	3195-3204	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9531	3195-3210	CL:0000445	denotes	apoptotic cells
T9532	3205-3210	CL_GO_EXT:cell	denotes	cells
T9533	3218-3222	UBERON:0002048	denotes	lung
T9534	3223-3230	UBERON:0000479	denotes	tissues
T9535	3331-3353	_FRAGMENT	denotes	clearance of apoptotic
T9536	3381-3386	GO:0043277	denotes	cells
T9537	3344-3353	_FRAGMENT	denotes	apoptotic
T9538	3381-3386	CL:0000445	denotes	cells
T9539	3354-3365	UBERON:0003104	denotes	mesenchymal
T9540	3354-3365	_FRAGMENT	denotes	mesenchymal
T9541	3381-3386	CL:0000134	denotes	cells
T9542	3370-3380	UBERON:0000483	denotes	epithelial
T9543	3370-3386	CL:0000066	denotes	epithelial cells
T9544	3381-3386	CL_GO_EXT:cell	denotes	cells
T9545	3407-3411	UBERON:0002048	denotes	lung
T9546	3407-3425	GO:0060425	denotes	lung morphogenesis
T9547	3429-3434	PR_EXT:000009218	denotes	Ptdsr
T9548	3445-3449	NCBITaxon:10088	denotes	mice
T9549	3514-3518	UBERON:0002048	denotes	lung
T9550	3514-3530	GO:0030324	denotes	lung development
T9551	3538-3551	GO:0009790	denotes	embryogenesis
T9552	3566-3578	_FRAGMENT	denotes	formation of
T9553	3583-3598	GO:0060428	denotes	epithelial lung
T9554	3583-3598	UBERON:0000115	denotes	epithelial lung
T9555	3603-3626	GO:0001763	denotes	branching morphogenesis
T9556	3717-3722	UBERON:0000062	denotes	organ
T9557	3723-3729	UBERON:0007688	denotes	anlage
T9558	3747-3754	UBERON_EXT:placode	denotes	placode
T9559	3789-3796	UBERON_EXT:placode	denotes	placode
T9641	6499-6522	GO:0003408	denotes	formation of optic cups
T9560	3932-3947	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9561	3951-3956	UBERON:0000062	denotes	organ
T9562	4057-4070	GO:0009790	denotes	embryogenesis
T9563	4080-4093	UBERON:0001911	denotes	mammary gland
T9564	4080-4103	GO:0030879	denotes	mammary gland formation
T9565	4109-4114	GO_UBERON_EXT:lumen	denotes	lumen
T9566	4122-4127	UBERON:0002048	denotes	lungs
T9567	4220-4229	GO:0006915	denotes	apoptosis
T9568	4260-4265	UBERON:0002048	denotes	lungs
T9569	4269-4274	PR_EXT:000009218	denotes	Ptdsr
T9570	4275-4276	SO_EXT:sequence_nullness_or_absence	denotes	-
T9571	4277-4278	SO_EXT:sequence_nullness_or_absence	denotes	-
T9572	4278-4286	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T9573	4364-4373	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T9574	4414-4419	PR_EXT:000009218	denotes	Ptdsr
T9575	4420-4427	SO_EXT:sequence_altered_entity	denotes	mutants
T9576	4428-4431	GO:0016265	denotes	die
T9577	4435-4446	UBERON:0001004	denotes	respiratory
T9578	4447-4451	UBERON:0002048	denotes	lung
T9579	4515-4525	CHEBI_EXT:35195	denotes	surfactant
T9580	4526-4536	GO:0010467	denotes	expression
T9581	4550-4555	PR_EXT:000009218	denotes	Ptdsr
T9582	4566-4573	NCBITaxon:33208	denotes	animals
T9583	4605-4618	_FRAGMENT	denotes	maturation of
T9584	4657-4673	GO:0002070	denotes	epithelial cells
T9585	4619-4629	CHEBI_EXT:35195	denotes	surfactant
T9586	4640-4673	CL:0002063	denotes	type II alveolar epithelial cells
T9587	4648-4667	UBERON:0004821	denotes	alveolar epithelial
T9588	4668-4673	CL_GO_EXT:cell	denotes	cells
T9589	4678-4682	UBERON:0002048	denotes	lung
T9590	4745-4750	GO:0016265	denotes	death
T9591	4754-4759	PR_EXT:000009218	denotes	Ptdsr
T9592	4760-4766	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9593	4767-4771	NCBITaxon:10088	denotes	mice
T9594	4800-4809	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	cutaneous
T9595	4838-4843	PR_EXT:000009218	denotes	Ptdsr
T9596	4886-4891	PR_EXT:000009218	denotes	Ptdsr
T9597	4907-4916	GO_EXT:fatality_or_lethality	denotes	lethality
T9598	4942-4956	UBERON:0004535	denotes	cardiovascular
T9599	5027-5032	PR_EXT:000009218	denotes	Ptdsr
T9600	5042-5046	NCBITaxon:10088	denotes	mice
T9601	5047-5050	GO:0016265	denotes	die
T9602	5077-5082	UBERON:0000948	denotes	heart
T9603	5077-5094	GO:0007507	denotes	heart development
T9604	5129-5144	UBERON_EXT:heart_or_lung	denotes	cardiopulmonary
T9605	5328-5331	UBERON:0000970	denotes	eye
T9606	5328-5343	GO:0001654	denotes	eye development
T9607	5366-5371	PR_EXT:000009218	denotes	Ptdsr
T9608	5372-5376	SO_EXT:0000704	denotes	gene
T9609	5378-5383	PR_EXT:000009218	denotes	Ptdsr
T9610	5394-5401	UBERON:0000922	denotes	embryos
T9611	5524-5536	_FRAGMENT	denotes	formation of
T9612	5545-5573	GO:0003406	denotes	retinal-pigmented epithelium
T9613	5545-5573	UBERON:0001782	denotes	retinal-pigmented epithelium
T9614	5553-5562	CHEBI_EXT:26130	denotes	pigmented
T9615	5591-5604	GO:0008283	denotes	proliferation
T9616	5619-5629	UBERON:0003104	denotes	mesenchyme
T9617	5637-5649	UBERON:0001707	denotes	nasal cavity
T9618	5768-5773	NCBITaxon:10088	denotes	mouse
T9619	5774-5780	SO_EXT:sequence_altered_entity	denotes	mutant
T9620	5821-5824	UBERON:0000970	denotes	eye
T9621	5859-5866	UBERON:0000966	denotes	retinal
T9622	5859-5878	GO:0060041	denotes	retinal development
T9623	5912-5921	GO:0007565	denotes	gestation
T9624	5949-5962	GO:0009653	denotes	morphogenesis
T9625	5970-5998	UBERON:0001791	denotes	inner granular retinal layer
T9626	6018-6031	GO:0009790	denotes	embryogenesis
T9627	6101-6111	GO:0010467	denotes	expression
T9628	6127-6132	PR_EXT:000009218	denotes	Ptdsr
T9629	6133-6137	SO_EXT:0000704	denotes	gene
T9630	6150-6155	PR_EXT:000009218	denotes	Ptdsr
T9631	6159-6168	GO:0010467	denotes	expressed
T9632	6201-6215	UBERON:0001016	denotes	nervous system
T9633	6276-6285	UBERON:0001890	denotes	forebrain
T9634	6293-6303	GO:0010467	denotes	expression
T9635	6346-6352	UBERON:0000966	denotes	retina
T9636	6357-6361	UBERON_EXT:lens	denotes	lens
T9637	6369-6374	PR_EXT:000009218	denotes	Ptdsr
T9638	6423-6429	UBERON:0000970	denotes	ocular
T9639	6423-6443	GO:0048592	denotes	ocular morphogenesis
T9640	6484-6487	UBERON:0000970	denotes	eye
T9642	6512-6522	UBERON:0003072	denotes	optic cups
T9643	6536-6539	UBERON:0000970	denotes	eye
T9644	6536-6549	GO:0001654	denotes	eye-formation
T9645	6588-6602	_FRAGMENT	denotes	development of
T9646	6607-6616	GO:0030900	denotes	forebrain
T9647	6633-6637	GO:0043584	denotes	nose
T9648	6607-6616	UBERON:0001890	denotes	forebrain
T9649	6633-6637	UBERON:0000004	denotes	nose
T9650	6712-6721	UBERON:0001890	denotes	forebrain
T9651	6726-6731	UBERON:0000004	denotes	nasal
T9652	6746-6751	PR_EXT:000009218	denotes	Ptdsr
T9653	6761-6768	UBERON:0000922	denotes	embryos
T9654	6839-6845	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9655	6846-6852	UBERON:0000922	denotes	embryo
T9656	6887-6892	PR_EXT:000009218	denotes	Ptdsr
T9657	6912-6922	GO:0065007	denotes	regulation
T9658	6926-6941	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9659	6959-6968	UBERON:0001890	denotes	forebrain
T9660	6999-7004	PR_EXT:000009218	denotes	Ptdsr
T9661	7045-7048	UBERON:0000970	denotes	eye
T9662	7045-7058	GO:0001654	denotes	eye formation
T9663	7089-7095	UBERON_EXT:lens	denotes	lenses
T9664	7099-7104	PR_EXT:000009218	denotes	Ptdsr
T9665	7114-7118	NCBITaxon:10088	denotes	mice
T9666	7150-7157	UBERON:0000966	denotes	retinal
T9667	7158-7169	UBERON:0004529	denotes	protrusions
T9668	7206-7221	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9669	7233-7240	UBERON:0000966	denotes	retinal
T9670	7233-7245	CL:0009004	denotes	retinal cell
T9671	7241-7245	CL_GO_EXT:cell	denotes	cell
T9672	7241-7252	UBERON:0000119	denotes	cell layers
T9673	7320-7323	UBERON:0000970	denotes	eye
T9674	7377-7403	GO:0043277	denotes	removal of apoptotic cells
T9675	7388-7403	CL:0000445	denotes	apoptotic cells
T9676	7398-7403	CL_GO_EXT:cell	denotes	cells
T9677	7411-7414	UBERON:0000970	denotes	eye
T9678	7411-7426	GO:0001654	denotes	eye development
T9679	7497-7511	CL:0000445	denotes	apoptotic cell
