Id |
Subject |
Object |
Predicate |
Lexical cue |
T4974 |
2411-2415 |
NN |
denotes |
note |
T4518 |
0-5 |
NN |
denotes |
Ptdsr |
T4519 |
9-17 |
VBN |
denotes |
required |
T4520 |
6-8 |
VBZ |
denotes |
is |
T4521 |
18-21 |
IN |
denotes |
for |
T4522 |
22-28 |
JJ |
denotes |
normal |
T4523 |
46-61 |
NN |
denotes |
differentiation |
T4524 |
29-35 |
NN |
denotes |
tissue |
T4525 |
36-39 |
CC |
denotes |
and |
T4526 |
40-45 |
NN |
denotes |
organ |
T4527 |
61-118 |
sentence |
denotes |
We next examined the role of Ptdsr in organ development. |
T4528 |
62-64 |
PRP |
denotes |
We |
T4529 |
70-78 |
VBD |
denotes |
examined |
T4530 |
65-69 |
RB |
denotes |
next |
T4531 |
79-82 |
DT |
denotes |
the |
T4532 |
83-87 |
NN |
denotes |
role |
T4533 |
88-90 |
IN |
denotes |
of |
T4534 |
91-96 |
NN |
denotes |
Ptdsr |
T4535 |
97-99 |
IN |
denotes |
in |
T4536 |
100-105 |
NN |
denotes |
organ |
T4537 |
106-117 |
NN |
denotes |
development |
T4538 |
117-118 |
. |
denotes |
. |
T4539 |
118-277 |
sentence |
denotes |
Serial histological sections of Ptdsr -/- and control embryos were taken to perform a detailed morphological analysis of all organ systems during development. |
T4540 |
119-125 |
JJ |
denotes |
Serial |
T4541 |
139-147 |
NNS |
denotes |
sections |
T4542 |
126-138 |
JJ |
denotes |
histological |
T4543 |
186-191 |
VBN |
denotes |
taken |
T4544 |
148-150 |
IN |
denotes |
of |
T4545 |
151-156 |
NN |
denotes |
Ptdsr |
T4546 |
173-180 |
NNS |
denotes |
embryos |
T4547 |
157-158 |
SYM |
denotes |
- |
T4548 |
158-159 |
HYPH |
denotes |
/ |
T4549 |
159-160 |
SYM |
denotes |
- |
T4550 |
161-164 |
CC |
denotes |
and |
T4551 |
165-172 |
NN |
denotes |
control |
T4552 |
181-185 |
VBD |
denotes |
were |
T4553 |
192-194 |
TO |
denotes |
to |
T4554 |
195-202 |
VB |
denotes |
perform |
T4555 |
203-204 |
DT |
denotes |
a |
T4556 |
228-236 |
NN |
denotes |
analysis |
T4557 |
205-213 |
JJ |
denotes |
detailed |
T4558 |
214-227 |
JJ |
denotes |
morphological |
T4559 |
237-239 |
IN |
denotes |
of |
T4560 |
240-243 |
DT |
denotes |
all |
T4561 |
250-257 |
NNS |
denotes |
systems |
T4562 |
244-249 |
NN |
denotes |
organ |
T4563 |
258-264 |
IN |
denotes |
during |
T4564 |
265-276 |
NN |
denotes |
development |
T4565 |
276-277 |
. |
denotes |
. |
T4566 |
277-388 |
sentence |
denotes |
A significant delay in organ and tissue differentiation was observed at E16.5 in lungs, kidneys and intestine. |
T4567 |
278-279 |
DT |
denotes |
A |
T4568 |
292-297 |
NN |
denotes |
delay |
T4569 |
280-291 |
JJ |
denotes |
significant |
T4570 |
338-346 |
VBN |
denotes |
observed |
T4571 |
298-300 |
IN |
denotes |
in |
T4572 |
301-306 |
NN |
denotes |
organ |
T4573 |
318-333 |
NN |
denotes |
differentiation |
T4574 |
307-310 |
CC |
denotes |
and |
T4575 |
311-317 |
NN |
denotes |
tissue |
T4576 |
334-337 |
VBD |
denotes |
was |
T4577 |
347-349 |
IN |
denotes |
at |
T4578 |
350-355 |
NN |
denotes |
E16.5 |
T4579 |
356-358 |
IN |
denotes |
in |
T4580 |
359-364 |
NNS |
denotes |
lungs |
T4581 |
364-366 |
, |
denotes |
, |
T4582 |
366-373 |
NNS |
denotes |
kidneys |
T4583 |
374-377 |
CC |
denotes |
and |
T4584 |
378-387 |
NN |
denotes |
intestine |
T4585 |
387-388 |
. |
denotes |
. |
T4586 |
388-477 |
sentence |
denotes |
Lungs of control littermates were properly developed with expanding alveoli (Figure 3a). |
T4587 |
389-394 |
NNS |
denotes |
Lungs |
T4588 |
418-422 |
VBD |
denotes |
were |
T4589 |
395-397 |
IN |
denotes |
of |
T4590 |
398-405 |
NN |
denotes |
control |
T4591 |
406-417 |
NNS |
denotes |
littermates |
T4592 |
423-431 |
RB |
denotes |
properly |
T4593 |
432-441 |
JJ |
denotes |
developed |
T4594 |
442-446 |
IN |
denotes |
with |
T4595 |
447-456 |
VBG |
denotes |
expanding |
T4596 |
457-464 |
NNS |
denotes |
alveoli |
T4597 |
465-466 |
-LRB- |
denotes |
( |
T4598 |
473-475 |
NN |
denotes |
3a |
T4599 |
466-472 |
NN |
denotes |
Figure |
T4600 |
475-476 |
-RRB- |
denotes |
) |
T4601 |
476-477 |
. |
denotes |
. |
T4602 |
477-639 |
sentence |
denotes |
Terminal bronchi and bronchioles were already well developed, and terminally differentiated epithelial cells with cilia on the luminal cell surface were present. |
T4603 |
478-486 |
JJ |
denotes |
Terminal |
T4604 |
487-494 |
NNS |
denotes |
bronchi |
T4605 |
511-515 |
VBD |
denotes |
were |
T4606 |
495-498 |
CC |
denotes |
and |
T4607 |
499-510 |
NNS |
denotes |
bronchioles |
T4608 |
516-523 |
RB |
denotes |
already |
T4609 |
524-528 |
RB |
denotes |
well |
T4610 |
529-538 |
JJ |
denotes |
developed |
T4611 |
538-540 |
, |
denotes |
, |
T4612 |
540-543 |
CC |
denotes |
and |
T4613 |
544-554 |
RB |
denotes |
terminally |
T4614 |
555-569 |
VBN |
denotes |
differentiated |
T4615 |
581-586 |
NNS |
denotes |
cells |
T4616 |
570-580 |
JJ |
denotes |
epithelial |
T4617 |
626-630 |
VBD |
denotes |
were |
T4618 |
587-591 |
IN |
denotes |
with |
T4619 |
592-597 |
NNS |
denotes |
cilia |
T4620 |
598-600 |
IN |
denotes |
on |
T4621 |
601-604 |
DT |
denotes |
the |
T4622 |
618-625 |
NN |
denotes |
surface |
T4623 |
605-612 |
JJ |
denotes |
luminal |
T4624 |
613-617 |
NN |
denotes |
cell |
T4625 |
631-638 |
JJ |
denotes |
present |
T4626 |
638-639 |
. |
denotes |
. |
T4627 |
639-783 |
sentence |
denotes |
In contrast, almost no alveoli or bronchioles were present in Ptdsr -/- lungs, indicating a delay or arrest in lung sacculation and expansion. |
T4628 |
640-642 |
IN |
denotes |
In |
T4629 |
686-690 |
VBD |
denotes |
were |
T4630 |
643-651 |
NN |
denotes |
contrast |
T4631 |
651-653 |
, |
denotes |
, |
T4632 |
653-659 |
RB |
denotes |
almost |
T4633 |
663-670 |
NNS |
denotes |
alveoli |
T4634 |
660-662 |
DT |
denotes |
no |
T4635 |
671-673 |
CC |
denotes |
or |
T4636 |
674-685 |
NNS |
denotes |
bronchioles |
T4637 |
691-698 |
JJ |
denotes |
present |
T4638 |
699-701 |
IN |
denotes |
in |
T4639 |
702-707 |
NN |
denotes |
Ptdsr |
T4640 |
713-718 |
NNS |
denotes |
lungs |
T4641 |
708-709 |
SYM |
denotes |
- |
T4642 |
709-710 |
HYPH |
denotes |
/ |
T4643 |
710-711 |
SYM |
denotes |
- |
T4644 |
718-720 |
, |
denotes |
, |
T4645 |
720-730 |
VBG |
denotes |
indicating |
T4646 |
731-732 |
DT |
denotes |
a |
T4647 |
733-738 |
NN |
denotes |
delay |
T4648 |
739-741 |
CC |
denotes |
or |
T4649 |
742-748 |
NN |
denotes |
arrest |
T4650 |
749-751 |
IN |
denotes |
in |
T4651 |
752-756 |
NN |
denotes |
lung |
T4652 |
757-768 |
NN |
denotes |
sacculation |
T4653 |
769-772 |
CC |
denotes |
and |
T4654 |
773-782 |
NN |
denotes |
expansion |
T4655 |
782-783 |
. |
denotes |
. |
T4656 |
783-874 |
sentence |
denotes |
Instead, we observed an abundance of mesenchyme that appeared highly immature (Figure 3g). |
T4657 |
784-791 |
RB |
denotes |
Instead |
T4658 |
796-804 |
VBD |
denotes |
observed |
T4659 |
791-793 |
, |
denotes |
, |
T4660 |
793-795 |
PRP |
denotes |
we |
T4661 |
805-807 |
DT |
denotes |
an |
T4662 |
808-817 |
NN |
denotes |
abundance |
T4663 |
818-820 |
IN |
denotes |
of |
T4664 |
821-831 |
NN |
denotes |
mesenchyme |
T4665 |
832-836 |
WDT |
denotes |
that |
T4666 |
837-845 |
VBD |
denotes |
appeared |
T4667 |
846-852 |
RB |
denotes |
highly |
T4668 |
853-861 |
JJ |
denotes |
immature |
T4669 |
862-863 |
-LRB- |
denotes |
( |
T4670 |
870-872 |
