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analyze whether macrophages are recruited into areas where apoptosis is prominent during embryogenesis, we stained consecutive serial sections either with the macrophage surface marker F4/80 or with aCasp3. Surprisingly, there was no co-localization of macrophages with apoptotic cells. In virtually all embryonic tissues, apoptotic cells and macrophages were localized in different compartments (Figure 6e,6i; and see also Additional data file 1, Figure S1). This suggests that at this stage of development it is mainly neighboring cells that are involved in removal of apoptotic cells, rather than professional macrophages. In summary, our analysis in vivo did not reveal any impairment in apoptotic cell clearance in Ptdsr-deficient embryos during development and further suggests that phagocytosis of apoptotic cells is mainly mediated by non-professional 'bystander' cells."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6630","span":{"begin":188,"end":193},"obj":"PR_EXT:000001813"},{"id":"T6623","span":{"begin":19,"end":30},"obj":"CL:0000235"},{"id":"T6624","span":{"begin":35,"end":44},"obj":"GO_EXT:biological_recruitment"},{"id":"T6625","span":{"begin":62,"end":71},"obj":"GO:0006915"},{"id":"T6626","span":{"begin":92,"end":105},"obj":"GO:0009790"},{"id":"T6627","span":{"begin":162,"end":172},"obj":"CL:0000235"},{"id":"T6628","span":{"begin":173,"end":180},"obj":"GO:0009986"},{"id":"T6629","span":{"begin":181,"end":187},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T6631","span":{"begin":202,"end":208},"obj":"PR:000026878"},{"id":"T6632","span":{"begin":240,"end":252},"obj":"GO_PATO_EXT:biological_localization_process_or_quality"},{"id":"T6633","span":{"begin":256,"end":267},"obj":"CL:0000235"},{"id":"T6634","span":{"begin":273,"end":282},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T6635","span":{"begin":273,"end":288},"obj":"CL:0000445"},{"id":"T6636","span":{"begin":283,"end":288},"obj":"CL_GO_EXT:cell"},{"id":"T6637","span":{"begin":307,"end":324},"obj":"UBERON:0005291"},{"id":"T6638","span":{"begin":326,"end":335},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T6639","span":{"begin":326,"end":341},"obj":"CL:0000445"},{"id":"T6640","span":{"begin":336,"end":341},"obj":"CL_GO_EXT:cell"},{"id":"T6641","span":{"begin":346,"end":357},"obj":"CL:0000235"},{"id":"T6642","span":{"begin":363,"end":372},"obj":"GO_PATO_EXT:biological_localization_process_or_quality"},{"id":"T6643","span":{"begin":536,"end":541},"obj":"CL_GO_EXT:cell"},{"id":"T6644","span":{"begin":563,"end":589},"obj":"GO:0043277"},{"id":"T6645","span":{"begin":574,"end":589},"obj":"CL:0000445"},{"id":"T6646","span":{"begin":584,"end":589},"obj":"CL_GO_EXT:cell"},{"id":"T6647","span":{"begin":616,"end":627},"obj":"CL:0000235"},{"id":"T6648","span":{"begin":695,"end":709},"obj":"CL:0000445"},{"id":"T6649","span":{"begin":695,"end":719},"obj":"GO:0043277"},{"id":"T6650","span":{"begin":705,"end":709},"obj":"CL_GO_EXT:cell"},{"id":"T6651","span":{"begin":723,"end":728},"obj":"PR_EXT:000009218"},{"id":"T6652","span":{"begin":739,"end":746},"obj":"UBERON:0000922"},{"id":"T6653","span":{"begin":792,"end":823},"obj":"GO:0043277"},{"id":"T6654","span":{"begin":808,"end":823},"obj":"CL:0000445"},{"id":"T6655","span":{"begin":818,"end":823},"obj":"CL_GO_EXT:cell"},{"id":"T6656","span":{"begin":875,"end":880},"obj":"CL_GO_EXT:cell"}],"text":"To analyze whether macrophages are recruited into areas where apoptosis is prominent during embryogenesis, we stained consecutive serial sections either with the macrophage surface marker F4/80 or with aCasp3. Surprisingly, there was no co-localization of macrophages with apoptotic cells. In virtually all embryonic tissues, apoptotic cells and macrophages were localized in different compartments (Figure 6e,6i; and see also Additional data file 1, Figure S1). This suggests that at this stage of development it is mainly neighboring cells that are involved in removal of apoptotic cells, rather than professional macrophages. In summary, our analysis in vivo did not reveal any impairment in apoptotic cell clearance in Ptdsr-deficient embryos during development and further suggests that phagocytosis of apoptotic cells is mainly mediated by non-professional 'bystander' cells."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T6363","span":{"begin":19,"end":30},"obj":"CL:0000235"},{"id":"T6364","span":{"begin":62,"end":71},"obj":"GO:0006915"},{"id":"T6365","span":{"begin":92,"end":105},"obj":"GO:0009790"},{"id":"T6366","span":{"begin":162,"end":172},"obj":"CL:0000235"},{"id":"T6367","span":{"begin":173,"end":180},"obj":"GO:0009986"},{"id":"T6368","span":{"begin":188,"end":193},"obj":"PR:000001813"},{"id":"T6369","span":{"begin":202,"end":208},"obj":"PR:000026878"},{"id":"T6370","span":{"begin":256,"end":267},"obj":"CL:0000235"},{"id":"T6371","span":{"begin":273,"end":288},"obj":"CL:0000445"},{"id":"T6372","span":{"begin":307,"end":324},"obj":"UBERON:0005291"},{"id":"T6373","span":{"begin":326,"end":341},"obj":"CL:0000445"},{"id":"T6374","span":{"begin":346,"end":357},"obj":"CL:0000235"},{"id":"T6375","span":{"begin":563,"end":589},"obj":"GO:0043277"},{"id":"T6376","span":{"begin":574,"end":589},"obj":"CL:0000445"},{"id":"T6377","span":{"begin":616,"end":627},"obj":"CL:0000235"},{"id":"T6378","span":{"begin":695,"end":709},"obj":"CL:0000445"},{"id":"T6379","span":{"begin":695,"end":719},"obj":"GO:0043277"},{"id":"T6380","span":{"begin":723,"end":728},"obj":"PR:000009218"},{"id":"T6381","span":{"begin":739,"end":746},"obj":"UBERON:0000922"},{"id":"T6382","span":{"begin":792,"end":823},"obj":"GO:0043277"},{"id":"T6383","span":{"begin":808,"end":823},"obj":"CL:0000445"}],"text":"To analyze whether macrophages are recruited into areas where apoptosis is prominent during embryogenesis, we stained consecutive serial sections either with the macrophage surface marker F4/80 or with aCasp3. Surprisingly, there was no co-localization of macrophages with apoptotic cells. In virtually all embryonic tissues, apoptotic cells and macrophages were localized in different compartments (Figure 6e,6i; and see also Additional data file 1, Figure S1). This suggests that at this stage of development it is mainly neighboring cells that are involved in removal of apoptotic cells, rather than professional macrophages. In summary, our analysis in vivo did not reveal any impairment in apoptotic cell clearance in Ptdsr-deficient embryos during development and further suggests that phagocytosis of apoptotic cells is mainly mediated by non-professional 'bystander' cells."}