T9680	7497-7521	GO:0043277	denotes	apoptotic cell clearance
T9681	7507-7511	CL_GO_EXT:cell	denotes	cell
T9682	7566-7575	GO:0006915	denotes	apoptosis
T9683	7593-7598	NCBITaxon:10088	denotes	mouse
T9684	7599-7606	UBERON:0000966	denotes	retinal
T9685	7599-7618	GO:0060041	denotes	retinal development
T9686	7649-7663	CL:0000445	denotes	apoptotic cell
T9687	7649-7669	GO:0006915	denotes	apoptotic cell death
T9688	7659-7663	CL_GO_EXT:cell	denotes	cell
T9689	7734-7738	CL_GO_EXT:cell	denotes	cell
T9690	7734-7744	GO:0008219	denotes	cell death
T9691	7776-7785	UBERON:0003072	denotes	optic cup
T9692	7827-7836	GO:0006915	denotes	apoptosis
T9693	7876-7881	GO:0007567	denotes	birth
T9694	7896-7901	GO:0007567	denotes	natal
T9695	7924-7929	GO:0007567	denotes	natal
T9696	8001-8006	_FRAGMENT	denotes	inner
T9697	8017-8026	_FRAGMENT	denotes	layers of
T9699	8011-8026	_FRAGMENT	denotes	outer layers of
T9700	8031-8040	UBERON:0005424	denotes	optic cup
T9701	8050-8053	UBERON:0000970	denotes	eye
T9702	8050-8065	GO:0001654	denotes	eye development
T9703	8089-8096	UBERON:0000966	denotes	retinal
T9704	8089-8101	CL:0009004	denotes	retinal cell
T9705	8097-8101	CL_GO_EXT:cell	denotes	cell
T9706	8097-8111	GO:0006915	denotes	cell apoptosis
T9707	8132-8139	GO:0007567	denotes	natally
T9708	8200-8208	CL:0000540	denotes	neuronal
T9709	8235-8239	CL_GO_EXT:cell	denotes	cell
T9710	8235-8245	GO:0008219	denotes	cell death
T9711	8260-8267	UBERON:0000966	denotes	retinal
T9712	8260-8279	GO:0060041	denotes	retinal development
T9713	8290-8304	UBERON:0001781	denotes	retinal layers
T9714	8323-8343	UBERON:0001791	denotes	inner granular layer
T9715	8382-8397	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9716	8413-8418	PR_EXT:000009218	denotes	Ptdsr
T9717	8419-8420	SO_EXT:sequence_nullness_or_absence	denotes	-
T9718	8421-8422	SO_EXT:sequence_nullness_or_absence	denotes	-
T9719	8423-8430	SO_EXT:sequence_altered_entity	denotes	mutants
T9720	8482-8487	GO:0007567	denotes	natal
T9721	8488-8512	_FRAGMENT	denotes	elimination of apoptotic
T9722	8527-8532	GO:0043277	denotes	cells
T9723	8503-8512	_FRAGMENT	denotes	apoptotic
T9724	8527-8532	CL:0000445	denotes	cells
T9725	8513-8532	CL:0000210	denotes	photoreceptor cells
T9726	8527-8532	CL_GO_EXT:cell	denotes	cells
T9727	8536-8541	PR_EXT:000009218	denotes	Ptdsr
T9728	8551-8561	CL:0000235	denotes	macrophage
T9729	8672-8677	PR_EXT:000009218	denotes	Ptdsr
T9730	8678-8686	GO:0042571	denotes	antibody
T9731	8787-8792	UBERON:0000955	denotes	brain
T9732	8814-8819	PR_EXT:000009218	denotes	Ptdsr
T9733	8820-8821	SO_EXT:sequence_nullness_or_absence	denotes	-
T9734	8822-8823	SO_EXT:sequence_nullness_or_absence	denotes	-
T9735	8824-8828	NCBITaxon:10088	denotes	mice
T9736	8859-8864	UBERON:0000955	denotes	brain
T9737	8913-8918	PR_EXT:000009218	denotes	Ptdsr
T9738	8919-8925	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9739	8926-8930	NCBITaxon:10088	denotes	mice
T9740	9008-9013	UBERON:0000955	denotes	brain
T9741	9018-9024	GO_EXT:biological_growth_entity_or_process	denotes	growth
T9742	9051-9056	PR_EXT:000002194	denotes	Apaf1
T9743	9066-9070	NCBITaxon:10088	denotes	mice
T9744	9181-9190	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T9745	9181-9196	CL:0000445	denotes	apoptotic cells
T9746	9191-9196	CL_GO_EXT:cell	denotes	cells
T9747	9200-9208	GO:0030263	denotes	pyknotic
T9748	9209-9213	CL_GO_EXT:cell	denotes	cell
T9749	9209-9222	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cell clusters
T9750	9230-9245	UBERON:0034705	denotes	neuroepithelium
T9751	9249-9254	PR_EXT:000009218	denotes	Ptdsr
T9752	9255-9256	SO_EXT:sequence_nullness_or_absence	denotes	-
T9753	9257-9258	SO_EXT:sequence_nullness_or_absence	denotes	-
T9754	9263-9268	PR_EXT:000009218	denotes	Ptdsr
T9755	9268-9269	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9756	9270-9271	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9757	9272-9276	NCBITaxon:10088	denotes	mice
T9758	9292-9296	CL_GO_EXT:cell	denotes	cell
T9759	9292-9302	GO:0008219	denotes	cell death
T9760	9317-9339	_FRAGMENT	denotes	clearance of apoptotic
T9761	9358-9363	GO:0043277	denotes	cells
T9762	9330-9339	_FRAGMENT	denotes	apoptotic
T9763	9358-9363	CL:0000445	denotes	cells
T9764	9340-9346	UBERON_EXT:neural_tissue_or_nerve_or_nervous_system	denotes	neural
T9765	9358-9363	CL_GO_EXT:cell	denotes	cells
T9766	9399-9404	UBERON:0000955	denotes	brain
T9767	9459-9464	PR_EXT:000009218	denotes	Ptdsr
T9768	9488-9494	UBERON:0000479	denotes	tissue
T9769	9495-9510	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9770	9538-9547	GO:0007565	denotes	gestation
T9771	9588-9603	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9772	9622-9628	UBERON:0000062	denotes	organs
T9773	9632-9637	PR_EXT:000009218	denotes	Ptdsr
T9774	9647-9651	NCBITaxon:10088	denotes	mice
T9775	9677-9683	UBERON:0000479	denotes	tissue
T9776	9684-9699	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9777	9734-9748	CL:0000445	denotes	apoptotic cell
T9778	9734-9758	GO:0043277	denotes	apoptotic cell clearance
T9779	9744-9748	CL_GO_EXT:cell	denotes	cell
T9780	9793-9798	PR_EXT:000009218	denotes	Ptdsr
T9781	9851-9856	PR_EXT:000009218	denotes	Ptdsr
T9782	9909-9915	UBERON:0000479	denotes	tissue
T12128	10148-10153	PR_EXT:000009218	denotes	Ptdsr
T12129	10179-10207	GO:0043277	denotes	clearance of apoptotic cells
T12130	10192-10207	CL:0000445	denotes	apoptotic cells
T12131	10202-10207	CL_GO_EXT:cell	denotes	cells
T12132	10237-10242	PR_EXT:000009218	denotes	Ptdsr
T12133	10260-10268	GO_EXT:0004872	denotes	receptor
T12134	10277-10302	GO:0043652	denotes	uptake of apoptotic cells
T12135	10287-10302	CL:0000445	denotes	apoptotic cells
T12136	10297-10302	CL_GO_EXT:cell	denotes	cells
T12137	10321-10335	CL:0000445	denotes	apoptotic cell
T12138	10321-10345	GO:0043277	denotes	apoptotic cell clearance
T12139	10331-10335	CL_GO_EXT:cell	denotes	cell
T12140	10357-10362	PR_EXT:000009218	denotes	Ptdsr
T12141	10363-10364	SO_EXT:sequence_nullness_or_absence	denotes	-
T12142	10365-10366	SO_EXT:sequence_nullness_or_absence	denotes	-
T12143	10367-10374	UBERON:0000922	denotes	embryos
T12144	10400-10426	GO:0043277	denotes	removal of apoptotic cells
T12145	10411-10426	CL:0000445	denotes	apoptotic cells
T12146	10421-10426	CL_GO_EXT:cell	denotes	cells
T12147	10461-10466	PR_EXT:000009218	denotes	Ptdsr
T12148	10515-10522	UBERON:0000479	denotes	tissues
T12149	10527-10533	UBERON:0000062	denotes	organs
T12150	10537-10542	PR_EXT:000009218	denotes	Ptdsr
T12151	10542-10543	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12152	10544-10545	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12153	10550-10555	PR_EXT:000009218	denotes	Ptdsr
T12154	10556-10557	SO_EXT:sequence_nullness_or_absence	denotes	-
T12155	10558-10559	SO_EXT:sequence_nullness_or_absence	denotes	-
T12156	10560-10567	NCBITaxon:33208	denotes	animals
T12157	10589-10598	UBERON:0000922	denotes	embryonic
T12158	10589-10610	GO:0009790	denotes	embryonic development
T12159	10618-10626	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T12160	10655-10680	GO:0043652	denotes	uptake of apoptotic cells
T12161	10665-10680	CL:0000445	denotes	apoptotic cells
T12162	10675-10680	CL_GO_EXT:cell	denotes	cells
T12163	10726-10738	GO:0006909	denotes	phagocytosis
T12164	10788-10813	GO:0043652	denotes	uptake of apoptotic cells
T12165	10798-10813	CL:0000445	denotes	apoptotic cells
T12166	10808-10813	CL_GO_EXT:cell	denotes	cells
T12167	10817-10822	PR_EXT:000009218	denotes	Ptdsr
T12168	10823-10824	SO_EXT:sequence_nullness_or_absence	denotes	-
T12169	10825-10826	SO_EXT:sequence_nullness_or_absence	denotes	-
T12170	10827-10838	CL:0000235	denotes	macrophages