NN |
denotes |
3g |
T4671 |
863-869 |
NN |
denotes |
Figure |
T4672 |
872-873 |
-RRB- |
denotes |
) |
T4673 |
873-874 |
. |
denotes |
. |
T4674 |
874-975 |
sentence |
denotes |
A similar delay in tissue differentiation of Ptdsr -/- embryos was found in the kidneys (Figure 3h). |
T4675 |
875-876 |
DT |
denotes |
A |
T4676 |
885-890 |
NN |
denotes |
delay |
T4677 |
877-884 |
JJ |
denotes |
similar |
T4678 |
942-947 |
VBN |
denotes |
found |
T4679 |
891-893 |
IN |
denotes |
in |
T4680 |
894-900 |
NN |
denotes |
tissue |
T4681 |
901-916 |
NN |
denotes |
differentiation |
T4682 |
917-919 |
IN |
denotes |
of |
T4683 |
920-925 |
NN |
denotes |
Ptdsr |
T4684 |
930-937 |
NNS |
denotes |
embryos |
T4685 |
926-927 |
SYM |
denotes |
- |
T4686 |
927-928 |
HYPH |
denotes |
/ |
T4687 |
928-929 |
SYM |
denotes |
- |
T4688 |
938-941 |
VBD |
denotes |
was |
T4689 |
948-950 |
IN |
denotes |
in |
T4690 |
951-954 |
DT |
denotes |
the |
T4691 |
955-962 |
NNS |
denotes |
kidneys |
T4692 |
963-964 |
-LRB- |
denotes |
( |
T4693 |
971-973 |
NN |
denotes |
3h |
T4694 |
964-970 |
NN |
denotes |
Figure |
T4695 |
973-974 |
-RRB- |
denotes |
) |
T4696 |
974-975 |
. |
denotes |
. |
T4697 |
975-1175 |
sentence |
denotes |
Kidneys from Ptdsr+/+ embryos were well developed at E16.5, showing terminally differentiated glomeruli with Bowman's capsule and collecting tubules lined with cuboidal epithelial cells (Figure 3b). |
T4698 |
976-983 |
NNS |
denotes |
Kidneys |
T4699 |
1007-1011 |
VBD |
denotes |
were |
T4700 |
984-988 |
IN |
denotes |
from |
T4701 |
989-994 |
NN |
denotes |
Ptdsr |
T4702 |
999-1006 |
NNS |
denotes |
embryos |
T4703 |
994-995 |
SYM |
denotes |
+ |
T4704 |
995-996 |
HYPH |
denotes |
/ |
T4705 |
996-997 |
SYM |
denotes |
+ |
T4706 |
1012-1016 |
RB |
denotes |
well |
T4707 |
1017-1026 |
JJ |
denotes |
developed |
T4708 |
1027-1029 |
IN |
denotes |
at |
T4709 |
1030-1035 |
NN |
denotes |
E16.5 |
T4710 |
1035-1037 |
, |
denotes |
, |
T4711 |
1037-1044 |
VBG |
denotes |
showing |
T4712 |
1045-1055 |
RB |
denotes |
terminally |
T4713 |
1056-1070 |
VBN |
denotes |
differentiated |
T4714 |
1071-1080 |
NNS |
denotes |
glomeruli |
T4715 |
1081-1085 |
IN |
denotes |
with |
T4716 |
1086-1092 |
NNP |
denotes |
Bowman |
T4717 |
1095-1102 |
NN |
denotes |
capsule |
T4718 |
1092-1094 |
POS |
denotes |
's |
T4719 |
1103-1106 |
CC |
denotes |
and |
T4720 |
1107-1117 |
VBG |
denotes |
collecting |
T4721 |
1118-1125 |
NNS |
denotes |
tubules |
T4722 |
1126-1131 |
VBN |
denotes |
lined |
T4723 |
1132-1136 |
IN |
denotes |
with |
T4724 |
1137-1145 |
JJ |
denotes |
cuboidal |
T4725 |
1157-1162 |
NNS |
denotes |
cells |
T4726 |
1146-1156 |
JJ |
denotes |
epithelial |
T4727 |
1163-1164 |
-LRB- |
denotes |
( |
T4728 |
1171-1173 |
NN |
denotes |
3b |
T4729 |
1164-1170 |
NN |
denotes |
Figure |
T4730 |
1173-1174 |
-RRB- |
denotes |
) |
T4731 |
1174-1175 |
. |
denotes |
. |
T4732 |
1175-1300 |
sentence |
denotes |
In contrast, Ptdsr-deficient kidneys had only primitive glomeruli at E16.5, and collecting tubules were less well-developed. |
T4733 |
1176-1178 |
IN |
denotes |
In |
T4734 |
1213-1216 |
VBD |
denotes |
had |
T4735 |
1179-1187 |
NN |
denotes |
contrast |
T4736 |
1187-1189 |
, |
denotes |
, |
T4737 |
1189-1194 |
NN |
denotes |
Ptdsr |
T4738 |
1195-1204 |
JJ |
denotes |
deficient |
T4739 |
1194-1195 |
SYM |
denotes |
- |
T4740 |
1205-1212 |
NNS |
denotes |
kidneys |
T4741 |
1217-1221 |
RB |
denotes |
only |
T4742 |
1232-1241 |
NNS |
denotes |
glomeruli |
T4743 |
1222-1231 |
JJ |
denotes |
primitive |
T4744 |
1242-1244 |
IN |
denotes |
at |
T4745 |
1245-1250 |
NN |
denotes |
E16.5 |
T4746 |
1250-1252 |
, |
denotes |
, |
T4747 |
1252-1255 |
CC |
denotes |
and |
T4748 |
1256-1266 |
VBG |
denotes |
collecting |
T4749 |
1267-1274 |
NNS |
denotes |
tubules |
T4750 |
1275-1279 |
VBD |
denotes |
were |
T4751 |
1280-1284 |
RBR |
denotes |
less |
T4752 |
1290-1299 |
JJ |
denotes |
developed |
T4753 |
1285-1289 |
RB |
denotes |
well |
T4754 |
1289-1290 |
HYPH |
denotes |
- |
T4755 |
1299-1300 |
. |
denotes |
. |
T4756 |
1300-1401 |
sentence |
denotes |
Instead, a large amount of undifferentiated mesenchyme was present in Ptdsr -/- kidneys (Figure 3h). |
T4757 |
1301-1308 |
RB |
denotes |
Instead |
T4758 |
1356-1359 |
VBD |
denotes |
was |
T4759 |
1308-1310 |
, |
denotes |
, |
T4760 |
1310-1311 |
DT |
denotes |
a |
T4761 |
1318-1324 |
NN |
denotes |
amount |
T4762 |
1312-1317 |
JJ |
denotes |
large |
T4763 |
1325-1327 |
IN |
denotes |
of |
T4764 |
1328-1344 |
JJ |
denotes |
undifferentiated |
T4765 |
1345-1355 |
NN |
denotes |
mesenchyme |
T4766 |
1360-1367 |
JJ |
denotes |
present |
T4767 |
1368-1370 |
IN |
denotes |
in |
T4768 |
1371-1376 |
NN |
denotes |
Ptdsr |
T4769 |
1381-1388 |
NNS |
denotes |
kidneys |
T4770 |
1377-1378 |
SYM |
denotes |
- |
T4771 |
1378-1379 |
HYPH |
denotes |
/ |
T4772 |
1379-1380 |
SYM |
denotes |
- |
T4773 |
1389-1390 |
-LRB- |
denotes |
( |
T4774 |
1397-1399 |
NN |
denotes |
3h |
T4775 |
1390-1396 |
NN |
denotes |
Figure |
T4776 |
1399-1400 |
-RRB- |
denotes |
) |
T4777 |
1400-1401 |
. |
denotes |
. |
T4778 |
1401-1497 |
sentence |
denotes |
A delay in tissue differentiation was also found in the intestine at this stage of development. |
T4779 |
1402-1403 |
DT |
denotes |
A |
T4780 |
1404-1409 |
NN |
denotes |
delay |
T4781 |
1445-1450 |
VBN |
denotes |
found |
T4782 |
1410-1412 |
IN |
denotes |
in |
T4783 |
1413-1419 |
NN |
denotes |
tissue |
T4784 |
1420-1435 |
NN |
denotes |
differentiation |
T4785 |
1436-1439 |
VBD |
denotes |
was |
T4786 |
1440-1444 |
RB |
denotes |
also |
T4787 |
1451-1453 |
IN |
denotes |
in |
T4788 |
1454-1457 |
DT |
denotes |
the |
T4789 |
1458-1467 |
NN |
denotes |
intestine |
T4790 |
1468-1470 |
IN |
denotes |
at |
T4791 |
1471-1475 |
DT |
denotes |
this |
T4792 |
1476-1481 |
NN |
denotes |
stage |
T4793 |
1482-1484 |
IN |
denotes |
of |
T4794 |
1485-1496 |
NN |
denotes |
development |
T4795 |
1496-1497 |
. |
denotes |
. |
T4796 |
1497-1607 |
sentence |
denotes |
Ptdsr -/- embryos displayed improperly developed villi and an underdeveloped or absent submucosa (Figure 3i). |
T4797 |
1498-1503 |
NN |
denotes |
Ptdsr |
T4798 |
1508-1515 |
NNS |
denotes |
embryos |
T4799 |
1504-1505 |
SYM |
denotes |
- |
T4800 |
1505-1506 |
HYPH |
denotes |
/ |
T4801 |
1506-1507 |
SYM |
denotes |
- |
T4802 |
1516-1525 |
VBD |
denotes |
displayed |
T4803 |
1526-1536 |
RB |
denotes |
improperly |
T4804 |
1537-1546 |
VBN |
denotes |
developed |
T4805 |
1547-1552 |
NNS |
denotes |
villi |
T4806 |
1553-1556 |
CC |
denotes |
and |
T4807 |
1557-1559 |
DT |
denotes |
an |
T4808 |
1585-1594 |
NN |
denotes |
submucosa |
T4809 |
1560-1574 |
JJ |
denotes |
underdeveloped |
T4810 |
1575-1577 |
CC |
denotes |
or |
T4811 |
1578-1584 |
JJ |
denotes |
absent |
T4812 |
1595-1596 |
-LRB- |
denotes |
( |
T4813 |
1603-1605 |
NN |
denotes |
3i |
T4814 |
1596-1602 |
NN |
denotes |
Figure |
T4815 |
1605-1606 |
-RRB- |
denotes |
) |
T4816 |
1606-1607 |
. |
denotes |
. |
T4817 |
1607-1789 |
sentence |
denotes |
In wild-type embryos (Figure 3c), intestinal cellular differentiation was already highly organized, with intramural ganglion cells between the external and internal muscular layers. |
