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PMC:548520 / 2909-4388 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
15676071-15231395-12933255 63-65 15231395 denotes 17
15676071-9792858-12933256 252-254 9792858 denotes 14
15676071-9537410-12933257 255-257 9537410 denotes 15
15676071-8944027-12933258 279-281 8944027 denotes 18
15676071-9326927-12933259 291-293 9326927 denotes 19
15676071-10615133-12933260 304-306 10615133 denotes 20
15676071-12567265-12933261 316-318 12567265 denotes 21
15676071-11283794-12933262 335-337 11283794 denotes 22
15676071-10631161-12933263 448-450 10631161 denotes 23
15676071-9792858-12933264 587-589 9792858 denotes 14
15676071-9537410-12933265 590-592 9537410 denotes 15
15676071-9931337-12933266 718-720 9931337 denotes 16
15676071-15231395-12933267 926-928 15231395 denotes 17
15676071-12124981-12933268 1132-1134 12124981 denotes 24
15676071-9448321-12933269 1274-1276 9448321 denotes 25
15676071-15180294-12933269 1274-1276 15180294 denotes 25
15676071-12692160-12933269 1274-1276 12692160 denotes 25
15676071-11528395-12933269 1274-1276 11528395 denotes 25

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T694 23-30 SO_EXT:0000704 denotes genetic
T695 42-56 CL:0000210 denotes photoreceptors
T696 152-158 GO:0007601 denotes vision
T697 164-169 GO:0007567 denotes birth
T698 171-180 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T699 184-191 UBERON:0000966 denotes retinal
T700 201-206 SO_EXT:0000704 denotes genes
T701 216-219 PR_EXT:000005904 denotes Crx
T702 271-277 PR_EXT:000008353 denotes GUCY2D
T703 284-289 PR_EXT:000014179 denotes RPE65
T704 296-302 PR_EXT:000003876 denotes AIPL-1
T705 309-314 PR_EXT:000005848 denotes CRB-1
T706 325-333 PR_EXT:000014182 denotes RPGRIP-1
T707 386-409 SO_EXT:0000018 denotes genetically linked loci
T708 416-421 SO_EXT:0000704 denotes genes
T709 453-456 PR_EXT:000005904 denotes Crx
T710 457-466 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T711 518-526 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T712 547-553 SO_EXT:sequence_coding_function denotes encode
T713 582-585 PR_EXT:000005904 denotes Crx
T714 605-614 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T715 656-662 SO_EXT:0001023 denotes allele
T716 663-670 SO_EXT:sequence_coding_function denotes encodes
T717 673-680 CHEBI_PR_EXT:protein denotes protein
T718 696-699 CHEBI_SO_EXT:DNA denotes DNA
T719 700-707 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T720 902-907 NCBITaxon:9606 denotes human
T721 976-982 UBERON:0010230 denotes globes
T722 986-992 UBERON:0007023 denotes adults
T723 1013-1019 UBERON:0000479 denotes tissue
T724 1101-1104 UBERON:0000970 denotes eye
T725 1111-1117 UBERON_EXT:baby_or_infant denotes infant
T726 1137-1143 NCBITaxon:33208 denotes Animal
T727 1312-1323 SO_EXT:0000704 denotes genetically
T728 1359-1364 NCBITaxon:10088 denotes mouse
T729 1441-1454 CL:0000210 denotes photoreceptor
T730 1441-1466 GO:0042461 denotes photoreceptor development

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T532 23-30 SO:0000704 denotes genetic
T533 42-56 CL:0000210 denotes photoreceptors
T534 152-158 GO:0007601 denotes vision
T535 164-169 GO:0007567 denotes birth
T536 184-191 UBERON:0000966 denotes retinal
T537 201-206 SO:0000704 denotes genes
T538 216-219 PR:000005904 denotes Crx
T539 271-277 PR:000008353 denotes GUCY2D
T540 284-289 PR:000014179 denotes RPE65
T541 296-302 PR:000003876 denotes AIPL-1
T542 309-314 PR:000005848 denotes CRB-1
T543 325-333 PR:000014182 denotes RPGRIP-1
T544 386-409 SO:0000018 denotes genetically linked loci
T545 416-421 SO:0000704 denotes genes