T12171	10859-10870	CL:0000235	denotes	macrophages
T12172	10902-10911	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T12173	10929-10934	CL_GO_EXT:cell	denotes	cells
T12174	10987-10992	PR_EXT:000009218	denotes	Ptdsr
T12175	10996-11010	CL:0000445	denotes	apoptotic cell
T12176	10996-11020	GO:0043277	denotes	apoptotic cell clearance
T12177	11006-11010	CL_GO_EXT:cell	denotes	cell
T12178	11128-11146	CHEBI:18303	denotes	phosphatidylserine
T12179	11128-11155	PR_EXT:000009218	denotes	phosphatidylserine receptor
T12180	11147-11155	GO_EXT:0004872	denotes	receptor
T12181	11156-11160	SO_EXT:sequence_nullness	denotes	null
T12182	11161-11167	SO_EXT:0001023	denotes	allele
T12183	11171-11181	NCBITaxon:6239	denotes	C. elegans
T12184	11215-11220	NCBITaxon:10088	denotes	mouse
T12185	11253-11262	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T12186	11253-11268	CL:0000445	denotes	apoptotic cells
T12187	11263-11268	CL_GO_EXT:cell	denotes	cells
T12188	11272-11277	PR_EXT:000009218	denotes	Ptdsr
T12189	11299-11306	NCBITaxon:33208	denotes	animals
T12190	11339-11346	UBERON:0000479	denotes	tissues
T12191	11421-11425	UBERON:0002048	denotes	lung
T12192	11427-11435	UBERON:0001891	denotes	midbrain
T12193	11440-11446	UBERON:0000966	denotes	retina
T12194	11463-11472	GO:0007565	denotes	gestation
T12195	11488-11497	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T12196	11488-11503	CL:0000445	denotes	apoptotic cells
T12197	11498-11503	CL_GO_EXT:cell	denotes	cells
T12198	11593-11601	CL_GO_EXT:cell	denotes	cellular
T12199	11616-11625	GO:0006915	denotes	apoptosis
T12200	11638-11651	UBERON:0001781	denotes	retina layers
T12201	11681-11688	GO:0007567	denotes	natally
T12202	11699-11708	GO:0006915	denotes	apoptosis
T12203	11728-11741	GO_PATO_EXT:physiological_process_or_quality	denotes	physiological
T12204	11770-11781	GO:0042592	denotes	homeostasis
T12205	11785-11800	UBERON:0000115	denotes	lung epithelium
T12206	11807-11812	GO:0007567	denotes	birth
T12207	11853-11862	UBERON:0002048	denotes	pulmonary
T12208	11863-11875	GO_PATO_EXT:inflammatory_process_or_quality	denotes	inflammation
T12209	11891-11895	UBERON:0002048	denotes	lung
T12210	11891-11907	GO:0030324	denotes	lung development
T12211	11923-11928	GO:0007567	denotes	natal
T12212	11938-11947	GO:0006915	denotes	apoptosis
T12213	12002-12011	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T12214	12002-12017	CL:0000445	denotes	apoptotic cells
T12215	12012-12017	CL_GO_EXT:cell	denotes	cells
T12216	12031-12035	UBERON:0002048	denotes	lung
T12217	12036-12042	UBERON:0000479	denotes	tissue
T12218	12054-12067	GO:0009790	denotes	embryogenesis
T12219	12071-12076	PR_EXT:000009218	denotes	Ptdsr
T12220	12076-12077	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12221	12078-12079	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12222	12084-12089	PR_EXT:000009218	denotes	Ptdsr
T12223	12090-12091	SO_EXT:sequence_nullness_or_absence	denotes	-
T12224	12092-12093	SO_EXT:sequence_nullness_or_absence	denotes	-
T12225	12094-12098	NCBITaxon:10088	denotes	mice
T12226	12156-12161	UBERON:0002107	denotes	liver
T12227	12166-12172	UBERON:0002370	denotes	thymus
T12228	12215-12220	PR_EXT:000009218	denotes	Ptdsr
T12229	12220-12221	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12230	12222-12223	SO_EXT:sequence_nullness_or_absence	denotes	-
T12231	12228-12233	PR_EXT:000009218	denotes	Ptdsr
T12232	12234-12235	SO_EXT:sequence_nullness_or_absence	denotes	-
T12233	12236-12237	SO_EXT:sequence_nullness_or_absence	denotes	-
T12234	12238-12245	UBERON:0000922	denotes	embryos
T12235	12312-12317	CL_GO_EXT:cell	denotes	cells
T12236	12321-12326	PR_EXT:000009218	denotes	Ptdsr
T12237	12337-12344	UBERON:0000922	denotes	embryos
T12238	12355-12367	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T12239	12386-12391	CL_GO_EXT:cell	denotes	cells
T12240	12397-12402	PR_EXT:000001813	denotes	F4/80
T12241	12412-12423	CL:0000235	denotes	macrophages
T12242	12444-12449	PR_EXT:000009218	denotes	Ptdsr
T12243	12450-12451	SO_EXT:sequence_nullness_or_absence	denotes	-
T12244	12452-12453	SO_EXT:sequence_nullness_or_absence	denotes	-
T12245	12454-12461	UBERON:0000922	denotes	embryos
T12246	12516-12528	GO:0006909	denotes	phagocytosed
T12247	12544-12549	CL_GO_EXT:cell	denotes	cells
T12248	12593-12598	PR_EXT:000001813	denotes	F4/80
T12249	12608-12613	CL_GO_EXT:cell	denotes	cells
T12250	12747-12752	CL_GO_EXT:cell	denotes	cells
T12251	12767-12778	CL:0000235	denotes	macrophages
T12252	12788-12795	UBERON:0000479	denotes	tissues
T12253	12866-12879	GO:0009790	denotes	embryogenesis
T12254	12881-12891	CL:0000235	denotes	macrophage
T12255	12901-12929	GO:0043277	denotes	clearance of apoptotic cells
T12256	12914-12929	CL:0000445	denotes	apoptotic cells
T12257	12924-12929	CL_GO_EXT:cell	denotes	cells
T12258	12988-13014	GO:0043277	denotes	removal of apoptotic cells
T12259	12999-13014	CL:0000445	denotes	apoptotic cells
T12260	13009-13014	CL_GO_EXT:cell	denotes	cells
T12261	13024-13031	UBERON:0000479	denotes	tissues
T12262	13038-13059	GO:0012501	denotes	programmed cell death
T12263	13049-13053	CL_GO_EXT:cell	denotes	cell
T12264	13095-13108	GO:0009790	denotes	embryogenesis
T12265	13136-13149	UBERON:0005294	denotes	genital ridge
T12266	13157-13162	UBERON:0000991	denotes	gonad
T12267	13157-13176	GO:0035262	denotes	gonad morphogenesis
T12268	13181-13196	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T12269	13204-13215	UBERON:0001049	denotes	neural tube
T12270	13239-13251	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T12271	13255-13264	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T12272	13255-13270	CL:0000445	denotes	apoptotic cells
T12273	13265-13270	CL_GO_EXT:cell	denotes	cells
T12274	13275-13286	CL:0000235	denotes	macrophages
T12275	13323-13351	GO:0043277	denotes	clearance of apoptotic cells
T12276	13336-13351	CL:0000445	denotes	apoptotic cells
T12277	13346-13351	CL_GO_EXT:cell	denotes	cells
T12278	13400-13405	CL_GO_EXT:cell	denotes	cells
T12279	13421-13432	CL:0000235	denotes	macrophages
T12280	13448-13457	GO_EXT:biological_recruitment	denotes	recruited
T12281	13475-13484	GO:0006915	denotes	apoptosis
T12282	13561-13566	PR_EXT:000009218	denotes	Ptdsr
T12283	13594-13600	SO_EXT:sequence_altered_entity	denotes	mutant
T12284	13642-13652	CL:0000235	denotes	macrophage
T12285	13657-13662	PR_EXT:000001944	denotes	Sfpi1
T12286	13672-13679	UBERON:0000922	denotes	embryos
T12287	13707-13720	GO:0030097	denotes	hematopoietic
T12288	13738-13751	GO_EXT:transcription	denotes	transcription
T12289	13738-13758	GO_EXT:transcription_factor	denotes	transcription factor
T12290	13759-13763	PR_EXT:000001944	denotes	PU.1
T12291	13775-13806	GO:0043277	denotes	phagocytosis of apoptotic cells
T12292	13791-13806	CL:0000445	denotes	apoptotic cells
T12293	13801-13806	CL_GO_EXT:cell	denotes	cells
T12294	13814-13827	GO:0009790	denotes	embryogenesis
T12295	13856-13867	UBERON:0003104	denotes	mesenchymal
T12296	13902-13920	CHEBI:18303	denotes	phosphatidylserine
T12297	13979-13984	CL_GO_EXT:cell	denotes	cells
T12298	14002-14013	GO:0006909	denotes	phagocytose
T12299	14014-14023	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T12300	14014-14029	CL:0000445	denotes	apoptotic cells
T12301	14024-14029	CL_GO_EXT:cell	denotes	cells
T12302	14056-14070	CL:0000445	denotes	apoptotic cell
T12303	14056-14080	GO:0043277	denotes	apoptotic cell clearance
T12304	14066-14070	CL_GO_EXT:cell	denotes	cell
T12305	14120-14125	CL_GO_EXT:cell	denotes	cells
T12306	14153-14158	PR_EXT:000009218	denotes	Ptdsr
T12307	14243-14268	GO:0043652	denotes	uptake of apoptotic cells
