| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1686 |
0-3 |
JJ |
denotes |
Few |
| T1687 |
4-11 |
NNS |
denotes |
studies |
| T1688 |
38-46 |
VBN |
denotes |
extended |
| T1689 |
12-14 |
IN |
denotes |
of |
| T1690 |
15-18 |
NN |
denotes |
LCA |
| T1691 |
26-32 |
NNS |
denotes |
models |
| T1692 |
19-25 |
NN |
denotes |
animal |
| T1693 |
33-37 |
VBP |
denotes |
have |
| T1694 |
47-52 |
PRP$ |
denotes |
their |
| T1695 |
53-64 |
NN |
denotes |
examination |
| T1696 |
65-67 |
IN |
denotes |
of |
| T1697 |
68-75 |
JJ |
denotes |
retinal |
| T1698 |
76-85 |
NN |
denotes |
pathology |
| T1699 |
86-88 |
IN |
denotes |
to |
| T1700 |
89-92 |
DT |
denotes |
the |
| T1701 |
109-114 |
NN |
denotes |
level |
| T1702 |
93-108 |
JJ |
denotes |
ultrastructural |
| T1703 |
114-115 |
. |
denotes |
. |
| T1704 |
115-244 |
sentence |
denotes |
Certain features of neuronal differentiation, such as synapse formation, can be detected definitively at this level of analysis. |
| T1705 |
116-123 |
JJ |
denotes |
Certain |
| T1706 |
124-132 |
NNS |
denotes |
features |
| T1707 |
196-204 |
VBN |
denotes |
detected |
| T1708 |
133-135 |
IN |
denotes |
of |
| T1709 |
136-144 |
JJ |
denotes |
neuronal |
| T1710 |
145-160 |
NN |
denotes |
differentiation |
| T1711 |
160-162 |
, |
denotes |
, |
| T1712 |
162-166 |
JJ |
denotes |
such |
| T1713 |
167-169 |
IN |
denotes |
as |
| T1714 |
170-177 |
NN |
denotes |
synapse |
| T1715 |
178-187 |
NN |
denotes |
formation |
| T1716 |
187-189 |
, |
denotes |
, |
| T1717 |
189-192 |
MD |
denotes |
can |
| T1718 |
193-195 |
VB |
denotes |
be |
| T1719 |
205-217 |
RB |
denotes |
definitively |
| T1720 |
218-220 |
IN |
denotes |
at |
| T1721 |
221-225 |
DT |
denotes |
this |
| T1722 |
226-231 |
NN |
denotes |
level |
| T1723 |
232-234 |
IN |
denotes |
of |
| T1724 |
235-243 |
NN |
denotes |
analysis |
| T1725 |
243-244 |
. |
denotes |
. |
| T1726 |
244-422 |
sentence |
denotes |
With the hope of understanding the neuropathology of LCA in greater detail, we have analyzed the differentiation of the outer retina in Crx-/- mice at the ultrastructural level. |
| T1727 |
245-249 |
IN |
denotes |
With |
| T1728 |
329-337 |
VBN |
denotes |
analyzed |
| T1729 |
250-253 |
DT |
denotes |
the |
| T1730 |
254-258 |
NN |
denotes |
hope |
| T1731 |
259-261 |
IN |
denotes |
of |
| T1732 |
262-275 |
VBG |
denotes |
understanding |
| T1733 |
276-279 |
DT |
denotes |
the |
| T1734 |
280-294 |
NN |
denotes |
neuropathology |
| T1735 |
295-297 |
IN |
denotes |
of |
| T1736 |
298-301 |
NN |
denotes |
LCA |
| T1737 |
302-304 |
IN |
denotes |
in |
| T1738 |
305-312 |
JJR |
denotes |
greater |
| T1739 |
313-319 |
NN |
denotes |
detail |
| T1740 |
319-321 |
, |
denotes |
, |
| T1741 |
321-323 |
PRP |
denotes |
we |
| T1742 |
324-328 |
VBP |
denotes |
have |
| T1743 |
338-341 |
DT |
denotes |
the |
| T1744 |
342-357 |
NN |
denotes |
differentiation |
| T1745 |
358-360 |
IN |
denotes |
of |
| T1746 |
361-364 |
DT |
denotes |
the |
| T1747 |
371-377 |
NN |
denotes |
retina |
| T1748 |
365-370 |
JJ |
denotes |
outer |
| T1749 |
378-380 |
IN |
denotes |
in |
| T1750 |
381-384 |
NN |
denotes |
Crx |
| T1751 |
388-392 |
NNS |
denotes |
mice |
| T1752 |