T546 453-456 PR:000005904 denotes Crx
T547 582-585 PR:000005904 denotes Crx
T548 656-662 SO:0001023 denotes allele
T549 902-907 NCBITaxon:9606 denotes human
T550 976-982 UBERON:0010230 denotes globes
T551 986-992 UBERON:0007023 denotes adults
T552 1013-1019 UBERON:0000479 denotes tissue
T553 1101-1104 UBERON:0000970 denotes eye
T554 1137-1143 NCBITaxon:33208 denotes Animal
T555 1312-1323 SO:0000704 denotes genetically
T556 1359-1364 NCBITaxon:10088 denotes mouse
T557 1441-1454 CL:0000210 denotes photoreceptor
T558 1441-1466 GO:0042461 denotes photoreceptor development

craft-sa-dev

Id Subject Object Predicate Lexical cue
T1154 0-3 NN denotes LCA
T1155 4-6 VBZ denotes is
T1156 7-10 DT denotes the
T1157 31-38 NN denotes disease
T1158 11-15 RBS denotes most
T1159 16-22 JJ denotes severe
T1160 23-30 JJ denotes genetic
T1161 39-41 IN denotes of
T1162 42-56 NNS denotes photoreceptors
T1163 57-58 -LRB- denotes (
T1164 58-61 VB denotes see
T1165 62-63 -LRB- denotes [
T1166 63-65 CD denotes 17
T1167 65-66 -RRB- denotes ]
T1168 66-68 , denotes ,
T1169 68-71 IN denotes for
T1170 72-78 JJ denotes recent
T1171 79-85 NN denotes review
T1172 85-86 -RRB- denotes )
T1173 86-87 . denotes .
T1174 87-170 sentence denotes Affected infants exhibit a complete or near complete absence of vision from birth.
T1175 88-96 VBN denotes Affected
T1176 97-104 NNS denotes infants
T1177 105-112 VBP denotes exhibit
T1178 113-114 DT denotes a
T1179 141-148 NN denotes absence
T1180 115-123 JJ denotes complete
T1181 124-126 CC denotes or
T1182 127-131 RB denotes near
T1183 132-140 JJ denotes complete
T1184 149-151 IN denotes of
T1185 152-158 NN denotes vision
T1186 159-163 IN denotes from
T1187 164-169 NN denotes birth
T1188 169-170 . denotes .
T1189 170-339 sentence denotes Mutations in retinal specific genes, such as Crx, have been associated with LCA [14,15], as well as GUCY2D [18], RPE65 [19], AIPL-1 [20], CRB-1 [21], and RPGRIP-1 [22].
T1190 171-180 NNS denotes Mutations
T1191 231-241 VBN denotes associated
T1192 181-183 IN denotes in
T1193 184-191 NN denotes retinal
T1194 192-200 JJ denotes specific
T1195 201-206 NNS denotes genes
T1196 206-208 , denotes ,
T1197 208-212 JJ denotes such
T1198 213-215 IN denotes as
T1199 216-219 NN denotes Crx
T1200 219-221 , denotes ,
T1201 221-225 VBP denotes have
T1202 226-230 VBN denotes been
T1203 242-246 IN denotes with
T1204 247-250 NN denotes LCA
T1205 251-252 -LRB- denotes [
T1206 255-257 CD denotes 15
T1207 252-254 CD denotes 14
T1208 254-255 , denotes ,
T1209 257-258 -RRB- denotes ]
T1210 258-260 , denotes ,
T1211 260-262 RB denotes as
T1212 268-270 IN denotes as
T1213 263-267 RB denotes well
T1214 271-277 NN denotes GUCY2D
T1215 278-279 -LRB- denotes [
T1216 279-281 CD denotes 18
T1217 281-282 -RRB- denotes ]
T1218 282-284 , denotes ,
T1219 284-289 NN denotes RPE65
T1220 290-291 -LRB- denotes [
T1221 291-293 CD denotes 19
T1222 293-294 -RRB- denotes ]
T1223 294-296 , denotes ,
T1224 296-300 NN denotes AIPL
T1225 300-301 HYPH denotes -
T1226 301-302 CD denotes 1
T1227 303-304 -LRB- denotes [
T1228 304-306 CD denotes 20
T1229 306-307 -RRB- denotes ]
T1230 307-309 , denotes ,
T1231 309-312 NN denotes CRB
T1232 312-313 HYPH denotes -
T1233 313-314 CD denotes 1
T1234 315-316 -LRB- denotes [
T1235 316-318 CD denotes 21
T1236 318-319 -RRB- denotes ]
T1237 319-321 , denotes ,
T1238 321-324 CC denotes and
T1239 325-331 NN denotes RPGRIP
T1240 331-332 HYPH denotes -
T1241 332-333 CD denotes 1
T1242 334-335 -LRB- denotes [
T1243 335-337 CD denotes 22
T1244 337-338 -RRB- denotes ]
T1245 338-339 . denotes .