T12308	14253-14268	CL:0000445	denotes	apoptotic cells
T12309	14263-14268	CL_GO_EXT:cell	denotes	cells
T12310	14272-14277	PR_EXT:000009218	denotes	Ptdsr
T12311	14278-14279	SO_EXT:sequence_nullness_or_absence	denotes	-
T12312	14280-14281	SO_EXT:sequence_nullness_or_absence	denotes	-
T12313	14282-14293	CL:0000235	denotes	macrophages
T12314	14317-14329	GO:0006909	denotes	phagocytosis
T12315	14357-14362	UBERON:0002107	denotes	liver
T12316	14371-14382	CL:0000235	denotes	macrophages
T12317	14430-14444	CHEBI_EXT:thioglycolate	denotes	thioglycollate
T12318	14445-14453	_FRAGMENT	denotes	elicited
T12319	14465-14476	CL:0000861	denotes	macrophages
T12320	14454-14464	UBERON:0001179	denotes	peritoneal
T12321	14454-14476	CL:0000581	denotes	peritoneal macrophages
T12322	14492-14500	GO_EXT:biological_movement_or_translocation_process	denotes	transfer
T12323	14504-14509	PR_EXT:000009218	denotes	Ptdsr
T12324	14510-14511	SO_EXT:sequence_nullness_or_absence	denotes	-
T12325	14512-14513	SO_EXT:sequence_nullness_or_absence	denotes	-
T12326	14514-14527	GO:0030097	denotes	hematopoietic
T12327	14514-14538	CL:0000037	denotes	hematopoietic stem cells
T12328	14533-14538	CL_GO_EXT:cell	denotes	cells
T12329	14646-14656	CL:0000235	denotes	macrophage
T12330	14660-14664	CL_GO_EXT:cell	denotes	cell
T12331	14660-14676	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cell populations
T12332	14717-14722	PR_EXT:000009218	denotes	Ptdsr
T12333	14779-14792	GO:0030097	denotes	hematopoiesis
T12334	14823-14834	GO_EXT:biological_recruitment	denotes	recruitment
T12335	14839-14849	_FRAGMENT	denotes	activation
T12336	14866-14880	GO:0042116	denotes	of macrophages
T12337	14850-14865	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T12338	14869-14880	CL:0000235	denotes	macrophages
T12339	14896-14904	GO_EXT:biological_movement_or_translocation_process	denotes	transfer
T12340	14909-14923	CHEBI_EXT:thioglycolate	denotes	thioglycollate
T12341	14952-14957	PR_EXT:000009218	denotes	Ptdsr
T12342	15025-15030	PR_EXT:000009218	denotes	Ptdsr
T12343	15040-15044	NCBITaxon:10088	denotes	mice
T12344	15136-15143	SO_EXT:0000704	denotes	genetic
T12345	15178-15192	CL:0000445	denotes	apoptotic cell
T12346	15178-15203	GO:0043652	denotes	apoptotic cell engulfment
T12347	15188-15192	CL_GO_EXT:cell	denotes	cell
T12348	15218-15232	CHEBI_EXT:thioglycolate	denotes	thioglycollate
T12349	15233-15253	CL:0000861	denotes	elicited macrophages
T12350	15285-15289	NCBITaxon:10088	denotes	mice
T12351	15322-15336	CL:0000445	denotes	apoptotic cell
T12352	15322-15343	GO:0043652	denotes	apoptotic cell uptake
T12353	15332-15336	CL_GO_EXT:cell	denotes	cell
T12354	15484-15507	GO:0006911	denotes	phagocytotic engulfment
T12355	15520-15525	PR_EXT:000009218	denotes	Ptdsr
T12356	15536-15547	CL:0000235	denotes	macrophages
T12357	15596-15601	PR_EXT:000009218	denotes	Ptdsr
T12358	15601-15602	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12359	15603-15604	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12360	15609-15614	PR_EXT:000009218	denotes	Ptdsr
T12361	15615-15616	SO_EXT:sequence_nullness_or_absence	denotes	-
T12362	15617-15618	SO_EXT:sequence_nullness_or_absence	denotes	-
T12363	15619-15630	CL:0000235	denotes	macrophages
T12364	15638-15647	GO_EXT:secretion_entity_or_process	denotes	secretion
T12365	15665-15677	GO_PATO_EXT:inflammatory_process_or_quality	denotes	inflammatory
T12366	15678-15687	GO_EXT:0005125	denotes	cytokines
T12367	15711-15714	CHEBI:16412	denotes	LPS
T12368	15719-15728	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T12369	15719-15734	CL:0000445	denotes	apoptotic cells
T12370	15729-15734	CL_GO_EXT:cell	denotes	cells
T12371	15764-15772	CL_GO_EXT:cell	denotes	cellular
T12372	15764-15783	GO:0001775	denotes	cellular activation
T12373	15788-15796	CHEBI_EXT:35224	denotes	effector
T12374	15824-15829	PR_EXT:000009218	denotes	Ptdsr
T12375	15830-15837	SO_EXT:sequence_deletion_process	denotes	deleted
T12376	15838-15849	CL:0000235	denotes	macrophages
T12377	15907-15917	CL:0000235	denotes	macrophage
T12378	15907-15928	GO:0042116	denotes	macrophage activation
T12379	15950-15955	PR_EXT:000009218	denotes	Ptdsr
T12380	16032-16039	GO:0005634	denotes	nuclear
T12381	16040-16052	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T12382	16060-16065	PR_EXT:000009218	denotes	Ptdsr
T12383	16066-16073	CHEBI_PR_EXT:protein	denotes	protein
T12384	16139-16146	SO_EXT:0000704	denotes	genetic
T12385	16175-16193	CHEBI:18303	denotes	phosphatidylserine
T12386	16175-16202	PR_EXT:000009218	denotes	phosphatidylserine receptor
T12387	16194-16202	GO_EXT:0004872	denotes	receptor
T12388	16215-16225	NCBITaxon:6239	denotes	C. elegans
T12389	16281-16286	PR_EXT:Q9GYI4	denotes	psr-1
T12390	16292-16302	NCBITaxon:6239	denotes	C. elegans
T12391	16303-16310	SO_EXT:0000853	denotes	homolog
T12392	16314-16319	PR_EXT:000009218	denotes	Ptdsr
T12393	16338-16342	CL_GO_EXT:cell	denotes	cell
T12394	16338-16360	GO:0043652	denotes	cell-corpse engulfment
T12395	16370-16375	PR_EXT:Q9GYI4	denotes	psr-1
T12396	16376-16380	GO:0016246	denotes	RNAi
T12397	16534-16539	PR_EXT:Q9GYI4	denotes	psr-1
T12398	16596-16601	PR_EXT:Q9NHC3	denotes	Ced-2
T12399	16603-16609	PR_EXT:000039485	denotes	Crk II
T12400	16619-16627	PR_EXT:000006616	denotes	Dock 180
T12401	16630-16636	PR_EXT:Q03206	denotes	Ced-10
T12402	16638-16643	PR_EXT:000013660	denotes	Rac 1
T12403	16649-16655	PR_EXT:Q8STE5	denotes	Ced-12
T12404	16657-16661	PR_EXT:ELMO	denotes	Elmo
T12405	16681-16685	CL_GO_EXT:cell	denotes	cell
T12406	16681-16703	GO:0043652	denotes	cell-corpse engulfment
T12407	16720-16724	NCBITaxon_EXT:worm	denotes	worm
T12408	16769-16774	PR_EXT:Q9GYI4	denotes	psr-1
T12409	16775-16782	SO_EXT:sequence_altered_entity	denotes	mutants
T12410	16825-16835	GO:0010467	denotes	expressing
T12411	16836-16846	SO_EXT:transgenic_entity	denotes	transgenic
T12412	16847-16852	NCBITaxon_EXT:worm	denotes	worms
T12413	16924-16934	NCBITaxon:6239	denotes	C. elegans
T12414	16946-16953	SO_EXT:sequence_altered_entity	denotes	mutants
T12415	17024-17029	PR_EXT:000009218	denotes	Ptdsr
T12416	17038-17069	GO:0043277	denotes	phagocytosis of apoptotic cells
T12417	17054-17069	CL:0000445	denotes	apoptotic cells
T12418	17064-17069	CL_GO_EXT:cell	denotes	cells
T12419	17095-17100	PR_EXT:000009218	denotes	Ptdsr
T12420	17101-17109	GO:0042571	denotes	antibody
T12421	17133-17141	GO:0042571	denotes	antibody
T12422	17154-17159	PR_EXT:000009218	denotes	Ptdsr
T12423	17160-17167	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T12424	17208-17219	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T12425	17211-17219	CL_GO_EXT:cell	denotes	cellular
T12426	17220-17232	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T12427	17275-17280	PR_EXT:000009218	denotes	Ptdsr
T12428	17291-17299	GO:0016020	denotes	membrane
T12429	17300-17308	GO_EXT:0004872	denotes	receptor
T12430	17322-17341	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signal transduction
T12431	17400-17407	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T12432	17432-17437	NCBITaxon:9606	denotes	human
T12433	17442-17446	NCBITaxon_EXT:worm	denotes	worm
T12434	17447-17452	PR_EXT:000009218	denotes	Ptdsr
T12435	17453-17462	CHEBI:36357	denotes	molecules
T12436	17477-17495	CHEBI:18303	denotes	phosphatidylserine
T12437	17582-17587	PR_EXT:000009218	denotes	Ptdsr
T12438	17608-17617	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T12439	17622-17627	PR_EXT:000009218	denotes	Ptdsr
T12440	17638-17649	CL:0000235	denotes	macrophages
T12441	17654-17665	CL:0000057	denotes	fibroblasts
T12442	17786-17791	CL_GO_EXT:cell	denotes	cells
