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contrast to the study of Li et al. [31], however, we found almost normally developed lungs at birth. Ptdsr -/-lungs showed, in comparison to wild-type, only a slight delay in maturation and were fully ventilated in neonates in most cases (Figure 3e,k). This demonstrates that Ptdsr-deficient mice can overcome the delay in embryonic lung differentiation and display normal lung morphology at birth. Thus, it would appear highly unlikely that Ptdsr -/- mice die from respiratory failure. Consistent with the observations of Kunisaki and colleagues [32], we found severely blocked erythropoietic differentiation at an early erythroblast stage in the liver (Figure 3f,3l), suggesting an explanation for the grossly anemic appearance that we observed in our Ptdsr -/- mice."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T4489","span":{"begin":88,"end":93},"obj":"UBERON:0002048"},{"id":"T4490","span":{"begin":97,"end":102},"obj":"GO:0007567"},{"id":"T4491","span":{"begin":104,"end":109},"obj":"PR_EXT:000009218"},{"id":"T4492","span":{"begin":110,"end":111},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T4493","span":{"begin":112,"end":113},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T4494","span":{"begin":113,"end":118},"obj":"UBERON:0002048"},{"id":"T4495","span":{"begin":144,"end":153},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T4496","span":{"begin":178,"end":188},"obj":"GO_PATO_EXT:biological_maturation"},{"id":"T4497","span":{"begin":218,"end":226},"obj":"PATO_UBERON_EXT:neonate_or_newborn"},{"id":"T4498","span":{"begin":279,"end":284},"obj":"PR_EXT:000009218"},{"id":"T4499","span":{"begin":295,"end":299},"obj":"NCBITaxon:10088"},{"id":"T4500","span":{"begin":326,"end":335},"obj":"UBERON:0000922"},{"id":"T4501","span":{"begin":336,"end":340},"obj":"UBERON:0002048"},{"id":"T4502","span":{"begin":341,"end":356},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T4503","span":{"begin":376,"end":380},"obj":"UBERON:0002048"},{"id":"T4504","span":{"begin":395,"end":400},"obj":"GO:0007567"},{"id":"T4505","span":{"begin":445,"end":450},"obj":"PR_EXT:000009218"},{"id":"T4506","span":{"begin":451,"end":452},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T4507","span":{"begin":453,"end":454},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T4508","span":{"begin":455,"end":459},"obj":"NCBITaxon:10088"},{"id":"T4509","span":{"begin":460,"end":463},"obj":"GO:0016265"},{"id":"T4510","span":{"begin":469,"end":480},"obj":"UBERON:0001004"},{"id":"T4511","span":{"begin":582,"end":612},"obj":"GO:0030218"},{"id":"T4512","span":{"begin":619,"end":637},"obj":"CL:0000549"},{"id":"T4513","span":{"begin":651,"end":656},"obj":"UBERON:0002107"},{"id":"T4514","span":{"begin":757,"end":762},"obj":"PR_EXT:000009218"},{"id":"T4515","span":{"begin":763,"end":764},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T4516","span":{"begin":765,"end":766},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T4517","span":{"begin":767,"end":771},"obj":"NCBITaxon:10088"}],"text":"In contrast to the study of Li et al. [31], however, we found almost normally developed lungs at birth. Ptdsr -/-lungs showed, in comparison to wild-type, only a slight delay in maturation and were fully ventilated in neonates in most cases (Figure 3e,k). This demonstrates that Ptdsr-deficient mice can overcome the delay in embryonic lung differentiation and display normal lung morphology at birth. Thus, it would appear highly unlikely that Ptdsr -/- mice die from respiratory failure. Consistent with the observations of Kunisaki and colleagues [32], we found severely blocked erythropoietic differentiation at an early erythroblast stage in the liver (Figure 3f,3l), suggesting an explanation for the grossly anemic appearance that we observed in our Ptdsr -/- mice."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T4356","span":{"begin":88,"end":93},"obj":"UBERON:0002048"},{"id":"T4357","span":{"begin":97,"end":102},"obj":"GO:0007567"},{"id":"T4358","span":{"begin":104,"end":109},"obj":"PR:000009218"},{"id":"T4359","span":{"begin":113,"end":118},"obj":"UBERON:0002048"},{"id":"T4360","span":{"begin":279,"end":284},"obj":"PR:000009218"},{"id":"T4361","span":{"begin":295,"end":299},"obj":"NCBITaxon:10088"},{"id":"T4362","span":{"begin":326,"end":335},"obj":"UBERON:0000922"},{"id":"T4363","span":{"begin":336,"end":340},"obj":"UBERON:0002048"},{"id":"T4364","span":{"begin":376,"end":380},"obj":"UBERON:0002048"},{"id":"T4365","span":{"begin":395,"end":400},"obj":"GO:0007567"},{"id":"T4366","span":{"begin":445,"end":450},"obj":"PR:000009218"},{"id":"T4367","span":{"begin":455,"end":459},"obj":"NCBITaxon:10088"},{"id":"T4368","span":{"begin":460,"end":463},"obj":"GO:0016265"},{"id":"T4369","span":{"begin":469,"end":480},"obj":"UBERON:0001004"},{"id":"T4370","span":{"begin":582,"end":612},"obj":"GO:0030218"},{"id":"T4371","span":{"begin":619,"end":637},"obj":"CL:0000549"},{"id":"T4372","span":{"begin":651,"end":656},"obj":"UBERON:0002107"},{"id":"T4373","span":{"begin":757,"end":762},"obj":"PR:000009218"},{"id":"T4374","span":{"begin":767,"end":771},"obj":"NCBITaxon:10088"}],"text":"In contrast to the study of Li et al. [31], however, we found almost normally developed lungs at birth. Ptdsr -/-lungs showed, in comparison to wild-type, only a slight delay in maturation and were fully ventilated in neonates in most cases (Figure 3e,k). This demonstrates that Ptdsr-deficient mice can overcome the delay in embryonic lung differentiation and display normal lung morphology at birth. Thus, it would appear highly unlikely that Ptdsr -/- mice die from respiratory failure. Consistent with the observations of Kunisaki and colleagues [32], we found severely blocked erythropoietic differentiation at an early erythroblast stage in the liver (Figure 3f,3l), suggesting an explanation for the grossly anemic appearance that we observed in our Ptdsr -/- mice."}

{"project":"2_test","denotations":[{"id":"15345036-14645847-55938507","span":{"begin":39,"end":41},"obj":"14645847"},{"id":"15345036-14715629-55938508","span":{"begin":551,"end":553},"obj":"14715629"}],"text":"In contrast to the study of Li et al. [31], however, we found almost normally developed lungs at birth. Ptdsr -/-lungs showed, in comparison to wild-type, only a slight delay in maturation and were fully ventilated in neonates in most cases (Figure 3e,k). This demonstrates that Ptdsr-deficient mice can overcome the delay in embryonic lung differentiation and display normal lung morphology at birth. Thus, it would appear highly unlikely that Ptdsr -/- mice die from respiratory failure. Consistent with the observations of Kunisaki and colleagues [32], we found severely blocked erythropoietic differentiation at an early erythroblast stage in the liver (Figure 3f,3l), suggesting an explanation for the grossly anemic appearance that we observed in our Ptdsr -/- mice."}