T1246 339-452 sentence denotes There also may be as many as three additional genetically linked loci where genes have not been identified [23].
T1247 340-345 EX denotes There
T1248 355-357 VB denotes be
T1249 346-350 RB denotes also
T1250 351-354 MD denotes may
T1251 358-360 RB denotes as
T1252 369-374 CD denotes three
T1253 361-365 JJ denotes many
T1254 366-368 IN denotes as
T1255 405-409 NNS denotes loci
T1256 375-385 JJ denotes additional
T1257 386-397 RB denotes genetically
T1258 398-404 VBN denotes linked
T1259 410-415 WRB denotes where
T1260 436-446 VBN denotes identified
T1261 416-421 NNS denotes genes
T1262 422-426 VBP denotes have
T1263 427-430 RB denotes not
T1264 431-435 VBN denotes been
T1265 447-448 -LRB- denotes [
T1266 448-450 CD denotes 23
T1267 450-451 -RRB- denotes ]
T1268 451-452 . denotes .
T1269 452-594 sentence denotes Crx mutations in LCA are varied, and include a putative dominant mutation that is proposed to encode a dominant-negative form of Crx [14,15].
T1270 453-456 NN denotes Crx
T1271 457-466 NNS denotes mutations
T1272 474-477 VBP denotes are
T1273 467-469 IN denotes in
T1274 470-473 NN denotes LCA
T1275 478-484 JJ denotes varied
T1276 484-486 , denotes ,
T1277 486-489 CC denotes and
T1278 490-497 VBP denotes include
T1279 498-499 DT denotes a
T1280 518-526 NN denotes mutation
T1281 500-508 JJ denotes putative
T1282 509-517 JJ denotes dominant
T1283 527-531 WDT denotes that
T1284 535-543 VBN denotes proposed
T1285 532-534 VBZ denotes is
T1286 544-546 TO denotes to
T1287 547-553 VB denotes encode
T1288 554-555 DT denotes a
T1289 574-578 NN denotes form
T1290 556-564 JJ denotes dominant
T1291 565-573 JJ denotes negative
T1292 564-565 HYPH denotes -
T1293 579-581 IN denotes of
T1294 582-585 NN denotes Crx
T1295 586-587 -LRB- denotes [
T1296 590-592 CD denotes 15
T1297 587-589 CD denotes 14
T1298 589-590 , denotes ,
T1299 592-593 -RRB- denotes ]
T1300 593-594 . denotes .
T1301 594-722 sentence denotes Recessive mutations also have been reported and at least one allele encodes a protein with decreased DNA-binding activity [16].
T1302 595-604 JJ denotes Recessive
T1303 605-614 NNS denotes mutations
T1304 630-638 VBN denotes reported
T1305 615-619 RB denotes also
T1306 620-624 VBP denotes have
T1307 625-629 VBN denotes been
T1308 639-642 CC denotes and
T1309 643-645 RB denotes at
T1310 652-655 CD denotes one
T1311 646-651 RBS denotes least
T1312 656-662 NN denotes allele
T1313 663-670 VBZ denotes encodes
T1314 671-672 DT denotes a
T1315 673-680 NN denotes protein
T1316 681-685 IN denotes with
T1317 686-695 VBN denotes decreased
T1318 708-716 NN denotes activity
T1319 696-699 NN denotes DNA
T1320 699-700 HYPH denotes -
T1321 700-707 VBG denotes binding
T1322 717-718 -LRB- denotes [
T1323 718-720 CD denotes 16
T1324 720-721 -RRB- denotes ]
T1325 721-722 . denotes .