T12443	17800-17809	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T12444	17832-17837	PR_EXT:000009218	denotes	Ptdsr
T12445	17838-17845	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T12446	17882-17886	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T12447	17899-17904	PR_EXT:000009218	denotes	Ptdsr
T12448	17905-17912	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptide
T12449	17951-17956	PR_EXT:000009218	denotes	Ptdsr
T12450	17957-17968	SO_EXT:0000317	denotes	cDNA clones
T12451	18000-18008	GO:0042571	denotes	antibody
T12452	18055-18063	GO:0016020	denotes	membrane
T12453	18075-18085	CHEBI_PR_EXT:protein	denotes	protein(s)
T12454	18159-18167	GO:0042571	denotes	antibody
T9786	10020-10024	NCBITaxon:10088	denotes	mice
T9787	10086-10091	PR_EXT:000009218	denotes	Ptdsr
T9788	10092-10102	GO:0010467	denotes	expression
T9789	10123-10129	UBERON:0000479	denotes	tissue
T9698	8031-8040	UBERON:0005425	denotes	optic cup
T9783	9916-9926	GO_PATO_EXT:biological_maturation	denotes	maturation
T9784	9940-9955	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T9785	10004-10009	PR_EXT:000009218	denotes	Ptdsr
T9790	10130-10145	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
R5281	T9584	T9583	_lexicallyChainedTo	epithelial cells,maturation of
R5282	T9612	T9611	_lexicallyChainedTo	retinal-pigmented epithelium,formation of
R5283	T9646	T9645	_lexicallyChainedTo	forebrain,development of
R5284	T9647	T9645	_lexicallyChainedTo	nose,development of
R5285	T9697	T9696	_lexicallyChainedTo	layers of,inner
R5286	T9698	T9697	_lexicallyChainedTo	optic cup,layers of
R5287	T9700	T9699	_lexicallyChainedTo	optic cup,outer layers of
R5288	T9722	T9721	_lexicallyChainedTo	cells,elimination of apoptotic
R5289	T9724	T9723	_lexicallyChainedTo	cells,apoptotic
R5290	T9761	T9760	_lexicallyChainedTo	cells,clearance of apoptotic
R5291	T9763	T9762	_lexicallyChainedTo	cells,apoptotic
R7018	T12319	T12318	_lexicallyChainedTo	macrophages,elicited
R7019	T12336	T12335	_lexicallyChainedTo	of macrophages,activation
R5276	T9467	T9466	_lexicallyChainedTo	lung epithelium,branching morphogenesis of
R5277	T9536	T9535	_lexicallyChainedTo	cells,clearance of apoptotic
R5278	T9538	T9537	_lexicallyChainedTo	cells,apoptotic
R5279	T9541	T9540	_lexicallyChainedTo	cells,mesenchymal
R5280	T9553	T9552	_lexicallyChainedTo	epithelial lung,formation of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T9131	12-17	PR:000009218	denotes	Ptdsr
T9132	66-79	UBERON:0000467	denotes	organ systems
T9133	155-173	CHEBI:18303	denotes	phosphatidylserine
T9134	155-182	PR:000009218	denotes	phosphatidylserine receptor
T9135	184-189	PR:000009218	denotes	Ptdsr
T9136	191-195	SO:0000704	denotes	gene
T9137	208-212	NCBITaxon:10088	denotes	mice
T9138	239-244	PR:000009218	denotes	Ptdsr
T9139	301-307	UBERON:0000062	denotes	organs
T9140	312-319	UBERON:0000479	denotes	tissues
T9141	327-340	GO:0009790	denotes	embryogenesis
T9142	454-459	PR:000009218	denotes	Ptdsr
T9143	470-474	NCBITaxon:10088	denotes	mice
T9144	506-511	NCBITaxon:10088	denotes	mouse
T9145	533-538	SO:0000147	denotes	exons
T9146	564-569	SO:0000147	denotes	exons
T9147	623-631	CHEBI:7507	denotes	neomycin
T9148	642-650	SO:0005853	denotes	cassette
T9149	656-661	PR:000009218	denotes	Ptdsr
T9150	671-676	NCBITaxon:10088	denotes	mouse
T9151	697-704	SO:0000704	denotes	genetic
T9152	794-799	PR:000009218	denotes	Ptdsr
T9153	805-811	SO:0001023	denotes	allele
T9154	946-951	PR:000009218	denotes	Ptdsr
T9155	961-965	NCBITaxon:10088	denotes	mice
T9156	1019-1024	PR:000009218	denotes	Ptdsr
T9157	1045-1054	UBERON:0012101	denotes	perinatal
T9158	1049-1054	GO:0007567	denotes	natal
T9159	1181-1186	PR:000009218	denotes	Ptdsr
T9160	1197-1202	NCBITaxon:10088	denotes	mouse
T9161	1253-1260	SO:0000704	denotes	genetic
T9162	1393-1398	PR:000009218	denotes	Ptdsr
T9163	1408-1413	NCBITaxon:10088	denotes	mouse
T9164	1539-1545	UBERON:0000062	denotes	organs
T9165	1555-1560	PR:000009218	denotes	Ptdsr
T9166	1564-1573	GO:0010467	denotes	expressed
T9167	1588-1601	GO:0009790	denotes	embryogenesis
T9168	1614-1623	UBERON:0000113	denotes	adulthood
T9169	1644-1670	_FRAGMENT	denotes	branching morphogenesis of
T9170	1675-1690	GO:0060441	denotes	lung epithelium
T9171	1675-1690	UBERON:0000115	denotes	lung epithelium
T9172	1707-1712	PR:000009218	denotes	Ptdsr
T9173	1717-1722	UBERON:0002048	denotes	lungs
T9174	1735-1745	UBERON:0000483	denotes	epithelial
T9175	1797-1804	UBERON:0002113	denotes	kidneys
T9176	1842-1858	UBERON:0001230	denotes	Bowman's capsule
T9177	1919-1937	UBERON:0001232	denotes	collecting tubules
T9178	1976-1985	UBERON:0000160	denotes	intestine
T9179	2080-2090	UBERON:0000160	denotes	intestinal
T9180	2091-2098	UBERON:0000479	denotes	tissues
T9181	2102-2107	PR:000009218	denotes	Ptdsr
T9182	2117-2121	NCBITaxon:10088	denotes	mice
T9183	2164-2179	UBERON:0001809	denotes	enteric ganglia
T9184	2202-2222	UBERON:0001135	denotes	smooth muscle tissue
T9185	2250-2256	UBERON:0002113	denotes	kidney
T9186	2261-2270	UBERON:0000160	denotes	intestine
T9187	2313-2318	PR:000009218	denotes	Ptdsr
T9188	2414-2419	PR:000009218	denotes	Ptdsr
T9189	2423-2430	UBERON:0000922	denotes	embryos
T9190	2446-2451	GO:0007567	denotes	birth
T9191	2520-2526	UBERON:0000062	denotes	organs
T9192	2566-2575	GO:0007565	denotes	gestation
T9193	2613-2618	PR:000009218	denotes	Ptdsr
T9194	2623-2628	UBERON:0002048	denotes	lungs
T9195	2654-2659	UBERON:0002048	denotes	lungs
T9196	2676-2680	NCBITaxon:10088	denotes	mice
T9197	2740-2747	UBERON:0003215	denotes	alveoli
T9198	2752-2763	UBERON:0002186	denotes	bronchioles
T9199	2799-2820	GO:0012501	denotes	programmed cell death
T9200	2828-2832	UBERON:0002048	denotes	lung
T9201	2828-2844	GO:0030324	denotes	lung development
T9202	2862-2867	PR:000009218	denotes	Ptdsr
T9203	2877-2881	NCBITaxon:10088	denotes	mice
T9204	2893-2906	GO:0009790	denotes	embryogenesis
T9205	2959-2965	PR:000026878	denotes	aCasp3
T9206	2980-2989	GO:0006915	denotes	apoptosis
T9207	3013-3017	UBERON:0002048	denotes	lung
T9208	3013-3031	GO:0060425	denotes	lung morphogenesis
T9209	3099-3114	CL:0000445	denotes	apoptotic cells
T9210	3118-3123	PR:000009218	denotes	Ptdsr
T9211	3147-3154	NCBITaxon:33208	denotes	animals
T9212	3195-3210	CL:0000445	denotes	apoptotic cells
T9213	3218-3222	UBERON:0002048	denotes	lung
T9214	3223-3230	UBERON:0000479	denotes	tissues
T9215	3331-3353	_FRAGMENT	denotes	clearance of apoptotic
T9216	3381-3386	GO:0043277	denotes	cells
T9217	3344-3353	_FRAGMENT	denotes	apoptotic
T9218	3381-3386	CL:0000445	denotes	cells
T9219	3354-3365	UBERON:0003104	denotes	mesenchymal
T9220	3354-3365	_FRAGMENT	denotes	mesenchymal
T9221	3381-3386	CL:0000134	denotes	cells
T9222	3370-3380	UBERON:0000483	denotes	epithelial
T9223	3370-3386	CL:0000066	denotes	epithelial cells
T9224	3407-3411	UBERON:0002048	denotes	lung
T9225	3407-3425	GO:0060425	denotes	lung morphogenesis
T9226	3429-3434	PR:000009218	denotes	Ptdsr
T9227	3445-3449	NCBITaxon:10088	denotes	mice
T9228	3514-3518	UBERON:0002048	denotes	lung
T9229	3514-3530	GO:0030324	denotes	lung development
T9230	3538-3551	GO:0009790	denotes	embryogenesis
T9231	3566-3578	_FRAGMENT	denotes	formation of
T9232	3583-3598	GO:0060428	denotes	epithelial lung
T9233	3583-3598	UBERON:0000115	denotes	epithelial lung
T9234	3603-3626	GO:0001763	denotes	branching morphogenesis
T9235	3717-3722	UBERON:0000062	denotes	organ
T9236	3723-3729	UBERON:0007688	denotes	anlage
T9237	3951-3956	UBERON:0000062	denotes	organ
T9238	4057-4070	GO:0009790	denotes	embryogenesis
T9239	4080-4093	UBERON:0001911	denotes	mammary gland
T9240	4080-4103	GO:0030879	denotes	mammary gland formation
T9241	4122-4127	UBERON:0002048	denotes	lungs