T4818 |
1608-1610 |
IN |
denotes |
In |
T4819 |
1678-1681 |
VBD |
denotes |
was |
T4820 |
1611-1615 |
JJ |
denotes |
wild |
T4821 |
1616-1620 |
NN |
denotes |
type |
T4822 |
1615-1616 |
HYPH |
denotes |
- |
T4823 |
1621-1628 |
NNS |
denotes |
embryos |
T4824 |
1629-1630 |
-LRB- |
denotes |
( |
T4825 |
1637-1639 |
NN |
denotes |
3c |
T4826 |
1630-1636 |
NN |
denotes |
Figure |
T4827 |
1639-1640 |
-RRB- |
denotes |
) |
T4828 |
1640-1642 |
, |
denotes |
, |
T4829 |
1642-1652 |
JJ |
denotes |
intestinal |
T4830 |
1662-1677 |
NN |
denotes |
differentiation |
T4831 |
1653-1661 |
JJ |
denotes |
cellular |
T4832 |
1682-1689 |
RB |
denotes |
already |
T4833 |
1690-1696 |
RB |
denotes |
highly |
T4834 |
1697-1706 |
JJ |
denotes |
organized |
T4835 |
1706-1708 |
, |
denotes |
, |
T4836 |
1708-1712 |
IN |
denotes |
with |
T4837 |
1713-1723 |
JJ |
denotes |
intramural |
T4838 |
1733-1738 |
NNS |
denotes |
cells |
T4839 |
1724-1732 |
NN |
denotes |
ganglion |
T4840 |
1739-1746 |
IN |
denotes |
between |
T4841 |
1747-1750 |
DT |
denotes |
the |
T4842 |
1782-1788 |
NNS |
denotes |
layers |
T4843 |
1751-1759 |
JJ |
denotes |
external |
T4844 |
1760-1763 |
CC |
denotes |
and |
T4845 |
1764-1772 |
JJ |
denotes |
internal |
T4846 |
1773-1781 |
JJ |
denotes |
muscular |
T4847 |
1788-1789 |
. |
denotes |
. |
T4848 |
1789-1883 |
sentence |
denotes |
Such neuronal cells were absent from the intestine of Ptdsr -/- embryos (Figure 3i), however. |
T4849 |
1790-1794 |
JJ |
denotes |
Such |
T4850 |
1804-1809 |
NNS |
denotes |
cells |
T4851 |
1795-1803 |
JJ |
denotes |
neuronal |
T4852 |
1810-1814 |
VBD |
denotes |
were |
T4853 |
1815-1821 |
JJ |
denotes |
absent |
T4854 |
1822-1826 |
IN |
denotes |
from |
T4855 |
1827-1830 |
DT |
denotes |
the |
T4856 |
1831-1840 |
NN |
denotes |
intestine |
T4857 |
1841-1843 |
IN |
denotes |
of |
T4858 |
1844-1849 |
NN |
denotes |
Ptdsr |
T4859 |
1854-1861 |
NNS |
denotes |
embryos |
T4860 |
1850-1851 |
SYM |
denotes |
- |
T4861 |
1851-1852 |
HYPH |
denotes |
/ |
T4862 |
1852-1853 |
SYM |
denotes |
- |
T4863 |
1862-1863 |
-LRB- |
denotes |
( |
T4864 |
1870-1872 |
NN |
denotes |
3i |
T4865 |
1863-1869 |
NN |
denotes |
Figure |
T4866 |
1872-1873 |
-RRB- |
denotes |
) |
T4867 |
1873-1875 |
, |
denotes |
, |
T4868 |
1875-1882 |
RB |
denotes |
however |
T4869 |
1882-1883 |
. |
denotes |
. |
T4870 |
1883-2091 |
sentence |
denotes |
Some Ptdsr -/- mice (4.5 %) also displayed extensive brain malformations that resulted in externally visible head abnormalities, with occasional ectopic tissue outside the skull or exencephaly (Figure 1f,h). |
T4871 |
1884-1888 |
DT |
denotes |
Some |
T4872 |
1899-1903 |
NNS |
denotes |
mice |
T4873 |
1889-1894 |
NN |
denotes |
Ptdsr |
T4874 |
1895-1896 |
SYM |
denotes |
- |
T4875 |
1896-1897 |
HYPH |
denotes |
/ |
T4876 |
1897-1898 |
SYM |
denotes |
- |
T4877 |
1917-1926 |
VBD |
denotes |
displayed |
T4878 |
1904-1905 |
-LRB- |
denotes |
( |
T4879 |
1909-1910 |
NN |
denotes |
% |
T4880 |
1905-1908 |
CD |
denotes |
4.5 |
T4881 |
1910-1911 |
-RRB- |
denotes |
) |
T4882 |
1912-1916 |
RB |
denotes |
also |
T4883 |
1927-1936 |
JJ |
denotes |
extensive |
T4884 |
1943-1956 |
NNS |
denotes |
malformations |
T4885 |
1937-1942 |
NN |
denotes |
brain |
T4886 |
1957-1961 |
WDT |
denotes |
that |
T4887 |
1962-1970 |
VBD |
denotes |
resulted |
T4888 |
1971-1973 |
IN |
denotes |
in |
T4889 |
1974-1984 |
RB |
denotes |
externally |
T4890 |
1985-1992 |
JJ |
denotes |
visible |
T4891 |
1998-2011 |
NNS |
denotes |
abnormalities |
T4892 |
1993-1997 |
NN |
denotes |
head |
T4893 |
2011-2013 |
, |
denotes |
, |
T4894 |
2013-2017 |
IN |
denotes |
with |
T4895 |
2018-2028 |
JJ |
denotes |
occasional |
T4896 |
2037-2043 |
NN |
denotes |
tissue |
T4897 |
2029-2036 |
JJ |
denotes |
ectopic |
T4898 |
2044-2051 |
IN |
denotes |
outside |
T4899 |
2052-2055 |
DT |
denotes |
the |
T4900 |
2056-2061 |
NN |
denotes |
skull |
T4901 |
2062-2064 |
CC |
denotes |
or |
T4902 |
2065-2076 |
NN |
denotes |
exencephaly |
T4903 |
2077-2078 |
-LRB- |
denotes |
( |
T4904 |
2088-2089 |
NN |
denotes |
h |
T4905 |
2078-2084 |
NN |
denotes |
Figure |
T4906 |
2085-2087 |
NN |
denotes |
1f |
T4907 |
2087-2088 |
, |
denotes |
, |
T4908 |
2089-2090 |
-RRB- |
denotes |
) |
T4909 |
2090-2091 |
. |
denotes |
. |
T4910 |
2091-2268 |
sentence |
denotes |
Histological analysis revealed an extensive hyperplasia of brain tissue with herniation of brain tissue either through the skull-cap or through the ventral skull (Figure 3d,j). |
T4911 |
2092-2104 |
JJ |
denotes |
Histological |
T4912 |
2105-2113 |
NN |
denotes |
analysis |
T4913 |
2114-2122 |
VBD |
denotes |
revealed |
T4914 |
2123-2125 |
DT |
denotes |
an |
T4915 |
2136-2147 |
NN |
denotes |
hyperplasia |
T4916 |
2126-2135 |
JJ |
denotes |
extensive |
T4917 |
2148-2150 |
IN |
denotes |
of |
T4918 |
2151-2156 |
NN |
denotes |
brain |
T4919 |
2157-2163 |
NN |
denotes |
tissue |
T4920 |
2164-2168 |
IN |
denotes |
with |
T4921 |
2169-2179 |
NN |
denotes |
herniation |
T4922 |
2180-2182 |
IN |
denotes |
of |
T4923 |
2183-2188 |
NN |
denotes |
brain |
T4924 |
2189-2195 |
NN |
denotes |
tissue |
T4925 |
2196-2202 |
CC |
denotes |
either |
T4926 |
2203-2210 |
IN |
denotes |
through |
T4927 |
2211-2214 |
DT |
denotes |
the |
T4928 |
2221-2224 |
NN |
denotes |
cap |
T4929 |
2215-2220 |
NN |
denotes |
skull |
T4930 |
2220-2221 |
HYPH |
denotes |
- |
T4931 |
2225-2227 |
CC |
denotes |
or |
T4932 |
2228-2235 |
IN |
denotes |
through |
T4933 |
2236-2239 |
DT |
denotes |
the |
T4934 |
2248-2253 |
NN |
denotes |
skull |
T4935 |
2240-2247 |
JJ |
denotes |
ventral |
T4936 |
2254-2255 |
-LRB- |
denotes |
( |
T4937 |
2265-2266 |
NN |
denotes |
j |
T4938 |
2255-2261 |
NN |
denotes |
Figure |
T4939 |
2262-2264 |
NN |
denotes |
3d |
T4940 |
2264-2265 |
, |
denotes |
, |
T4941 |
2266-2267 |
-RRB- |
denotes |
) |
T4942 |
2267-2268 |
. |
denotes |
. |
T4943 |
2268-2407 |
sentence |
denotes |
In the most severe cases, expansion of brain tissue in mutant mice resulted in further perturbations of cortical structures (Figure 3d,j). |
T4944 |
2269-2271 |
IN |
denotes |
In |
T4945 |
2336-2344 |
VBD |
denotes |
resulted |
T4946 |
2272-2275 |
DT |
denotes |
the |
T4947 |
2288-2293 |
NNS |
denotes |
cases |
T4948 |
2276-2280 |
RBS |
denotes |
most |
T4949 |
2281-2287 |
JJ |
denotes |
severe |
T4950 |
2293-2295 |
, |
denotes |
, |
T4951 |
2295-2304 |
NN |
denotes |
expansion |
T4952 |
2305-2307 |
IN |
denotes |
of |
T4953 |
2308-2313 |
NN |
denotes |
brain |
T4954 |
2314-2320 |
NN |
denotes |
tissue |
T4955 |
2321-2323 |
IN |
denotes |
in |
T4956 |
2324-2330 |
JJ |
denotes |
mutant |
T4957 |
2331-2335 |
NNS |
denotes |
mice |
T4958 |
2345-2347 |
IN |
denotes |
in |
T4959 |
2348-2355 |
JJ |
denotes |
further |
T4960 |
2356-2369 |
NNS |
denotes |
perturbations |
T4961 |
2370-2372 |
IN |
denotes |
of |
T4962 |
2373-2381 |
JJ |
denotes |
cortical |
T4963 |
2382-2392 |
NNS |
denotes |
structures |
T4964 |
2393-2394 |
-LRB- |
denotes |
( |
T4965 |
2404-2405 |
NN |
denotes |
j |
T4966 |
2394-2400 |
NN |
denotes |
Figure |
T4967 |
2401-2403 |
NN |
denotes |
3d |
T4968 |
2403-2404 |
, |
denotes |
, |
T4969 |
2405-2406 |