T1326 722-874 sentence denotes Histopathological and ultrastructural studies of LCA should enable a better understanding of the disease process, and the design of suitable therapies.
T1327 723-740 JJ denotes Histopathological
T1328 761-768 NNS denotes studies
T1329 741-744 CC denotes and
T1330 745-760 JJ denotes ultrastructural
T1331 783-789 VB denotes enable
T1332 769-771 IN denotes of
T1333 772-775 NN denotes LCA
T1334 776-782 MD denotes should
T1335 790-791 DT denotes a
T1336 799-812 NN denotes understanding
T1337 792-798 JJR denotes better
T1338 813-815 IN denotes of
T1339 816-819 DT denotes the
T1340 828-835 NN denotes process
T1341 820-827 NN denotes disease
T1342 835-837 , denotes ,
T1343 837-840 CC denotes and
T1344 841-844 DT denotes the
T1345 845-851 NN denotes design
T1346 852-854 IN denotes of
T1347 855-863 JJ denotes suitable
T1348 864-873 NNS denotes therapies
T1349 873-874 . denotes .
T1350 874-1052 sentence denotes Few such studies exist for human LCA (reviewed in [17]) and the majority of such studies examine the globes of adults with LCA, after the tissue has undergone secondary changes.
T1351 875-878 JJ denotes Few
T1352 884-891 NNS denotes studies
T1353 879-883 JJ denotes such
T1354 892-897 VBP denotes exist
T1355 898-901 IN denotes for
T1356 902-907 JJ denotes human
T1357 908-911 NN denotes LCA
T1358 912-913 -LRB- denotes (
T1359 913-921 VBN denotes reviewed
T1360 922-924 IN denotes in
T1361 925-926 -LRB- denotes [
T1362 926-928 CD denotes 17
T1363 928-929 -RRB- denotes ]
T1364 929-930 -RRB- denotes )
T1365 931-934 CC denotes and
T1366 935-938 DT denotes the
T1367 939-947 NN denotes majority
T1368 964-971 VBP denotes examine
T1369 948-950 IN denotes of
T1370 951-955 JJ denotes such
T1371 956-963 NNS denotes studies
T1372 972-975 DT denotes the
T1373 976-982 NNS denotes globes
T1374 983-985 IN denotes of
T1375 986-992 NNS denotes adults
T1376 993-997 IN denotes with
T1377 998-1001 NN denotes LCA
T1378 1001-1003 , denotes ,
T1379 1003-1008 IN denotes after
T1380 1024-1033 VBN denotes undergone
T1381 1009-1012 DT denotes the
T1382 1013-1019 NN denotes tissue
T1383 1020-1023 VBZ denotes has
T1384 1034-1043 JJ denotes secondary
T1385 1044-1051 NNS denotes changes
T1386 1051-1052 . denotes .
T1387 1052-1136 sentence denotes Only a single study exists where the developing eye of an infant was examined [24].
T1388 1053-1057 RB denotes Only
T1389 1067-1072 NN denotes study
T1390 1058-1059 DT denotes a
T1391 1060-1066 JJ denotes single
T1392 1073-1079 VBZ denotes exists
T1393 1080-1085 WRB denotes where
T1394 1122-1130 VBN denotes examined
T1395 1086-1089 DT denotes the
T1396 1101-1104 NN denotes eye
T1397 1090-1100 VBG denotes developing
T1398 1105-1107 IN denotes of
T1399 1108-1110 DT denotes an
T1400 1111-1117 NN denotes infant
T1401 1118-1121 VBD denotes was
T1402 1131-1132 -LRB- denotes [
T1403 1132-1134 CD denotes 24
T1404 1134-1135 -RRB- denotes ]
T1405 1135-1136 . denotes .
T1406 1136-1281 sentence denotes Animal models for LCA have recently been reported and have already served to broaden our understanding of the pathology of this disease [25-28].