T9242	4220-4229	GO:0006915	denotes	apoptosis
T9243	4260-4265	UBERON:0002048	denotes	lungs
T9244	4269-4274	PR:000009218	denotes	Ptdsr
T9245	4414-4419	PR:000009218	denotes	Ptdsr
T9246	4428-4431	GO:0016265	denotes	die
T9247	4435-4446	UBERON:0001004	denotes	respiratory
T9248	4447-4451	UBERON:0002048	denotes	lung
T9249	4515-4525	CHEBI:35195	denotes	surfactant
T9250	4526-4536	GO:0010467	denotes	expression
T9251	4550-4555	PR:000009218	denotes	Ptdsr
T9252	4566-4573	NCBITaxon:33208	denotes	animals
T9253	4605-4618	_FRAGMENT	denotes	maturation of
T9254	4657-4673	GO:0002070	denotes	epithelial cells
T9255	4619-4629	CHEBI:35195	denotes	surfactant
T9256	4640-4673	CL:0002063	denotes	type II alveolar epithelial cells
T9257	4648-4667	UBERON:0004821	denotes	alveolar epithelial
T9258	4678-4682	UBERON:0002048	denotes	lung
T9259	4745-4750	GO:0016265	denotes	death
T9260	4754-4759	PR:000009218	denotes	Ptdsr
T9261	4767-4771	NCBITaxon:10088	denotes	mice
T9262	4838-4843	PR:000009218	denotes	Ptdsr
T9263	4886-4891	PR:000009218	denotes	Ptdsr
T9264	4942-4956	UBERON:0004535	denotes	cardiovascular
T9265	5027-5032	PR:000009218	denotes	Ptdsr
T9266	5042-5046	NCBITaxon:10088	denotes	mice
T9267	5047-5050	GO:0016265	denotes	die
T9268	5077-5082	UBERON:0000948	denotes	heart
T9269	5077-5094	GO:0007507	denotes	heart development
T9270	5328-5331	UBERON:0000970	denotes	eye
T9271	5328-5343	GO:0001654	denotes	eye development
T9272	5366-5371	PR:000009218	denotes	Ptdsr
T9273	5372-5376	SO:0000704	denotes	gene
T9274	5378-5383	PR:000009218	denotes	Ptdsr
T9275	5394-5401	UBERON:0000922	denotes	embryos
T9276	5524-5536	_FRAGMENT	denotes	formation of
T9277	5545-5573	GO:0003406	denotes	retinal-pigmented epithelium
T9278	5545-5573	UBERON:0001782	denotes	retinal-pigmented epithelium
T9279	5553-5562	CHEBI:26130	denotes	pigmented
T9280	5591-5604	GO:0008283	denotes	proliferation
T9281	5619-5629	UBERON:0003104	denotes	mesenchyme
T9282	5637-5649	UBERON:0001707	denotes	nasal cavity
T9283	5768-5773	NCBITaxon:10088	denotes	mouse
T9284	5821-5824	UBERON:0000970	denotes	eye
T9285	5859-5866	UBERON:0000966	denotes	retinal
T9286	5859-5878	GO:0060041	denotes	retinal development
T9287	5912-5921	GO:0007565	denotes	gestation
T9288	5949-5962	GO:0009653	denotes	morphogenesis
T9289	5970-5998	UBERON:0001791	denotes	inner granular retinal layer
T9290	6018-6031	GO:0009790	denotes	embryogenesis
T9291	6101-6111	GO:0010467	denotes	expression
T9292	6127-6132	PR:000009218	denotes	Ptdsr
T9293	6133-6137	SO:0000704	denotes	gene
T9294	6150-6155	PR:000009218	denotes	Ptdsr
T9295	6159-6168	GO:0010467	denotes	expressed
T9296	6201-6215	UBERON:0001016	denotes	nervous system
T9297	6276-6285	UBERON:0001890	denotes	forebrain
T9298	6293-6303	GO:0010467	denotes	expression
T9299	6346-6352	UBERON:0000966	denotes	retina
T9300	6369-6374	PR:000009218	denotes	Ptdsr
T9301	6423-6429	UBERON:0000970	denotes	ocular
T9302	6423-6443	GO:0048592	denotes	ocular morphogenesis
T9303	6484-6487	UBERON:0000970	denotes	eye
T9304	6499-6522	GO:0003408	denotes	formation of optic cups
T9305	6512-6522	UBERON:0003072	denotes	optic cups
T9306	6536-6539	UBERON:0000970	denotes	eye
T9307	6536-6549	GO:0001654	denotes	eye-formation
T9308	6588-6602	_FRAGMENT	denotes	development of
T9309	6607-6616	GO:0030900	denotes	forebrain
T9310	6633-6637	GO:0043584	denotes	nose
T9311	6607-6616	UBERON:0001890	denotes	forebrain
T9312	6633-6637	UBERON:0000004	denotes	nose
T9313	6712-6721	UBERON:0001890	denotes	forebrain
T9314	6726-6731	UBERON:0000004	denotes	nasal
T9315	6746-6751	PR:000009218	denotes	Ptdsr
T9316	6761-6768	UBERON:0000922	denotes	embryos
T9317	6846-6852	UBERON:0000922	denotes	embryo
T9318	6887-6892	PR:000009218	denotes	Ptdsr
T9319	6912-6922	GO:0065007	denotes	regulation
T9320	6959-6968	UBERON:0001890	denotes	forebrain
T9321	6999-7004	PR:000009218	denotes	Ptdsr
T9322	7045-7048	UBERON:0000970	denotes	eye
T9323	7045-7058	GO:0001654	denotes	eye formation
T9324	7099-7104	PR:000009218	denotes	Ptdsr
T9325	7114-7118	NCBITaxon:10088	denotes	mice
T9326	7150-7157	UBERON:0000966	denotes	retinal
T9327	7158-7169	UBERON:0004529	denotes	protrusions
T9328	7233-7240	UBERON:0000966	denotes	retinal
T9329	7233-7245	CL:0009004	denotes	retinal cell
T9330	7241-7252	UBERON:0000119	denotes	cell layers
T9331	7320-7323	UBERON:0000970	denotes	eye
T9332	7377-7403	GO:0043277	denotes	removal of apoptotic cells
T9333	7388-7403	CL:0000445	denotes	apoptotic cells
T9334	7411-7414	UBERON:0000970	denotes	eye
T9335	7411-7426	GO:0001654	denotes	eye development
T9336	7497-7511	CL:0000445	denotes	apoptotic cell
T9337	7497-7521	GO:0043277	denotes	apoptotic cell clearance
T9338	7566-7575	GO:0006915	denotes	apoptosis
T9339	7593-7598	NCBITaxon:10088	denotes	mouse
T9340	7599-7606	UBERON:0000966	denotes	retinal
T9341	7599-7618	GO:0060041	denotes	retinal development
T9342	7649-7663	CL:0000445	denotes	apoptotic cell
T9343	7649-7669	GO:0006915	denotes	apoptotic cell death
T9344	7734-7744	GO:0008219	denotes	cell death
T9345	7776-7785	UBERON:0003072	denotes	optic cup
T9346	7827-7836	GO:0006915	denotes	apoptosis
T9347	7876-7881	GO:0007567	denotes	birth
T9348	7896-7901	GO:0007567	denotes	natal
T9349	7924-7929	GO:0007567	denotes	natal
T9350	8001-8006	_FRAGMENT	denotes	inner
T9351	8017-8026	_FRAGMENT	denotes	layers of
T9352	8031-8040	UBERON:0005425	denotes	optic cup
T9353	8011-8026	_FRAGMENT	denotes	outer layers of
T9354	8031-8040	UBERON:0005424	denotes	optic cup
T9355	8050-8053	UBERON:0000970	denotes	eye
T9356	8050-8065	GO:0001654	denotes	eye development
T9357	8089-8096	UBERON:0000966	denotes	retinal
T9358	8089-8101	CL:0009004	denotes	retinal cell
T9359	8097-8111	GO:0006915	denotes	cell apoptosis
T9360	8132-8139	GO:0007567	denotes	natally
T9361	8200-8208	CL:0000540	denotes	neuronal
T9362	8235-8245	GO:0008219	denotes	cell death
T9363	8260-8267	UBERON:0000966	denotes	retinal
T9364	8260-8279	GO:0060041	denotes	retinal development
T9365	8290-8304	UBERON:0001781	denotes	retinal layers
T9366	8323-8343	UBERON:0001791	denotes	inner granular layer
T9367	8413-8418	PR:000009218	denotes	Ptdsr
T9368	8482-8487	GO:0007567	denotes	natal
T9369	8488-8512	_FRAGMENT	denotes	elimination of apoptotic
T9370	8527-8532	GO:0043277	denotes	cells
T9371	8503-8512	_FRAGMENT	denotes	apoptotic
T9372	8527-8532	CL:0000445	denotes	cells
T9373	8513-8532	CL:0000210	denotes	photoreceptor cells
T9374	8536-8541	PR:000009218	denotes	Ptdsr
T9375	8551-8561	CL:0000235	denotes	macrophage
T9376	8672-8677	PR:000009218	denotes	Ptdsr
T9377	8678-8686	GO:0042571	denotes	antibody
T9378	8787-8792	UBERON:0000955	denotes	brain
T9379	8814-8819	PR:000009218	denotes	Ptdsr
T9380	8824-8828	NCBITaxon:10088	denotes	mice
T9381	8859-8864	UBERON:0000955	denotes	brain
T9382	8913-8918	PR:000009218	denotes	Ptdsr
T9383	8926-8930	NCBITaxon:10088	denotes	mice
T9384	9008-9013	UBERON:0000955	denotes	brain
T9385	9051-9056	PR:000002194	denotes	Apaf1
T9386	9066-9070	NCBITaxon:10088	denotes	mice
T9387	9181-9196	CL:0000445	denotes	apoptotic cells
T9388	9200-9208	GO:0030263	denotes	pyknotic
T9389	9230-9245	UBERON:0034705	denotes	neuroepithelium
T9390	9249-9254	PR:000009218	denotes	Ptdsr
T9391	9263-9268	PR:000009218	denotes	Ptdsr
T9392	9272-9276	NCBITaxon:10088	denotes	mice
T9393	9292-9302	GO:0008219	denotes	cell death
T9394	9317-9339	_FRAGMENT	denotes	clearance of apoptotic
T9395	9358-9363	GO:0043277	denotes	cells
T11921	10148-10153	PR:000009218	denotes	Ptdsr
T11922	10179-10207	GO:0043277	denotes	clearance of apoptotic cells
T11923	10192-10207	CL:0000445	denotes	apoptotic cells
T11924	10237-10242	PR:000009218	denotes	Ptdsr