384-385 |
SYM |
denotes |
- |
| T1753 |
385-386 |
HYPH |
denotes |
/ |
| T1754 |
386-387 |
SYM |
denotes |
- |
| T1755 |
393-395 |
IN |
denotes |
at |
| T1756 |
396-399 |
DT |
denotes |
the |
| T1757 |
416-421 |
NN |
denotes |
level |
| T1758 |
400-415 |
JJ |
denotes |
ultrastructural |
| T1759 |
421-422 |
. |
denotes |
. |
| T1760 |
422-471 |
sentence |
denotes |
These retinas exhibit several prominent defects. |
| T1761 |
423-428 |
DT |
denotes |
These |
| T1762 |
429-436 |
NNS |
denotes |
retinas |
| T1763 |
437-444 |
VBP |
denotes |
exhibit |
| T1764 |
445-452 |
JJ |
denotes |
several |
| T1765 |
463-470 |
NNS |
denotes |
defects |
| T1766 |
453-462 |
JJ |
denotes |
prominent |
| T1767 |
470-471 |
. |
denotes |
. |
| T1768 |
471-574 |
sentence |
denotes |
Crx-/- photoreceptors demonstrate a complete block in outer segment formation at the elongation stage. |
| T1769 |
472-475 |
NN |
denotes |
Crx |
| T1770 |
479-493 |
NNS |
denotes |
photoreceptors |
| T1771 |
475-476 |
SYM |
denotes |
- |
| T1772 |
476-477 |
HYPH |
denotes |
/ |
| T1773 |
477-478 |
SYM |
denotes |
- |
| T1774 |
494-505 |
VBP |
denotes |
demonstrate |
| T1775 |
506-507 |
DT |
denotes |
a |
| T1776 |
517-522 |
NN |
denotes |
block |
| T1777 |
508-516 |
JJ |
denotes |
complete |
| T1778 |
523-525 |
IN |
denotes |
in |
| T1779 |
526-531 |
JJ |
denotes |
outer |
| T1780 |
532-539 |
NN |
denotes |
segment |
| T1781 |
540-549 |
NN |
denotes |
formation |
| T1782 |
550-552 |
IN |
denotes |
at |
| T1783 |
553-556 |
DT |
denotes |
the |
| T1784 |
568-573 |
NN |
denotes |
stage |
| T1785 |
557-567 |
NN |
denotes |
elongation |
| T1786 |
573-574 |
. |
denotes |
. |
| T1787 |
574-705 |
sentence |
denotes |
Further, these cells exhibit abnormal synaptic morphology, thereby broadening the function of Crx to photoreceptor synaptogenesis. |
| T1788 |
575-582 |
RB |
denotes |
Further |
| T1789 |
596-603 |
VBP |
denotes |
exhibit |
| T1790 |
582-584 |
, |
denotes |
, |
| T1791 |
584-589 |
DT |
denotes |
these |
| T1792 |
590-595 |
NNS |
denotes |
cells |
| T1793 |
604-612 |
JJ |
denotes |
abnormal |
| T1794 |
622-632 |
NN |
denotes |
morphology |
| T1795 |
613-621 |
JJ |
denotes |
synaptic |
| T1796 |
632-634 |
, |
denotes |
, |
| T1797 |
634-641 |
RB |
denotes |
thereby |
| T1798 |
642-652 |
VBG |
denotes |
broadening |
| T1799 |
653-656 |
DT |
denotes |
the |
| T1800 |
657-665 |
NN |
denotes |
function |
| T1801 |
666-668 |
IN |
denotes |
of |
| T1802 |
669-672 |
NN |
denotes |
Crx |
| T1803 |
673-675 |
IN |
denotes |
to |
| T1804 |
676-689 |
NN |
denotes |
photoreceptor |
| T1805 |
690-704 |
NN |
denotes |
synaptogenesis |
| T1806 |
704-705 |
. |
denotes |
. |
| T1807 |
705-800 |
sentence |
denotes |
This represents the first report strongly implicating the process of synapse formation in LCA. |
| T1808 |
706-710 |
DT |
denotes |
This |
| T1809 |
711-721 |
VBZ |
denotes |
represents |
| T1810 |
722-725 |
DT |
denotes |
the |
| T1811 |
732-738 |
NN |
denotes |
report |
| T1812 |
726-731 |
JJ |
denotes |
first |
| T1813 |
739-747 |
RB |
denotes |
strongly |
| T1814 |
748-759 |
VBG |
denotes |
implicating |
| T1815 |
760-763 |
DT |
denotes |
the |
| T1816 |
764-771 |
NN |
denotes |