-RRB- |
denotes |
) |
T4970 |
2406-2407 |
. |
denotes |
. |
T4971 |
2407-2526 |
sentence |
denotes |
Of note, a similar brain phenotype was observed in the Ptdsr-deficient mouse line generated by Li and colleagues [31]. |
T4972 |
2408-2410 |
IN |
denotes |
Of |
T4973 |
2447-2455 |
VBN |
denotes |
observed |
T4975 |
2415-2417 |
, |
denotes |
, |
T4976 |
2417-2418 |
DT |
denotes |
a |
T4977 |
2433-2442 |
NN |
denotes |
phenotype |
T4978 |
2419-2426 |
JJ |
denotes |
similar |
T4979 |
2427-2432 |
NN |
denotes |
brain |
T4980 |
2443-2446 |
VBD |
denotes |
was |
T4981 |
2456-2458 |
IN |
denotes |
in |
T4982 |
2459-2462 |
DT |
denotes |
the |
T4983 |
2485-2489 |
NN |
denotes |
line |
T4984 |
2463-2468 |
NN |
denotes |
Ptdsr |
T4985 |
2469-2478 |
JJ |
denotes |
deficient |
T4986 |
2468-2469 |
HYPH |
denotes |
- |
T4987 |
2479-2484 |
NN |
denotes |
mouse |
T4988 |
2490-2499 |
VBN |
denotes |
generated |
T4989 |
2500-2502 |
IN |
denotes |
by |
T4990 |
2503-2505 |
NNP |
denotes |
Li |
T4991 |
2506-2509 |
CC |
denotes |
and |
T4992 |
2510-2520 |
NNS |
denotes |
colleagues |
T4993 |
2521-2522 |
-LRB- |
denotes |
[ |
T4994 |
2522-2524 |
CD |
denotes |
31 |
T4995 |
2524-2525 |
-RRB- |
denotes |
] |
T4996 |
2525-2526 |
. |
denotes |
. |
T4997 |
2526-2630 |
sentence |
denotes |
In contrast to the study of Li et al. [31], however, we found almost normally developed lungs at birth. |
T4998 |
2527-2529 |
IN |
denotes |
In |
T4999 |
2583-2588 |
VBD |
denotes |
found |
T5000 |
2530-2538 |
NN |
denotes |
contrast |
T5001 |
2539-2541 |
IN |
denotes |
to |
T5002 |
2542-2545 |
DT |
denotes |
the |
T5003 |
2546-2551 |
NN |
denotes |
study |
T5004 |
2552-2554 |
IN |
denotes |
of |
T5005 |
2555-2557 |
NNP |
denotes |
Li |
T5006 |
2558-2560 |
FW |
denotes |
et |
T5007 |
2561-2564 |
FW |
denotes |
al. |
T5008 |
2565-2566 |
-LRB- |
denotes |
[ |
T5009 |
2566-2568 |
CD |
denotes |
31 |
T5010 |
2568-2569 |
-RRB- |
denotes |
] |
T5011 |
2569-2571 |
, |
denotes |
, |
T5012 |
2571-2578 |
RB |
denotes |
however |
T5013 |
2578-2580 |
, |
denotes |
, |
T5014 |
2580-2582 |
PRP |
denotes |
we |
T5015 |
2589-2595 |
RB |
denotes |
almost |
T5016 |
2605-2614 |
VBN |
denotes |
developed |
T5017 |
2596-2604 |
RB |
denotes |
normally |
T5018 |
2615-2620 |
NNS |
denotes |
lungs |
T5019 |
2621-2623 |
IN |
denotes |
at |
T5020 |
2624-2629 |
NN |
denotes |
birth |
T5021 |
2629-2630 |
. |
denotes |
. |
T5022 |
2630-2782 |
sentence |
denotes |
Ptdsr -/-lungs showed, in comparison to wild-type, only a slight delay in maturation and were fully ventilated in neonates in most cases (Figure 3e,k). |
T5023 |
2631-2636 |
NN |
denotes |
Ptdsr |
T5024 |
2640-2645 |
NNS |
denotes |
lungs |
T5025 |
2637-2638 |
SYM |
denotes |
- |
T5026 |
2638-2639 |
HYPH |
denotes |
/ |
T5027 |
2639-2640 |
SYM |
denotes |
- |
T5028 |
2646-2652 |
VBD |
denotes |
showed |
T5029 |
2652-2654 |
, |
denotes |
, |
T5030 |
2654-2656 |
IN |
denotes |
in |
T5031 |
2657-2667 |
NN |
denotes |
comparison |
T5032 |
2668-2670 |
IN |
denotes |
to |
T5033 |
2671-2675 |
JJ |
denotes |
wild |
T5034 |
2676-2680 |
NN |
denotes |
type |
T5035 |
2675-2676 |
HYPH |
denotes |
- |
T5036 |
2680-2682 |
, |
denotes |
, |
T5037 |
2682-2686 |
RB |
denotes |
only |
T5038 |
2696-2701 |
NN |
denotes |
delay |
T5039 |
2687-2688 |
DT |
denotes |
a |
T5040 |
2689-2695 |
JJ |
denotes |
slight |
T5041 |
2702-2704 |
IN |
denotes |
in |
T5042 |
2705-2715 |
NN |
denotes |
maturation |
T5043 |
2716-2719 |
CC |
denotes |
and |
T5044 |
2720-2724 |
VBD |
denotes |
were |
T5045 |
2725-2730 |
RB |
denotes |
fully |
T5046 |
2731-2741 |
JJ |
denotes |
ventilated |
T5047 |
2742-2744 |
IN |
denotes |
in |
T5048 |
2745-2753 |
NNS |
denotes |
neonates |
T5049 |
2754-2756 |
IN |
denotes |
in |
T5050 |
2757-2761 |
JJS |
denotes |
most |
T5051 |
2762-2767 |
NNS |
denotes |
cases |
T5052 |
2768-2769 |
-LRB- |
denotes |
( |
T5053 |
2779-2780 |
NN |
denotes |
k |
T5054 |
2769-2775 |
NN |
denotes |
Figure |
T5055 |
2776-2778 |
NN |
denotes |
3e |
T5056 |
2778-2779 |
, |
denotes |
, |
T5057 |
2780-2781 |
-RRB- |
denotes |
) |
T5058 |
2781-2782 |
. |
denotes |
. |
T5059 |
2782-2928 |
sentence |
denotes |
This demonstrates that Ptdsr-deficient mice can overcome the delay in embryonic lung differentiation and display normal lung morphology at birth. |
T5060 |
2783-2787 |
DT |
denotes |
This |
T5061 |
2788-2800 |
VBZ |
denotes |
demonstrates |
T5062 |
2801-2805 |
IN |
denotes |
that |
T5063 |
2831-2839 |
VB |
denotes |
overcome |
T5064 |
2806-2811 |
NN |
denotes |
Ptdsr |
T5065 |
2812-2821 |
JJ |
denotes |
deficient |
T5066 |
2811-2812 |
HYPH |
denotes |
- |
T5067 |
2822-2826 |
NNS |
denotes |
mice |
T5068 |
2827-2830 |
MD |
denotes |
can |
T5069 |
2840-2843 |
DT |
denotes |
the |
T5070 |
2844-2849 |
NN |
denotes |
delay |
T5071 |
2850-2852 |
IN |
denotes |
in |
T5072 |
2853-2862 |
JJ |
denotes |
embryonic |
T5073 |
2868-2883 |
NN |
denotes |
differentiation |
T5074 |
2863-2867 |
NN |
denotes |
lung |
T5075 |
2884-2887 |
CC |
denotes |
and |
T5076 |
2888-2895 |
VB |
denotes |
display |
T5077 |
2896-2902 |
JJ |
denotes |
normal |
T5078 |
2908-2918 |
NN |
denotes |
morphology |
T5079 |
2903-2907 |
NN |
denotes |
lung |
T5080 |
2919-2921 |
IN |
denotes |
at |
T5081 |
2922-2927 |
NN |
denotes |
birth |
T5082 |
2927-2928 |
. |
denotes |
. |
T5083 |
2928-3016 |
sentence |
denotes |
Thus, it would appear highly unlikely that Ptdsr -/- mice die from respiratory failure. |
T5084 |
2929-2933 |
RB |
denotes |
Thus |
T5085 |
2944-2950 |
VB |
denotes |
appear |
T5086 |
2933-2935 |
, |
denotes |
, |
T5087 |
2935-2937 |
PRP |
denotes |
it |
T5088 |
2938-2943 |
MD |
denotes |
would |
T5089 |
2951-2957 |
RB |
denotes |
highly |
T5090 |
2958-2966 |
JJ |
denotes |
unlikely |
T5091 |
2967-2971 |
IN |
denotes |
that |
T5092 |
2987-2990 |
VBP |
denotes |
die |
T5093 |
2972-2977 |
NN |
denotes |
Ptdsr |
T5094 |
2982-2986 |
NNS |
denotes |
mice |
T5095 |
2978-2979 |
SYM |
denotes |
- |
T5096 |
2979-2980 |
HYPH |
denotes |
/ |
T5097 |
2980-2981 |
SYM |
denotes |
- |
T5098 |
2991-2995 |
IN |
denotes |
from |
T5099 |
2996-3007 |
JJ |
denotes |
respiratory |
T5100 |
3008-3015 |
NN |
denotes |
failure |
T5101 |
3015-3016 |
. |
denotes |
. |
T5102 |
3016-3299 |
sentence |
denotes |
Consistent with the observations of Kunisaki and colleagues [32], we found severely blocked erythropoietic differentiation at an early erythroblast stage in the liver (Figure 3f,3l), suggesting an explanation for the grossly anemic appearance that we observed in our Ptdsr -/- mice. |
T5103 |
3017-3027 |
JJ |
denotes |
Consistent |
T5104 |
3086-3091 |
VBD |
denotes |
found |
T5105 |
3028-3032 |
IN |
denotes |
with |
T5106 |
3033-3036 |
DT |
denotes |
the |
T5107 |
3037-3049 |
NNS |
denotes |
observations |
T5108 |
3050-3052 |
IN |
denotes |
of |
T5109 |
3053-3061 |
NNP |
denotes |
Kunisaki |
T5110 |
3062-3065 |
CC |
denotes |
and |
T5111 |
3066-3076 |
NNS |
denotes |
colleagues |
T5112 |
3077-3078 |
-LRB- |
denotes |
[ |
T5113 |
3078-3080 |
CD |
denotes |
32 |
T5114 |
3080-3081 |
-RRB- |
denotes |
] |
T5115 |
3081-3083 |
, |
denotes |
, |
T5116 |
3083-3085 |
PRP |
denotes |
we |
T5117 |
3092-3100 |
RB |
denotes |
severely |