T11925	10277-10302	GO:0043652	denotes	uptake of apoptotic cells
T11926	10287-10302	CL:0000445	denotes	apoptotic cells
T11927	10321-10335	CL:0000445	denotes	apoptotic cell
T11928	10321-10345	GO:0043277	denotes	apoptotic cell clearance
T11929	10357-10362	PR:000009218	denotes	Ptdsr
T11930	10367-10374	UBERON:0000922	denotes	embryos
T11931	10400-10426	GO:0043277	denotes	removal of apoptotic cells
T11932	10411-10426	CL:0000445	denotes	apoptotic cells
T11933	10461-10466	PR:000009218	denotes	Ptdsr
T11934	10515-10522	UBERON:0000479	denotes	tissues
T11935	10527-10533	UBERON:0000062	denotes	organs
T11936	10537-10542	PR:000009218	denotes	Ptdsr
T11937	10550-10555	PR:000009218	denotes	Ptdsr
T11938	10560-10567	NCBITaxon:33208	denotes	animals
T11939	10589-10598	UBERON:0000922	denotes	embryonic
T11940	10589-10610	GO:0009790	denotes	embryonic development
T11941	10655-10680	GO:0043652	denotes	uptake of apoptotic cells
T11942	10665-10680	CL:0000445	denotes	apoptotic cells
T11943	10726-10738	GO:0006909	denotes	phagocytosis
T11944	10788-10813	GO:0043652	denotes	uptake of apoptotic cells
T11945	10798-10813	CL:0000445	denotes	apoptotic cells
T11946	10817-10822	PR:000009218	denotes	Ptdsr
T11947	10827-10838	CL:0000235	denotes	macrophages
T11948	10859-10870	CL:0000235	denotes	macrophages
T11949	10987-10992	PR:000009218	denotes	Ptdsr
T11950	10996-11010	CL:0000445	denotes	apoptotic cell
T11951	10996-11020	GO:0043277	denotes	apoptotic cell clearance
T11952	11128-11146	CHEBI:18303	denotes	phosphatidylserine
T11953	11128-11155	PR:000009218	denotes	phosphatidylserine receptor
T11954	11161-11167	SO:0001023	denotes	allele
T11955	11171-11181	NCBITaxon:6239	denotes	C. elegans
T11956	11215-11220	NCBITaxon:10088	denotes	mouse
T11957	11253-11268	CL:0000445	denotes	apoptotic cells
T11958	11272-11277	PR:000009218	denotes	Ptdsr
T11959	11299-11306	NCBITaxon:33208	denotes	animals
T11960	11339-11346	UBERON:0000479	denotes	tissues
T11961	11421-11425	UBERON:0002048	denotes	lung
T11962	11427-11435	UBERON:0001891	denotes	midbrain
T11963	11440-11446	UBERON:0000966	denotes	retina
T11964	11463-11472	GO:0007565	denotes	gestation
T11965	11488-11503	CL:0000445	denotes	apoptotic cells
T11966	11616-11625	GO:0006915	denotes	apoptosis
T11967	11638-11651	UBERON:0001781	denotes	retina layers
T11968	11681-11688	GO:0007567	denotes	natally
T11969	11699-11708	GO:0006915	denotes	apoptosis
T11970	11770-11781	GO:0042592	denotes	homeostasis
T11971	11785-11800	UBERON:0000115	denotes	lung epithelium
T11972	11807-11812	GO:0007567	denotes	birth
T11973	11853-11862	UBERON:0002048	denotes	pulmonary
T11974	11891-11895	UBERON:0002048	denotes	lung
T11975	11891-11907	GO:0030324	denotes	lung development
T11976	11923-11928	GO:0007567	denotes	natal
T11977	11938-11947	GO:0006915	denotes	apoptosis
T11978	12002-12017	CL:0000445	denotes	apoptotic cells
T11979	12031-12035	UBERON:0002048	denotes	lung
T11980	12036-12042	UBERON:0000479	denotes	tissue
T11981	12054-12067	GO:0009790	denotes	embryogenesis
T11982	12071-12076	PR:000009218	denotes	Ptdsr
T11983	12084-12089	PR:000009218	denotes	Ptdsr
T11984	12094-12098	NCBITaxon:10088	denotes	mice
T11985	12156-12161	UBERON:0002107	denotes	liver
T11986	12166-12172	UBERON:0002370	denotes	thymus
T11987	12215-12220	PR:000009218	denotes	Ptdsr
T11988	12228-12233	PR:000009218	denotes	Ptdsr
T11989	12238-12245	UBERON:0000922	denotes	embryos
T11990	12321-12326	PR:000009218	denotes	Ptdsr
T11991	12337-12344	UBERON:0000922	denotes	embryos
T11992	12397-12402	PR:000001813	denotes	F4/80
T11993	12412-12423	CL:0000235	denotes	macrophages
T11994	12444-12449	PR:000009218	denotes	Ptdsr
T11995	12454-12461	UBERON:0000922	denotes	embryos
T11996	12516-12528	GO:0006909	denotes	phagocytosed
T11997	12593-12598	PR:000001813	denotes	F4/80
T11998	12767-12778	CL:0000235	denotes	macrophages
T11999	12788-12795	UBERON:0000479	denotes	tissues
T12000	12866-12879	GO:0009790	denotes	embryogenesis
T12001	12881-12891	CL:0000235	denotes	macrophage
T12002	12901-12929	GO:0043277	denotes	clearance of apoptotic cells
T12003	12914-12929	CL:0000445	denotes	apoptotic cells
T12004	12988-13014	GO:0043277	denotes	removal of apoptotic cells
T12005	12999-13014	CL:0000445	denotes	apoptotic cells
T12006	13024-13031	UBERON:0000479	denotes	tissues
T12007	13038-13059	GO:0012501	denotes	programmed cell death
T12008	13095-13108	GO:0009790	denotes	embryogenesis
T12009	13136-13149	UBERON:0005294	denotes	genital ridge
T12010	13157-13162	UBERON:0000991	denotes	gonad
T12011	13157-13176	GO:0035262	denotes	gonad morphogenesis
T12012	13204-13215	UBERON:0001049	denotes	neural tube
T12013	13255-13270	CL:0000445	denotes	apoptotic cells
T12014	13275-13286	CL:0000235	denotes	macrophages
T12015	13323-13351	GO:0043277	denotes	clearance of apoptotic cells
T12016	13336-13351	CL:0000445	denotes	apoptotic cells
T12017	13421-13432	CL:0000235	denotes	macrophages
T12018	13475-13484	GO:0006915	denotes	apoptosis
T12019	13561-13566	PR:000009218	denotes	Ptdsr
T12020	13642-13652	CL:0000235	denotes	macrophage
T12021	13657-13662	PR:000001944	denotes	Sfpi1
T12022	13672-13679	UBERON:0000922	denotes	embryos
T12023	13707-13720	GO:0030097	denotes	hematopoietic
T12024	13759-13763	PR:000001944	denotes	PU.1
T12025	13775-13806	GO:0043277	denotes	phagocytosis of apoptotic cells
T12026	13791-13806	CL:0000445	denotes	apoptotic cells
T12027	13814-13827	GO:0009790	denotes	embryogenesis
T12028	13856-13867	UBERON:0003104	denotes	mesenchymal
T12029	13902-13920	CHEBI:18303	denotes	phosphatidylserine
T12030	14002-14013	GO:0006909	denotes	phagocytose
T12031	14014-14029	CL:0000445	denotes	apoptotic cells
T12032	14056-14070	CL:0000445	denotes	apoptotic cell
T12033	14056-14080	GO:0043277	denotes	apoptotic cell clearance
T12034	14153-14158	PR:000009218	denotes	Ptdsr
T12035	14243-14268	GO:0043652	denotes	uptake of apoptotic cells
T12036	14253-14268	CL:0000445	denotes	apoptotic cells
T12037	14272-14277	PR:000009218	denotes	Ptdsr
T12038	14282-14293	CL:0000235	denotes	macrophages
T12039	14317-14329	GO:0006909	denotes	phagocytosis
T12040	14357-14362	UBERON:0002107	denotes	liver
T12041	14371-14382	CL:0000235	denotes	macrophages
T12042	14445-14453	_FRAGMENT	denotes	elicited
T12043	14465-14476	CL:0000861	denotes	macrophages
T12044	14454-14464	UBERON:0001179	denotes	peritoneal
T12045	14454-14476	CL:0000581	denotes	peritoneal macrophages
T12046	14504-14509	PR:000009218	denotes	Ptdsr
T12047	14514-14527	GO:0030097	denotes	hematopoietic
T12048	14514-14538	CL:0000037	denotes	hematopoietic stem cells
T12049	14646-14656	CL:0000235	denotes	macrophage
T12050	14717-14722	PR:000009218	denotes	Ptdsr
T12051	14779-14792	GO:0030097	denotes	hematopoiesis
T12052	14839-14849	_FRAGMENT	denotes	activation
T12053	14866-14880	GO:0042116	denotes	of macrophages
T12054	14869-14880	CL:0000235	denotes	macrophages
T12055	14952-14957	PR:000009218	denotes	Ptdsr
T12056	15025-15030	PR:000009218	denotes	Ptdsr
T12057	15040-15044	NCBITaxon:10088	denotes	mice
T12058	15136-15143	SO:0000704	denotes	genetic
T12059	15178-15192	CL:0000445	denotes	apoptotic cell
T12060	15178-15203	GO:0043652	denotes	apoptotic cell engulfment
T12061	15233-15253	CL:0000861	denotes	elicited macrophages
T12062	15285-15289	NCBITaxon:10088	denotes	mice
T12063	15322-15336	CL:0000445	denotes	apoptotic cell
T12064	15322-15343	GO:0043652	denotes	apoptotic cell uptake
T12065	15484-15507	GO:0006911	denotes	phagocytotic engulfment
T12066	15520-15525	PR:000009218	denotes	Ptdsr
T12067	15536-15547	CL:0000235	denotes	macrophages
T12068	15596-15601	PR:000009218	denotes	Ptdsr
T12069	15609-15614	PR:000009218	denotes	Ptdsr
T12070	15619-15630	CL:0000235	denotes	macrophages