process |
| T1817 |
772-774 |
IN |
denotes |
of |
| T1818 |
775-782 |
NN |
denotes |
synapse |
| T1819 |
783-792 |
NN |
denotes |
formation |
| T1820 |
793-795 |
IN |
denotes |
in |
| T1821 |
796-799 |
NN |
denotes |
LCA |
| T1822 |
799-800 |
. |
denotes |
. |
| R955 |
T1695 |
T1688 |
dobj |
examination,extended |
| R956 |
T1696 |
T1695 |
prep |
of,examination |
| R958 |
T1697 |
T1698 |
amod |
retinal,pathology |
| R959 |
T1698 |
T1696 |
pobj |
pathology,of |
| R961 |
T1699 |
T1688 |
prep |
to,extended |
| R962 |
T1700 |
T1701 |
det |
the,level |
| R963 |
T1701 |
T1699 |
pobj |
level,to |
| R964 |
T1702 |
T1701 |
amod |
ultrastructural,level |
| R966 |
T1703 |
T1688 |
punct |
.,extended |
| R968 |
T1705 |
T1706 |
amod |
Certain,features |
| R969 |
T1706 |
T1707 |
nsubjpass |
features,detected |
| R971 |
T1708 |
T1706 |
prep |
of,features |
| R972 |
T1709 |
T1710 |
amod |
neuronal,differentiation |
| R974 |
T1710 |
T1708 |
pobj |
differentiation,of |
| R975 |
T1711 |
T1706 |
punct |
", ",features |
| R977 |
T1712 |
T1713 |
amod |
such,as |
| R978 |
T1713 |
T1706 |
prep |
as,features |
| R979 |
T1714 |
T1715 |
compound |
synapse,formation |
| R981 |
T1715 |
T1713 |
pobj |
formation,as |
| R982 |
T1716 |
T1707 |
punct |
", ",detected |
| R983 |
T1717 |
T1707 |
aux |
can,detected |
| R985 |
T1718 |
T1707 |
auxpass |
be,detected |
| R986 |
T1719 |
T1707 |
advmod |
definitively,detected |
| R987 |
T1720 |
T1707 |
prep |
at,detected |
| R988 |
T1721 |
T1722 |
det |
this,level |
| R989 |
T1722 |
T1720 |
pobj |
level,at |
| R990 |
T1723 |
T1722 |
prep |
of,level |
| R992 |
T1724 |
T1723 |
pobj |
analysis,of |
| R993 |
T1725 |
T1707 |
punct |
.,detected |
| R995 |
T1727 |
T1728 |
prep |
With,analyzed |
| R996 |
T1729 |
T1730 |
det |
the,hope |
| R998 |
T1730 |
T1727 |
pobj |
hope,With |
| R999 |
T1731 |
T1730 |
prep |
of,hope |
| R1001 |
T1732 |
T1731 |
pcomp |
understanding,of |
| R1002 |
T1733 |
T1734 |
det |
the,neuropathology |
| R1003 |
T1734 |
T1732 |
dobj |
neuropathology,understanding |
| R1004 |
T1735 |
T1734 |
prep |
of,neuropathology |
| R1006 |
T1736 |
T1735 |
pobj |
LCA,of |
| R1007 |
T1737 |
T1732 |
prep |
in,understanding |
| R1008 |
T1738 |
T1739 |
amod |
greater,detail |
| R1010 |
T1739 |
T1737 |
pobj |
detail,in |
| R1011 |
T1740 |
T1728 |
punct |
", ",analyzed |
| R1012 |
T1741 |
T1728 |
nsubj |
we,analyzed |
| R1014 |
T1742 |
T1728 |
aux |
have,analyzed |
| R1015 |
T1743 |
T1744 |
det |
the,differentiation |
| R1017 |
T1744 |
T1728 |
dobj |
differentiation,analyzed |
| R1018 |
T1745 |
T1744 |
prep |
of,differentiation |
| R1019 |
T1746 |
T1747 |
det |
the,retina |
| R1021 |
T1747 |
T1745 |
pobj |
retina,of |
| R1022 |
T1748 |
T1747 |
amod |
outer,retina |
| R1023 |
T1749 |
T1744 |
prep |
in,differentiation |
| R1025 |
T1750 |
T1751 |
nmod |
Crx,mice |
| R1026 |
T1751 |
T1749 |
pobj |
mice,in |
| R1027 |
T1752 |
T1750 |
punct |
-,Crx |
| R1029 |
T1753 |
T1750 |
punct |
/,Crx |
| R1030 |
T1754 |
T1750 |
punct |
-,Crx |
| R1031 |
T1755 |
T1728 |
prep |
at,analyzed |
| R1033 |
T1756 |
T1757 |
det |
the,level |
| R1034 |
T1757 |
T1755 |
pobj |
level,at |
| R1036 |
T1758 |
T1757 |
amod |
ultrastructural,level |
| R1037 |