T1407 1137-1143 NN denotes Animal
T1408 1144-1150 NNS denotes models
T1409 1178-1186 VBN denotes reported
T1410 1151-1154 IN denotes for
T1411 1155-1158 NN denotes LCA
T1412 1159-1163 VBP denotes have
T1413 1164-1172 RB denotes recently
T1414 1173-1177 VBN denotes been
T1415 1187-1190 CC denotes and
T1416 1191-1195 VBP denotes have
T1417 1204-1210 VBN denotes served
T1418 1196-1203 RB denotes already
T1419 1211-1213 TO denotes to
T1420 1214-1221 VB denotes broaden
T1421 1222-1225 PRP$ denotes our
T1422 1226-1239 NN denotes understanding
T1423 1240-1242 IN denotes of
T1424 1243-1246 DT denotes the
T1425 1247-1256 NN denotes pathology
T1426 1257-1259 IN denotes of
T1427 1260-1264 DT denotes this
T1428 1265-1272 NN denotes disease
T1429 1273-1274 -LRB- denotes [
T1430 1274-1276 CD denotes 25
T1431 1276-1277 SYM denotes -
T1432 1277-1279 CD denotes 28
T1433 1279-1280 -RRB- denotes ]
T1434 1280-1281 . denotes .
T1435 1281-1479 sentence denotes Since LCA is a clinically and genetically heterogeneous disorder, additional mouse models are in order to allow a full understanding of the many ways in which photoreceptor development can go awry.
T1436 1282-1287 IN denotes Since
T1437 1292-1294 VBZ denotes is
T1438 1288-1291 NN denotes LCA
T1439 1372-1375 VBP denotes are
T1440 1295-1296 DT denotes a
T1441 1338-1346 NN denotes disorder
T1442 1297-1307 RB denotes clinically
T1443 1324-1337 JJ denotes heterogeneous
T1444 1308-1311 CC denotes and
T1445 1312-1323 RB denotes genetically
T1446 1346-1348 , denotes ,
T1447 1348-1358 JJ denotes additional
T1448 1365-1371 NNS denotes models
T1449 1359-1364 NN denotes mouse
T1450 1376-1378 IN denotes in
T1451 1379-1384 NN denotes order
T1452 1385-1387 TO denotes to
T1453 1388-1393 VB denotes allow
T1454 1394-1395 DT denotes a
T1455 1401-1414 NN denotes understanding
T1456 1396-1400 JJ denotes full
T1457 1415-1417 IN denotes of
T1458 1418-1421 DT denotes the
T1459 1427-1431 NNS denotes ways
T1460 1422-1426 JJ denotes many
T1461 1432-1434 IN denotes in
T1462 1471-1473 VB denotes go
T1463 1435-1440 WDT denotes which
T1464 1441-1454 NN denotes photoreceptor
T1465 1455-1466 NN denotes development
T1466 1467-1470 MD denotes can
T1467 1474-1478 JJ denotes awry
T1468 1478-1479 . denotes .
R528 T1154 T1155 nsubj LCA,is
R529 T1156 T1157 det the,disease
R530 T1157 T1155 attr disease,is
R531 T1158 T1159 advmod most,severe
R532 T1159 T1157 amod severe,disease
R533 T1160 T1157 amod genetic,disease
R534 T1161 T1157 prep of,disease
R535 T1162 T1161 pobj photoreceptors,of
R536 T1163 T1164 punct (,see
R537 T1164 T1155 parataxis see,is
R538 T1165 T1164 punct [,see
R539 T1166 T1164 dobj 17,see
R540 T1167 T1164 punct ],see
R541 T1168 T1164 punct ", ",see
R542 T1169 T1164 prep for,see
R543 T1170 T1171 amod recent,review
R544 T1171 T1169 pobj review,for
R545 T1172 T1164 punct ),see
R546 T1173 T1155 punct .,is
R547 T1175 T1176 amod Affected,infants
R548 T1176 T1177 nsubj infants,exhibit
R549 T1178 T1179 det a,absence
R550 T1179 T1177 dobj absence,exhibit
R551 T1180 T1179 amod complete,absence
R552 T1181 T1180 cc or,complete