T5118 |
3101-3108 |
VBN |
denotes |
blocked |
T5119 |
3124-3139 |
NN |
denotes |
differentiation |
T5120 |
3109-3123 |
JJ |
denotes |
erythropoietic |
T5121 |
3140-3142 |
IN |
denotes |
at |
T5122 |
3143-3145 |
DT |
denotes |
an |
T5123 |
3165-3170 |
NN |
denotes |
stage |
T5124 |
3146-3151 |
JJ |
denotes |
early |
T5125 |
3152-3164 |
NN |
denotes |
erythroblast |
T5126 |
3171-3173 |
IN |
denotes |
in |
T5127 |
3174-3177 |
DT |
denotes |
the |
T5128 |
3178-3183 |
NN |
denotes |
liver |
T5129 |
3184-3185 |
-LRB- |
denotes |
( |
T5130 |
3195-3197 |
NN |
denotes |
3l |
T5131 |
3185-3191 |
NN |
denotes |
Figure |
T5132 |
3192-3194 |
NN |
denotes |
3f |
T5133 |
3194-3195 |
, |
denotes |
, |
T5134 |
3197-3198 |
-RRB- |
denotes |
) |
T5135 |
3198-3200 |
, |
denotes |
, |
T5136 |
3200-3210 |
VBG |
denotes |
suggesting |
T5137 |
3211-3213 |
DT |
denotes |
an |
T5138 |
3214-3225 |
NN |
denotes |
explanation |
T5139 |
3226-3229 |
IN |
denotes |
for |
T5140 |
3230-3233 |
DT |
denotes |
the |
T5141 |
3249-3259 |
NN |
denotes |
appearance |
T5142 |
3234-3241 |
RB |
denotes |
grossly |
T5143 |
3242-3248 |
JJ |
denotes |
anemic |
T5144 |
3260-3264 |
WDT |
denotes |
that |
T5145 |
3268-3276 |
VBD |
denotes |
observed |
T5146 |
3265-3267 |
PRP |
denotes |
we |
T5147 |
3277-3279 |
IN |
denotes |
in |
T5148 |
3280-3283 |
PRP$ |
denotes |
our |
T5149 |
3294-3298 |
NNS |
denotes |
mice |
T5150 |
3284-3289 |
NN |
denotes |
Ptdsr |
T5151 |
3290-3291 |
SYM |
denotes |
- |
T5152 |
3291-3292 |
HYPH |
denotes |
/ |
T5153 |
3292-3293 |
SYM |
denotes |
- |
T5154 |
3298-3299 |
. |
denotes |
. |
R2450 |
T4518 |
T4519 |
nsubjpass |
Ptdsr,required |
R2451 |
T4520 |
T4519 |
auxpass |
is,required |
R2452 |
T4521 |
T4519 |
prep |
for,required |
R2453 |
T4522 |
T4523 |
amod |
normal,differentiation |
R2454 |
T4523 |
T4521 |
pobj |
differentiation,for |
R2455 |
T4524 |
T4523 |
nmod |
tissue,differentiation |
R2456 |
T4525 |
T4524 |
cc |
and,tissue |
R2457 |
T4526 |
T4524 |
conj |
organ,tissue |
R2458 |
T4528 |
T4529 |
nsubj |
We,examined |
R2459 |
T4530 |
T4529 |
advmod |
next,examined |
R2460 |
T4531 |
T4532 |
det |
the,role |
R2461 |
T4532 |
T4529 |
dobj |
role,examined |
R2462 |
T4533 |
T4532 |
prep |
of,role |
R2463 |
T4534 |
T4533 |
pobj |
Ptdsr,of |
R2464 |
T4535 |
T4532 |
prep |
in,role |
R2465 |
T4536 |
T4537 |
compound |
organ,development |
R2466 |
T4537 |
T4535 |
pobj |
development,in |
R2467 |
T4538 |
T4529 |
punct |
.,examined |
R2468 |
T4540 |
T4541 |
amod |
Serial,sections |
R2469 |
T4541 |
T4543 |
nsubjpass |
sections,taken |
R2470 |
T4542 |
T4541 |
amod |
histological,sections |
R2471 |
T4544 |
T4541 |
prep |
of,sections |
R2472 |
T4545 |
T4546 |
nmod |
Ptdsr,embryos |
R2473 |
T4546 |
T4544 |
pobj |
embryos,of |
R2474 |
T4547 |
T4545 |
punct |
-,Ptdsr |
R2475 |
T4548 |
T4545 |
punct |
/,Ptdsr |
R2476 |
T4549 |
T4545 |
punct |
-,Ptdsr |
R2477 |
T4550 |
T4545 |
cc |
and,Ptdsr |
R2478 |
T4551 |
T4545 |
conj |
control,Ptdsr |
R2479 |
T4552 |
T4543 |
auxpass |
were,taken |
R2480 |
T4553 |
T4554 |
aux |
to,perform |
R2481 |
T4554 |
T4543 |
advcl |
perform,taken |
R2482 |
T4555 |
T4556 |
det |
a,analysis |
R2483 |
T4556 |
T4554 |
dobj |
analysis,perform |
R2484 |
T4557 |
T4556 |
amod |
detailed,analysis |
R2485 |
T4558 |
T4556 |
amod |
morphological,analysis |
R2486 |
T4559 |
T4556 |
prep |
of,analysis |
R2487 |
T4560 |
T4561 |
det |
all,systems |
R2488 |
T4561 |
T4559 |
pobj |
systems,of |
R2489 |
T4562 |
T4561 |
compound |
organ,systems |
R2490 |
T4563 |
T4554 |
prep |
during,perform |
R2491 |
T4564 |
T4563 |
pobj |
development,during |
R2492 |
T4565 |
T4543 |
punct |
.,taken |
R2493 |
T4567 |
T4568 |
det |
A,delay |
R2494 |
T4568 |
T4570 |
nsubjpass |
delay,observed |
R2495 |
T4569 |
T4568 |
amod |
significant,delay |
R2496 |
T4571 |
T4568 |
prep |
in,delay |
R2497 |
T4572 |
T4573 |
nmod |
organ,differentiation |
R2498 |
T4573 |
T4571 |
pobj |
differentiation,in |
R2499 |
T4574 |
T4572 |
cc |
and,organ |
R2500 |
T4575 |
T4572 |
conj |
tissue,organ |
R2501 |
T4576 |
T4570 |
auxpass |
was,observed |
R2502 |
T4577 |
T4570 |
prep |
at,observed |
R2503 |
T4578 |
T4577 |
pobj |
E16.5,at |
R2504 |
T4579 |
T4570 |
prep |
in,observed |
R2505 |
T4580 |
T4579 |
pobj |
lungs,in |
R2506 |
T4581 |
T4580 |
punct |
", ",lungs |
R2507 |
T4582 |
T4580 |
conj |
kidneys,lungs |
R2508 |
T4583 |
T4582 |
cc |
and,kidneys |
R2509 |
T4584 |
T4582 |
conj |
intestine,kidneys |
R2510 |
T4585 |
T4570 |
punct |
.,observed |
R2511 |
T4587 |
T4588 |
nsubj |
Lungs,were |
R2512 |
T4589 |
T4587 |
prep |
of,Lungs |
R2513 |
T4590 |
T4591 |
compound |
control,littermates |
R2514 |
T4591 |
T4589 |
pobj |
littermates,of |
R2515 |
T4592 |
T4593 |
advmod |
properly,developed |
R2516 |
T4593 |
T4588 |
acomp |
developed,were |
R2517 |
T4594 |
T4588 |
prep |
with,were |
R2518 |
T4595 |
T4596 |
amod |
expanding,alveoli |
R2519 |
T4596 |
T4594 |
pobj |
alveoli,with |
R2520 |
T4597 |
T4598 |
punct |
(,3a |
R2521 |
T4598 |
T4588 |
parataxis |
3a,were |
R2522 |
T4599 |
T4598 |
compound |
Figure,3a |
R2523 |
T4600 |
T4598 |
punct |
),3a |
R2524 |
T4601 |
T4588 |
punct |
.,were |
R2525 |
T4603 |
T4604 |
amod |
Terminal,bronchi |
R2526 |
T4604 |
T4605 |
nsubj |
bronchi,were |
R2527 |
T4606 |
T4604 |
cc |
and,bronchi |
R2528 |
T4607 |
T4604 |
conj |
bronchioles,bronchi |
R2529 |
T4608 |
T4605 |
advmod |
already,were |
R2530 |
T4609 |
T4610 |
advmod |
well,developed |
R2531 |
T4610 |
T4605 |
acomp |
developed,were |
R2532 |
T4611 |
T4605 |
punct |
", ",were |
R2533 |
T4612 |
T4605 |
cc |
and,were |
R2534 |
T4613 |
T4614 |
advmod |
terminally,differentiated |
R2535 |
T4614 |
T4615 |
amod |
differentiated,cells |
R2536 |
T4615 |
T4617 |
nsubj |
cells,were |
R2537 |
T4616 |
T4615 |
amod |
epithelial,cells |
R2538 |
T4617 |
T4605 |
conj |
were,were |
R2539 |
T4618 |
T4615 |
prep |
with,cells |
R2540 |
T4619 |
T4618 |
pobj |
cilia,with |
R2541 |
T4620 |
T4619 |
prep |
on,cilia |
R2542 |
T4621 |
T4622 |
det |
the,surface |
R2543 |
T4622 |
T4620 |
pobj |
surface,on |
R2544 |
T4623 |
T4622 |
amod |
luminal,surface |
R2545 |
T4624 |
T4622 |
compound |
cell,surface |
R2546 |
T4625 |
T4617 |
acomp |
present,were |
R2547 |
T4626 |
T4617 |
punct |
.,were |
R2548 |
T4628 |
T4629 |
prep |
In,were |
R2549 |
T4630 |
T4628 |
pobj |
contrast,In |
R2550 |
T4631 |
T4629 |
punct |
", ",were |
R2551 |
T4632 |
T4633 |
advmod |
almost,alveoli |
R2552 |
T4633 |
T4629 |
nsubj |
alveoli,were |
R2553 |
T4634 |
T4633 |
det |
no,alveoli |
R2554 |
T4635 |
T4633 |
cc |
or,alveoli |
R2555 |
T4636 |
T4633 |
conj |
bronchioles,alveoli |
R2556 |
T4637 |
T4629 |
acomp |
present,were |
R2557 |
T4638 |
T4629 |
prep |
in,were |
R2558 |
T4639 |
T4640 |
nmod |
Ptdsr,lungs |
R2559 |
T4640 |
T4638 |
pobj |
lungs,in |
R2560 |
T4641 |
T4639 |
punct |
-,Ptdsr |
R2561 |
T4642 |
T4639 |
punct |
/,Ptdsr |
R2562 |
T4643 |
T4639 |
punct |
-,Ptdsr |
R2563 |
T4644 |
T4629 |
punct |
", ",were |
R2564 |
T4645 |
T4629 |
advcl |
indicating,were |
R2565 |
T4646 |
T4647 |
det |
a,delay |
R2566 |
T4647 |
T4645 |
dobj |
delay,indicating |
R2567 |
T4648 |
T4647 |
cc |
or,delay |
R2568 |
T4649 |
T4647 |
conj |
arrest,delay |
R2569 |
T4650 |
T4647 |
prep |
in,delay |
R2570 |