T1759 |
T1728 |
punct |
.,analyzed |
| R1038 |
T1761 |
T1762 |
det |
These,retinas |
| R1039 |
T1762 |
T1763 |
nsubj |
retinas,exhibit |
| R1040 |
T1764 |
T1765 |
amod |
several,defects |
| R1042 |
T1765 |
T1763 |
dobj |
defects,exhibit |
| R1043 |
T1766 |
T1765 |
amod |
prominent,defects |
| R1044 |
T1767 |
T1763 |
punct |
.,exhibit |
| R1046 |
T1769 |
T1770 |
nmod |
Crx,photoreceptors |
| R1047 |
T1770 |
T1774 |
nsubj |
photoreceptors,demonstrate |
| R1049 |
T1771 |
T1769 |
punct |
-,Crx |
| R1050 |
T1772 |
T1769 |
punct |
/,Crx |
| R1052 |
T1773 |
T1769 |
punct |
-,Crx |
| R1053 |
T1775 |
T1776 |
det |
a,block |
| R1055 |
T1776 |
T1774 |
dobj |
block,demonstrate |
| R1056 |
T1777 |
T1776 |
amod |
complete,block |
| R1057 |
T1778 |
T1776 |
prep |
in,block |
| R1059 |
T1779 |
T1780 |
amod |
outer,segment |
| R1061 |
T1780 |
T1781 |
compound |
segment,formation |
| R1063 |
T1781 |
T1778 |
pobj |
formation,in |
| R1064 |
T1782 |
T1774 |
prep |
at,demonstrate |
| R1066 |
T1783 |
T1784 |
det |
the,stage |
| R1067 |
T1784 |
T1782 |
pobj |
stage,at |
| R1068 |
T1785 |
T1784 |
compound |
elongation,stage |
| R1069 |
T1786 |
T1774 |
punct |
.,demonstrate |
| R1071 |
T1788 |
T1789 |
advmod |
Further,exhibit |
| R1073 |
T1790 |
T1789 |
punct |
", ",exhibit |
| R1075 |
T1791 |
T1792 |
det |
these,cells |
| R1076 |
T1792 |
T1789 |
nsubj |
cells,exhibit |
| R1077 |
T1793 |
T1794 |
amod |
abnormal,morphology |
| R1078 |
T1794 |
T1789 |
dobj |
morphology,exhibit |
| R1080 |
T1795 |
T1794 |
amod |
synaptic,morphology |
| R1082 |
T1796 |
T1789 |
punct |
", ",exhibit |
| R1083 |
T1797 |
T1798 |
advmod |
thereby,broadening |
| R1084 |
T1798 |
T1789 |
advcl |
broadening,exhibit |
| R1086 |
T1799 |
T1800 |
det |
the,function |
| R1087 |
T1800 |
T1798 |
dobj |
function,broadening |
| R1090 |
T1801 |
T1800 |
prep |
of,function |
| R1091 |
T1802 |
T1801 |
pobj |
Crx,of |
| R1092 |
T1803 |
T1798 |
prep |
to,broadening |
| R1093 |
T1804 |
T1805 |
compound |
photoreceptor,synaptogenesis |
| R1094 |
T1805 |
T1803 |
pobj |
synaptogenesis,to |
| R1096 |
T1806 |
T1789 |
punct |
.,exhibit |
| R1097 |
T1808 |
T1809 |
nsubj |
This,represents |
| R1099 |
T1810 |
T1811 |
det |
the,report |
| R1100 |
T1811 |
T1809 |
dobj |
report,represents |
| R1102 |
T1812 |
T1811 |
amod |
first,report |
| R1103 |
T1813 |
T1814 |
advmod |
strongly,implicating |
| R1104 |
T1814 |
T1811 |
acl |
implicating,report |
| R1107 |
T1815 |
T1816 |
det |
the,process |
| R1108 |
T1816 |
T1814 |
dobj |
process,implicating |
| R1110 |
T1817 |
T1816 |
prep |
of,process |
| R1111 |
T1818 |
T1819 |
compound |
synapse,formation |
| R1112 |
T1819 |
T1817 |
pobj |
formation,of |
| R1114 |
T1820 |
T1814 |
prep |
in,implicating |
| R1115 |
T1821 |
T1820 |
pobj |
LCA,in |
| R1116 |
T1822 |
T1809 |
punct |
.,represents |
| R1134 |
T1686 |
T1687 |
amod |
Few,studies |
| R1135 |
T1687 |
T1688 |
nsubj |
studies,extended |
| R1136 |
T1689 |
T1687 |
prep |
of,studies |
| R1137 |
T1690 |
T1691 |
compound |
LCA,models |
| R1138 |
T1691 |
T1689 |
pobj |
models,of |
| R1139 |
T1692 |
T1691 |
compound |
animal,models |
| R1140 |
T1693 |
T1688 |
aux |
have,extended |
| R1141 |
T1694 |
T1695 |
poss |
their,examination |