R553 T1182 T1183 advmod near,complete
R554 T1183 T1180 conj complete,complete
R555 T1184 T1179 prep of,absence
R556 T1185 T1184 pobj vision,of
R557 T1186 T1177 prep from,exhibit
R558 T1187 T1186 pobj birth,from
R559 T1188 T1177 punct .,exhibit
R560 T1190 T1191 nsubjpass Mutations,associated
R561 T1192 T1190 prep in,Mutations
R562 T1193 T1194 npadvmod retinal,specific
R563 T1194 T1195 amod specific,genes
R564 T1195 T1192 pobj genes,in
R565 T1196 T1195 punct ", ",genes
R566 T1197 T1198 amod such,as
R567 T1198 T1195 prep as,genes
R568 T1199 T1198 pobj Crx,as
R569 T1200 T1191 punct ", ",associated
R570 T1201 T1191 aux have,associated
R571 T1202 T1191 auxpass been,associated
R572 T1203 T1191 prep with,associated
R573 T1204 T1203 pobj LCA,with
R574 T1205 T1206 punct [,15
R575 T1206 T1204 parataxis 15,LCA
R576 T1207 T1206 nummod 14,15
R577 T1208 T1206 punct ",",15
R578 T1209 T1206 punct ],15
R579 T1210 T1204 punct ", ",LCA
R580 T1211 T1212 advmod as,as
R581 T1212 T1204 cc as,LCA
R582 T1213 T1212 advmod well,as
R583 T1214 T1204 conj GUCY2D,LCA
R584 T1215 T1216 punct [,18
R585 T1216 T1214 parataxis 18,GUCY2D
R586 T1217 T1216 punct ],18
R587 T1218 T1214 punct ", ",GUCY2D
R588 T1219 T1214 conj RPE65,GUCY2D
R589 T1220 T1221 punct [,19
R590 T1221 T1219 parataxis 19,RPE65
R591 T1222 T1221 punct ],19
R592 T1223 T1219 punct ", ",RPE65
R593 T1224 T1219 conj AIPL,RPE65
R594 T1225 T1224 punct -,AIPL
R595 T1226 T1224 nummod 1,AIPL
R596 T1227 T1228 punct [,20
R597 T1228 T1224 parataxis 20,AIPL
R598 T1229 T1228 punct ],20
R599 T1230 T1224 punct ", ",AIPL
R600 T1231 T1224 conj CRB,AIPL
R601 T1232 T1231 punct -,CRB
R602 T1233 T1231 nummod 1,CRB
R603 T1234 T1235 punct [,21
R604 T1235 T1231 parataxis 21,CRB
R605 T1236 T1235 punct ],21
R606 T1237 T1231 punct ", ",CRB
R607 T1238 T1231 cc and,CRB
R608 T1239 T1231 conj RPGRIP,CRB
R609 T1240 T1239 punct -,RPGRIP
R610 T1241 T1239 nummod 1,RPGRIP
R611 T1242 T1243 punct [,22
R612 T1243 T1239 parataxis 22,RPGRIP
R613 T1244 T1243 punct ],22
R614 T1245 T1191 punct .,associated
R615 T1247 T1248 expl There,be
R616 T1249 T1248 advmod also,be
R617 T1250 T1248 aux may,be
R618 T1251 T1252 advmod as,three
R619 T1252 T1255 nummod three,loci
R620 T1253 T1252 amod many,three
R621 T1254 T1252 quantmod as,three
R622 T1255 T1248 attr loci,be
R623 T1256 T1255 amod additional,loci
R624 T1257 T1258 advmod genetically,linked
R625 T1258 T1255 amod linked,loci
R626 T1259 T1260 advmod where,identified
R627 T1260 T1255 relcl identified,loci
R628 T1261 T1260 nsubjpass genes,identified
R629 T1262 T1260 aux have,identified
R630 T1263 T1260 neg not,identified
R631 T1264 T1260 auxpass been,identified
R632 T1265 T1266 punct [,23
R633 T1266 T1255 parataxis 23,loci
R634 T1267 T1266 punct ],23
R635 T1268 T1248 punct .,be
R636 T1270 T1271 compound Crx,mutations
R637 T1271 T1272 nsubj mutations,are
R638 T1273 T1271 prep in,mutations
R639 T1274 T1273 pobj LCA,in
R640 T1275 T1272 acomp varied,are
R641 T1276 T1272 punct ", ",are
R642 T1277 T1272 cc and,are
R643 T1278 T1272 conj include,are
R644 T1279 T1280 det a,mutation
R645 T1280 T1278 dobj mutation,include