T4651 |
T4652 |
compound |
lung,sacculation |
R2571 |
T4652 |
T4650 |
pobj |
sacculation,in |
R2572 |
T4653 |
T4652 |
cc |
and,sacculation |
R2573 |
T4654 |
T4652 |
conj |
expansion,sacculation |
R2574 |
T4655 |
T4629 |
punct |
.,were |
R2575 |
T4657 |
T4658 |
advmod |
Instead,observed |
R2576 |
T4659 |
T4658 |
punct |
", ",observed |
R2577 |
T4660 |
T4658 |
nsubj |
we,observed |
R2578 |
T4661 |
T4662 |
det |
an,abundance |
R2579 |
T4662 |
T4658 |
dobj |
abundance,observed |
R2580 |
T4663 |
T4662 |
prep |
of,abundance |
R2581 |
T4664 |
T4663 |
pobj |
mesenchyme,of |
R2582 |
T4665 |
T4666 |
dep |
that,appeared |
R2583 |
T4666 |
T4662 |
relcl |
appeared,abundance |
R2584 |
T4667 |
T4668 |
advmod |
highly,immature |
R2585 |
T4668 |
T4666 |
oprd |
immature,appeared |
R2586 |
T4669 |
T4670 |
punct |
(,3g |
R2587 |
T4670 |
T4658 |
parataxis |
3g,observed |
R2588 |
T4671 |
T4670 |
compound |
Figure,3g |
R2589 |
T4672 |
T4670 |
punct |
),3g |
R2590 |
T4673 |
T4658 |
punct |
.,observed |
R2591 |
T4675 |
T4676 |
det |
A,delay |
R2592 |
T4676 |
T4678 |
nsubjpass |
delay,found |
R2593 |
T4677 |
T4676 |
amod |
similar,delay |
R2594 |
T4679 |
T4676 |
prep |
in,delay |
R2595 |
T4680 |
T4681 |
compound |
tissue,differentiation |
R2596 |
T4681 |
T4679 |
pobj |
differentiation,in |
R2597 |
T4682 |
T4681 |
prep |
of,differentiation |
R2598 |
T4683 |
T4684 |
nmod |
Ptdsr,embryos |
R2599 |
T4684 |
T4682 |
pobj |
embryos,of |
R2600 |
T4685 |
T4683 |
punct |
-,Ptdsr |
R2601 |
T4686 |
T4683 |
punct |
/,Ptdsr |
R2602 |
T4687 |
T4683 |
punct |
-,Ptdsr |
R2603 |
T4688 |
T4678 |
auxpass |
was,found |
R2604 |
T4689 |
T4678 |
prep |
in,found |
R2605 |
T4690 |
T4691 |
det |
the,kidneys |
R2606 |
T4691 |
T4689 |
pobj |
kidneys,in |
R2607 |
T4692 |
T4693 |
punct |
(,3h |
R2608 |
T4693 |
T4678 |
parataxis |
3h,found |
R2609 |
T4694 |
T4693 |
compound |
Figure,3h |
R2610 |
T4695 |
T4693 |
punct |
),3h |
R2611 |
T4696 |
T4678 |
punct |
.,found |
R2612 |
T4698 |
T4699 |
nsubj |
Kidneys,were |
R2613 |
T4700 |
T4698 |
prep |
from,Kidneys |
R2614 |
T4701 |
T4702 |
nmod |
Ptdsr,embryos |
R2615 |
T4702 |
T4700 |
pobj |
embryos,from |
R2616 |
T4703 |
T4701 |
punct |
+,Ptdsr |
R2617 |
T4704 |
T4701 |
punct |
/,Ptdsr |
R2618 |
T4705 |
T4701 |
punct |
+,Ptdsr |
R2619 |
T4706 |
T4707 |
advmod |
well,developed |
R2620 |
T4707 |
T4699 |
acomp |
developed,were |
R2621 |
T4708 |
T4699 |
prep |
at,were |
R2622 |
T4709 |
T4708 |
pobj |
E16.5,at |
R2623 |
T4710 |
T4699 |
punct |
", ",were |
R2624 |
T4711 |
T4699 |
advcl |
showing,were |
R2625 |
T4712 |
T4713 |
advmod |
terminally,differentiated |
R2626 |
T4713 |
T4714 |
amod |
differentiated,glomeruli |
R2627 |
T4714 |
T4711 |
dobj |
glomeruli,showing |
R2628 |
T4715 |
T4714 |
prep |
with,glomeruli |
R2629 |
T4716 |
T4717 |
poss |
Bowman,capsule |
R2630 |
T4717 |
T4715 |
pobj |
capsule,with |
R2631 |
T4718 |
T4716 |
case |
's,Bowman |
R2632 |
T4719 |
T4717 |
cc |
and,capsule |
R2633 |
T4720 |
T4721 |
amod |
collecting,tubules |
R2634 |
T4721 |
T4717 |
conj |
tubules,capsule |
R2635 |
T4722 |
T4714 |
acl |
lined,glomeruli |
R2636 |
T4723 |
T4722 |
prep |
with,lined |
R2637 |
T4724 |
T4725 |
amod |
cuboidal,cells |
R2638 |
T4725 |
T4723 |
pobj |
cells,with |
R2639 |
T4726 |
T4725 |
amod |
epithelial,cells |
R2640 |
T4727 |
T4728 |
punct |
(,3b |
R2641 |
T4728 |
T4699 |
parataxis |
3b,were |
R2642 |
T4729 |
T4728 |
compound |
Figure,3b |
R2643 |
T4730 |
T4728 |
punct |
),3b |
R2644 |
T4731 |
T4699 |
punct |
.,were |
R2645 |
T4733 |
T4734 |
prep |
In,had |
R2646 |
T4735 |
T4733 |
pobj |
contrast,In |
R2647 |
T4736 |
T4734 |
punct |
", ",had |
R2648 |
T4737 |
T4738 |
npadvmod |
Ptdsr,deficient |
R2649 |
T4738 |
T4740 |
amod |
deficient,kidneys |
R2650 |
T4739 |
T4738 |
punct |
-,deficient |
R2651 |
T4740 |
T4734 |
nsubj |
kidneys,had |
R2652 |
T4741 |
T4742 |
advmod |
only,glomeruli |
R2653 |
T4742 |
T4734 |
dobj |
glomeruli,had |
R2654 |
T4743 |
T4742 |
amod |
primitive,glomeruli |
R2655 |
T4744 |
T4734 |
prep |
at,had |
R2656 |
T4745 |
T4744 |
pobj |
E16.5,at |
R2657 |
T4746 |
T4734 |
punct |
", ",had |
R2658 |
T4747 |
T4734 |
cc |
and,had |
R2659 |
T4748 |
T4749 |
amod |
collecting,tubules |
R2660 |
T4749 |
T4750 |
nsubj |
tubules,were |
R2661 |
T4750 |
T4734 |
conj |
were,had |
R2662 |
T4751 |
T4752 |
advmod |
less,developed |
R2663 |
T4752 |
T4750 |
acomp |
developed,were |
R2664 |
T4753 |
T4752 |
advmod |
well,developed |
R2665 |
T4754 |
T4752 |
punct |
-,developed |
R2666 |
T4755 |
T4734 |
punct |
.,had |
R2667 |
T4757 |
T4758 |
advmod |
Instead,was |
R2668 |
T4759 |
T4758 |
punct |
", ",was |
R2669 |
T4760 |
T4761 |
det |
a,amount |
R2670 |
T4761 |
T4758 |
nsubj |
amount,was |
R2671 |
T4762 |
T4761 |
amod |
large,amount |
R2672 |
T4763 |
T4761 |
prep |
of,amount |
R2673 |
T4764 |
T4765 |
amod |
undifferentiated,mesenchyme |
R2674 |
T4765 |
T4763 |
pobj |
mesenchyme,of |
R2675 |
T4766 |
T4758 |
acomp |
present,was |
R2676 |
T4767 |
T4758 |
prep |
in,was |
R2677 |
T4768 |
T4769 |
nmod |
Ptdsr,kidneys |
R2678 |
T4769 |
T4767 |
pobj |
kidneys,in |
R2679 |
T4770 |
T4768 |
punct |
-,Ptdsr |
R2680 |
T4771 |
T4768 |
punct |
/,Ptdsr |
R2681 |
T4772 |
T4768 |
punct |
-,Ptdsr |
R2682 |
T4773 |
T4774 |
punct |
(,3h |
R2683 |
T4774 |
T4758 |
parataxis |
3h,was |
R2684 |
T4775 |
T4774 |
compound |
Figure,3h |
R2685 |
T4776 |
T4774 |
punct |
),3h |
R2686 |
T4777 |
T4758 |
punct |
.,was |
R2687 |
T4779 |
T4780 |
det |
A,delay |
R2688 |
T4780 |
T4781 |
nsubjpass |
delay,found |
R2689 |
T4782 |
T4780 |
prep |
in,delay |
R2690 |
T4783 |
T4784 |
compound |
tissue,differentiation |
R2691 |
T4784 |
T4782 |
pobj |
differentiation,in |
R2692 |
T4785 |
T4781 |
auxpass |
was,found |
R2693 |
T4786 |
T4781 |
advmod |
also,found |
R2694 |
T4787 |
T4781 |
prep |
in,found |
R2695 |
T4788 |
T4789 |
det |
the,intestine |
R2696 |
T4789 |
T4787 |
pobj |
intestine,in |
R2697 |
T4790 |
T4781 |
prep |
at,found |
R2698 |
T4791 |
T4792 |
det |
this,stage |
R2699 |
T4792 |
T4790 |
pobj |
stage,at |
R2700 |
T4793 |
T4792 |
prep |
of,stage |
R2701 |
T4794 |
T4793 |
pobj |
development,of |
R2702 |
T4795 |
T4781 |
punct |
.,found |
R2703 |
T4797 |
T4798 |
nmod |
Ptdsr,embryos |
R2704 |
T4798 |
T4802 |
nsubj |
embryos,displayed |
R2705 |
T4799 |
T4797 |
punct |
-,Ptdsr |
R2706 |
T4800 |
T4797 |
punct |
/,Ptdsr |
R2707 |
T4801 |
T4797 |
punct |
-,Ptdsr |
R2708 |
T4803 |
T4804 |
advmod |
improperly,developed |
R2709 |
T4804 |
T4805 |
amod |
developed,villi |
R2710 |
T4805 |
T4802 |
dobj |
villi,displayed |
R2711 |
T4806 |
T4805 |
cc |
and,villi |
R2712 |
T4807 |
T4808 |
det |
an,submucosa |
R2713 |
T4808 |
T4805 |
conj |
submucosa,villi |
R2714 |
T4809 |
T4808 |
amod |
underdeveloped,submucosa |
R2715 |
T4810 |
T4809 |
cc |
or,underdeveloped |
R2716 |
T4811 |
T4809 |
conj |
absent,underdeveloped |
R2717 |
T4812 |
T4813 |
punct |
(,3i |
R2718 |
T4813 |
T4802 |
parataxis |
3i,displayed |
R2719 |
T4814 |
T4813 |
compound |
Figure,3i |
R2720 |
T4815 |
T4813 |
punct |
),3i |
R2721 |
T4816 |
T4802 |
punct |
.,displayed |
R2722 |
T4818 |
T4819 |
prep |
In,was |
R2723 |
T4820 |
T4821 |
amod |
wild,type |
R2724 |
T4821 |
T4823 |
compound |
type,embryos |
R2725 |
T4822 |
T4821 |
punct |