T12071	15711-15714	CHEBI:16412	denotes	LPS
T12072	15719-15734	CL:0000445	denotes	apoptotic cells
T12073	15764-15783	GO:0001775	denotes	cellular activation
T12074	15788-15796	CHEBI:35224	denotes	effector
T12075	15824-15829	PR:000009218	denotes	Ptdsr
T12076	15838-15849	CL:0000235	denotes	macrophages
T12077	15907-15917	CL:0000235	denotes	macrophage
T12078	15907-15928	GO:0042116	denotes	macrophage activation
T12079	15950-15955	PR:000009218	denotes	Ptdsr
T12080	16032-16039	GO:0005634	denotes	nuclear
T12081	16060-16065	PR:000009218	denotes	Ptdsr
T12082	16139-16146	SO:0000704	denotes	genetic
T12083	16175-16193	CHEBI:18303	denotes	phosphatidylserine
T12084	16175-16202	PR:000009218	denotes	phosphatidylserine receptor
T12085	16215-16225	NCBITaxon:6239	denotes	C. elegans
T12086	16281-16286	PR:Q9GYI4	denotes	psr-1
T12087	16292-16302	NCBITaxon:6239	denotes	C. elegans
T12088	16303-16310	SO:0000853	denotes	homolog
T12089	16314-16319	PR:000009218	denotes	Ptdsr
T12090	16338-16360	GO:0043652	denotes	cell-corpse engulfment
T12091	16370-16375	PR:Q9GYI4	denotes	psr-1
T12092	16376-16380	GO:0016246	denotes	RNAi
T12093	16534-16539	PR:Q9GYI4	denotes	psr-1
T12094	16596-16601	PR:Q9NHC3	denotes	Ced-2
T12095	16603-16609	PR:000039485	denotes	Crk II
T12096	16619-16627	PR:000006616	denotes	Dock 180
T12097	16630-16636	PR:Q03206	denotes	Ced-10
T12098	16638-16643	PR:000013660	denotes	Rac 1
T12099	16649-16655	PR:Q8STE5	denotes	Ced-12
T12100	16681-16703	GO:0043652	denotes	cell-corpse engulfment
T12101	16769-16774	PR:Q9GYI4	denotes	psr-1
T12102	16825-16835	GO:0010467	denotes	expressing
T12103	16924-16934	NCBITaxon:6239	denotes	C. elegans
T12104	17024-17029	PR:000009218	denotes	Ptdsr
T12105	17038-17069	GO:0043277	denotes	phagocytosis of apoptotic cells
T12106	17054-17069	CL:0000445	denotes	apoptotic cells
T12107	17095-17100	PR:000009218	denotes	Ptdsr
T12108	17101-17109	GO:0042571	denotes	antibody
T12109	17133-17141	GO:0042571	denotes	antibody
T12110	17154-17159	PR:000009218	denotes	Ptdsr
T12111	17275-17280	PR:000009218	denotes	Ptdsr
T12112	17291-17299	GO:0016020	denotes	membrane
T12113	17432-17437	NCBITaxon:9606	denotes	human
T12114	17447-17452	PR:000009218	denotes	Ptdsr
T12115	17453-17462	CHEBI:36357	denotes	molecules
T12116	17477-17495	CHEBI:18303	denotes	phosphatidylserine
T12117	17582-17587	PR:000009218	denotes	Ptdsr
T12118	17622-17627	PR:000009218	denotes	Ptdsr
T12119	17638-17649	CL:0000235	denotes	macrophages
T12120	17654-17665	CL:0000057	denotes	fibroblasts
T12121	17832-17837	PR:000009218	denotes	Ptdsr
T12122	17899-17904	PR:000009218	denotes	Ptdsr
T12123	17951-17956	PR:000009218	denotes	Ptdsr
T12124	17957-17968	SO:0000317	denotes	cDNA clones
T12125	18000-18008	GO:0042571	denotes	antibody
T12126	18055-18063	GO:0016020	denotes	membrane
T12127	18159-18167	GO:0042571	denotes	antibody
T9396	9330-9339	_FRAGMENT	denotes	apoptotic
T9397	9358-9363	CL:0000445	denotes	cells
T9398	9399-9404	UBERON:0000955	denotes	brain
T9399	9459-9464	PR:000009218	denotes	Ptdsr
T9400	9488-9494	UBERON:0000479	denotes	tissue
T9401	9538-9547	GO:0007565	denotes	gestation
T9402	9622-9628	UBERON:0000062	denotes	organs
T9403	9632-9637	PR:000009218	denotes	Ptdsr
T9404	9647-9651	NCBITaxon:10088	denotes	mice
T9405	9677-9683	UBERON:0000479	denotes	tissue
T9406	9734-9748	CL:0000445	denotes	apoptotic cell
T9407	9734-9758	GO:0043277	denotes	apoptotic cell clearance
T9408	9793-9798	PR:000009218	denotes	Ptdsr
T9409	9851-9856	PR:000009218	denotes	Ptdsr
T9410	9909-9915	UBERON:0000479	denotes	tissue
T9411	10004-10009	PR:000009218	denotes	Ptdsr
T9412	10020-10024	NCBITaxon:10088	denotes	mice
T9413	10086-10091	PR:000009218	denotes	Ptdsr
T9414	10092-10102	GO:0010467	denotes	expression
T9415	10123-10129	UBERON:0000479	denotes	tissue
R5260	T9170	T9169	_lexicallyChainedTo	lung epithelium,branching morphogenesis of
R5261	T9216	T9215	_lexicallyChainedTo	cells,clearance of apoptotic
R5262	T9218	T9217	_lexicallyChainedTo	cells,apoptotic
R5263	T9221	T9220	_lexicallyChainedTo	cells,mesenchymal
R5264	T9232	T9231	_lexicallyChainedTo	epithelial lung,formation of
R5265	T9254	T9253	_lexicallyChainedTo	epithelial cells,maturation of
R5266	T9277	T9276	_lexicallyChainedTo	retinal-pigmented epithelium,formation of
R5267	T9309	T9308	_lexicallyChainedTo	forebrain,development of
R5268	T9310	T9308	_lexicallyChainedTo	nose,development of
R5269	T9351	T9350	_lexicallyChainedTo	layers of,inner
R5270	T9352	T9351	_lexicallyChainedTo	optic cup,layers of
R5271	T9354	T9353	_lexicallyChainedTo	optic cup,outer layers of
R5272	T9370	T9369	_lexicallyChainedTo	cells,elimination of apoptotic
R5273	T9372	T9371	_lexicallyChainedTo	cells,apoptotic
R5274	T9395	T9394	_lexicallyChainedTo	cells,clearance of apoptotic
R5275	T9397	T9396	_lexicallyChainedTo	cells,apoptotic
R7016	T12043	T12042	_lexicallyChainedTo	macrophages,elicited
R7017	T12053	T12052	_lexicallyChainedTo	of macrophages,activation

2_test

Id	Subject	Object	Predicate	Lexical cue
15345036-14645847-55938512	476-478	14645847	denotes	31
15345036-14715629-55938513	479-481	14715629	denotes	32
15345036-14645847-55938514	541-543	14645847	denotes	31
15345036-14715629-55938515	584-586	14715629	denotes	32
15345036-14645847-55938516	881-883	14645847	denotes	31
15345036-14715629-55938517	906-908	14715629	denotes	32
15345036-14645847-55938518	2353-2355	14645847	denotes	31
15345036-14715629-55938519	2378-2380	14715629	denotes	32
15345036-14645847-55938520	3298-3300	14645847	denotes	31
15345036-12530959-55938521	3998-4000	12530959	denotes	34
15345036-12559759-55938522	4001-4003	12559759	denotes	35
15345036-12530959-55938523	4231-4233	12530959	denotes	34
15345036-12372298-55938524	4234-4236	12372298	denotes	36
15345036-14645847-55938525	4493-4495	14645847	denotes	31
15345036-11687490-55938526	6618-6620	11687490	denotes	37
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15345036-12569128-55938528	6639-6641	12569128	denotes	39
15345036-7789273-55938528	6639-6641	7789273	denotes	39
15345036-11105055-55938528	6639-6641	11105055	denotes	39
15345036-14645847-55938529	7071-7073	14645847	denotes	31
15345036-14645847-55938530	7307-7309	14645847	denotes	31
15345036-14517994-55938531	7671-7673	14517994	denotes	42
15345036-14517994-55938532	7961-7963	14517994	denotes	42
15345036-12759244-55938533	8574-8576	12759244	denotes	43
15345036-10811223-55938534	8700-8702	10811223	denotes	26
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15345036-14645847-55938541	11359-11361	14645847	denotes	31
15345036-14715629-55938542	11371-11373	14715629	denotes	32
15345036-14645847-55938543	11408-11410	14645847	denotes	31
15345036-14517994-55938544	11690-11692	14517994	denotes	42
15345036-14634325-55938545	11909-11911	14634325	denotes	46
15345036-14715629-55938546	12117-12119	14715629	denotes	32
15345036-11076747-55938547	13879-13881	11076747	denotes	47
15345036-14645847-55938548	14197-14199	14645847	denotes	31
15345036-14715629-55938549	14702-14704	14715629	denotes	32
15345036-14645847-55938550	15444-15446	14645847	denotes	31
15345036-14715629-55938551	15469-15471	14715629	denotes	32
15345036-14729065-55938552	16075-16077	14729065	denotes	29
15345036-14645848-55938553	16263-16265	14645848	denotes	45
15345036-12689596-55938554	16415-16417	12689596	denotes	25
15345036-14645848-55938555	16726-16728	14645848	denotes	45
15345036-14645848-55938556	16875-16877	14645848	denotes	45
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PMC:549712 / 29676-47948 JSONTXT

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craft-sa-dev

craft-ca-core-ex-dev

craft-ca-core-dev

2_test

PMC:549712 / 29676-47948 JSON TXT