R646 T1281 T1280 amod putative,mutation
R647 T1282 T1280 amod dominant,mutation
R648 T1283 T1284 dep that,proposed
R649 T1284 T1280 relcl proposed,mutation
R650 T1285 T1284 auxpass is,proposed
R651 T1286 T1287 aux to,encode
R652 T1287 T1284 xcomp encode,proposed
R653 T1288 T1289 det a,form
R654 T1289 T1287 dobj form,encode
R655 T1290 T1291 amod dominant,negative
R656 T1291 T1289 nmod negative,form
R657 T1292 T1291 punct -,negative
R658 T1293 T1289 prep of,form
R659 T1294 T1293 pobj Crx,of
R660 T1295 T1296 punct [,15
R661 T1296 T1287 parataxis 15,encode
R662 T1297 T1296 nummod 14,15
R663 T1298 T1296 punct ",",15
R664 T1299 T1296 punct ],15
R665 T1300 T1272 punct .,are
R666 T1302 T1303 amod Recessive,mutations
R667 T1303 T1304 nsubjpass mutations,reported
R668 T1305 T1304 advmod also,reported
R669 T1306 T1304 aux have,reported
R670 T1307 T1304 auxpass been,reported
R671 T1308 T1304 cc and,reported
R672 T1309 T1310 advmod at,one
R673 T1310 T1312 nummod one,allele
R674 T1311 T1310 advmod least,one
R675 T1312 T1313 nsubj allele,encodes
R676 T1313 T1304 conj encodes,reported
R677 T1314 T1315 det a,protein
R678 T1315 T1313 dobj protein,encodes
R679 T1316 T1315 prep with,protein
R680 T1317 T1318 amod decreased,activity
R681 T1318 T1316 pobj activity,with
R682 T1319 T1318 nmod DNA,activity
R683 T1320 T1319 punct -,DNA
R684 T1321 T1319 amod binding,DNA
R685 T1322 T1323 punct [,16
R686 T1323 T1313 parataxis 16,encodes
R687 T1324 T1323 punct ],16
R688 T1325 T1313 punct .,encodes
R689 T1327 T1328 amod Histopathological,studies
R690 T1328 T1331 nsubj studies,enable
R691 T1329 T1327 cc and,Histopathological
R692 T1330 T1327 conj ultrastructural,Histopathological
R693 T1332 T1328 prep of,studies
R694 T1333 T1332 pobj LCA,of
R695 T1334 T1331 aux should,enable
R696 T1335 T1336 det a,understanding
R697 T1336 T1331 dobj understanding,enable
R698 T1337 T1336 amod better,understanding
R699 T1338 T1336 prep of,understanding
R700 T1339 T1340 det the,process
R701 T1340 T1338 pobj process,of
R702 T1341 T1340 compound disease,process
R703 T1342 T1336 punct ", ",understanding
R704 T1343 T1336 cc and,understanding
R705 T1344 T1345 det the,design
R706 T1345 T1336 conj design,understanding
R707 T1346 T1345 prep of,design
R708 T1347 T1348 amod suitable,therapies
R709 T1348 T1346 pobj therapies,of
R710 T1349 T1331 punct .,enable
R711 T1351 T1352 amod Few,studies
R712 T1352 T1354 nsubj studies,exist
R713 T1353 T1352 amod such,studies
R714 T1355 T1354 prep for,exist
R715 T1356 T1357 amod human,LCA
R716 T1357 T1355 pobj LCA,for
R717 T1358 T1359 punct (,reviewed
R718 T1359 T1354 parataxis reviewed,exist
R719 T1360 T1359 prep in,reviewed
R720 T1361 T1360 punct [,in
R721 T1362 T1360 pobj 17,in
R722 T1363 T1359 punct ],reviewed
R723 T1364 T1359 punct ),reviewed
R724 T1365 T1354 cc and,exist
R725 T1366 T1367 det the,majority
R726 T1367 T1368 nsubj majority,examine
R727 T1368 T1354 conj examine,exist
R728 T1369 T1367 prep of,majority
R729 T1370 T1371 amod such,studies
R730 T1371 T1369 pobj studies,of
R731 T1372 T1373 det the,globes
R732 T1373 T1368 dobj globes,examine
R733 T1374 T1373 prep of,globes