-,type |
R2726 |
T4823 |
T4818 |
pobj |
embryos,In |
R2727 |
T4824 |
T4825 |
punct |
(,3c |
R2728 |
T4825 |
T4819 |
parataxis |
3c,was |
R2729 |
T4826 |
T4825 |
compound |
Figure,3c |
R2730 |
T4827 |
T4825 |
punct |
),3c |
R2731 |
T4828 |
T4819 |
punct |
", ",was |
R2732 |
T4829 |
T4830 |
amod |
intestinal,differentiation |
R2733 |
T4830 |
T4819 |
nsubj |
differentiation,was |
R2734 |
T4831 |
T4830 |
amod |
cellular,differentiation |
R2735 |
T4832 |
T4819 |
advmod |
already,was |
R2736 |
T4833 |
T4834 |
advmod |
highly,organized |
R2737 |
T4834 |
T4819 |
acomp |
organized,was |
R2738 |
T4835 |
T4819 |
punct |
", ",was |
R2739 |
T4836 |
T4819 |
prep |
with,was |
R2740 |
T4837 |
T4838 |
amod |
intramural,cells |
R2741 |
T4838 |
T4836 |
pobj |
cells,with |
R2742 |
T4839 |
T4838 |
compound |
ganglion,cells |
R2743 |
T4840 |
T4838 |
prep |
between,cells |
R2744 |
T4841 |
T4842 |
det |
the,layers |
R2745 |
T4842 |
T4840 |
pobj |
layers,between |
R2746 |
T4843 |
T4842 |
amod |
external,layers |
R2747 |
T4844 |
T4843 |
cc |
and,external |
R2748 |
T4845 |
T4843 |
conj |
internal,external |
R2749 |
T4846 |
T4842 |
amod |
muscular,layers |
R2750 |
T4847 |
T4819 |
punct |
.,was |
R2751 |
T4849 |
T4850 |
amod |
Such,cells |
R2752 |
T4850 |
T4852 |
nsubj |
cells,were |
R2753 |
T4851 |
T4850 |
amod |
neuronal,cells |
R2754 |
T4853 |
T4852 |
acomp |
absent,were |
R2755 |
T4854 |
T4853 |
prep |
from,absent |
R2756 |
T4855 |
T4856 |
det |
the,intestine |
R2757 |
T4856 |
T4854 |
pobj |
intestine,from |
R2758 |
T4857 |
T4856 |
prep |
of,intestine |
R2759 |
T4858 |
T4859 |
nmod |
Ptdsr,embryos |
R2760 |
T4859 |
T4857 |
pobj |
embryos,of |
R2761 |
T4860 |
T4858 |
punct |
-,Ptdsr |
R2762 |
T4861 |
T4858 |
punct |
/,Ptdsr |
R2763 |
T4862 |
T4858 |
punct |
-,Ptdsr |
R2764 |
T4863 |
T4864 |
punct |
(,3i |
R2765 |
T4864 |
T4852 |
parataxis |
3i,were |
R2766 |
T4865 |
T4864 |
compound |
Figure,3i |
R2767 |
T4866 |
T4864 |
punct |
),3i |
R2768 |
T4867 |
T4852 |
punct |
", ",were |
R2769 |
T4868 |
T4852 |
advmod |
however,were |
R2770 |
T4869 |
T4852 |
punct |
.,were |
R2771 |
T4871 |
T4872 |
det |
Some,mice |
R2772 |
T4872 |
T4877 |
nsubj |
mice,displayed |
R2773 |
T4873 |
T4872 |
nmod |
Ptdsr,mice |
R2774 |
T4874 |
T4873 |
punct |
-,Ptdsr |
R2775 |
T4875 |
T4873 |
punct |
/,Ptdsr |
R2776 |
T4876 |
T4873 |
punct |
-,Ptdsr |
R2777 |
T4878 |
T4879 |
punct |
(,% |
R2778 |
T4879 |
T4872 |
parataxis |
%,mice |
R2779 |
T4880 |
T4879 |
nummod |
4.5,% |
R2780 |
T4881 |
T4879 |
punct |
),% |
R2781 |
T4882 |
T4877 |
advmod |
also,displayed |
R2782 |
T4883 |
T4884 |
amod |
extensive,malformations |
R2783 |
T4884 |
T4877 |
dobj |
malformations,displayed |
R2784 |
T4885 |
T4884 |
compound |
brain,malformations |
R2785 |
T4886 |
T4887 |
dep |
that,resulted |
R2786 |
T4887 |
T4884 |
relcl |
resulted,malformations |
R2787 |
T4888 |
T4887 |
prep |
in,resulted |
R2788 |
T4889 |
T4890 |
advmod |
externally,visible |
R2789 |
T4890 |
T4891 |
amod |
visible,abnormalities |
R2790 |
T4891 |
T4888 |
pobj |
abnormalities,in |
R2791 |
T4892 |
T4891 |
compound |
head,abnormalities |
R2792 |
T4893 |
T4891 |
punct |
", ",abnormalities |
R2793 |
T4894 |
T4891 |
prep |
with,abnormalities |
R2794 |
T4895 |
T4896 |
amod |
occasional,tissue |
R2795 |
T4896 |
T4894 |
pobj |
tissue,with |
R2796 |
T4897 |
T4896 |
amod |
ectopic,tissue |
R2797 |
T4898 |
T4896 |
prep |
outside,tissue |
R2798 |
T4899 |
T4900 |
det |
the,skull |
R2799 |
T4900 |
T4898 |
pobj |
skull,outside |
R2800 |
T4901 |
T4900 |
cc |
or,skull |
R2801 |
T4902 |
T4900 |
conj |
exencephaly,skull |
R2802 |
T4903 |
T4904 |
punct |
(,h |
R2803 |
T4904 |
T4877 |
parataxis |
h,displayed |
R2804 |
T4905 |
T4904 |
nmod |
Figure,h |
R2805 |
T4906 |
T4904 |
nmod |
1f,h |
R2806 |
T4907 |
T4904 |
punct |
",",h |
R2807 |
T4908 |
T4904 |
punct |
),h |
R2808 |
T4909 |
T4877 |
punct |
.,displayed |
R2809 |
T4911 |
T4912 |
amod |
Histological,analysis |
R2810 |
T4912 |
T4913 |
nsubj |
analysis,revealed |
R2811 |
T4914 |
T4915 |
det |
an,hyperplasia |
R2812 |
T4915 |
T4913 |
dobj |
hyperplasia,revealed |
R2813 |
T4916 |
T4915 |
amod |
extensive,hyperplasia |
R2814 |
T4917 |
T4915 |
prep |
of,hyperplasia |
R2815 |
T4918 |
T4919 |
compound |
brain,tissue |
R2816 |
T4919 |
T4917 |
pobj |
tissue,of |
R2817 |
T4920 |
T4913 |
prep |
with,revealed |
R2818 |
T4921 |
T4920 |
pobj |
herniation,with |
R2819 |
T4922 |
T4921 |
prep |
of,herniation |
R2820 |
T4923 |
T4924 |
compound |
brain,tissue |
R2821 |
T4924 |
T4922 |
pobj |
tissue,of |
R2822 |
T4925 |
T4926 |
preconj |
either,through |
R2823 |
T4926 |
T4921 |
prep |
through,herniation |
R2824 |
T4927 |
T4928 |
det |
the,cap |
R2825 |
T4928 |
T4926 |
pobj |
cap,through |
R2826 |
T4929 |
T4928 |
compound |
skull,cap |
R2827 |
T4930 |
T4928 |
punct |
-,cap |
R2828 |
T4931 |
T4926 |
cc |
or,through |
R2829 |
T4932 |
T4926 |
conj |
through,through |
R2830 |
T4933 |
T4934 |
det |
the,skull |
R2831 |
T4934 |
T4932 |
pobj |
skull,through |
R2832 |
T4935 |
T4934 |
amod |
ventral,skull |
R2833 |
T4936 |
T4937 |
punct |
(,j |
R2834 |
T4937 |
T4913 |
parataxis |
j,revealed |
R2835 |
T4938 |
T4937 |
nmod |
Figure,j |
R2836 |
T4939 |
T4937 |
nmod |
3d,j |
R2837 |
T4940 |
T4937 |
punct |
",",j |
R2838 |
T4941 |
T4937 |
punct |
),j |
R2839 |
T4942 |
T4913 |
punct |
.,revealed |
R2840 |
T4944 |
T4945 |
prep |
In,resulted |
R2841 |
T4946 |
T4947 |
det |
the,cases |
R2842 |
T4947 |
T4944 |
pobj |
cases,In |
R2843 |
T4948 |
T4949 |
advmod |
most,severe |
R2844 |
T4949 |
T4947 |
amod |
severe,cases |
R2845 |
T4950 |
T4945 |
punct |
", ",resulted |
R2846 |
T4951 |
T4945 |
nsubj |
expansion,resulted |
R2847 |
T4952 |
T4951 |
prep |
of,expansion |
R2848 |
T4953 |
T4954 |
compound |
brain,tissue |
R2849 |
T4954 |
T4952 |
pobj |
tissue,of |
R2850 |
T4955 |
T4951 |
prep |
in,expansion |
R2851 |
T4956 |
T4957 |
amod |
mutant,mice |
R2852 |
T4957 |
T4955 |
pobj |
mice,in |
R2853 |
T4958 |
T4945 |
prep |
in,resulted |
R2854 |
T4959 |
T4960 |
amod |
further,perturbations |
R2855 |
T4960 |
T4958 |
pobj |
perturbations,in |
R2856 |
T4961 |
T4960 |
prep |
of,perturbations |
R2857 |
T4962 |
T4963 |
amod |
cortical,structures |
R2858 |
T4963 |
T4961 |
pobj |
structures,of |
R2859 |
T4964 |
T4965 |
punct |
(,j |
R2860 |
T4965 |
T4945 |
parataxis |
j,resulted |
R2861 |
T4966 |
T4965 |
nmod |
Figure,j |
R2862 |
T4967 |
T4965 |
nmod |
3d,j |
R2863 |
T4968 |
T4965 |
punct |
",",j |
R2864 |
T4969 |
T4965 |
punct |
),j |
R2865 |
T4970 |
T4945 |
punct |
.,resulted |
R2866 |
T4972 |
T4973 |
prep |
Of,observed |
R2867 |
T4974 |
T4972 |
pobj |
note,Of |
R2868 |
T4975 |
T4973 |
punct |
", ",observed |
R2869 |
T4976 |
T4977 |
det |
a,phenotype |
R2870 |
T4977 |
T4973 |
nsubjpass |
phenotype,observed |
R2871 |
T4978 |
T4977 |
amod |
similar,phenotype |
R2872 |
T4979 |
T4977 |
compound |
brain,phenotype |
R2873 |
T4980 |
T4973 |
auxpass |
was,observed |
R2874 |
T4981 |
T4973 |
prep |
in,observed |
R2875 |
T4982 |
T4983 |
det |
the,line |
R2876 |
T4983 |
T4981 |
pobj |
line,in |
R2877 |
T4984 |
T4985 |
npadvmod |
Ptdsr,deficient |
R2878 |
T4985 |
T4983 |
amod |
deficient,line |
R2879 |
T4986 |
T4985 |
punct |
-,deficient |
R2880 |
T4987 |
T4983 |
compound |