R734 T1375 T1374 pobj adults,of
R735 T1376 T1375 prep with,adults
R736 T1377 T1376 pobj LCA,with
R737 T1378 T1368 punct ", ",examine
R738 T1379 T1380 mark after,undergone
R739 T1380 T1368 advcl undergone,examine
R740 T1381 T1382 det the,tissue
R741 T1382 T1380 nsubj tissue,undergone
R742 T1383 T1380 aux has,undergone
R743 T1384 T1385 amod secondary,changes
R744 T1385 T1380 dobj changes,undergone
R745 T1386 T1368 punct .,examine
R746 T1388 T1389 advmod Only,study
R747 T1389 T1392 nsubj study,exists
R748 T1390 T1389 det a,study
R749 T1391 T1389 amod single,study
R750 T1393 T1394 advmod where,examined
R751 T1394 T1392 ccomp examined,exists
R752 T1395 T1396 det the,eye
R753 T1396 T1394 nsubjpass eye,examined
R754 T1397 T1396 amod developing,eye
R755 T1398 T1396 prep of,eye
R756 T1399 T1400 det an,infant
R757 T1400 T1398 pobj infant,of
R758 T1401 T1394 auxpass was,examined
R759 T1402 T1403 punct [,24
R760 T1403 T1394 parataxis 24,examined
R761 T1404 T1403 punct ],24
R762 T1405 T1392 punct .,exists
R763 T1407 T1408 compound Animal,models
R764 T1408 T1409 nsubjpass models,reported
R765 T1410 T1408 prep for,models
R766 T1411 T1410 pobj LCA,for
R767 T1412 T1409 aux have,reported
R768 T1413 T1409 advmod recently,reported
R769 T1414 T1409 auxpass been,reported
R770 T1415 T1409 cc and,reported
R771 T1416 T1417 aux have,served
R772 T1417 T1409 conj served,reported
R773 T1418 T1417 advmod already,served
R774 T1419 T1420 aux to,broaden
R775 T1420 T1417 xcomp broaden,served
R776 T1421 T1422 poss our,understanding
R777 T1422 T1420 dobj understanding,broaden
R778 T1423 T1422 prep of,understanding
R779 T1424 T1425 det the,pathology
R780 T1425 T1423 pobj pathology,of
R781 T1426 T1425 prep of,pathology
R782 T1427 T1428 det this,disease
R783 T1428 T1426 pobj disease,of
R784 T1429 T1430 punct [,25
R785 T1430 T1420 parataxis 25,broaden
R786 T1431 T1432 punct -,28
R787 T1432 T1430 prep 28,25
R788 T1433 T1430 punct ],25
R789 T1434 T1409 punct .,reported
R790 T1436 T1437 mark Since,is
R791 T1437 T1439 advcl is,are
R792 T1438 T1437 nsubj LCA,is
R793 T1440 T1441 det a,disorder
R794 T1441 T1437 attr disorder,is
R795 T1442 T1443 advmod clinically,heterogeneous
R796 T1443 T1441 amod heterogeneous,disorder
R797 T1444 T1442 cc and,clinically
R798 T1445 T1442 conj genetically,clinically
R799 T1446 T1439 punct ", ",are
R800 T1447 T1448 amod additional,models
R801 T1448 T1439 nsubj models,are
R802 T1449 T1448 compound mouse,models
R803 T1450 T1439 prep in,are
R804 T1451 T1450 pobj order,in
R805 T1452 T1453 aux to,allow
R806 T1453 T1439 advcl allow,are
R807 T1454 T1455 det a,understanding
R808 T1455 T1453 dobj understanding,allow
R809 T1456 T1455 amod full,understanding
R810 T1457 T1455 prep of,understanding
R811 T1458 T1459 det the,ways
R812 T1459 T1457 pobj ways,of
R813 T1460 T1459 amod many,ways
R814 T1461 T1462 prep in,go
R815 T1462 T1459 relcl go,ways
R816 T1463 T1461 pobj which,in
R817 T1464 T1465 compound photoreceptor,development
R818 T1465 T1462 nsubj development,go
R819 T1466 T1462 aux can,go
R821 T1467 T1462 advcl awry,go
R823 T1468 T1439 punct .,are