mouse,line |
R2881 |
T4988 |
T4983 |
acl |
generated,line |
R2882 |
T4989 |
T4988 |
agent |
by,generated |
R2883 |
T4990 |
T4989 |
pobj |
Li,by |
R2884 |
T4991 |
T4990 |
cc |
and,Li |
R2885 |
T4992 |
T4990 |
conj |
colleagues,Li |
R2886 |
T4993 |
T4994 |
punct |
[,31 |
R2887 |
T4994 |
T4973 |
parataxis |
31,observed |
R2888 |
T4995 |
T4994 |
punct |
],31 |
R2889 |
T4996 |
T4973 |
punct |
.,observed |
R2890 |
T4998 |
T4999 |
prep |
In,found |
R2891 |
T5000 |
T4998 |
pobj |
contrast,In |
R2892 |
T5001 |
T5000 |
prep |
to,contrast |
R2893 |
T5002 |
T5003 |
det |
the,study |
R2894 |
T5003 |
T5001 |
pobj |
study,to |
R2895 |
T5004 |
T5003 |
prep |
of,study |
R2896 |
T5005 |
T5004 |
pobj |
Li,of |
R2897 |
T5006 |
T5007 |
advmod |
et,al. |
R2898 |
T5007 |
T5005 |
advmod |
al.,Li |
R2899 |
T5008 |
T5009 |
punct |
[,31 |
R2900 |
T5009 |
T5000 |
parataxis |
31,contrast |
R2901 |
T5010 |
T5009 |
punct |
],31 |
R2902 |
T5011 |
T4999 |
punct |
", ",found |
R2903 |
T5012 |
T4999 |
advmod |
however,found |
R2904 |
T5013 |
T4999 |
punct |
", ",found |
R2905 |
T5014 |
T4999 |
nsubj |
we,found |
R2906 |
T5015 |
T5016 |
advmod |
almost,developed |
R2907 |
T5016 |
T5018 |
amod |
developed,lungs |
R2908 |
T5017 |
T5016 |
advmod |
normally,developed |
R2909 |
T5018 |
T4999 |
dobj |
lungs,found |
R2910 |
T5019 |
T4999 |
prep |
at,found |
R2911 |
T5020 |
T5019 |
pobj |
birth,at |
R2912 |
T5021 |
T4999 |
punct |
.,found |
R2913 |
T5023 |
T5024 |
nmod |
Ptdsr,lungs |
R2914 |
T5024 |
T5028 |
nsubj |
lungs,showed |
R2915 |
T5025 |
T5023 |
punct |
-,Ptdsr |
R2916 |
T5026 |
T5023 |
punct |
/,Ptdsr |
R2917 |
T5027 |
T5023 |
punct |
-,Ptdsr |
R2918 |
T5029 |
T5028 |
punct |
", ",showed |
R2919 |
T5030 |
T5028 |
prep |
in,showed |
R2920 |
T5031 |
T5030 |
pobj |
comparison,in |
R2921 |
T5032 |
T5031 |
prep |
to,comparison |
R2922 |
T5033 |
T5034 |
amod |
wild,type |
R2923 |
T5034 |
T5032 |
pobj |
type,to |
R2924 |
T5035 |
T5034 |
punct |
-,type |
R2925 |
T5036 |
T5028 |
punct |
", ",showed |
R2926 |
T5037 |
T5038 |
advmod |
only,delay |
R2927 |
T5038 |
T5028 |
dobj |
delay,showed |
R2928 |
T5039 |
T5038 |
det |
a,delay |
R2929 |
T5040 |
T5038 |
amod |
slight,delay |
R2930 |
T5041 |
T5038 |
prep |
in,delay |
R2931 |
T5042 |
T5041 |
pobj |
maturation,in |
R2932 |
T5043 |
T5028 |
cc |
and,showed |
R2933 |
T5044 |
T5028 |
conj |
were,showed |
R2934 |
T5045 |
T5046 |
advmod |
fully,ventilated |
R2935 |
T5046 |
T5044 |
acomp |
ventilated,were |
R2936 |
T5047 |
T5044 |
prep |
in,were |
R2937 |
T5048 |
T5047 |
pobj |
neonates,in |
R2938 |
T5049 |
T5044 |
prep |
in,were |
R2939 |
T5050 |
T5051 |
amod |
most,cases |
R2940 |
T5051 |
T5049 |
pobj |
cases,in |
R2941 |
T5052 |
T5053 |
punct |
(,k |
R2942 |
T5053 |
T5044 |
parataxis |
k,were |
R2943 |
T5054 |
T5053 |
nmod |
Figure,k |
R2944 |
T5055 |
T5053 |
nmod |
3e,k |
R2945 |
T5056 |
T5053 |
punct |
",",k |
R2946 |
T5057 |
T5053 |
punct |
),k |
R2947 |
T5058 |
T5028 |
punct |
.,showed |
R2948 |
T5060 |
T5061 |
nsubj |
This,demonstrates |
R2949 |
T5062 |
T5063 |
mark |
that,overcome |
R2950 |
T5063 |
T5061 |
ccomp |
overcome,demonstrates |
R2951 |
T5064 |
T5065 |
npadvmod |
Ptdsr,deficient |
R2952 |
T5065 |
T5067 |
amod |
deficient,mice |
R2953 |
T5066 |
T5065 |
punct |
-,deficient |
R2954 |
T5067 |
T5063 |
nsubj |
mice,overcome |
R2955 |
T5068 |
T5063 |
aux |
can,overcome |
R2956 |
T5069 |
T5070 |
det |
the,delay |
R2957 |
T5070 |
T5063 |
dobj |
delay,overcome |
R2958 |
T5071 |
T5070 |
prep |
in,delay |
R2959 |
T5072 |
T5073 |
amod |
embryonic,differentiation |
R2960 |
T5073 |
T5071 |
pobj |
differentiation,in |
R2961 |
T5074 |
T5073 |
compound |
lung,differentiation |
R2962 |
T5075 |
T5063 |
cc |
and,overcome |
R2963 |
T5076 |
T5063 |
conj |
display,overcome |
R2964 |
T5077 |
T5078 |
amod |
normal,morphology |
R2965 |
T5078 |
T5076 |
dobj |
morphology,display |
R2966 |
T5079 |
T5078 |
compound |
lung,morphology |
R2967 |
T5080 |
T5076 |
prep |
at,display |
R2968 |
T5081 |
T5080 |
pobj |
birth,at |
R2969 |
T5082 |
T5061 |
punct |
.,demonstrates |
R2970 |
T5084 |
T5085 |
advmod |
Thus,appear |
R2971 |
T5086 |
T5085 |
punct |
", ",appear |
R2972 |
T5087 |
T5085 |
nsubj |
it,appear |
R2973 |
T5088 |
T5085 |
aux |
would,appear |
R2974 |
T5089 |
T5090 |
advmod |
highly,unlikely |
R2975 |
T5090 |
T5085 |
oprd |
unlikely,appear |
R2976 |
T5091 |
T5092 |
mark |
that,die |
R2977 |
T5092 |
T5085 |
ccomp |
die,appear |
R2978 |
T5093 |
T5094 |
nmod |
Ptdsr,mice |
R2979 |
T5094 |
T5092 |
nsubj |
mice,die |
R2980 |
T5095 |
T5093 |
punct |
-,Ptdsr |
R2981 |
T5096 |
T5093 |
punct |
/,Ptdsr |
R2982 |
T5097 |
T5093 |
punct |
-,Ptdsr |
R2983 |
T5098 |
T5092 |
prep |
from,die |
R2984 |
T5099 |
T5100 |
amod |
respiratory,failure |
R2985 |
T5100 |
T5098 |
pobj |
failure,from |
R2986 |
T5101 |
T5085 |
punct |
.,appear |
R2987 |
T5103 |
T5104 |
advcl |
Consistent,found |
R2988 |
T5105 |
T5103 |
prep |
with,Consistent |
R2989 |
T5106 |
T5107 |
det |
the,observations |
R2990 |
T5107 |
T5105 |
pobj |
observations,with |
R2991 |
T5108 |
T5107 |
prep |
of,observations |
R2992 |
T5109 |
T5108 |
pobj |
Kunisaki,of |
R2993 |
T5110 |
T5109 |
cc |
and,Kunisaki |
R2994 |
T5111 |
T5109 |
conj |
colleagues,Kunisaki |
R2995 |
T5112 |
T5113 |
punct |
[,32 |
R2996 |
T5113 |
T5103 |
parataxis |
32,Consistent |
R2997 |
T5114 |
T5113 |
punct |
],32 |
R2998 |
T5115 |
T5104 |
punct |
", ",found |
R2999 |
T5116 |
T5104 |
nsubj |
we,found |
R3000 |
T5117 |
T5118 |
advmod |
severely,blocked |
R3001 |
T5118 |
T5119 |
amod |
blocked,differentiation |
R3002 |
T5119 |
T5104 |
dobj |
differentiation,found |
R3003 |
T5120 |
T5119 |
amod |
erythropoietic,differentiation |
R3004 |
T5121 |
T5104 |
prep |
at,found |
R3005 |
T5122 |
T5123 |
det |
an,stage |
R3006 |
T5123 |
T5121 |
pobj |
stage,at |
R3007 |
T5124 |
T5123 |
amod |
early,stage |
R3008 |
T5125 |
T5123 |
compound |
erythroblast,stage |
R3009 |
T5126 |
T5104 |
prep |
in,found |
R3010 |
T5127 |
T5128 |
det |
the,liver |
R3011 |
T5128 |
T5126 |
pobj |
liver,in |
R3012 |
T5129 |
T5130 |
punct |
(,3l |
R3013 |
T5130 |
T5104 |
parataxis |
3l,found |
R3014 |
T5131 |
T5130 |
nmod |
Figure,3l |
R3015 |
T5132 |
T5130 |
nmod |
3f,3l |
R3016 |
T5133 |
T5130 |
punct |
",",3l |
R3017 |
T5134 |
T5130 |
punct |
),3l |
R3018 |
T5135 |
T5104 |
punct |
", ",found |
R3019 |
T5136 |
T5104 |
advcl |
suggesting,found |
R3020 |
T5137 |
T5138 |
det |
an,explanation |
R3021 |
T5138 |
T5136 |
dobj |
explanation,suggesting |
R3022 |
T5139 |
T5138 |
prep |
for,explanation |
R3023 |
T5140 |
T5141 |
det |
the,appearance |
R3024 |
T5141 |
T5139 |
pobj |
appearance,for |
R3025 |
T5142 |
T5143 |
advmod |
grossly,anemic |
R3026 |
T5143 |
T5141 |
amod |
anemic,appearance |
R3027 |
T5144 |
T5145 |
dep |
that,observed |
R3028 |
T5145 |
T5141 |
relcl |
observed,appearance |
R3029 |
T5146 |
T5145 |
nsubj |
we,observed |
R3030 |
T5147 |
T5145 |
prep |
in,observed |
R3031 |
T5148 |
T5149 |
poss |
our,mice |
R3032 |
T5149 |
T5147 |
pobj |
mice,in |
R3033 |
T5150 |
T5149 |
nmod |
Ptdsr,mice |
R3034 |
T5151 |
T5150 |
punct |
-,Ptdsr |
R3035 |
T5152 |
T5150 |
punct |
/,Ptdsr |
R3036 |
T5153 |
T5150 |
punct |
-,Ptdsr |
R3037 |
T5154 |
T5104 |
punct |
.,found |